RNA ligase (ATP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA ligase (ATP)

Gene product:

KREL1

Species:

Leishmania braziliensis

UniProt:

A4H382_LEIBR

TriTrypDb:

LbrM.01.0620 , LBRM2903_010011400

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

A4H382

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H382

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	23
GO:0003824	catalytic activity	1	23
GO:0003972	RNA ligase (ATP) activity	5	23
GO:0005488	binding	1	23
GO:0005524	ATP binding	5	23
GO:0008452	RNA ligase activity	4	23
GO:0016874	ligase activity	2	23
GO:0016886	ligase activity, forming phosphoric ester bonds	3	23
GO:0017076	purine nucleotide binding	4	23
GO:0030554	adenyl nucleotide binding	5	23
GO:0032553	ribonucleotide binding	3	23
GO:0032555	purine ribonucleotide binding	4	23
GO:0032559	adenyl ribonucleotide binding	5	23
GO:0035639	purine ribonucleoside triphosphate binding	4	23
GO:0036094	small molecule binding	2	23
GO:0043167	ion binding	2	23
GO:0043168	anion binding	3	23
GO:0097159	organic cyclic compound binding	2	23
GO:0097367	carbohydrate derivative binding	2	23
GO:0140098	catalytic activity, acting on RNA	3	23
GO:0140640	catalytic activity, acting on a nucleic acid	2	23
GO:1901265	nucleoside phosphate binding	3	23
GO:1901363	heterocyclic compound binding	2	23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.525
CLV_C14_Caspase3-7	409	413	PF00656	0.372
CLV_NRD_NRD_1	244	246	PF00675	0.409
CLV_NRD_NRD_1	28	30	PF00675	0.492
CLV_NRD_NRD_1	377	379	PF00675	0.414
CLV_NRD_NRD_1	95	97	PF00675	0.416
CLV_PCSK_KEX2_1	136	138	PF00082	0.378
CLV_PCSK_KEX2_1	244	246	PF00082	0.344
CLV_PCSK_KEX2_1	28	30	PF00082	0.481
CLV_PCSK_KEX2_1	398	400	PF00082	0.477
CLV_PCSK_KEX2_1	62	64	PF00082	0.317
CLV_PCSK_KEX2_1	95	97	PF00082	0.472
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.378
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.487
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.317
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.315
CLV_PCSK_PC7_1	394	400	PF00082	0.285
CLV_PCSK_SKI1_1	106	110	PF00082	0.323
CLV_PCSK_SKI1_1	125	129	PF00082	0.463
CLV_PCSK_SKI1_1	29	33	PF00082	0.264
CLV_PCSK_SKI1_1	298	302	PF00082	0.531
CLV_PCSK_SKI1_1	360	364	PF00082	0.430
CLV_PCSK_SKI1_1	378	382	PF00082	0.353
CLV_PCSK_SKI1_1	59	63	PF00082	0.279
DOC_CDC14_PxL_1	216	224	PF14671	0.411
DOC_CKS1_1	215	220	PF01111	0.325
DOC_MAPK_gen_1	260	269	PF00069	0.401
DOC_MAPK_gen_1	293	302	PF00069	0.593
DOC_PP1_RVXF_1	381	388	PF00149	0.439
DOC_PP4_FxxP_1	215	218	PF00568	0.325
