C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H395_LEIBR

TriTrypDb:

LbrM.01.0760 , LBRM2903_010014000

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H395

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H395

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.481
CLV_C14_Caspase3-7	274	278	PF00656	0.735
CLV_C14_Caspase3-7	40	44	PF00656	0.535
CLV_NRD_NRD_1	130	132	PF00675	0.536
CLV_NRD_NRD_1	298	300	PF00675	0.554
CLV_NRD_NRD_1	63	65	PF00675	0.797
CLV_NRD_NRD_1	77	79	PF00675	0.538
CLV_PCSK_FUR_1	296	300	PF00082	0.551
CLV_PCSK_KEX2_1	130	132	PF00082	0.553
CLV_PCSK_KEX2_1	298	300	PF00082	0.554
CLV_PCSK_KEX2_1	63	65	PF00082	0.797
CLV_PCSK_KEX2_1	77	79	PF00082	0.538
CLV_PCSK_SKI1_1	138	142	PF00082	0.551
CLV_PCSK_SKI1_1	268	272	PF00082	0.741
DEG_SPOP_SBC_1	110	114	PF00917	0.574
DEG_SPOP_SBC_1	29	33	PF00917	0.521
DOC_CYCLIN_yCln2_LP_2	386	392	PF00134	0.388
DOC_MAPK_gen_1	150	158	PF00069	0.570
DOC_MAPK_gen_1	304	312	PF00069	0.595
DOC_MAPK_gen_1	77	84	PF00069	0.496
DOC_MAPK_JIP1_4	299	305	PF00069	0.540
DOC_MAPK_JIP1_4	78	84	PF00069	0.493
DOC_PP1_RVXF_1	282	289	PF00149	0.518
DOC_PP1_RVXF_1	311	318	PF00149	0.602
DOC_USP7_MATH_1	109	113	PF00917	0.734
DOC_USP7_MATH_1	159	163	PF00917	0.534
DOC_USP7_MATH_1	17	21	PF00917	0.641
DOC_USP7_MATH_1	217	221	PF00917	0.651
DOC_USP7_MATH_1	23	27	PF00917	0.706
DOC_USP7_MATH_1	270	274	PF00917	0.722
DOC_USP7_MATH_1	275	279	PF00917	0.678
DOC_USP7_MATH_1	29	33	PF00917	0.665
DOC_USP7_MATH_1	333	337	PF00917	0.515
DOC_USP7_MATH_1	37	41	PF00917	0.579
DOC_USP7_MATH_1	52	56	PF00917	0.495
DOC_USP7_MATH_1	59	63	PF00917	0.511
DOC_USP7_MATH_1	95	99	PF00917	0.566
DOC_WW_Pin1_4	116	121	PF00397	0.595
DOC_WW_Pin1_4	2	7	PF00397	0.453
DOC_WW_Pin1_4	268	273	PF00397	0.749
DOC_WW_Pin1_4	33	38	PF00397	0.541
DOC_WW_Pin1_4	334	339	PF00397	0.547
DOC_WW_Pin1_4	406	411	PF00397	0.714
LIG_14-3-3_CanoR_1	94	100	PF00244	0.547
LIG_Actin_WH2_2	252	270	PF00022	0.350
LIG_BIR_III_4	382	386	PF00653	0.631
LIG_Clathr_ClatBox_1	227	231	PF01394	0.667
LIG_eIF4E_1	306	312	PF01652	0.588
LIG_FHA_1	222	228	PF00498	0.669
LIG_FHA_1	339	345	PF00498	0.731
LIG_FHA_2	34	40	PF00498	0.686
LIG_FHA_2	362	368	PF00498	0.410
LIG_MYND_1	46	50	PF01753	0.797
LIG_Pex14_1	14	18	PF04695	0.483
LIG_SH2_STAT5	314	317	PF00017	0.509
LIG_SH3_1	393	399	PF00018	0.470
LIG_SH3_3	115	121	PF00018	0.654
LIG_SH3_3	255	261	PF00018	0.479
LIG_SH3_3	393	399	PF00018	0.489
