Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H377_LEIBR

TriTrypDb:

LbrM.01.0570 , LBRM2903_010010900

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H377

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H377

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.631
CLV_C14_Caspase3-7	596	600	PF00656	0.853
CLV_C14_Caspase3-7	680	684	PF00656	0.527
CLV_NRD_NRD_1	104	106	PF00675	0.606
CLV_NRD_NRD_1	144	146	PF00675	0.783
CLV_NRD_NRD_1	16	18	PF00675	0.744
CLV_NRD_NRD_1	160	162	PF00675	0.502
CLV_NRD_NRD_1	181	183	PF00675	0.717
CLV_NRD_NRD_1	211	213	PF00675	0.731
CLV_NRD_NRD_1	35	37	PF00675	0.428
CLV_NRD_NRD_1	389	391	PF00675	0.711
CLV_NRD_NRD_1	50	52	PF00675	0.687
CLV_NRD_NRD_1	54	56	PF00675	0.691
CLV_NRD_NRD_1	638	640	PF00675	0.634
CLV_NRD_NRD_1	676	678	PF00675	0.596
CLV_NRD_NRD_1	694	696	PF00675	0.671
CLV_PCSK_FUR_1	387	391	PF00082	0.820
CLV_PCSK_FUR_1	674	678	PF00082	0.556
CLV_PCSK_KEX2_1	104	106	PF00082	0.610
CLV_PCSK_KEX2_1	144	146	PF00082	0.783
CLV_PCSK_KEX2_1	16	18	PF00082	0.744
CLV_PCSK_KEX2_1	181	183	PF00082	0.717
CLV_PCSK_KEX2_1	211	213	PF00082	0.731
CLV_PCSK_KEX2_1	263	265	PF00082	0.766
CLV_PCSK_KEX2_1	35	37	PF00082	0.428
CLV_PCSK_KEX2_1	389	391	PF00082	0.691
CLV_PCSK_KEX2_1	50	52	PF00082	0.687
CLV_PCSK_KEX2_1	54	56	PF00082	0.691
CLV_PCSK_KEX2_1	676	678	PF00082	0.634
CLV_PCSK_KEX2_1	693	695	PF00082	0.690
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.766
CLV_PCSK_PC1ET2_1	693	695	PF00082	0.755
CLV_PCSK_PC7_1	50	56	PF00082	0.743
CLV_PCSK_SKI1_1	320	324	PF00082	0.544
CLV_PCSK_SKI1_1	458	462	PF00082	0.867
CLV_PCSK_SKI1_1	54	58	PF00082	0.792
CLV_PCSK_SKI1_1	625	629	PF00082	0.610
CLV_PCSK_SKI1_1	676	680	PF00082	0.582
CLV_PCSK_SKI1_1	72	76	PF00082	0.573
DEG_APCC_DBOX_1	49	57	PF00400	0.784
DOC_ANK_TNKS_1	211	218	PF00023	0.607
DOC_ANK_TNKS_1	594	601	PF00023	0.601
DOC_CKS1_1	272	277	PF01111	0.585
DOC_CYCLIN_RxL_1	673	683	PF00134	0.542
DOC_MAPK_gen_1	263	270	PF00069	0.676
DOC_MAPK_gen_1	666	675	PF00069	0.799
DOC_MAPK_gen_1	693	701	PF00069	0.796
DOC_MAPK_MEF2A_6	571	580	PF00069	0.592
DOC_MAPK_MEF2A_6	693	701	PF00069	0.753
DOC_PP2B_LxvP_1	27	30	PF13499	0.463
DOC_PP2B_PxIxI_1	334	340	PF00149	0.504
DOC_PP4_FxxP_1	200	203	PF00568	0.775
DOC_PP4_FxxP_1	9	12	PF00568	0.780
DOC_PP4_MxPP_1	700	703	PF00568	0.740
DOC_USP7_MATH_1	175	179	PF00917	0.780
DOC_USP7_MATH_1	248	252	PF00917	0.740
