Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H394_LEIBR

TriTrypDb:

LbrM.01.0750 , LBRM2903_010013800

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H394

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H394

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	304	306	PF00675	0.803
CLV_NRD_NRD_1	344	346	PF00675	0.572
CLV_NRD_NRD_1	441	443	PF00675	0.578
CLV_NRD_NRD_1	67	69	PF00675	0.726
CLV_NRD_NRD_1	8	10	PF00675	0.553
CLV_NRD_NRD_1	87	89	PF00675	0.621
CLV_PCSK_KEX2_1	303	305	PF00082	0.796
CLV_PCSK_KEX2_1	344	346	PF00082	0.572
CLV_PCSK_KEX2_1	441	443	PF00082	0.578
CLV_PCSK_KEX2_1	448	450	PF00082	0.515
CLV_PCSK_KEX2_1	67	69	PF00082	0.726
CLV_PCSK_KEX2_1	8	10	PF00082	0.553
CLV_PCSK_KEX2_1	87	89	PF00082	0.621
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.515
CLV_PCSK_SKI1_1	157	161	PF00082	0.490
CLV_PCSK_SKI1_1	476	480	PF00082	0.584
DEG_APCC_DBOX_1	284	292	PF00400	0.515
DEG_SPOP_SBC_1	381	385	PF00917	0.789
DEG_SPOP_SBC_1	77	81	PF00917	0.570
DOC_MAPK_gen_1	275	284	PF00069	0.515
DOC_MAPK_gen_1	344	351	PF00069	0.563
DOC_MAPK_gen_1	448	455	PF00069	0.643
DOC_PP1_RVXF_1	452	458	PF00149	0.639
DOC_USP7_MATH_1	111	115	PF00917	0.686
DOC_USP7_MATH_1	12	16	PF00917	0.575
DOC_USP7_MATH_1	166	170	PF00917	0.557
DOC_USP7_MATH_1	237	241	PF00917	0.581
DOC_USP7_MATH_1	252	256	PF00917	0.795
DOC_USP7_MATH_1	381	385	PF00917	0.731
DOC_USP7_MATH_1	458	462	PF00917	0.678
DOC_USP7_MATH_1	52	56	PF00917	0.758
DOC_WW_Pin1_4	140	145	PF00397	0.677
DOC_WW_Pin1_4	164	169	PF00397	0.410
DOC_WW_Pin1_4	238	243	PF00397	0.703
DOC_WW_Pin1_4	324	329	PF00397	0.536
DOC_WW_Pin1_4	364	369	PF00397	0.626
LIG_14-3-3_CanoR_1	17	21	PF00244	0.562
LIG_14-3-3_CanoR_1	382	392	PF00244	0.791
LIG_14-3-3_CanoR_1	419	426	PF00244	0.744
LIG_14-3-3_CanoR_1	476	481	PF00244	0.579
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_BIR_III_1	1	5	PF00653	0.543
LIG_BIR_III_3	1	5	PF00653	0.543
LIG_BIR_III_4	352	356	PF00653	0.703
LIG_CtBP_PxDLS_1	213	217	PF00389	0.556
LIG_FHA_1	104	110	PF00498	0.540
LIG_FHA_1	388	394	PF00498	0.595
LIG_FHA_1	473	479	PF00498	0.581
LIG_LIR_Apic_2	162	168	PF02991	0.511
LIG_LIR_Apic_2	431	435	PF02991	0.643
LIG_LIR_Gen_1	132	140	PF02991	0.581
LIG_LIR_Gen_1	167	178	PF02991	0.466
LIG_LIR_Nem_3	132	138	PF02991	0.586
LIG_LIR_Nem_3	167	173	PF02991	0.478
LIG_LIR_Nem_3	356	362	PF02991	0.587
LIG_LIR_Nem_3	410	414	PF02991	0.623
LIG_SH2_GRB2like	411	414	PF00017	0.726
LIG_SH2_PTP2	271	274	PF00017	0.477
LIG_SH2_SRC	261	264	PF00017	0.427
LIG_SH2_SRC	432	435	PF00017	0.555
LIG_SH2_STAT5	261	264	PF00017	0.427
LIG_SH2_STAT5	271	274	PF00017	0.477
LIG_SH2_STAT5	414	417	PF00017	0.530
LIG_SH2_STAT5	432	435	PF00017	0.555
LIG_SH3_3	118	124	PF00018	0.576
LIG_SH3_3	196	202	PF00018	0.573
LIG_SH3_3	28	34	PF00018	0.529
LIG_SH3_3	398	404	PF00018	0.563
LIG_SH3_3	43	49	PF00018	0.702
