Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H386_LEIBR

TriTrypDb:

LbrM.01.0660 , LBRM2903_010012300

Length:

843

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H386

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H386

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.799
CLV_C14_Caspase3-7	22	26	PF00656	0.496
CLV_C14_Caspase3-7	304	308	PF00656	0.549
CLV_C14_Caspase3-7	350	354	PF00656	0.722
CLV_C14_Caspase3-7	713	717	PF00656	0.570
CLV_NRD_NRD_1	103	105	PF00675	0.738
CLV_NRD_NRD_1	116	118	PF00675	0.601
CLV_NRD_NRD_1	206	208	PF00675	0.598
CLV_NRD_NRD_1	273	275	PF00675	0.662
CLV_NRD_NRD_1	285	287	PF00675	0.602
CLV_NRD_NRD_1	40	42	PF00675	0.640
CLV_NRD_NRD_1	569	571	PF00675	0.562
CLV_NRD_NRD_1	644	646	PF00675	0.715
CLV_NRD_NRD_1	723	725	PF00675	0.561
CLV_PCSK_FUR_1	101	105	PF00082	0.629
CLV_PCSK_KEX2_1	103	105	PF00082	0.738
CLV_PCSK_KEX2_1	115	117	PF00082	0.624
CLV_PCSK_KEX2_1	206	208	PF00082	0.598
CLV_PCSK_KEX2_1	273	275	PF00082	0.671
CLV_PCSK_KEX2_1	285	287	PF00082	0.594
CLV_PCSK_KEX2_1	40	42	PF00082	0.647
CLV_PCSK_KEX2_1	644	646	PF00082	0.715
CLV_PCSK_KEX2_1	722	724	PF00082	0.565
CLV_PCSK_SKI1_1	27	31	PF00082	0.603
CLV_PCSK_SKI1_1	34	38	PF00082	0.580
CLV_PCSK_SKI1_1	62	66	PF00082	0.549
CLV_PCSK_SKI1_1	698	702	PF00082	0.713
DEG_APCC_DBOX_1	26	34	PF00400	0.534
DEG_APCC_DBOX_1	761	769	PF00400	0.565
DEG_SCF_FBW7_1	325	331	PF00400	0.775
DEG_SCF_FBW7_1	383	390	PF00400	0.546
DEG_SCF_FBW7_1	781	787	PF00400	0.584
DEG_SPOP_SBC_1	300	304	PF00917	0.561
DEG_SPOP_SBC_1	328	332	PF00917	0.572
DOC_ANK_TNKS_1	102	109	PF00023	0.659
DOC_CKS1_1	325	330	PF01111	0.836
DOC_CKS1_1	435	440	PF01111	0.570
DOC_CKS1_1	741	746	PF01111	0.567
DOC_CKS1_1	781	786	PF01111	0.585
DOC_CYCLIN_RxL_1	31	39	PF00134	0.459
DOC_MAPK_DCC_7	727	736	PF00069	0.556
DOC_MAPK_MEF2A_6	812	821	PF00069	0.537
DOC_PP2B_LxvP_1	629	632	PF13499	0.533
DOC_PP2B_LxvP_1	688	691	PF13499	0.546
DOC_PP2B_LxvP_1	734	737	PF13499	0.549
DOC_PP4_FxxP_1	389	392	PF00568	0.529
DOC_SPAK_OSR1_1	44	48	PF12202	0.529
DOC_USP7_MATH_1	133	137	PF00917	0.540
DOC_USP7_MATH_1	147	151	PF00917	0.511
DOC_USP7_MATH_1	215	219	PF00917	0.613
DOC_USP7_MATH_1	228	232	PF00917	0.671
DOC_USP7_MATH_1	260	264	PF00917	0.605
DOC_USP7_MATH_1	300	304	PF00917	0.655
DOC_USP7_MATH_1	316	320	PF00917	0.562
DOC_USP7_MATH_1	329	333	PF00917	0.630
DOC_USP7_MATH_1	392	396	PF00917	0.672
DOC_USP7_MATH_1	400	404	PF00917	0.625
DOC_USP7_MATH_1	57	61	PF00917	0.705
DOC_USP7_MATH_1	7	11	PF00917	0.570
DOC_USP7_MATH_1	714	718	PF00917	0.568
DOC_WW_Pin1_4	137	142	PF00397	0.689
DOC_WW_Pin1_4	165	170	PF00397	0.558
DOC_WW_Pin1_4	208	213	PF00397	0.693
DOC_WW_Pin1_4	233	238	PF00397	0.544
DOC_WW_Pin1_4	317	322	PF00397	0.677
DOC_WW_Pin1_4	324	329	PF00397	0.784