DOC_USP7_MATH_1	310	314	PF00917	0.556
DOC_USP7_MATH_1	393	397	PF00917	0.565
DOC_USP7_MATH_1	436	440	PF00917	0.788
DOC_USP7_MATH_1	559	563	PF00917	0.845
DOC_USP7_MATH_1	606	610	PF00917	0.776
DOC_USP7_MATH_1	662	666	PF00917	0.718
DOC_USP7_MATH_1	67	71	PF00917	0.593
DOC_USP7_MATH_1	682	686	PF00917	0.456
DOC_WW_Pin1_4	105	110	PF00397	0.596
DOC_WW_Pin1_4	271	276	PF00397	0.582
DOC_WW_Pin1_4	301	306	PF00397	0.583
DOC_WW_Pin1_4	421	426	PF00397	0.764
DOC_WW_Pin1_4	429	434	PF00397	0.815
DOC_WW_Pin1_4	460	465	PF00397	0.858
DOC_WW_Pin1_4	507	512	PF00397	0.828
DOC_WW_Pin1_4	523	528	PF00397	0.594
DOC_WW_Pin1_4	557	562	PF00397	0.757
DOC_WW_Pin1_4	587	592	PF00397	0.828
DOC_WW_Pin1_4	627	632	PF00397	0.851
DOC_WW_Pin1_4	652	657	PF00397	0.599
LIG_14-3-3_CanoR_1	161	168	PF00244	0.769
LIG_14-3-3_CanoR_1	233	242	PF00244	0.788
LIG_14-3-3_CanoR_1	394	404	PF00244	0.816
LIG_14-3-3_CanoR_1	583	593	PF00244	0.748
LIG_BRCT_BRCA1_1	272	276	PF00533	0.548
LIG_BRCT_BRCA1_2	272	278	PF00533	0.548
LIG_deltaCOP1_diTrp_1	33	38	PF00928	0.737
LIG_FHA_1	263	269	PF00498	0.575
LIG_FHA_1	350	356	PF00498	0.712
LIG_FHA_1	370	376	PF00498	0.806
LIG_FHA_1	481	487	PF00498	0.620
LIG_FHA_2	130	136	PF00498	0.511
LIG_FHA_2	152	158	PF00498	0.682
LIG_FHA_2	294	300	PF00498	0.824
LIG_FHA_2	326	332	PF00498	0.764
LIG_FHA_2	594	600	PF00498	0.770
LIG_FHA_2	642	648	PF00498	0.577
LIG_FHA_2	678	684	PF00498	0.530
LIG_LIR_Apic_2	197	203	PF02991	0.761
LIG_LIR_Apic_2	8	13	PF02991	0.779
LIG_LIR_Gen_1	273	284	PF02991	0.546
LIG_LIR_Gen_1	327	338	PF02991	0.531
LIG_LIR_Gen_1	348	359	PF02991	0.749
LIG_LIR_Nem_3	273	279	PF02991	0.549
LIG_LIR_Nem_3	327	333	PF02991	0.655
LIG_LIR_Nem_3	348	354	PF02991	0.666
LIG_MYND_1	507	511	PF01753	0.824
LIG_Pex14_1	34	38	PF04695	0.577
LIG_Rb_LxCxE_1	683	704	PF01857	0.548
LIG_SH2_CRK	330	334	PF00017	0.541
LIG_SH2_NCK_1	330	334	PF00017	0.541
LIG_SH2_SRC	286	289	PF00017	0.714
LIG_SH2_STAP1	351	355	PF00017	0.752
LIG_SH2_STAP1	412	416	PF00017	0.798
LIG_SH2_STAP1	671	675	PF00017	0.809
LIG_SH2_STAT3	646	649	PF00017	0.586
LIG_SH2_STAT5	159	162	PF00017	0.800
LIG_SH2_STAT5	190	193	PF00017	0.659
LIG_SH2_STAT5	286	289	PF00017	0.630
LIG_SH2_STAT5	351	354	PF00017	0.671
LIG_SH2_STAT5	377	380	PF00017	0.636
LIG_SH2_STAT5	383	386	PF00017	0.742
LIG_SH2_STAT5	643	646	PF00017	0.584
LIG_SH3_2	94	99	PF14604	0.589
LIG_SH3_3	186	192	PF00018	0.741
LIG_SH3_3	269	275	PF00018	0.578
