Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H391_LEIBR

TriTrypDb:

LbrM.01.0710 , LBRM2903_010013000

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H391

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H391

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.838
CLV_C14_Caspase3-7	541	545	PF00656	0.700
CLV_NRD_NRD_1	14	16	PF00675	0.602
CLV_NRD_NRD_1	173	175	PF00675	0.702
CLV_NRD_NRD_1	281	283	PF00675	0.633
CLV_NRD_NRD_1	489	491	PF00675	0.651
CLV_NRD_NRD_1	494	496	PF00675	0.596
CLV_NRD_NRD_1	695	697	PF00675	0.504
CLV_NRD_NRD_1	720	722	PF00675	0.613
CLV_NRD_NRD_1	737	739	PF00675	0.571
CLV_PCSK_KEX2_1	14	16	PF00082	0.602
CLV_PCSK_KEX2_1	173	175	PF00082	0.702
CLV_PCSK_KEX2_1	281	283	PF00082	0.633
CLV_PCSK_KEX2_1	304	306	PF00082	0.558
CLV_PCSK_KEX2_1	489	491	PF00082	0.661
CLV_PCSK_KEX2_1	494	496	PF00082	0.624
CLV_PCSK_KEX2_1	51	53	PF00082	0.466
CLV_PCSK_KEX2_1	568	570	PF00082	0.633
CLV_PCSK_KEX2_1	658	660	PF00082	0.643
CLV_PCSK_KEX2_1	694	696	PF00082	0.502
CLV_PCSK_KEX2_1	720	722	PF00082	0.613
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.612
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.466
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.643
CLV_PCSK_PC1ET2_1	658	660	PF00082	0.654
CLV_PCSK_PC7_1	169	175	PF00082	0.689
CLV_PCSK_PC7_1	490	496	PF00082	0.744
CLV_PCSK_SKI1_1	169	173	PF00082	0.684
CLV_PCSK_SKI1_1	272	276	PF00082	0.584
CLV_PCSK_SKI1_1	281	285	PF00082	0.623
CLV_PCSK_SKI1_1	335	339	PF00082	0.472
CLV_PCSK_SKI1_1	4	8	PF00082	0.611
CLV_PCSK_SKI1_1	490	494	PF00082	0.742
CLV_PCSK_SKI1_1	696	700	PF00082	0.582
CLV_Separin_Metazoa	608	612	PF03568	0.574
DEG_Nend_Nbox_1	1	3	PF02207	0.474
DEG_SCF_FBW7_2	601	608	PF00400	0.495
DEG_SPOP_SBC_1	227	231	PF00917	0.592
DOC_CKS1_1	257	262	PF01111	0.777
DOC_CYCLIN_yCln2_LP_2	312	318	PF00134	0.502
DOC_MAPK_gen_1	14	20	PF00069	0.574
DOC_MAPK_gen_1	494	502	PF00069	0.603
DOC_MAPK_gen_1	568	575	PF00069	0.591
DOC_MAPK_HePTP_8	318	330	PF00069	0.524
DOC_MAPK_MEF2A_6	205	214	PF00069	0.566
DOC_MAPK_MEF2A_6	321	330	PF00069	0.518
DOC_MAPK_MEF2A_6	593	600	PF00069	0.555
DOC_MAPK_MEF2A_6	602	609	PF00069	0.501
DOC_PP1_RVXF_1	651	657	PF00149	0.614
DOC_PP2B_LxvP_1	610	613	PF13499	0.487
DOC_PP4_FxxP_1	257	260	PF00568	0.782
DOC_USP7_MATH_1	158	162	PF00917	0.704
DOC_USP7_MATH_1	208	212	PF00917	0.793
DOC_USP7_MATH_1	213	217	PF00917	0.741
DOC_USP7_MATH_1	219	223	PF00917	0.640
