CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H378_LEIBR

TriTrypDb:

LbrM.01.0580 , LBRM2903_010011000

Length:

527

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H378

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H378

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	329	333	PF00656	0.658
CLV_NRD_NRD_1	13	15	PF00675	0.630
CLV_NRD_NRD_1	29	31	PF00675	0.556
CLV_NRD_NRD_1	347	349	PF00675	0.520
CLV_PCSK_KEX2_1	13	15	PF00082	0.630
CLV_PCSK_KEX2_1	143	145	PF00082	0.419
CLV_PCSK_KEX2_1	29	31	PF00082	0.520
CLV_PCSK_KEX2_1	304	306	PF00082	0.727
CLV_PCSK_KEX2_1	318	320	PF00082	0.532
CLV_PCSK_KEX2_1	324	326	PF00082	0.593
CLV_PCSK_KEX2_1	347	349	PF00082	0.520
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.266
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.699
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.510
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.579
CLV_PCSK_PC7_1	139	145	PF00082	0.416
CLV_PCSK_PC7_1	343	349	PF00082	0.498
CLV_PCSK_PC7_1	9	15	PF00082	0.604
CLV_PCSK_SKI1_1	144	148	PF00082	0.347
CLV_PCSK_SKI1_1	366	370	PF00082	0.407
CLV_PCSK_SKI1_1	478	482	PF00082	0.511
DEG_SPOP_SBC_1	246	250	PF00917	0.599
DEG_SPOP_SBC_1	338	342	PF00917	0.592
DEG_SPOP_SBC_1	409	413	PF00917	0.618
DEG_SPOP_SBC_1	462	466	PF00917	0.475
DOC_CDC14_PxL_1	266	274	PF14671	0.454
DOC_CYCLIN_yCln2_LP_2	418	424	PF00134	0.469
DOC_MAPK_gen_1	143	150	PF00069	0.395
DOC_MAPK_gen_1	17	26	PF00069	0.589
DOC_MAPK_gen_1	275	283	PF00069	0.458
DOC_MAPK_MEF2A_6	143	150	PF00069	0.425
DOC_MAPK_MEF2A_6	275	283	PF00069	0.456
DOC_MAPK_NFAT4_5	143	151	PF00069	0.430
DOC_PP2B_LxvP_1	224	227	PF13499	0.568
DOC_PP4_FxxP_1	225	228	PF00568	0.574
DOC_PP4_MxPP_1	97	100	PF00568	0.464
DOC_SPAK_OSR1_1	154	158	PF12202	0.368
DOC_USP7_MATH_1	116	120	PF00917	0.342
DOC_USP7_MATH_1	124	128	PF00917	0.375
DOC_USP7_MATH_1	129	133	PF00917	0.329
DOC_USP7_MATH_1	202	206	PF00917	0.525
DOC_USP7_MATH_1	235	239	PF00917	0.652
DOC_USP7_MATH_1	246	250	PF00917	0.793
DOC_USP7_MATH_1	303	307	PF00917	0.538
DOC_USP7_MATH_1	339	343	PF00917	0.659
DOC_USP7_MATH_1	394	398	PF00917	0.581
DOC_USP7_MATH_1	409	413	PF00917	0.451
DOC_USP7_MATH_1	458	462	PF00917	0.553
DOC_USP7_MATH_1	523	527	PF00917	0.379
DOC_USP7_MATH_1	89	93	PF00917	0.501
DOC_USP7_UBL2_3	312	316	PF12436	0.589
DOC_USP7_UBL2_3	494	498	PF12436	0.560
DOC_WW_Pin1_4	112	117	PF00397	0.490
DOC_WW_Pin1_4	228	233	PF00397	0.532
DOC_WW_Pin1_4	33	38	PF00397	0.443
DOC_WW_Pin1_4	405	410	PF00397	0.579
DOC_WW_Pin1_4	486	491	PF00397	0.614
DOC_WW_Pin1_4	51	56	PF00397	0.398
DOC_WW_Pin1_4	82	87	PF00397	0.480
LIG_14-3-3_CanoR_1	139	143	PF00244	0.487
LIG_14-3-3_CanoR_1	319	324	PF00244	0.666
LIG_14-3-3_CanoR_1	410	419	PF00244	0.562
LIG_BRCT_BRCA1_1	262	266	PF00533	0.512
LIG_BRCT_BRCA1_1	463	467	PF00533	0.482
LIG_FHA_1	10	16	PF00498	0.496
LIG_FHA_1	332	338	PF00498	0.693
LIG_FHA_1	34	40	PF00498	0.431
LIG_FHA_1	413	419	PF00498	0.488
LIG_FHA_1	424	430	PF00498	0.428
LIG_FHA_2	194	200	PF00498	0.465
LIG_FHA_2	218	224	PF00498	0.528
LIG_FHA_2	502	508	PF00498	0.496
LIG_LIR_Apic_2	223	228	PF02991	0.566
LIG_LIR_Gen_1	130	138	PF02991	0.346
LIG_LIR_Gen_1	263	273	PF02991	0.474
LIG_LIR_Nem_3	119	123	PF02991	0.356
LIG_LIR_Nem_3	130	136	PF02991	0.311
LIG_LIR_Nem_3	145	150	PF02991	0.360
LIG_LIR_Nem_3	263	269	PF02991	0.473
LIG_RPA_C_Fungi	343	355	PF08784	0.491
LIG_SH2_STAT5	271	274	PF00017	0.506
LIG_SH2_STAT5	511	514	PF00017	0.456