DOC_WW_Pin1_4	339	344	PF00397	0.553
DOC_WW_Pin1_4	383	388	PF00397	0.643
DOC_WW_Pin1_4	390	395	PF00397	0.613
DOC_WW_Pin1_4	411	416	PF00397	0.699
DOC_WW_Pin1_4	434	439	PF00397	0.687
DOC_WW_Pin1_4	683	688	PF00397	0.734
DOC_WW_Pin1_4	700	705	PF00397	0.552
DOC_WW_Pin1_4	740	745	PF00397	0.560
DOC_WW_Pin1_4	780	785	PF00397	0.583
DOC_WW_Pin1_4	9	14	PF00397	0.698
LIG_14-3-3_CanoR_1	173	178	PF00244	0.702
LIG_14-3-3_CanoR_1	229	233	PF00244	0.643
LIG_14-3-3_CanoR_1	285	290	PF00244	0.684
LIG_14-3-3_CanoR_1	292	296	PF00244	0.597
LIG_14-3-3_CanoR_1	463	472	PF00244	0.620
LIG_14-3-3_CanoR_1	606	614	PF00244	0.537
LIG_14-3-3_CanoR_1	664	673	PF00244	0.708
LIG_14-3-3_CanoR_1	698	704	PF00244	0.687
LIG_14-3-3_CanoR_1	75	81	PF00244	0.627
LIG_14-3-3_CanoR_1	762	768	PF00244	0.727
LIG_14-3-3_CanoR_1	818	824	PF00244	0.548
LIG_Actin_WH2_2	631	646	PF00022	0.547
LIG_BIR_II_1	1	5	PF00653	0.642
LIG_BIR_III_2	491	495	PF00653	0.651
LIG_BIR_III_4	307	311	PF00653	0.553
LIG_CaM_NSCaTE_8	461	468	PF13499	0.646
LIG_EVH1_1	166	170	PF00568	0.531
LIG_FHA_1	147	153	PF00498	0.544
LIG_FHA_1	200	206	PF00498	0.639
LIG_FHA_1	340	346	PF00498	0.599
LIG_FHA_1	482	488	PF00498	0.702
LIG_FHA_1	589	595	PF00498	0.541
LIG_FHA_1	634	640	PF00498	0.555
LIG_FHA_1	808	814	PF00498	0.700
LIG_FHA_2	219	225	PF00498	0.662
LIG_FHA_2	329	335	PF00498	0.646
LIG_FHA_2	339	345	PF00498	0.726
LIG_FHA_2	625	631	PF00498	0.563
LIG_FHA_2	711	717	PF00498	0.572
LIG_FHA_2	756	762	PF00498	0.591
LIG_LIR_Apic_2	386	392	PF02991	0.533
LIG_LIR_Nem_3	15	19	PF02991	0.656
LIG_LIR_Nem_3	176	181	PF02991	0.714
LIG_LIR_Nem_3	503	509	PF02991	0.583
LIG_LIR_Nem_3	517	522	PF02991	0.414
LIG_PTAP_UEV_1	118	123	PF05743	0.728
LIG_RPA_C_Fungi	718	730	PF08784	0.558
LIG_SH2_CRK	287	291	PF00017	0.554
LIG_SH2_NCK_1	287	291	PF00017	0.554
LIG_SH2_STAP1	189	193	PF00017	0.566
LIG_SH2_STAT5	521	524	PF00017	0.588
LIG_SH3_1	104	110	PF00018	0.638
LIG_SH3_1	116	122	PF00018	0.702
LIG_SH3_1	322	328	PF00018	0.574
LIG_SH3_2	280	285	PF14604	0.726
LIG_SH3_2	435	440	PF14604	0.570
LIG_SH3_2	687	692	PF14604	0.714
LIG_SH3_3	104	110	PF00018	0.638
LIG_SH3_3	116	122	PF00018	0.702
LIG_SH3_3	152	158	PF00018	0.589
LIG_SH3_3	164	170	PF00018	0.670
LIG_SH3_3	192	198	PF00018	0.525
LIG_SH3_3	277	283	PF00018	0.708
LIG_SH3_3	322	328	PF00018	0.823
LIG_SH3_3	412	418	PF00018	0.566
LIG_SH3_3	432	438	PF00018	0.677
LIG_SH3_3	592	598	PF00018	0.542
LIG_SH3_3	635	641	PF00018	0.552
LIG_SH3_3	684	690	PF00018	0.724
LIG_SH3_3	778	784	PF00018	0.586
LIG_SH3_3	797	803	PF00018	0.534
LIG_SH3_3	830	836	PF00018	0.575
LIG_SUMO_SIM_anti_2	612	618	PF11976	0.523
LIG_SUMO_SIM_anti_2	764	769	PF11976	0.562
LIG_SUMO_SIM_par_1	148	156	PF11976	0.580
LIG_UBA3_1	313	322	PF00899	0.565
LIG_WW_3	416	420	PF00397	0.574
MOD_CDC14_SPxK_1	689	692	PF00782	0.708