MOD_CK1_1	130	136	PF00069	0.614
MOD_CK1_1	142	148	PF00069	0.639
MOD_CK1_1	15	21	PF00069	0.649
MOD_CK1_1	22	28	PF00069	0.558
MOD_CK1_1	287	293	PF00069	0.533
MOD_CK1_1	384	390	PF00069	0.801
MOD_CK1_1	422	428	PF00069	0.572
MOD_CK1_1	461	467	PF00069	0.694
MOD_CK1_1	489	495	PF00069	0.552
MOD_CK1_1	56	62	PF00069	0.752
MOD_GlcNHglycan	101	104	PF01048	0.735
MOD_GlcNHglycan	129	132	PF01048	0.633
MOD_GlcNHglycan	14	17	PF01048	0.605
MOD_GlcNHglycan	180	183	PF01048	0.453
MOD_GlcNHglycan	189	192	PF01048	0.669
MOD_GlcNHglycan	202	205	PF01048	0.647
MOD_GlcNHglycan	21	24	PF01048	0.782
MOD_GlcNHglycan	306	309	PF01048	0.810
MOD_GlcNHglycan	319	322	PF01048	0.678
MOD_GlcNHglycan	336	339	PF01048	0.546
MOD_GlcNHglycan	42	45	PF01048	0.667
MOD_GlcNHglycan	488	491	PF01048	0.626
MOD_GlcNHglycan	55	58	PF01048	0.681
MOD_GlcNHglycan	60	63	PF01048	0.716
MOD_GSK3_1	12	19	PF00069	0.713
MOD_GSK3_1	127	134	PF00069	0.699
MOD_GSK3_1	139	146	PF00069	0.618
MOD_GSK3_1	250	257	PF00069	0.534
MOD_GSK3_1	334	341	PF00069	0.502
MOD_GSK3_1	36	43	PF00069	0.706
MOD_GSK3_1	369	376	PF00069	0.656
MOD_GSK3_1	380	387	PF00069	0.669
MOD_GSK3_1	403	410	PF00069	0.647
MOD_GSK3_1	472	479	PF00069	0.577
MOD_GSK3_1	485	492	PF00069	0.464
MOD_GSK3_1	52	59	PF00069	0.588
MOD_GSK3_1	76	83	PF00069	0.709
MOD_GSK3_1	99	106	PF00069	0.762
MOD_N-GLC_2	413	415	PF02516	0.548
MOD_N-GLC_2	421	423	PF02516	0.521
MOD_NEK2_1	180	185	PF00069	0.465
MOD_NEK2_2	112	117	PF00069	0.556
MOD_NEK2_2	436	441	PF00069	0.476
MOD_OFUCOSY	417	423	PF10250	0.744
MOD_PIKK_1	290	296	PF00454	0.529
MOD_PIKK_1	461	467	PF00454	0.557
MOD_PIKK_1	78	84	PF00454	0.573
MOD_PKA_1	304	310	PF00069	0.800
MOD_PKA_2	16	22	PF00069	0.600
MOD_PKA_2	284	290	PF00069	0.589
MOD_PKA_2	304	310	PF00069	0.800
MOD_PKA_2	317	323	PF00069	0.597
MOD_PKA_2	381	387	PF00069	0.782
MOD_PKA_2	77	83	PF00069	0.791
MOD_PKB_1	474	482	PF00069	0.579
MOD_Plk_4	254	260	PF00069	0.494
MOD_Plk_4	428	434	PF00069	0.570
MOD_Plk_4	458	464	PF00069	0.677
MOD_ProDKin_1	140	146	PF00069	0.670
MOD_ProDKin_1	164	170	PF00069	0.405
MOD_ProDKin_1	238	244	PF00069	0.702
MOD_ProDKin_1	324	330	PF00069	0.532
MOD_ProDKin_1	364	370	PF00069	0.626
MOD_SUMO_for_1	211	214	PF00179	0.564
TRG_DiLeu_BaEn_1	451	456	PF01217	0.631
TRG_DiLeu_LyEn_5	451	456	PF01217	0.631
TRG_ENDOCYTIC_2	271	274	PF00928	0.477
TRG_ER_diArg_1	303	305	PF00400	0.803
TRG_ER_diArg_1	440	442	PF00400	0.561
TRG_ER_diArg_1	473	476	PF00400	0.615
TRG_ER_diArg_1	66	68	PF00400	0.549
TRG_ER_diArg_1	87	89	PF00400	0.718
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	454	459	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB0	Leptomonas seymouri	43%	93%
A0A451EJD3	Leishmania donovani	61%	94%
A4HRK2	Leishmania infantum	61%	94%
E9AC70	Leishmania major	57%	99%
E9AJG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	97%