DOC_USP7_MATH_1	246	250	PF00917	0.593
DOC_USP7_MATH_1	267	271	PF00917	0.713
DOC_USP7_MATH_1	399	403	PF00917	0.660
DOC_USP7_MATH_1	460	464	PF00917	0.833
DOC_USP7_MATH_1	515	519	PF00917	0.528
DOC_USP7_MATH_1	531	535	PF00917	0.702
DOC_USP7_MATH_1	613	617	PF00917	0.619
DOC_USP7_MATH_1	646	650	PF00917	0.661
DOC_WW_Pin1_4	134	139	PF00397	0.736
DOC_WW_Pin1_4	195	200	PF00397	0.724
DOC_WW_Pin1_4	22	27	PF00397	0.547
DOC_WW_Pin1_4	256	261	PF00397	0.768
DOC_WW_Pin1_4	288	293	PF00397	0.490
DOC_WW_Pin1_4	392	397	PF00397	0.586
DOC_WW_Pin1_4	539	544	PF00397	0.726
DOC_WW_Pin1_4	601	606	PF00397	0.513
DOC_WW_Pin1_4	70	75	PF00397	0.683
DOC_WW_Pin1_4	704	709	PF00397	0.562
LIG_14-3-3_CanoR_1	173	177	PF00244	0.769
LIG_14-3-3_CanoR_1	268	272	PF00244	0.454
LIG_14-3-3_CanoR_1	456	460	PF00244	0.590
LIG_14-3-3_CanoR_1	720	726	PF00244	0.395
LIG_BIR_III_4	141	145	PF00653	0.594
LIG_BRCT_BRCA1_1	26	30	PF00533	0.353
LIG_CSL_BTD_1	377	380	PF09270	0.555
LIG_deltaCOP1_diTrp_1	555	564	PF00928	0.668
LIG_eIF4E_1	662	668	PF01652	0.665
LIG_FHA_1	103	109	PF00498	0.550
LIG_FHA_1	26	32	PF00498	0.609
LIG_FHA_1	291	297	PF00498	0.635
LIG_FHA_1	568	574	PF00498	0.573
LIG_FHA_1	602	608	PF00498	0.519
LIG_FHA_1	705	711	PF00498	0.566
LIG_FHA_2	227	233	PF00498	0.842
LIG_FHA_2	257	263	PF00498	0.629
LIG_FHA_2	320	326	PF00498	0.493
LIG_FHA_2	363	369	PF00498	0.633
LIG_FHA_2	481	487	PF00498	0.679
LIG_FHA_2	539	545	PF00498	0.789
LIG_Integrin_RGD_1	659	661	PF01839	0.744
LIG_LIR_Apic_2	255	260	PF02991	0.787
LIG_LIR_Apic_2	55	60	PF02991	0.633
LIG_LIR_Gen_1	320	330	PF02991	0.523
LIG_LIR_Gen_1	555	565	PF02991	0.564
LIG_LIR_Gen_1	619	626	PF02991	0.589
LIG_LIR_Gen_1	640	647	PF02991	0.609
LIG_LIR_Nem_3	110	115	PF02991	0.571
LIG_LIR_Nem_3	270	274	PF02991	0.525
LIG_LIR_Nem_3	310	316	PF02991	0.514
LIG_LIR_Nem_3	320	326	PF02991	0.626
LIG_LIR_Nem_3	377	381	PF02991	0.557
LIG_LIR_Nem_3	421	425	PF02991	0.668
LIG_LIR_Nem_3	555	561	PF02991	0.658
LIG_LIR_Nem_3	619	624	PF02991	0.441
LIG_LIR_Nem_3	640	644	PF02991	0.609
LIG_MAD2	113	121	PF02301	0.482
LIG_MAD2	335	343	PF02301	0.475
LIG_MLH1_MIPbox_1	26	30	PF16413	0.353
LIG_MYND_1	726	730	PF01753	0.568
LIG_Pex14_1	354	358	PF04695	0.499
LIG_REV1ctd_RIR_1	27	35	PF16727	0.628
LIG_RPA_C_Fungi	441	453	PF08784	0.634
LIG_SH2_CRK	112	116	PF00017	0.472
LIG_SH2_CRK	271	275	PF00017	0.585
LIG_SH2_CRK	309	313	PF00017	0.461
LIG_SH2_NCK_1	313	317	PF00017	0.503
LIG_SH2_NCK_1	57	61	PF00017	0.651