MOD_CDK_SPK_2	317	322	PF00069	0.584
MOD_CDK_SPxK_1	434	440	PF00069	0.572
MOD_CDK_SPxK_1	686	692	PF00069	0.716
MOD_CDK_SPxxK_3	233	240	PF00069	0.547
MOD_CK1_1	12	18	PF00069	0.681
MOD_CK1_1	136	142	PF00069	0.643
MOD_CK1_1	156	162	PF00069	0.545
MOD_CK1_1	199	205	PF00069	0.765
MOD_CK1_1	21	27	PF00069	0.516
MOD_CK1_1	218	224	PF00069	0.596
MOD_CK1_1	288	294	PF00069	0.784
MOD_CK1_1	302	308	PF00069	0.635
MOD_CK1_1	395	401	PF00069	0.698
MOD_CK1_1	439	445	PF00069	0.742
MOD_CK1_1	446	452	PF00069	0.609
MOD_CK1_1	466	472	PF00069	0.625
MOD_CK1_1	481	487	PF00069	0.600
MOD_CK1_1	549	555	PF00069	0.684
MOD_CK1_1	612	618	PF00069	0.584
MOD_CK1_1	633	639	PF00069	0.711
MOD_CK1_1	66	72	PF00069	0.560
MOD_CK1_1	665	671	PF00069	0.713
MOD_CK1_1	672	678	PF00069	0.677
MOD_CK1_1	686	692	PF00069	0.663
MOD_CK1_1	699	705	PF00069	0.598
MOD_CK1_1	73	79	PF00069	0.544
MOD_CK2_1	218	224	PF00069	0.667
MOD_CK2_1	260	266	PF00069	0.535
MOD_CK2_1	624	630	PF00069	0.571
MOD_CK2_1	755	761	PF00069	0.585
MOD_CK2_1	784	790	PF00069	0.655
MOD_Cter_Amidation	113	116	PF01082	0.588
MOD_DYRK1A_RPxSP_1	210	214	PF00069	0.574
MOD_GlcNHglycan	119	122	PF01048	0.728
MOD_GlcNHglycan	131	134	PF01048	0.572
MOD_GlcNHglycan	149	152	PF01048	0.658
MOD_GlcNHglycan	158	161	PF01048	0.591
MOD_GlcNHglycan	198	201	PF01048	0.668
MOD_GlcNHglycan	217	220	PF01048	0.711
MOD_GlcNHglycan	224	228	PF01048	0.648
MOD_GlcNHglycan	276	279	PF01048	0.702
MOD_GlcNHglycan	296	299	PF01048	0.644
MOD_GlcNHglycan	307	311	PF01048	0.638
MOD_GlcNHglycan	376	379	PF01048	0.606
MOD_GlcNHglycan	4	8	PF01048	0.702
MOD_GlcNHglycan	445	448	PF01048	0.581
MOD_GlcNHglycan	469	472	PF01048	0.687
MOD_GlcNHglycan	546	549	PF01048	0.716
MOD_GlcNHglycan	566	569	PF01048	0.534
MOD_GlcNHglycan	59	62	PF01048	0.613
MOD_GlcNHglycan	611	614	PF01048	0.591
MOD_GlcNHglycan	646	649	PF01048	0.611
MOD_GlcNHglycan	693	696	PF01048	0.582
MOD_GlcNHglycan	698	701	PF01048	0.566
MOD_GlcNHglycan	748	751	PF01048	0.577
MOD_GlcNHglycan	758	761	PF01048	0.542
MOD_GlcNHglycan	800	803	PF01048	0.556
MOD_GSK3_1	129	136	PF00069	0.724
MOD_GSK3_1	165	172	PF00069	0.555
MOD_GSK3_1	206	213	PF00069	0.746
MOD_GSK3_1	21	28	PF00069	0.495
MOD_GSK3_1	214	221	PF00069	0.691
MOD_GSK3_1	223	230	PF00069	0.626
MOD_GSK3_1	299	306	PF00069	0.735
MOD_GSK3_1	3	10	PF00069	0.570
MOD_GSK3_1	312	319	PF00069	0.607
MOD_GSK3_1	324	331	PF00069	0.792
MOD_GSK3_1	368	375	PF00069	0.659
MOD_GSK3_1	383	390	PF00069	0.578
MOD_GSK3_1	394	401	PF00069	0.671
MOD_GSK3_1	407	414	PF00069	0.542
MOD_GSK3_1	439	446	PF00069	0.663
MOD_GSK3_1	463	470	PF00069	0.707
MOD_GSK3_1	505	512	PF00069	0.472
MOD_GSK3_1	534	541	PF00069	0.644
MOD_GSK3_1	605	612	PF00069	0.704
MOD_GSK3_1	65	72	PF00069	0.681
MOD_GSK3_1	656	663	PF00069	0.697
MOD_GSK3_1	665	672	PF00069	0.676
