WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H381_LEIBR

TriTrypDb:

LbrM.01.0610 , LBRM2903_010011300

Length:

957

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H381

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H381

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	862	866	PF00656	0.724
CLV_C14_Caspase3-7	91	95	PF00656	0.512
CLV_C14_Caspase3-7	99	103	PF00656	0.521
CLV_NRD_NRD_1	381	383	PF00675	0.393
CLV_NRD_NRD_1	545	547	PF00675	0.579
CLV_NRD_NRD_1	641	643	PF00675	0.585
CLV_NRD_NRD_1	67	69	PF00675	0.702
CLV_PCSK_FUR_1	542	546	PF00082	0.436
CLV_PCSK_KEX2_1	541	543	PF00082	0.442
CLV_PCSK_KEX2_1	544	546	PF00082	0.532
CLV_PCSK_KEX2_1	643	645	PF00082	0.775
CLV_PCSK_KEX2_1	67	69	PF00082	0.627
CLV_PCSK_KEX2_1	784	786	PF00082	0.343
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.479
CLV_PCSK_PC1ET2_1	643	645	PF00082	0.638
CLV_PCSK_PC1ET2_1	784	786	PF00082	0.341
CLV_PCSK_SKI1_1	292	296	PF00082	0.548
CLV_PCSK_SKI1_1	382	386	PF00082	0.349
CLV_PCSK_SKI1_1	528	532	PF00082	0.381
CLV_PCSK_SKI1_1	79	83	PF00082	0.427
CLV_PCSK_SKI1_1	907	911	PF00082	0.523
DEG_APCC_DBOX_1	792	800	PF00400	0.415
DEG_MDM2_SWIB_1	786	794	PF02201	0.367
DEG_SCF_FBW7_1	404	410	PF00400	0.643
DEG_SCF_FBW7_2	125	132	PF00400	0.491
DEG_SPOP_SBC_1	155	159	PF00917	0.566
DEG_SPOP_SBC_1	864	868	PF00917	0.481
DEG_SPOP_SBC_1	96	100	PF00917	0.751
DOC_CKS1_1	17	22	PF01111	0.621
DOC_CKS1_1	34	39	PF01111	0.491
DOC_CKS1_1	404	409	PF01111	0.643
DOC_CKS1_1	723	728	PF01111	0.460
DOC_MAPK_DCC_7	793	801	PF00069	0.417
DOC_MAPK_gen_1	74	82	PF00069	0.468
DOC_MAPK_gen_1	947	955	PF00069	0.450
DOC_MAPK_MEF2A_6	457	466	PF00069	0.417
DOC_MAPK_MEF2A_6	611	620	PF00069	0.401
DOC_MAPK_MEF2A_6	793	801	PF00069	0.417
DOC_MAPK_MEF2A_6	949	957	PF00069	0.495
DOC_PP1_RVXF_1	415	421	PF00149	0.553
DOC_PP1_RVXF_1	945	951	PF00149	0.347
DOC_PP2B_LxvP_1	189	192	PF13499	0.407
DOC_PP2B_PxIxI_1	137	143	PF00149	0.455
DOC_PP2B_PxIxI_1	725	731	PF00149	0.355
DOC_PP4_FxxP_1	405	408	PF00568	0.689
DOC_SPAK_OSR1_1	457	461	PF12202	0.471
DOC_SPAK_OSR1_1	77	81	PF12202	0.516
DOC_USP7_MATH_1	151	155	PF00917	0.521
DOC_USP7_MATH_1	170	174	PF00917	0.598
DOC_USP7_MATH_1	193	197	PF00917	0.431
DOC_USP7_MATH_1	22	26	PF00917	0.784
DOC_USP7_MATH_1	319	323	PF00917	0.798
DOC_USP7_MATH_1	371	375	PF00917	0.407
DOC_USP7_MATH_1	44	48	PF00917	0.767
