Sidoreflexin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Sidoreflexin

Gene product:

tricarboxylate carrier, putative

Species:

Leishmania braziliensis

UniProt:

A4H380_LEIBR

TriTrypDb:

LbrM.01.0600 , LBRM2903_010011200

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0031090	organelle membrane	3	6
GO:0031966	mitochondrial membrane	4	6
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	5
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5

Expansion

Sequence features

A4H380

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H380

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006865	amino acid transport	5	11
GO:0015849	organic acid transport	5	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0009987	cellular process	1	1
GO:0055085	transmembrane transport	2	1
GO:1990542	mitochondrial transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0022857	transmembrane transporter activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	58	62	PF00656	0.383
CLV_NRD_NRD_1	199	201	PF00675	0.474
CLV_PCSK_KEX2_1	167	169	PF00082	0.274
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.274
CLV_PCSK_SKI1_1	318	322	PF00082	0.524
CLV_PCSK_SKI1_1	68	72	PF00082	0.183
DOC_CYCLIN_yCln2_LP_2	282	288	PF00134	0.457
DOC_MAPK_DCC_7	180	188	PF00069	0.333
DOC_MAPK_MEF2A_6	180	188	PF00069	0.333
DOC_MAPK_MEF2A_6	88	95	PF00069	0.540
DOC_MAPK_NFAT4_5	88	96	PF00069	0.540
DOC_PP1_RVXF_1	237	243	PF00149	0.313
DOC_PP2B_LxvP_1	282	285	PF13499	0.458
DOC_USP7_MATH_1	132	136	PF00917	0.260
DOC_USP7_MATH_1	70	74	PF00917	0.564
DOC_WW_Pin1_4	312	317	PF00397	0.260
LIG_14-3-3_CanoR_1	134	140	PF00244	0.260
LIG_14-3-3_CanoR_1	180	184	PF00244	0.333
LIG_14-3-3_CanoR_1	221	229	PF00244	0.289
LIG_14-3-3_CanoR_1	23	32	PF00244	0.536
LIG_14-3-3_CanoR_1	259	264	PF00244	0.509
LIG_14-3-3_CanoR_1	265	270	PF00244	0.547
LIG_14-3-3_CanoR_1	88	92	PF00244	0.534
LIG_BIR_II_1	1	5	PF00653	0.691
LIG_Clathr_ClatBox_1	32	36	PF01394	0.427
LIG_eIF4E_1	97	103	PF01652	0.205
LIG_FHA_1	113	119	PF00498	0.260
LIG_FHA_1	161	167	PF00498	0.275
LIG_FHA_1	191	197	PF00498	0.230
LIG_FHA_1	24	30	PF00498	0.383
LIG_FHA_1	249	255	PF00498	0.425
LIG_FHA_1	269	275	PF00498	0.424
LIG_FHA_1	279	285	PF00498	0.362
LIG_FHA_1	77	83	PF00498	0.476
LIG_FHA_2	56	62	PF00498	0.512
LIG_FHA_2	76	82	PF00498	0.436
LIG_LIR_Gen_1	182	192	PF02991	0.356
LIG_LIR_Nem_3	182	188	PF02991	0.356
LIG_LIR_Nem_3	303	309	PF02991	0.270
LIG_LIR_Nem_3	81	87	PF02991	0.422
LIG_SH2_GRB2like	131	134	PF00017	0.260
LIG_SH2_PTP2	97	100	PF00017	0.205
LIG_SH2_STAT5	148	151	PF00017	0.313
LIG_SH2_STAT5	97	100	PF00017	0.425
LIG_SH3_3	79	85	PF00018	0.474
LIG_SH3_3	95	101	PF00018	0.474
LIG_SUMO_SIM_anti_2	251	256	PF11976	0.244
LIG_SUMO_SIM_par_1	30	36	PF11976	0.535
LIG_TRAF2_1	78	81	PF00917	0.564
LIG_UBA3_1	160	167	PF00899	0.458
LIG_WRC_WIRS_1	15	20	PF05994	0.540
LIG_WRC_WIRS_1	260	265	PF05994	0.383
MOD_CDC14_SPxK_1	315	318	PF00782	0.183
MOD_CDK_SPxK_1	312	318	PF00069	0.270
MOD_CK1_1	124	130	PF00069	0.290
MOD_CK2_1	75	81	PF00069	0.491
MOD_GlcNHglycan	126	129	PF01048	0.491
MOD_GlcNHglycan	188	191	PF01048	0.278
MOD_GlcNHglycan	206	209	PF01048	0.519