LIG_SH2_PTP2	17	20	PF00017	0.553
LIG_SH2_SRC	57	60	PF00017	0.649
LIG_SH2_STAP1	309	313	PF00017	0.461
LIG_SH2_STAT5	17	20	PF00017	0.553
LIG_SH2_STAT5	273	276	PF00017	0.683
LIG_SH2_STAT5	309	312	PF00017	0.458
LIG_SH2_STAT5	61	64	PF00017	0.658
LIG_SH2_STAT5	621	624	PF00017	0.413
LIG_SH3_2	215	220	PF14604	0.564
LIG_SH3_3	118	124	PF00018	0.503
LIG_SH3_3	128	134	PF00018	0.815
LIG_SH3_3	20	26	PF00018	0.555
LIG_SH3_3	209	215	PF00018	0.699
LIG_SH3_3	340	346	PF00018	0.527
LIG_SH3_3	367	373	PF00018	0.714
LIG_SH3_3	390	396	PF00018	0.699
LIG_SH3_3	591	597	PF00018	0.626
LIG_SH3_3	66	72	PF00018	0.668
LIG_SH3_3	724	730	PF00018	0.503
LIG_SUMO_SIM_anti_2	322	328	PF11976	0.623
LIG_SUMO_SIM_anti_2	552	560	PF11976	0.686
LIG_SUMO_SIM_anti_2	606	611	PF11976	0.422
LIG_SUMO_SIM_anti_2	681	687	PF11976	0.619
LIG_SUMO_SIM_par_1	105	111	PF11976	0.583
LIG_SUMO_SIM_par_1	314	320	PF11976	0.525
LIG_TRAF2_1	283	286	PF00917	0.562
LIG_TRAF2_1	617	620	PF00917	0.549
LIG_TYR_ITIM	311	316	PF00017	0.584
LIG_TYR_ITSM	108	115	PF00017	0.461
LIG_UBA3_1	41	49	PF00899	0.448
MOD_CDC14_SPxK_1	291	294	PF00782	0.545
MOD_CDK_SPxK_1	288	294	PF00069	0.536
MOD_CK1_1	162	168	PF00069	0.536
MOD_CK1_1	233	239	PF00069	0.842
MOD_CK1_1	25	31	PF00069	0.467
MOD_CK1_1	384	390	PF00069	0.736
MOD_CK1_1	395	401	PF00069	0.582
MOD_CK1_1	534	540	PF00069	0.708
MOD_CK1_1	547	553	PF00069	0.721
MOD_CK1_1	559	565	PF00069	0.654
MOD_CK1_1	67	73	PF00069	0.670
MOD_CK2_1	319	325	PF00069	0.542
MOD_CK2_1	362	368	PF00069	0.625
MOD_CK2_1	399	405	PF00069	0.698
MOD_CK2_1	418	424	PF00069	0.667
MOD_CK2_1	460	466	PF00069	0.801
MOD_CK2_1	480	486	PF00069	0.778
MOD_CK2_1	589	595	PF00069	0.571
MOD_CK2_1	613	619	PF00069	0.619
MOD_Cter_Amidation	279	282	PF01082	0.617
MOD_Cter_Amidation	736	739	PF01082	0.647
MOD_GlcNHglycan	141	145	PF01048	0.695
MOD_GlcNHglycan	161	164	PF01048	0.629
MOD_GlcNHglycan	365	368	PF01048	0.552
MOD_GlcNHglycan	383	386	PF01048	0.497
MOD_GlcNHglycan	401	404	PF01048	0.650
MOD_GlcNHglycan	457	460	PF01048	0.721
MOD_GlcNHglycan	517	520	PF01048	0.543
MOD_GlcNHglycan	549	552	PF01048	0.671
MOD_GlcNHglycan	615	618	PF01048	0.641
MOD_GlcNHglycan	686	689	PF01048	0.607
MOD_GlcNHglycan	702	705	PF01048	0.570
MOD_GlcNHglycan	89	92	PF01048	0.614
MOD_GSK3_1	158	165	PF00069	0.742
MOD_GSK3_1	18	25	PF00069	0.554
MOD_GSK3_1	226	233	PF00069	0.826
MOD_GSK3_1	237	244	PF00069	0.765
MOD_GSK3_1	252	259	PF00069	0.648
