Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H385_LEIBR

TriTrypDb:

LbrM.01.0650 , LBRM2903_010012200

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H385

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H385

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	5	9	PF00656	0.495
CLV_PCSK_SKI1_1	16	20	PF00082	0.552
DEG_SCF_FBW7_1	146	153	PF00400	0.694
DOC_CKS1_1	123	128	PF01111	0.664
DOC_CKS1_1	147	152	PF01111	0.696
DOC_CYCLIN_yClb3_PxF_3	150	156	PF00134	0.600
DOC_PP1_RVXF_1	14	20	PF00149	0.538
DOC_PP4_FxxP_1	19	22	PF00568	0.515
DOC_USP7_MATH_1	106	110	PF00917	0.597
DOC_USP7_MATH_1	183	187	PF00917	0.608
DOC_USP7_MATH_1	196	200	PF00917	0.614
DOC_USP7_MATH_1	40	44	PF00917	0.775
DOC_WW_Pin1_4	122	127	PF00397	0.756
DOC_WW_Pin1_4	142	147	PF00397	0.615
DOC_WW_Pin1_4	150	155	PF00397	0.715
DOC_WW_Pin1_4	210	215	PF00397	0.563
DOC_WW_Pin1_4	220	225	PF00397	0.530
DOC_WW_Pin1_4	230	235	PF00397	0.574
LIG_14-3-3_CanoR_1	107	111	PF00244	0.650
LIG_14-3-3_CanoR_1	16	22	PF00244	0.544
LIG_14-3-3_CanoR_1	268	277	PF00244	0.593
LIG_BRCT_BRCA1_1	273	277	PF00533	0.578
LIG_EVH1_1	231	235	PF00568	0.527
LIG_FHA_1	210	216	PF00498	0.502
LIG_FHA_1	248	254	PF00498	0.488
LIG_FHA_1	49	55	PF00498	0.716
LIG_FHA_2	173	179	PF00498	0.589
LIG_FHA_2	22	28	PF00498	0.665
LIG_LIR_Gen_1	131	137	PF02991	0.487
LIG_LIR_Gen_1	169	179	PF02991	0.576
LIG_LIR_Gen_1	274	280	PF02991	0.585
LIG_LIR_Gen_1	8	18	PF02991	0.443
LIG_LIR_LC3C_4	12	15	PF02991	0.440
LIG_LIR_Nem_3	131	136	PF02991	0.600
LIG_LIR_Nem_3	169	174	PF02991	0.719
LIG_LIR_Nem_3	204	210	PF02991	0.553
LIG_LIR_Nem_3	274	280	PF02991	0.585
LIG_LIR_Nem_3	8	13	PF02991	0.438
LIG_PDZ_Class_3	275	280	PF00595	0.639
LIG_SH3_1	148	154	PF00018	0.533
LIG_SH3_3	144	150	PF00018	0.696
LIG_SH3_3	229	235	PF00018	0.591
LIG_SUMO_SIM_par_1	112	119	PF11976	0.605
LIG_SUMO_SIM_par_1	211	219	PF11976	0.506
LIG_TRAF2_1	175	178	PF00917	0.582
LIG_WRC_WIRS_1	168	173	PF05994	0.530
LIG_WW_3	145	149	PF00397	0.539
MOD_CDK_SPK_2	122	127	PF00069	0.672
MOD_CDK_SPxK_1	142	148	PF00069	0.533
MOD_CDK_SPxK_1	220	226	PF00069	0.639
MOD_CK1_1	109	115	PF00069	0.600
MOD_CK1_1	116	122	PF00069	0.615
MOD_CK1_1	128	134	PF00069	0.558
MOD_CK1_1	140	146	PF00069	0.655
MOD_CK1_1	219	225	PF00069	0.662
MOD_CK1_1	233	239	PF00069	0.740
MOD_CK1_1	269	275	PF00069	0.614
MOD_CK1_1	42	48	PF00069	0.602
MOD_CK1_1	62	68	PF00069	0.503
MOD_CK1_1	79	85	PF00069	0.586
MOD_CK2_1	172	178	PF00069	0.697
MOD_CK2_1	270	276	PF00069	0.658
MOD_CK2_1	28	34	PF00069	0.624
MOD_GlcNHglycan	127	130	PF01048	0.656
MOD_GlcNHglycan	139	142	PF01048	0.765
MOD_GlcNHglycan	185	188	PF01048	0.625
MOD_GlcNHglycan	191	194	PF01048	0.627
MOD_GlcNHglycan	203	206	PF01048	0.684
MOD_GlcNHglycan	218	221	PF01048	0.516
MOD_GlcNHglycan	261	264	PF01048	0.653
MOD_GlcNHglycan	42	45	PF01048	0.618
MOD_GlcNHglycan	78	81	PF01048	0.599
MOD_GSK3_1	105	112	PF00069	0.714
MOD_GSK3_1	121	128	PF00069	0.777
MOD_GSK3_1	142	149	PF00069	0.696
MOD_GSK3_1	150	157	PF00069	0.674
MOD_GSK3_1	159	166	PF00069	0.590
MOD_GSK3_1	17	24	PF00069	0.677
MOD_GSK3_1	209	216	PF00069	0.562
MOD_GSK3_1	230	237	PF00069	0.687
MOD_GSK3_1	253	260	PF00069	0.591
MOD_GSK3_1	266	273	PF00069	0.610
MOD_GSK3_1	42	49	PF00069	0.649
MOD_GSK3_1	67	74	PF00069	0.585
MOD_GSK3_1	75	82	PF00069	0.665
MOD_N-GLC_1	121	126	PF02516	0.675
MOD_N-GLC_1	40	45	PF02516	0.635
MOD_N-GLC_1	71	76	PF02516	0.493
MOD_NEK2_1	137	142	PF00069	0.599
MOD_NEK2_1	164	169	PF00069	0.760
MOD_NEK2_1	245	250	PF00069	0.693
MOD_NEK2_1	253	258	PF00069	0.623
MOD_NEK2_1	48	53	PF00069	0.560
MOD_NEK2_1	61	66	PF00069	0.524
MOD_NEK2_1	71	76	PF00069	0.535
MOD_PIKK_1	140	146	PF00454	0.684
MOD_PIKK_1	255	261	PF00454	0.610
MOD_PIKK_1	266	272	PF00454	0.576
MOD_PIKK_1	42	48	PF00454	0.577
MOD_PKA_2	106	112	PF00069	0.675
MOD_Plk_1	62	68	PF00069	0.527
MOD_Plk_1	71	77	PF00069	0.550
MOD_Plk_4	110	116	PF00069	0.599
MOD_Plk_4	128	134	PF00069	0.483
MOD_Plk_4	167	173	PF00069	0.589
MOD_ProDKin_1	122	128	PF00069	0.753
MOD_ProDKin_1	142	148	PF00069	0.620
MOD_ProDKin_1	150	156	PF00069	0.718
MOD_ProDKin_1	210	216	PF00069	0.563
MOD_ProDKin_1	220	226	PF00069	0.533
MOD_ProDKin_1	230	236	PF00069	0.573
TRG_DiLeu_BaEn_1	56	61	PF01217	0.500
TRG_DiLeu_BaEn_4	56	62	PF01217	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I318	Leptomonas seymouri	41%	86%
A0A3S5H4W5	Leishmania donovani	70%	93%
A4HRJ0	Leishmania infantum	70%	93%
E9AC58	Leishmania major	67%	99%
E9AJF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	97%