MOD_GlcNHglycan	235	238	PF01048	0.394
MOD_GSK3_1	104	111	PF00069	0.324
MOD_GSK3_1	156	163	PF00069	0.380
MOD_GSK3_1	170	177	PF00069	0.398
MOD_GSK3_1	186	193	PF00069	0.271
MOD_GSK3_1	217	224	PF00069	0.364
MOD_GSK3_1	312	319	PF00069	0.353
MOD_GSK3_1	4	11	PF00069	0.651
MOD_N-GLC_1	121	126	PF02516	0.460
MOD_N-GLC_1	132	137	PF02516	0.460
MOD_NEK2_1	1	6	PF00069	0.613
MOD_NEK2_1	121	126	PF00069	0.260
MOD_NEK2_1	160	165	PF00069	0.313
MOD_NEK2_1	186	191	PF00069	0.416
MOD_NEK2_1	258	263	PF00069	0.520
MOD_NEK2_1	270	275	PF00069	0.359
MOD_NEK2_1	278	283	PF00069	0.356
MOD_NEK2_1	293	298	PF00069	0.200
MOD_NEK2_1	8	13	PF00069	0.464
MOD_NEK2_1	87	92	PF00069	0.524
MOD_NEK2_2	228	233	PF00069	0.291
MOD_NEK2_2	316	321	PF00069	0.336
MOD_PIKK_1	76	82	PF00454	0.564
MOD_PKA_1	233	239	PF00069	0.312
MOD_PKA_2	133	139	PF00069	0.260
MOD_PKA_2	179	185	PF00069	0.333
MOD_PKA_2	258	264	PF00069	0.529
MOD_PKA_2	87	93	PF00069	0.534
MOD_PKB_1	21	29	PF00069	0.536
MOD_Plk_1	121	127	PF00069	0.260
MOD_Plk_1	37	43	PF00069	0.540
MOD_Plk_4	105	111	PF00069	0.202
MOD_Plk_4	14	20	PF00069	0.474
MOD_Plk_4	156	162	PF00069	0.397
MOD_Plk_4	174	180	PF00069	0.393
MOD_Plk_4	250	256	PF00069	0.305
MOD_Plk_4	259	265	PF00069	0.489
MOD_Plk_4	270	276	PF00069	0.128
MOD_Plk_4	87	93	PF00069	0.474
MOD_ProDKin_1	312	318	PF00069	0.260
MOD_SUMO_for_1	300	303	PF00179	0.183
TRG_ENDOCYTIC_2	323	326	PF00928	0.260
TRG_ENDOCYTIC_2	97	100	PF00928	0.425
TRG_ER_diArg_1	21	24	PF00400	0.540
TRG_ER_diArg_1	65	68	PF00400	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P786	Leptomonas seymouri	28%	94%
A0A0N1I4E4	Leptomonas seymouri	71%	100%
A0A0S4IJR6	Bodo saltans	30%	100%
A0A1X0P3C3	Trypanosomatidae	58%	100%
A0A3R7KD90	Trypanosoma rangeli	58%	100%
A0A3S5H4W1	Leishmania donovani	81%	100%
A0A3S5H5J2	Leishmania donovani	29%	94%
A4H4B2	Leishmania braziliensis	28%	94%
A4HRI0	Leishmania infantum	81%	100%
A4HSJ0	Leishmania infantum	29%	94%
A5A761	Sus scrofa	28%	100%
A6QP55	Bos taurus	28%	100%
A8E7G5	Danio rerio	24%	100%
B2LU20	Ovis aries	28%	100%
C9ZXK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AC48	Leishmania major	81%	100%
E9AJE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AKH4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	94%
O13793	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q09201	Caenorhabditis elegans	27%	99%
Q12029	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
Q3T0M2	Bos taurus	24%	100%
Q4QJD4	Leishmania major	29%	100%
Q54NQ9	Dictyostelium discoideum	36%	99%
Q5E9M8	Bos taurus	28%	100%
Q5EA43	Bos taurus	29%	100%
Q5FC79	Caenorhabditis elegans	32%	98%
Q5RD16	Pongo abelii	29%	100%
Q63965	Rattus norvegicus	28%	100%
Q6P4A7	Homo sapiens	23%	97%
Q8CFD0	Rattus norvegicus	31%	95%
Q8TD22	Homo sapiens	31%	96%
Q91V61	Mus musculus	29%	100%
Q925N0	Mus musculus	31%	95%
Q925N1	Mus musculus	22%	100%
Q925N2	Mus musculus	27%	100%
Q96NB2	Homo sapiens	28%	100%
Q99JR1	Mus musculus	28%	100%
Q9BWM7	Homo sapiens	29%	100%
Q9H9B4	Homo sapiens	27%	100%
Q9JHY2	Rattus norvegicus	29%	100%
Q9VN13	Drosophila melanogaster	27%	100%
Q9VVW3	Drosophila melanogaster	27%	100%
V5BCG0	Trypanosoma cruzi	56%	100%