DOC_USP7_MATH_1	61	65	PF00917	0.342
DOC_USP7_UBL2_3	270	274	PF12436	0.501
DOC_USP7_UBL2_3	360	364	PF12436	0.431
DOC_WW_Pin1_4	151	156	PF00397	0.273
DOC_WW_Pin1_4	214	219	PF00397	0.325
LIG_14-3-3_CanoR_1	262	267	PF00244	0.394
LIG_14-3-3_CanoR_1	405	415	PF00244	0.526
LIG_APCC_ABBA_1	107	112	PF00400	0.447
LIG_APCC_ABBA_1	177	182	PF00400	0.315
LIG_APCC_ABBAyCdc20_2	106	112	PF00400	0.447
LIG_BRCT_BRCA1_1	146	150	PF00533	0.414
LIG_BRCT_BRCA1_1	373	377	PF00533	0.501
LIG_BRCT_BRCA1_1	383	387	PF00533	0.455
LIG_BRCT_BRCA1_2	373	379	PF00533	0.497
LIG_Clathr_ClatBox_1	177	181	PF01394	0.447
LIG_DLG_GKlike_1	262	269	PF00625	0.409
LIG_FHA_1	117	123	PF00498	0.376
LIG_FHA_1	364	370	PF00498	0.556
LIG_FHA_1	82	88	PF00498	0.364
LIG_FHA_2	12	18	PF00498	0.393
LIG_FHA_2	20	26	PF00498	0.513
LIG_FHA_2	201	207	PF00498	0.382
LIG_FHA_2	279	285	PF00498	0.502
LIG_FHA_2	407	413	PF00498	0.512
LIG_Integrin_RGD_1	245	247	PF01839	0.340
LIG_LIR_Apic_2	213	218	PF02991	0.325
LIG_LIR_Gen_1	11	19	PF02991	0.423
LIG_LIR_Gen_1	126	133	PF02991	0.319
LIG_LIR_Gen_1	181	191	PF02991	0.342
LIG_LIR_Gen_1	264	272	PF02991	0.446
LIG_LIR_Nem_3	126	132	PF02991	0.382
LIG_LIR_Nem_3	147	153	PF02991	0.299
LIG_LIR_Nem_3	156	162	PF02991	0.336
LIG_LIR_Nem_3	181	186	PF02991	0.308
LIG_LIR_Nem_3	264	269	PF02991	0.424
LIG_LIR_Nem_3	396	400	PF02991	0.452
LIG_LIR_Nem_3	46	51	PF02991	0.307
LIG_LIR_Nem_3	71	76	PF02991	0.321
LIG_LIR_Nem_3	8	13	PF02991	0.441
LIG_MLH1_MIPbox_1	383	387	PF16413	0.388
LIG_MYND_3	308	312	PF01753	0.554
LIG_NRBOX	89	95	PF00104	0.340
LIG_PCNA_PIPBox_1	356	365	PF02747	0.505
LIG_PCNA_yPIPBox_3	356	364	PF02747	0.497
LIG_SH2_CRK	195	199	PF00017	0.411
LIG_SH2_CRK	76	80	PF00017	0.322
LIG_SH2_NCK_1	13	17	PF00017	0.478
LIG_SH2_STAT5	118	121	PF00017	0.349
LIG_SH2_STAT5	13	16	PF00017	0.339
LIG_SH2_STAT5	159	162	PF00017	0.462
LIG_SH2_STAT5	386	389	PF00017	0.390
LIG_SH2_STAT5	51	54	PF00017	0.314
LIG_SH3_1	118	124	PF00018	0.329
LIG_SH3_3	118	124	PF00018	0.323
LIG_SH3_3	173	179	PF00018	0.315
LIG_SUMO_SIM_anti_2	347	354	PF11976	0.399
LIG_SUMO_SIM_par_1	365	374	PF11976	0.584
LIG_TRAF2_1	33	36	PF00917	0.484
MOD_CK1_1	11	17	PF00069	0.416
MOD_CK1_1	253	259	PF00069	0.504
MOD_CK2_1	138	144	PF00069	0.483
MOD_CK2_1	166	172	PF00069	0.355
MOD_CK2_1	200	206	PF00069	0.389
MOD_CK2_1	262	268	PF00069	0.402
MOD_CK2_1	404	410	PF00069	0.427
MOD_Cter_Amidation	296	299	PF01082	0.683
MOD_GlcNHglycan	125	128	PF01048	0.362
MOD_GlcNHglycan	140	143	PF01048	0.296
MOD_GlcNHglycan	168	171	PF01048	0.325
MOD_GlcNHglycan	251	255	PF01048	0.542