LIG_SH3_3	184	190	PF00018	0.553
LIG_SH3_3	226	232	PF00018	0.469
LIG_SH3_3	314	320	PF00018	0.763
LIG_SH3_3	32	38	PF00018	0.560
LIG_SH3_3	413	419	PF00018	0.520
LIG_TRAF2_1	307	310	PF00917	0.482
LIG_TRAF2_1	75	78	PF00917	0.498
LIG_WW_2	37	40	PF00397	0.420
LIG_WW_3	227	231	PF00397	0.474
MOD_CDK_SPK_2	405	410	PF00069	0.600
MOD_CK1_1	111	117	PF00069	0.418
MOD_CK1_1	233	239	PF00069	0.703
MOD_CK1_1	247	253	PF00069	0.645
MOD_CK1_1	408	414	PF00069	0.536
MOD_CK1_1	452	458	PF00069	0.464
MOD_CK1_1	461	467	PF00069	0.460
MOD_CK1_1	51	57	PF00069	0.483
MOD_CK2_1	193	199	PF00069	0.467
MOD_CK2_1	202	208	PF00069	0.563
MOD_CK2_1	303	309	PF00069	0.612
MOD_CK2_1	330	336	PF00069	0.547
MOD_CK2_1	72	78	PF00069	0.493
MOD_GlcNHglycan	110	113	PF01048	0.627
MOD_GlcNHglycan	161	164	PF01048	0.533
MOD_GlcNHglycan	204	207	PF01048	0.646
MOD_GlcNHglycan	235	238	PF01048	0.685
MOD_GlcNHglycan	253	256	PF01048	0.517
MOD_GlcNHglycan	283	286	PF01048	0.479
MOD_GlcNHglycan	293	296	PF01048	0.515
MOD_GlcNHglycan	305	308	PF01048	0.561
MOD_GlcNHglycan	378	381	PF01048	0.424
MOD_GlcNHglycan	388	392	PF01048	0.552
MOD_GlcNHglycan	396	399	PF01048	0.490
MOD_GlcNHglycan	412	415	PF01048	0.457
MOD_GlcNHglycan	441	444	PF01048	0.392
MOD_GlcNHglycan	456	459	PF01048	0.434
MOD_GlcNHglycan	460	463	PF01048	0.434
MOD_GlcNHglycan	481	484	PF01048	0.525
MOD_GlcNHglycan	91	94	PF01048	0.492
MOD_GSK3_1	107	114	PF00069	0.614
MOD_GSK3_1	138	145	PF00069	0.423
MOD_GSK3_1	155	162	PF00069	0.375
MOD_GSK3_1	244	251	PF00069	0.707
MOD_GSK3_1	260	267	PF00069	0.487
MOD_GSK3_1	360	367	PF00069	0.581
MOD_GSK3_1	405	412	PF00069	0.588
MOD_GSK3_1	423	430	PF00069	0.631
MOD_GSK3_1	44	51	PF00069	0.417
MOD_GSK3_1	444	451	PF00069	0.446
MOD_GSK3_1	452	459	PF00069	0.515
MOD_GSK3_1	462	469	PF00069	0.451
MOD_GSK3_1	481	488	PF00069	0.483
MOD_GSK3_1	5	12	PF00069	0.492
MOD_N-GLC_1	108	113	PF02516	0.458
MOD_N-GLC_1	193	198	PF02516	0.572
MOD_N-GLC_1	251	256	PF02516	0.529
MOD_N-GLC_2	372	374	PF02516	0.303
MOD_N-GLC_2	435	437	PF02516	0.333
MOD_NEK2_1	138	143	PF00069	0.424
MOD_NEK2_1	291	296	PF00069	0.490
MOD_NEK2_1	44	49	PF00069	0.423
MOD_NEK2_1	481	486	PF00069	0.485
MOD_NEK2_1	88	93	PF00069	0.649
MOD_NEK2_2	235	240	PF00069	0.531
MOD_PIKK_1	62	68	PF00454	0.471
MOD_PKA_1	13	19	PF00069	0.494
MOD_PKA_1	318	324	PF00069	0.606
MOD_PKA_2	13	19	PF00069	0.500
MOD_PKA_2	138	144	PF00069	0.428
MOD_PKA_2	318	324	PF00069	0.638
MOD_PKA_2	409	415	PF00069	0.515
MOD_PKA_2	502	508	PF00069	0.515
MOD_Plk_1	129	135	PF00069	0.343
MOD_Plk_1	264	270	PF00069	0.453
MOD_Plk_2-3	217	223	PF00069	0.528
MOD_Plk_4	116	122	PF00069	0.421
MOD_Plk_4	129	135	PF00069	0.367
MOD_Plk_4	364	370	PF00069	0.418
MOD_Plk_4	424	430	PF00069	0.454
MOD_Plk_4	44	50	PF00069	0.515
MOD_Plk_4	463	469	PF00069	0.563
MOD_Plk_4	481	487	PF00069	0.730
MOD_ProDKin_1	112	118	PF00069	0.477
MOD_ProDKin_1	228	234	PF00069	0.536
MOD_ProDKin_1	33	39	PF00069	0.440
MOD_ProDKin_1	405	411	PF00069	0.578
MOD_ProDKin_1	486	492	PF00069	0.612
MOD_ProDKin_1	51	57	PF00069	0.402
MOD_ProDKin_1	82	88	PF00069	0.483
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.421
TRG_ER_diArg_1	13	15	PF00400	0.630
TRG_ER_diArg_1	152	155	PF00400	0.394
TRG_ER_diArg_1	17	20	PF00400	0.486
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P578	Leptomonas seymouri	41%	100%
A0A3S5H4V9	Leishmania donovani	61%	100%
E9AJE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
V5BH18	Trypanosoma cruzi	33%	100%