DOC_USP7_MATH_1	494	498	PF00917	0.605
DOC_USP7_MATH_1	499	503	PF00917	0.732
DOC_USP7_MATH_1	564	568	PF00917	0.628
DOC_USP7_MATH_1	612	616	PF00917	0.400
DOC_USP7_MATH_1	7	11	PF00917	0.754
DOC_USP7_MATH_1	893	897	PF00917	0.592
DOC_USP7_MATH_1	919	923	PF00917	0.375
DOC_USP7_MATH_1	95	99	PF00917	0.695
DOC_WW_Pin1_4	125	130	PF00397	0.527
DOC_WW_Pin1_4	16	21	PF00397	0.721
DOC_WW_Pin1_4	207	212	PF00397	0.616
DOC_WW_Pin1_4	25	30	PF00397	0.753
DOC_WW_Pin1_4	258	263	PF00397	0.617
DOC_WW_Pin1_4	285	290	PF00397	0.488
DOC_WW_Pin1_4	304	309	PF00397	0.497
DOC_WW_Pin1_4	33	38	PF00397	0.545
DOC_WW_Pin1_4	331	336	PF00397	0.591
DOC_WW_Pin1_4	403	408	PF00397	0.677
DOC_WW_Pin1_4	42	47	PF00397	0.782
DOC_WW_Pin1_4	511	516	PF00397	0.459
DOC_WW_Pin1_4	722	727	PF00397	0.467
LIG_14-3-3_CanoR_1	382	391	PF00244	0.338
LIG_14-3-3_CanoR_1	435	442	PF00244	0.568
LIG_14-3-3_CanoR_1	457	461	PF00244	0.450
LIG_14-3-3_CanoR_1	544	549	PF00244	0.503
LIG_14-3-3_CanoR_1	626	635	PF00244	0.536
LIG_14-3-3_CanoR_1	785	791	PF00244	0.584
LIG_14-3-3_CanoR_1	79	88	PF00244	0.452
LIG_14-3-3_CanoR_1	813	821	PF00244	0.514
LIG_14-3-3_CanoR_1	889	893	PF00244	0.499
LIG_Actin_WH2_2	278	294	PF00022	0.427
LIG_AP2alpha_2	403	405	PF02296	0.637
LIG_APCC_ABBA_1	666	671	PF00400	0.516
LIG_BIR_II_1	1	5	PF00653	0.652
LIG_BIR_III_2	443	447	PF00653	0.330
LIG_BIR_III_2	94	98	PF00653	0.522
LIG_Clathr_ClatBox_1	215	219	PF01394	0.342
LIG_deltaCOP1_diTrp_1	595	603	PF00928	0.374
LIG_Dynein_DLC8_1	246	252	PF01221	0.520
LIG_eIF4E_1	830	836	PF01652	0.460
LIG_FHA_1	13	19	PF00498	0.616
LIG_FHA_1	34	40	PF00498	0.535
LIG_FHA_1	367	373	PF00498	0.417
LIG_FHA_1	379	385	PF00498	0.451
LIG_FHA_1	49	55	PF00498	0.537
LIG_FHA_1	529	535	PF00498	0.452
LIG_FHA_1	548	554	PF00498	0.371
LIG_FHA_1	627	633	PF00498	0.512
LIG_FHA_1	655	661	PF00498	0.422
LIG_FHA_1	723	729	PF00498	0.449
LIG_FHA_1	767	773	PF00498	0.700
LIG_FHA_1	99	105	PF00498	0.771
LIG_FHA_2	43	49	PF00498	0.779
LIG_FHA_2	716	722	PF00498	0.382
LIG_FHA_2	97	103	PF00498	0.624
LIG_GBD_Chelix_1	267	275	PF00786	0.478
LIG_Integrin_isoDGR_2	775	777	PF01839	0.348
LIG_Integrin_RGD_1	228	230	PF01839	0.526
LIG_LIR_Apic_2	402	408	PF02991	0.547
LIG_LIR_Gen_1	177	186	PF02991	0.526
LIG_LIR_Gen_1	349	359	PF02991	0.344
LIG_LIR_Gen_1	701	712	PF02991	0.399
LIG_LIR_Gen_1	739	749	PF02991	0.508
LIG_LIR_Gen_1	838	848	PF02991	0.375
LIG_LIR_Gen_1	906	914	PF02991	0.540