MOD_GSK3_1	682	689	PF00069	0.789
MOD_GSK3_1	696	703	PF00069	0.624
MOD_GSK3_1	710	717	PF00069	0.593
MOD_GSK3_1	780	787	PF00069	0.714
MOD_GSK3_1	803	810	PF00069	0.674
MOD_N-GLC_1	274	279	PF02516	0.549
MOD_N-GLC_1	534	539	PF02516	0.542
MOD_N-GLC_1	88	93	PF02516	0.555
MOD_N-GLC_2	426	428	PF02516	0.585
MOD_NEK2_1	153	158	PF00069	0.534
MOD_NEK2_1	338	343	PF00069	0.799
MOD_NEK2_1	465	470	PF00069	0.708
MOD_NEK2_1	476	481	PF00069	0.611
MOD_NEK2_1	505	510	PF00069	0.640
MOD_NEK2_1	65	70	PF00069	0.559
MOD_NEK2_1	693	698	PF00069	0.723
MOD_NEK2_1	792	797	PF00069	0.539
MOD_NEK2_1	817	822	PF00069	0.707
MOD_PIKK_1	398	404	PF00454	0.712
MOD_PIKK_1	600	606	PF00454	0.688
MOD_PIKK_1	624	630	PF00454	0.571
MOD_PIKK_1	656	662	PF00454	0.709
MOD_PKA_1	206	212	PF00069	0.586
MOD_PKA_1	285	291	PF00069	0.623
MOD_PKA_1	644	650	PF00069	0.701
MOD_PKA_1	723	729	PF00069	0.555
MOD_PKA_2	206	212	PF00069	0.586
MOD_PKA_2	228	234	PF00069	0.642
MOD_PKA_2	285	291	PF00069	0.685
MOD_PKA_2	407	413	PF00069	0.642
MOD_PKA_2	605	611	PF00069	0.541
MOD_PKA_2	644	650	PF00069	0.695
MOD_PKA_2	663	669	PF00069	0.661
MOD_PKA_2	723	729	PF00069	0.555
MOD_PKA_2	74	80	PF00069	0.565
MOD_PKA_2	761	767	PF00069	0.693
MOD_PKA_2	792	798	PF00069	0.585
MOD_PKA_2	817	823	PF00069	0.544
MOD_PKB_1	115	123	PF00069	0.573
MOD_Plk_4	400	406	PF00069	0.550
MOD_Plk_4	763	769	PF00069	0.562
MOD_Plk_4	812	818	PF00069	0.639
MOD_Plk_4	819	825	PF00069	0.694
MOD_ProDKin_1	137	143	PF00069	0.687
MOD_ProDKin_1	165	171	PF00069	0.555
MOD_ProDKin_1	208	214	PF00069	0.690
MOD_ProDKin_1	233	239	PF00069	0.545
MOD_ProDKin_1	317	323	PF00069	0.679
MOD_ProDKin_1	324	330	PF00069	0.787
MOD_ProDKin_1	339	345	PF00069	0.555
MOD_ProDKin_1	383	389	PF00069	0.645
MOD_ProDKin_1	390	396	PF00069	0.611
MOD_ProDKin_1	411	417	PF00069	0.696
MOD_ProDKin_1	434	440	PF00069	0.688
MOD_ProDKin_1	683	689	PF00069	0.733
MOD_ProDKin_1	700	706	PF00069	0.552
MOD_ProDKin_1	740	746	PF00069	0.564
MOD_ProDKin_1	780	786	PF00069	0.584
MOD_ProDKin_1	9	15	PF00069	0.699
MOD_SUMO_rev_2	789	797	PF00179	0.557
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.713
TRG_ENDOCYTIC_2	178	181	PF00928	0.695
TRG_ENDOCYTIC_2	519	522	PF00928	0.610
TRG_ER_diArg_1	101	104	PF00400	0.569
TRG_ER_diArg_1	115	117	PF00400	0.554
TRG_ER_diArg_1	205	207	PF00400	0.599
TRG_ER_diArg_1	285	287	PF00400	0.665
TRG_ER_diArg_1	643	645	PF00400	0.715
TRG_ER_diArg_1	722	724	PF00400	0.565
TRG_NLS_MonoExtN_4	40	45	PF00514	0.497
TRG_Pf-PMV_PEXEL_1	267	272	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	34	39	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJC2	Leishmania donovani	51%	100%
A4HRJ1	Leishmania infantum	52%	100%
E9AC59	Leishmania major	47%	90%
E9AJF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%