MOD_GlcNHglycan	341	344	PF01048	0.325
MOD_GlcNHglycan	63	66	PF01048	0.317
MOD_GlcNHglycan	8	13	PF01048	0.566
MOD_GSK3_1	181	188	PF00069	0.416
MOD_GSK3_1	250	257	PF00069	0.517
MOD_GSK3_1	278	285	PF00069	0.494
MOD_N-GLC_1	321	326	PF02516	0.409
MOD_N-GLC_1	371	376	PF02516	0.485
MOD_N-GLC_1	53	58	PF02516	0.276
MOD_NEK2_1	261	266	PF00069	0.392
MOD_NEK2_1	278	283	PF00069	0.504
MOD_NEK2_1	371	376	PF00069	0.452
MOD_NEK2_1	381	386	PF00069	0.303
MOD_PIKK_1	185	191	PF00454	0.296
MOD_PIKK_1	404	410	PF00454	0.586
MOD_PKA_1	298	304	PF00069	0.637
MOD_PKA_2	200	206	PF00069	0.325
MOD_PKA_2	261	267	PF00069	0.389
MOD_PKA_2	27	33	PF00069	0.466
MOD_PKA_2	404	410	PF00069	0.428
MOD_Plk_1	371	377	PF00069	0.462
MOD_Plk_1	8	14	PF00069	0.518
MOD_Plk_4	254	260	PF00069	0.380
MOD_Plk_4	262	268	PF00069	0.396
MOD_Plk_4	278	284	PF00069	0.480
MOD_Plk_4	298	304	PF00069	0.547
MOD_ProDKin_1	151	157	PF00069	0.273
MOD_ProDKin_1	214	220	PF00069	0.325
MOD_SUMO_for_1	309	312	PF00179	0.598
MOD_SUMO_rev_2	264	272	PF00179	0.441
MOD_SUMO_rev_2	390	400	PF00179	0.531
TRG_DiLeu_BaEn_1	173	178	PF01217	0.342
TRG_DiLeu_BaEn_1	348	353	PF01217	0.530
TRG_DiLeu_BaLyEn_6	336	341	PF01217	0.421
TRG_ENDOCYTIC_2	13	16	PF00928	0.462
TRG_ENDOCYTIC_2	159	162	PF00928	0.454
TRG_ENDOCYTIC_2	76	79	PF00928	0.309
TRG_ER_diArg_1	243	245	PF00400	0.375
TRG_ER_diArg_1	27	29	PF00400	0.477
TRG_NLS_MonoExtC_3	134	139	PF00514	0.315
TRG_NLS_MonoExtN_4	133	139	PF00514	0.476
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTX0	Leptomonas seymouri	40%	100%
A0A0N1IKD9	Leptomonas seymouri	80%	83%
A0A0S4IH84	Bodo saltans	70%	86%
A0A0S4JRM1	Bodo saltans	41%	83%
A0A1X0NW43	Trypanosomatidae	44%	100%
A0A1X0P2V9	Trypanosomatidae	74%	91%
A0A3R7NWI2	Trypanosoma rangeli	42%	100%
A0A3S5H791	Leishmania donovani	39%	100%
A0A422NFE4	Trypanosoma rangeli	75%	92%
A0A451EJB4	Leishmania donovani	92%	100%
A4HRI2	Leishmania infantum	92%	100%
A4HZ02	Leishmania infantum	39%	100%
C9ZIM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZXL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	90%
E9AC50	Leishmania major	91%	100%
E9AIM1	Leishmania braziliensis	39%	100%
E9AJE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AUV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
P86924	Trypanosoma brucei brucei	42%	100%
P86925	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	42%	100%
P86926	Trypanosoma brucei brucei	74%	90%
P86927	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	74%	90%
Q6T452	Leishmania major	39%	100%
V5ASZ3	Trypanosoma cruzi	40%	100%
V5DD75	Trypanosoma cruzi	74%	85%