LIG_LIR_Nem_3	158	164	PF02991	0.552
LIG_LIR_Nem_3	173	178	PF02991	0.442
LIG_LIR_Nem_3	349	354	PF02991	0.364
LIG_LIR_Nem_3	701	707	PF02991	0.412
LIG_LIR_Nem_3	739	744	PF02991	0.452
LIG_LIR_Nem_3	838	843	PF02991	0.402
LIG_LIR_Nem_3	844	849	PF02991	0.349
LIG_LIR_Nem_3	906	911	PF02991	0.529
LIG_LYPXL_yS_3	161	164	PF13949	0.589
LIG_PDZ_Class_2	952	957	PF00595	0.481
LIG_Pex14_1	847	851	PF04695	0.438
LIG_Pex14_2	786	790	PF04695	0.386
LIG_PTAP_UEV_1	307	312	PF05743	0.661
LIG_PTB_Apo_2	602	609	PF02174	0.419
LIG_REV1ctd_RIR_1	431	441	PF16727	0.538
LIG_SH2_CRK	368	372	PF00017	0.428
LIG_SH2_CRK	704	708	PF00017	0.496
LIG_SH2_GRB2like	569	572	PF00017	0.365
LIG_SH2_NCK_1	704	708	PF00017	0.496
LIG_SH2_PTP2	908	911	PF00017	0.570
LIG_SH2_SRC	86	89	PF00017	0.637
LIG_SH2_STAP1	569	573	PF00017	0.349
LIG_SH2_STAP1	624	628	PF00017	0.455
LIG_SH2_STAT5	156	159	PF00017	0.612
LIG_SH2_STAT5	357	360	PF00017	0.446
LIG_SH2_STAT5	368	371	PF00017	0.479
LIG_SH2_STAT5	607	610	PF00017	0.363
LIG_SH2_STAT5	624	627	PF00017	0.417
LIG_SH2_STAT5	830	833	PF00017	0.475
LIG_SH2_STAT5	908	911	PF00017	0.570
LIG_SH3_2	404	409	PF14604	0.524
LIG_SH3_3	11	17	PF00018	0.737
LIG_SH3_3	259	265	PF00018	0.567
LIG_SH3_3	26	32	PF00018	0.740
LIG_SH3_3	305	311	PF00018	0.661
LIG_SH3_3	326	332	PF00018	0.568
LIG_SH3_3	398	404	PF00018	0.696
LIG_SH3_3	43	49	PF00018	0.600
LIG_SH3_3	615	621	PF00018	0.400
LIG_SH3_3	685	691	PF00018	0.473
LIG_SH3_3	796	802	PF00018	0.424
LIG_SH3_3	908	914	PF00018	0.465
LIG_TRAF2_1	426	429	PF00917	0.462
LIG_TYR_ITSM	157	164	PF00017	0.638
LIG_TYR_ITSM	700	707	PF00017	0.498
LIG_WRC_WIRS_1	175	180	PF05994	0.648
LIG_WRC_WIRS_1	843	848	PF05994	0.246
LIG_WW_1	621	624	PF00397	0.352
LIG_WW_2	329	332	PF00397	0.627
LIG_WW_3	406	410	PF00397	0.587
MOD_CDK_SPxK_1	403	409	PF00069	0.490
MOD_CDK_SPxxK_3	285	292	PF00069	0.482
MOD_CK1_1	10	16	PF00069	0.776
MOD_CK1_1	154	160	PF00069	0.606
MOD_CK1_1	182	188	PF00069	0.462
MOD_CK1_1	2	8	PF00069	0.752
MOD_CK1_1	25	31	PF00069	0.622
MOD_CK1_1	261	267	PF00069	0.586
MOD_CK1_1	306	312	PF00069	0.771
MOD_CK1_1	334	340	PF00069	0.532
MOD_CK1_1	347	353	PF00069	0.427
MOD_CK1_1	378	384	PF00069	0.500
MOD_CK1_1	436	442	PF00069	0.551
MOD_CK1_1	514	520	PF00069	0.366
MOD_CK1_1	547	553	PF00069	0.572
MOD_CK1_1	698	704	PF00069	0.552
MOD_CK1_1	812	818	PF00069	0.482
MOD_CK1_1	98	104	PF00069	0.712
