DUF1115 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pre-mRNA processing factor 3 (PRP3)/Protein of unknown function (DUF1115), putative

Species:

Leishmania braziliensis

UniProt:

A4H379_LEIBR

TriTrypDb:

LbrM.01.0590 , LBRM2903_010011100

Length:

530

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030532	small nuclear ribonucleoprotein complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	11
GO:0097525	spliceosomal snRNP complex	4	11
GO:0097526	spliceosomal tri-snRNP complex	5	11
GO:0120114	Sm-like protein family complex	2	11
GO:0140513	nuclear protein-containing complex	2	11
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

A4H379

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H379

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	11
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	11
GO:0000398	mRNA splicing, via spliceosome	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006397	mRNA processing	7	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008380	RNA splicing	7	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.552
CLV_C14_Caspase3-7	467	471	PF00656	0.733
CLV_NRD_NRD_1	19	21	PF00675	0.808
CLV_NRD_NRD_1	233	235	PF00675	0.283
CLV_NRD_NRD_1	321	323	PF00675	0.282
CLV_NRD_NRD_1	343	345	PF00675	0.516
CLV_NRD_NRD_1	52	54	PF00675	0.648
CLV_PCSK_KEX2_1	19	21	PF00082	0.808
CLV_PCSK_KEX2_1	233	235	PF00082	0.295
CLV_PCSK_KEX2_1	321	323	PF00082	0.282
CLV_PCSK_KEX2_1	337	339	PF00082	0.469
CLV_PCSK_KEX2_1	343	345	PF00082	0.481
CLV_PCSK_KEX2_1	448	450	PF00082	0.646
CLV_PCSK_KEX2_1	464	466	PF00082	0.748
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.480
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.646
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.748
CLV_PCSK_SKI1_1	158	162	PF00082	0.346
CLV_PCSK_SKI1_1	240	244	PF00082	0.315
CLV_PCSK_SKI1_1	406	410	PF00082	0.210
CLV_PCSK_SKI1_1	514	518	PF00082	0.467
CLV_PCSK_SKI1_1	55	59	PF00082	0.770
DEG_APCC_DBOX_1	405	413	PF00400	0.412
DEG_SPOP_SBC_1	259	263	PF00917	0.430
DEG_SPOP_SBC_1	270	274	PF00917	0.390
DOC_CYCLIN_RxL_1	155	163	PF00134	0.502
DOC_MAPK_gen_1	420	429	PF00069	0.562
DOC_PP2B_LxvP_1	499	502	PF13499	0.607
DOC_USP7_MATH_1	250	254	PF00917	0.546
DOC_USP7_MATH_1	259	263	PF00917	0.518
DOC_USP7_MATH_1	270	274	PF00917	0.420
DOC_USP7_MATH_1	47	51	PF00917	0.773
DOC_USP7_MATH_1	500	504	PF00917	0.614
DOC_USP7_MATH_1	66	70	PF00917	0.670
DOC_WW_Pin1_4	501	506	PF00397	0.611
LIG_14-3-3_CanoR_1	173	179	PF00244	0.574
LIG_14-3-3_CanoR_1	22	30	PF00244	0.594
LIG_14-3-3_CanoR_1	283	291	PF00244	0.562
LIG_14-3-3_CanoR_1	423	428	PF00244	0.482
LIG_14-3-3_CanoR_1	449	454	PF00244	0.510
LIG_14-3-3_CanoR_1	53	58	PF00244	0.795
LIG_Actin_WH2_2	324	339	PF00022	0.683
LIG_APCC_Cbox_2	325	331	PF00515	0.586
LIG_BIR_II_1	1	5	PF00653	0.532
LIG_BRCT_BRCA1_1	433	437	PF00533	0.586
LIG_Clathr_ClatBox_2	169	174	PF01394	0.482
LIG_deltaCOP1_diTrp_1	169	174	PF00928	0.482
LIG_deltaCOP1_diTrp_1	405	414	PF00928	0.482
LIG_FHA_1	151	157	PF00498	0.641
LIG_FHA_1	284	290	PF00498	0.562
LIG_FHA_1	304	310	PF00498	0.350
