PLAC8 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PLAC8 family, putative

Species:

Leishmania braziliensis

UniProt:

A4H387_LEIBR

TriTrypDb:

LbrM.01.0670 , LBRM2903_010012400

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H387

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H387

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.502
CLV_NRD_NRD_1	77	79	PF00675	0.504
CLV_PCSK_KEX2_1	77	79	PF00082	0.504
DEG_APCC_DBOX_1	158	166	PF00400	0.253
DOC_CYCLIN_yCln2_LP_2	225	231	PF00134	0.594
DOC_PP2B_LxvP_1	225	228	PF13499	0.565
DOC_USP7_MATH_1	136	140	PF00917	0.480
DOC_USP7_MATH_1	7	11	PF00917	0.618
DOC_USP7_UBL2_3	45	49	PF12436	0.522
LIG_14-3-3_CanoR_1	180	190	PF00244	0.253
LIG_14-3-3_CanoR_1	222	226	PF00244	0.599
LIG_BIR_II_1	1	5	PF00653	0.775
LIG_BRCT_BRCA1_1	81	85	PF00533	0.256
LIG_Clathr_ClatBox_1	127	131	PF01394	0.343
LIG_deltaCOP1_diTrp_1	213	219	PF00928	0.715
LIG_eIF4E_1	146	152	PF01652	0.253
LIG_eIF4E_1	30	36	PF01652	0.501
LIG_FHA_1	114	120	PF00498	0.389
LIG_FHA_1	182	188	PF00498	0.393
LIG_FHA_1	196	202	PF00498	0.246
LIG_FHA_1	60	66	PF00498	0.532
LIG_FHA_1	99	105	PF00498	0.253
LIG_FHA_2	51	57	PF00498	0.545
LIG_LIR_LC3C_4	32	37	PF02991	0.501
LIG_NRBOX	186	192	PF00104	0.253
LIG_SH2_STAT5	102	105	PF00017	0.343
LIG_SH2_STAT5	120	123	PF00017	0.343
LIG_SH2_STAT5	146	149	PF00017	0.440
LIG_SH2_STAT5	150	153	PF00017	0.354
LIG_SH3_3	116	122	PF00018	0.253
LIG_SUMO_SIM_anti_2	183	192	PF11976	0.428
LIG_SUMO_SIM_par_1	189	194	PF11976	0.375
LIG_WW_3	74	78	PF00397	0.506
MOD_CK1_1	135	141	PF00069	0.480
MOD_CK1_1	183	189	PF00069	0.374
MOD_CK1_1	220	226	PF00069	0.580
MOD_CK2_1	26	32	PF00069	0.734
MOD_CK2_1	57	63	PF00069	0.657
MOD_GlcNHglycan	105	108	PF01048	0.515
MOD_GlcNHglycan	134	137	PF01048	0.484
MOD_GlcNHglycan	153	156	PF01048	0.489
MOD_GlcNHglycan	175	178	PF01048	0.340
MOD_GlcNHglycan	81	84	PF01048	0.352
MOD_GSK3_1	132	139	PF00069	0.348
MOD_GSK3_1	191	198	PF00069	0.290
MOD_GSK3_1	217	224	PF00069	0.740
MOD_N-GLC_1	113	118	PF02516	0.352
MOD_N-GLC_1	220	225	PF02516	0.498
MOD_N-GLC_1	57	62	PF02516	0.534
MOD_NEK2_1	113	118	PF00069	0.355
MOD_NEK2_1	151	156	PF00069	0.486
MOD_NEK2_1	191	196	PF00069	0.253
MOD_PIKK_1	7	13	PF00454	0.529
MOD_PKA_2	221	227	PF00069	0.725
MOD_Plk_1	220	226	PF00069	0.515
MOD_Plk_1	26	32	PF00069	0.542
MOD_Plk_2-3	50	56	PF00069	0.532
MOD_Plk_4	141	147	PF00069	0.367
MOD_Plk_4	183	189	PF00069	0.440
TRG_ER_diArg_1	156	159	PF00400	0.369
TRG_ER_diArg_1	76	78	PF00400	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I201	Leptomonas seymouri	43%	100%
A0A451EJC3	Leishmania donovani	66%	100%
A4HRJ2	Leishmania infantum	66%	100%
E9AC60	Leishmania major	67%	97%
E9AJF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%