MOD_CK2_1	184	190	PF00069	0.519
MOD_CK2_1	319	325	PF00069	0.700
MOD_CK2_1	42	48	PF00069	0.686
MOD_CK2_1	747	753	PF00069	0.512
MOD_CK2_1	764	770	PF00069	0.769
MOD_CK2_1	877	883	PF00069	0.570
MOD_Cter_Amidation	640	643	PF01082	0.587
MOD_GlcNHglycan	153	156	PF01048	0.509
MOD_GlcNHglycan	2	5	PF01048	0.730
MOD_GlcNHglycan	308	311	PF01048	0.676
MOD_GlcNHglycan	321	324	PF01048	0.641
MOD_GlcNHglycan	346	349	PF01048	0.475
MOD_GlcNHglycan	375	378	PF01048	0.509
MOD_GlcNHglycan	451	454	PF01048	0.396
MOD_GlcNHglycan	496	499	PF01048	0.545
MOD_GlcNHglycan	501	504	PF01048	0.559
MOD_GlcNHglycan	680	683	PF01048	0.378
MOD_GlcNHglycan	731	734	PF01048	0.446
MOD_GlcNHglycan	749	752	PF01048	0.448
MOD_GlcNHglycan	867	870	PF01048	0.663
MOD_GlcNHglycan	9	12	PF01048	0.742
MOD_GSK3_1	140	147	PF00069	0.432
MOD_GSK3_1	151	158	PF00069	0.495
MOD_GSK3_1	170	177	PF00069	0.552
MOD_GSK3_1	202	209	PF00069	0.577
MOD_GSK3_1	249	256	PF00069	0.673
MOD_GSK3_1	296	303	PF00069	0.527
MOD_GSK3_1	330	337	PF00069	0.659
MOD_GSK3_1	371	378	PF00069	0.364
MOD_GSK3_1	399	406	PF00069	0.653
MOD_GSK3_1	44	51	PF00069	0.770
MOD_GSK3_1	5	12	PF00069	0.765
MOD_GSK3_1	547	554	PF00069	0.434
MOD_GSK3_1	622	629	PF00069	0.318
MOD_GSK3_1	642	649	PF00069	0.581
MOD_GSK3_1	654	661	PF00069	0.452
MOD_GSK3_1	695	702	PF00069	0.509
MOD_GSK3_1	764	771	PF00069	0.656
MOD_GSK3_1	808	815	PF00069	0.573
MOD_GSK3_1	86	93	PF00069	0.711
MOD_GSK3_1	884	891	PF00069	0.632
MOD_LATS_1	640	646	PF00433	0.631
MOD_N-GLC_1	285	290	PF02516	0.561
MOD_N-GLC_1	494	499	PF02516	0.521
MOD_N-GLC_1	646	651	PF02516	0.512
MOD_N-GLC_1	759	764	PF02516	0.637
MOD_NEK2_1	144	149	PF00069	0.591
MOD_NEK2_1	163	168	PF00069	0.582
MOD_NEK2_1	366	371	PF00069	0.463
MOD_NEK2_1	375	380	PF00069	0.437
MOD_NEK2_1	433	438	PF00069	0.571
MOD_NEK2_1	474	479	PF00069	0.312
MOD_NEK2_1	627	632	PF00069	0.509
MOD_NEK2_1	747	752	PF00069	0.489
MOD_NEK2_1	768	773	PF00069	0.578
MOD_NEK2_1	786	791	PF00069	0.348
MOD_NEK2_1	835	840	PF00069	0.317
MOD_NEK2_1	888	893	PF00069	0.726
MOD_NEK2_1	938	943	PF00069	0.333
MOD_NEK2_2	170	175	PF00069	0.534
MOD_NEK2_2	884	889	PF00069	0.474
MOD_NEK2_2	933	938	PF00069	0.368
MOD_OFUCOSY	513	518	PF10250	0.462
MOD_PIKK_1	191	197	PF00454	0.296
MOD_PIKK_1	247	253	PF00454	0.528
MOD_PIKK_1	273	279	PF00454	0.495
MOD_PK_1	949	955	PF00069	0.389
MOD_PKA_1	382	388	PF00069	0.347
MOD_PKA_1	528	534	PF00069	0.419