LIG_SH3_3	329	335	PF00018	0.789
LIG_SH3_3	448	454	PF00018	0.799
LIG_SH3_3	53	59	PF00018	0.564
LIG_SH3_3	555	561	PF00018	0.601
LIG_SH3_3	696	702	PF00018	0.797
LIG_SH3_3	90	96	PF00018	0.591
LIG_SUMO_SIM_anti_2	577	582	PF11976	0.600
LIG_TRFH_1	377	381	PF08558	0.812
LIG_TYR_ITSM	326	333	PF00017	0.549
LIG_WRC_WIRS_1	267	272	PF05994	0.531
MOD_CDC14_SPxK_1	108	111	PF00782	0.588
MOD_CDK_SPK_2	301	306	PF00069	0.583
MOD_CDK_SPK_2	460	465	PF00069	0.605
MOD_CDK_SPK_2	631	636	PF00069	0.618
MOD_CDK_SPxK_1	105	111	PF00069	0.595
MOD_CDK_SPxxK_3	271	278	PF00069	0.583
MOD_CK1_1	139	145	PF00069	0.601
MOD_CK1_1	271	277	PF00069	0.701
MOD_CK1_1	396	402	PF00069	0.818
MOD_CK1_1	421	427	PF00069	0.812
MOD_CK1_1	432	438	PF00069	0.664
MOD_CK1_1	456	462	PF00069	0.615
MOD_CK1_1	489	495	PF00069	0.788
MOD_CK1_1	574	580	PF00069	0.634
MOD_CK1_1	587	593	PF00069	0.755
MOD_CK1_1	609	615	PF00069	0.603
MOD_CK1_1	634	640	PF00069	0.594
MOD_CK1_1	665	671	PF00069	0.793
MOD_CK2_1	129	135	PF00069	0.514
MOD_CK2_1	151	157	PF00069	0.677
MOD_CK2_1	412	418	PF00069	0.821
MOD_CK2_1	507	513	PF00069	0.864
MOD_CK2_1	609	615	PF00069	0.597
MOD_GlcNHglycan	114	117	PF01048	0.699
MOD_GlcNHglycan	124	127	PF01048	0.759
MOD_GlcNHglycan	138	141	PF01048	0.529
MOD_GlcNHglycan	162	165	PF01048	0.607
MOD_GlcNHglycan	235	238	PF01048	0.540
MOD_GlcNHglycan	312	315	PF01048	0.541
MOD_GlcNHglycan	362	365	PF01048	0.776
MOD_GlcNHglycan	390	393	PF01048	0.642
MOD_GlcNHglycan	40	43	PF01048	0.571
MOD_GlcNHglycan	412	415	PF01048	0.815
MOD_GlcNHglycan	420	423	PF01048	0.714
MOD_GlcNHglycan	438	441	PF01048	0.599
MOD_GlcNHglycan	451	454	PF01048	0.647
MOD_GlcNHglycan	553	556	PF01048	0.633
MOD_GlcNHglycan	563	566	PF01048	0.586
MOD_GlcNHglycan	611	614	PF01048	0.845
MOD_GSK3_1	105	112	PF00069	0.642
MOD_GSK3_1	118	125	PF00069	0.656
MOD_GSK3_1	262	269	PF00069	0.624
MOD_GSK3_1	365	372	PF00069	0.599
MOD_GSK3_1	375	382	PF00069	0.642
MOD_GSK3_1	406	413	PF00069	0.804
MOD_GSK3_1	420	427	PF00069	0.617
MOD_GSK3_1	428	435	PF00069	0.729
MOD_GSK3_1	449	456	PF00069	0.859
MOD_GSK3_1	537	544	PF00069	0.762
MOD_GSK3_1	557	564	PF00069	0.804
MOD_GSK3_1	581	588	PF00069	0.766
MOD_GSK3_1	589	596	PF00069	0.712
MOD_GSK3_1	627	634	PF00069	0.852
MOD_N-GLC_1	465	470	PF02516	0.733
MOD_N-GLC_1	585	590	PF02516	0.793
MOD_N-GLC_1	609	614	PF02516	0.604
MOD_NEK2_1	160	165	PF00069	0.709
MOD_NEK2_1	194	199	PF00069	0.589