LIG_FHA_1	417	423	PF00498	0.484
LIG_FHA_1	448	454	PF00498	0.501
LIG_FHA_1	476	482	PF00498	0.469
LIG_FHA_2	134	140	PF00498	0.651
LIG_FHA_2	142	148	PF00498	0.708
LIG_FHA_2	223	229	PF00498	0.421
LIG_Integrin_isoDGR_2	17	19	PF01839	0.538
LIG_LIR_Gen_1	479	489	PF02991	0.472
LIG_LIR_Gen_1	503	512	PF02991	0.579
LIG_LIR_Nem_3	210	214	PF02991	0.567
LIG_LIR_Nem_3	503	509	PF02991	0.479
LIG_Pex14_1	513	517	PF04695	0.544
LIG_SH2_CRK	21	25	PF00017	0.791
LIG_SH2_STAP1	205	209	PF00017	0.482
LIG_SH2_STAT3	114	117	PF00017	0.510
LIG_SH2_STAT5	114	117	PF00017	0.548
LIG_SH2_STAT5	205	208	PF00017	0.539
LIG_SH2_STAT5	384	387	PF00017	0.562
LIG_SH2_STAT5	41	44	PF00017	0.679
LIG_SH3_3	192	198	PF00018	0.411
LIG_SH3_3	295	301	PF00018	0.482
LIG_SH3_3	499	505	PF00018	0.605
LIG_SH3_3	59	65	PF00018	0.655
LIG_SH3_3	74	80	PF00018	0.704
LIG_SUMO_SIM_anti_2	389	395	PF11976	0.496
LIG_TRAF2_1	225	228	PF00917	0.429
MOD_CK1_1	261	267	PF00069	0.524
MOD_CK1_1	274	280	PF00069	0.511
MOD_CK1_1	285	291	PF00069	0.529
MOD_CK1_1	504	510	PF00069	0.532
MOD_CK1_1	82	88	PF00069	0.549
MOD_CK2_1	133	139	PF00069	0.624
MOD_CK2_1	222	228	PF00069	0.421
MOD_CMANNOS	171	174	PF00535	0.282
MOD_Cter_Amidation	17	20	PF01082	0.788
MOD_Cter_Amidation	51	54	PF01082	0.781
MOD_GlcNHglycan	102	105	PF01048	0.643
MOD_GlcNHglycan	252	255	PF01048	0.302
MOD_GlcNHglycan	273	276	PF01048	0.351
MOD_GlcNHglycan	361	364	PF01048	0.360
MOD_GlcNHglycan	456	459	PF01048	0.567
MOD_GlcNHglycan	49	52	PF01048	0.737
MOD_GlcNHglycan	69	72	PF01048	0.728
MOD_GSK3_1	258	265	PF00069	0.512
MOD_GSK3_1	270	277	PF00069	0.472
MOD_GSK3_1	500	507	PF00069	0.607
MOD_GSK3_1	79	86	PF00069	0.602
MOD_LATS_1	281	287	PF00433	0.562
MOD_N-GLC_1	265	270	PF02516	0.306
MOD_NEK2_1	269	274	PF00069	0.508
MOD_NEK2_1	293	298	PF00069	0.517
MOD_NEK2_1	83	88	PF00069	0.714
MOD_PIKK_1	113	119	PF00454	0.494
MOD_PIKK_1	203	209	PF00454	0.496
MOD_PIKK_1	83	89	PF00454	0.721
MOD_PK_1	423	429	PF00069	0.586
MOD_PKA_1	53	59	PF00069	0.547
MOD_PKA_2	172	178	PF00069	0.553
MOD_PKA_2	282	288	PF00069	0.482
MOD_PKA_2	39	45	PF00069	0.794
MOD_PKB_1	20	28	PF00069	0.515
MOD_Plk_1	265	271	PF00069	0.405
MOD_Plk_4	152	158	PF00069	0.355
MOD_Plk_4	294	300	PF00069	0.482
MOD_Plk_4	53	59	PF00069	0.547
MOD_ProDKin_1	501	507	PF00069	0.615
TRG_DiLeu_BaEn_3	490	496	PF01217	0.555
TRG_DiLeu_BaLyEn_6	275	280	PF01217	0.586
TRG_DiLeu_BaLyEn_6	347	352	PF01217	0.572
TRG_ENDOCYTIC_2	21	24	PF00928	0.797
TRG_ENDOCYTIC_2	211	214	PF00928	0.535
TRG_ENDOCYTIC_2	355	358	PF00928	0.498
TRG_ER_diArg_1	107	110	PF00400	0.419
TRG_ER_diArg_1	19	21	PF00400	0.776
TRG_Pf-PMV_PEXEL_1	158	163	PF00026	0.302
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.205
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXQ4	Leptomonas seymouri	60%	87%
A0A1X0P2M3	Trypanosomatidae	46%	95%
A0A3R7KZ00	Trypanosoma rangeli	45%	100%
A0A3S5H4W0	Leishmania donovani	75%	85%
A4HRH9	Leishmania infantum	75%	85%
C9ZXK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	95%
E9AC47	Leishmania major	75%	100%
E9AJE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	85%
V5BLJ6	Trypanosoma cruzi	43%	97%