MOD_PKA_1	544	550	PF00069	0.379
MOD_PKA_1	642	648	PF00069	0.562
MOD_PKA_2	170	176	PF00069	0.443
MOD_PKA_2	456	462	PF00069	0.510
MOD_PKA_2	544	550	PF00069	0.529
MOD_PKA_2	643	649	PF00069	0.775
MOD_PKA_2	812	818	PF00069	0.507
MOD_PKA_2	888	894	PF00069	0.714
MOD_PKB_1	542	550	PF00069	0.420
MOD_Plk_1	140	146	PF00069	0.460
MOD_Plk_1	421	427	PF00069	0.459
MOD_Plk_1	734	740	PF00069	0.370
MOD_Plk_1	759	765	PF00069	0.639
MOD_Plk_4	144	150	PF00069	0.405
MOD_Plk_4	170	176	PF00069	0.549
MOD_Plk_4	193	199	PF00069	0.339
MOD_Plk_4	217	223	PF00069	0.491
MOD_Plk_4	341	347	PF00069	0.364
MOD_Plk_4	352	358	PF00069	0.340
MOD_Plk_4	564	570	PF00069	0.516
MOD_Plk_4	573	579	PF00069	0.321
MOD_Plk_4	655	661	PF00069	0.404
MOD_Plk_4	768	774	PF00069	0.472
MOD_Plk_4	842	848	PF00069	0.330
MOD_Plk_4	933	939	PF00069	0.442
MOD_ProDKin_1	125	131	PF00069	0.523
MOD_ProDKin_1	16	22	PF00069	0.722
MOD_ProDKin_1	207	213	PF00069	0.612
MOD_ProDKin_1	25	31	PF00069	0.753
MOD_ProDKin_1	258	264	PF00069	0.609
MOD_ProDKin_1	285	291	PF00069	0.480
MOD_ProDKin_1	304	310	PF00069	0.501
MOD_ProDKin_1	33	39	PF00069	0.546
MOD_ProDKin_1	331	337	PF00069	0.587
MOD_ProDKin_1	403	409	PF00069	0.678
MOD_ProDKin_1	42	48	PF00069	0.782
MOD_ProDKin_1	511	517	PF00069	0.458
MOD_ProDKin_1	722	728	PF00069	0.466
MOD_SUMO_rev_2	521	531	PF00179	0.415
TRG_DiLeu_BaEn_1	120	125	PF01217	0.500
TRG_DiLeu_BaEn_1	217	222	PF01217	0.487
TRG_DiLeu_BaEn_1	396	401	PF01217	0.565
TRG_DiLeu_BaEn_1	461	466	PF01217	0.358
TRG_DiLeu_BaEn_1	595	600	PF01217	0.263
TRG_ENDOCYTIC_2	161	164	PF00928	0.548
TRG_ENDOCYTIC_2	175	178	PF00928	0.454
TRG_ENDOCYTIC_2	607	610	PF00928	0.367
TRG_ENDOCYTIC_2	624	627	PF00928	0.342
TRG_ENDOCYTIC_2	704	707	PF00928	0.497
TRG_ENDOCYTIC_2	830	833	PF00928	0.475
TRG_ENDOCYTIC_2	840	843	PF00928	0.439
TRG_ENDOCYTIC_2	908	911	PF00928	0.536
TRG_ER_diArg_1	544	546	PF00400	0.547
TRG_ER_diArg_1	777	780	PF00400	0.405
TRG_NLS_MonoExtN_4	639	646	PF00514	0.581
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5V6	Leptomonas seymouri	53%	91%
A0A1X0P2P9	Trypanosomatidae	27%	100%
A0A3S5IR38	Trypanosoma rangeli	29%	100%
A0A451EJB3	Leishmania donovani	70%	99%
A4HRI1	Leishmania infantum	70%	99%
C9ZXL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AC49	Leishmania major	66%	98%
E9AJE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
V5AX28	Trypanosoma cruzi	29%	100%