MOD_NEK2_1	242	247	PF00069	0.750
MOD_NEK2_1	268	273	PF00069	0.627
MOD_NEK2_1	354	359	PF00069	0.495
MOD_NEK2_1	375	380	PF00069	0.811
MOD_NEK2_1	38	43	PF00069	0.610
MOD_NEK2_1	388	393	PF00069	0.689
MOD_NEK2_1	420	425	PF00069	0.845
MOD_NEK2_1	581	586	PF00069	0.852
MOD_NEK2_1	593	598	PF00069	0.656
MOD_NEK2_2	67	72	PF00069	0.595
MOD_PIKK_1	166	172	PF00454	0.789
MOD_PIKK_1	396	402	PF00454	0.780
MOD_PIKK_1	486	492	PF00454	0.568
MOD_PIKK_1	559	565	PF00454	0.663
MOD_PIKK_1	634	640	PF00454	0.594
MOD_PK_1	465	471	PF00069	0.599
MOD_PK_1	497	503	PF00069	0.608
MOD_PKA_2	100	106	PF00069	0.609
MOD_PKA_2	160	166	PF00069	0.713
MOD_PKA_2	210	216	PF00069	0.605
MOD_PKA_2	232	238	PF00069	0.653
MOD_PKA_2	293	299	PF00069	0.568
MOD_PKA_2	379	385	PF00069	0.804
MOD_PKA_2	388	394	PF00069	0.539
MOD_PKA_2	551	557	PF00069	0.613
MOD_PKB_1	358	366	PF00069	0.526
MOD_Plk_1	456	462	PF00069	0.754
MOD_Plk_1	465	471	PF00069	0.817
MOD_Plk_1	682	688	PF00069	0.697
MOD_Plk_2-3	293	299	PF00069	0.607
MOD_Plk_4	129	135	PF00069	0.528
MOD_Plk_4	194	200	PF00069	0.581
MOD_Plk_4	379	385	PF00069	0.804
MOD_Plk_4	403	409	PF00069	0.554
MOD_Plk_4	576	582	PF00069	0.671
MOD_Plk_4	589	595	PF00069	0.751
MOD_Plk_4	682	688	PF00069	0.794
MOD_ProDKin_1	105	111	PF00069	0.595
MOD_ProDKin_1	271	277	PF00069	0.582
MOD_ProDKin_1	301	307	PF00069	0.585
MOD_ProDKin_1	421	427	PF00069	0.765
MOD_ProDKin_1	429	435	PF00069	0.815
MOD_ProDKin_1	460	466	PF00069	0.857
MOD_ProDKin_1	507	513	PF00069	0.829
MOD_ProDKin_1	523	529	PF00069	0.595
MOD_ProDKin_1	557	563	PF00069	0.761
MOD_ProDKin_1	587	593	PF00069	0.831
MOD_ProDKin_1	627	633	PF00069	0.852
MOD_ProDKin_1	652	658	PF00069	0.601
MOD_SUMO_for_1	324	327	PF00179	0.590
MOD_SUMO_for_1	366	369	PF00179	0.685
MOD_SUMO_rev_2	255	265	PF00179	0.776
TRG_ENDOCYTIC_2	330	333	PF00928	0.635
TRG_ENDOCYTIC_2	351	354	PF00928	0.653
TRG_ENDOCYTIC_2	84	87	PF00928	0.578
TRG_ER_diArg_1	211	214	PF00400	0.769
TRG_ER_diArg_1	34	36	PF00400	0.529
TRG_ER_diArg_1	387	390	PF00400	0.824
TRG_ER_diArg_1	50	52	PF00400	0.684
TRG_ER_diArg_1	53	55	PF00400	0.684
TRG_ER_diArg_1	673	676	PF00400	0.701
TRG_NLS_Bipartite_1	676	697	PF00514	0.549
TRG_NLS_MonoExtN_4	692	697	PF00514	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4V8	Leishmania donovani	62%	100%
A4HRH7	Leishmania infantum	62%	100%
E9AC45	Leishmania major	58%	91%
E9AJE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%