MOD_GSK3_1	379	386	PF00069	0.682
MOD_GSK3_1	388	395	PF00069	0.735
MOD_GSK3_1	534	541	PF00069	0.585
MOD_GSK3_1	559	566	PF00069	0.516
MOD_GSK3_1	627	634	PF00069	0.470
MOD_GSK3_1	680	687	PF00069	0.527
MOD_GSK3_1	700	707	PF00069	0.639
MOD_N-GLC_1	547	552	PF02516	0.774
MOD_NEK2_1	102	107	PF00069	0.547
MOD_NEK2_1	172	177	PF00069	0.804
MOD_NEK2_1	381	386	PF00069	0.569
MOD_NEK2_2	715	720	PF00069	0.608
MOD_PIKK_1	177	183	PF00454	0.784
MOD_PIKK_1	567	573	PF00454	0.526
MOD_PIKK_1	67	73	PF00454	0.670
MOD_PK_1	119	125	PF00069	0.682
MOD_PKA_2	159	165	PF00069	0.552
MOD_PKA_2	172	178	PF00069	0.807
MOD_PKA_2	227	233	PF00069	0.590
MOD_PKA_2	267	273	PF00069	0.460
MOD_PKA_2	445	451	PF00069	0.635
MOD_PKA_2	455	461	PF00069	0.651
MOD_PKA_2	588	594	PF00069	0.579
MOD_Plk_1	102	108	PF00069	0.536
MOD_Plk_1	319	325	PF00069	0.542
MOD_Plk_1	559	565	PF00069	0.667
MOD_Plk_4	102	108	PF00069	0.536
MOD_Plk_4	246	252	PF00069	0.761
MOD_Plk_4	25	31	PF00069	0.609
MOD_Plk_4	307	313	PF00069	0.518
MOD_Plk_4	559	565	PF00069	0.660
MOD_Plk_4	646	652	PF00069	0.601
MOD_Plk_4	680	686	PF00069	0.622
MOD_ProDKin_1	134	140	PF00069	0.738
MOD_ProDKin_1	195	201	PF00069	0.723
MOD_ProDKin_1	22	28	PF00069	0.538
MOD_ProDKin_1	256	262	PF00069	0.765
MOD_ProDKin_1	288	294	PF00069	0.493
MOD_ProDKin_1	392	398	PF00069	0.585
MOD_ProDKin_1	539	545	PF00069	0.727
MOD_ProDKin_1	601	607	PF00069	0.532
MOD_ProDKin_1	70	76	PF00069	0.688
MOD_ProDKin_1	704	710	PF00069	0.556
TRG_DiLeu_BaEn_3	80	86	PF01217	0.636
TRG_DiLeu_BaLyEn_6	367	372	PF01217	0.600
TRG_ENDOCYTIC_2	112	115	PF00928	0.490
TRG_ENDOCYTIC_2	17	20	PF00928	0.553
TRG_ENDOCYTIC_2	254	257	PF00928	0.704
TRG_ENDOCYTIC_2	271	274	PF00928	0.590
TRG_ENDOCYTIC_2	309	312	PF00928	0.458
TRG_ENDOCYTIC_2	313	316	PF00928	0.492
TRG_ENDOCYTIC_2	621	624	PF00928	0.472
TRG_ENDOCYTIC_2	641	644	PF00928	0.391
TRG_ENDOCYTIC_2	671	674	PF00928	0.551
TRG_ER_diArg_1	13	15	PF00400	0.583
TRG_ER_diArg_1	172	174	PF00400	0.697
TRG_ER_diArg_1	31	34	PF00400	0.548
TRG_ER_diArg_1	493	495	PF00400	0.620
TRG_ER_diArg_1	581	584	PF00400	0.564
TRG_ER_diArg_1	694	696	PF00400	0.506
TRG_ER_diArg_1	719	721	PF00400	0.610
TRG_Pf-PMV_PEXEL_1	282	286	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II66	Leptomonas seymouri	58%	98%
A0A3S5H4W8	Leishmania donovani	76%	98%
A4HRJ7	Leishmania infantum	76%	98%
E9AC65	Leishmania major	76%	98%
E9AJG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%