RNA ligase (ATP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA ligase (ATP)

Gene product:

KREL1

Species:

Leishmania braziliensis

UniProt:

A4H382_LEIBR

TriTrypDb:

LbrM.01.0620 , LBRM2903_010011400

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Show entries

Cellular components
Term	Name	Level	Count
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Previous1Next

Expansion

Sequence features

A4H382

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H382

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1

Previous1 2Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	23
GO:0003824	catalytic activity	1	23
GO:0003972	RNA ligase (ATP) activity	5	23
GO:0005488	binding	1	23
GO:0005524	ATP binding	5	23
GO:0008452	RNA ligase activity	4	23
GO:0016874	ligase activity	2	23
GO:0016886	ligase activity, forming phosphoric ester bonds	3	23
GO:0017076	purine nucleotide binding	4	23
GO:0030554	adenyl nucleotide binding	5	23

Previous1 2 3Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.525
CLV_C14_Caspase3-7	409	413	PF00656	0.372
CLV_NRD_NRD_1	244	246	PF00675	0.409
CLV_NRD_NRD_1	28	30	PF00675	0.492
CLV_NRD_NRD_1	377	379	PF00675	0.414
CLV_NRD_NRD_1	95	97	PF00675	0.416
CLV_PCSK_KEX2_1	136	138	PF00082	0.378
CLV_PCSK_KEX2_1	244	246	PF00082	0.344
CLV_PCSK_KEX2_1	28	30	PF00082	0.481
CLV_PCSK_KEX2_1	398	400	PF00082	0.477

Previous1 2 3 4 5…15Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTX0	Leptomonas seymouri	40%	100%
A0A0N1IKD9	Leptomonas seymouri	80%	83%
A0A0S4IH84	Bodo saltans	70%	86%
A0A0S4JRM1	Bodo saltans	41%	83%
A0A1X0NW43	Trypanosomatidae	44%	100%
A0A1X0P2V9	Trypanosomatidae	74%	91%
A0A3R7NWI2	Trypanosoma rangeli	42%	100%
A0A3S5H791	Leishmania donovani	39%	100%
A0A422NFE4	Trypanosoma rangeli	75%	92%
A0A451EJB4	Leishmania donovani	92%	100%

Previous1 2 3Next