LIG_SH3_3	97	103	PF00018	0.682
LIG_SUMO_SIM_par_1	260	266	PF11976	0.620
LIG_TRAF2_1	126	129	PF00917	0.492
LIG_TRAF2_1	198	201	PF00917	0.477
MOD_CDC14_SPxK_1	409	412	PF00782	0.617
MOD_CDK_SPxK_1	406	412	PF00069	0.621
MOD_CK1_1	105	111	PF00069	0.659
MOD_CK1_1	204	210	PF00069	0.559
MOD_CK1_1	21	27	PF00069	0.693
MOD_CK1_1	278	284	PF00069	0.650
MOD_CK1_1	33	39	PF00069	0.647
MOD_CK1_1	336	342	PF00069	0.490
MOD_CK1_1	370	376	PF00069	0.677
MOD_CK1_1	71	77	PF00069	0.558
MOD_CK1_1	98	104	PF00069	0.612
MOD_CK2_1	33	39	PF00069	0.686
MOD_GlcNHglycan	104	107	PF01048	0.632
MOD_GlcNHglycan	113	116	PF01048	0.631
MOD_GlcNHglycan	159	162	PF01048	0.568
MOD_GlcNHglycan	195	198	PF01048	0.518
MOD_GlcNHglycan	20	23	PF01048	0.742
MOD_GlcNHglycan	203	206	PF01048	0.598
MOD_GlcNHglycan	219	222	PF01048	0.654
MOD_GlcNHglycan	240	243	PF01048	0.656
MOD_GlcNHglycan	273	276	PF01048	0.675
MOD_GlcNHglycan	277	281	PF01048	0.652
MOD_GlcNHglycan	32	35	PF01048	0.707
MOD_GlcNHglycan	330	333	PF01048	0.784
MOD_GlcNHglycan	372	375	PF01048	0.519
MOD_GlcNHglycan	54	57	PF01048	0.780
MOD_GlcNHglycan	87	90	PF01048	0.671
MOD_GlcNHglycan	97	100	PF01048	0.571
MOD_GSK3_1	105	112	PF00069	0.669
MOD_GSK3_1	17	24	PF00069	0.511
MOD_GSK3_1	207	214	PF00069	0.627
MOD_GSK3_1	217	224	PF00069	0.635
MOD_GSK3_1	271	278	PF00069	0.682
MOD_GSK3_1	29	36	PF00069	0.606
MOD_GSK3_1	333	340	PF00069	0.645
MOD_GSK3_1	94	101	PF00069	0.561
MOD_NEK2_1	141	146	PF00069	0.422
MOD_NEK2_1	18	23	PF00069	0.511
MOD_NEK2_1	30	35	PF00069	0.521
MOD_PKA_1	77	83	PF00069	0.605
MOD_PKA_2	141	147	PF00069	0.581
MOD_PKA_2	149	155	PF00069	0.616
MOD_PKA_2	201	207	PF00069	0.614
MOD_PKA_2	238	244	PF00069	0.752
MOD_PKA_2	77	83	PF00069	0.702
MOD_Plk_4	247	253	PF00069	0.520
MOD_Plk_4	254	260	PF00069	0.359
MOD_ProDKin_1	116	122	PF00069	0.594
MOD_ProDKin_1	2	8	PF00069	0.451
MOD_ProDKin_1	268	274	PF00069	0.752
MOD_ProDKin_1	33	39	PF00069	0.544
MOD_ProDKin_1	334	340	PF00069	0.546
MOD_ProDKin_1	406	412	PF00069	0.719
MOD_SUMO_for_1	288	291	PF00179	0.325
TRG_ER_diArg_1	130	132	PF00400	0.438
TRG_ER_diArg_1	298	300	PF00400	0.554
TRG_ER_diArg_1	45	48	PF00400	0.690
TRG_ER_diArg_1	63	65	PF00400	0.508
TRG_ER_diArg_1	77	79	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS86	Leptomonas seymouri	47%	95%
A0A3S7WNL4	Leishmania donovani	72%	85%
A4HRK3	Leishmania infantum	72%	85%
E9AC71	Leishmania major	69%	100%
E9AJG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	88%