Putative long-chain-fatty-acid-CoA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

long-chain-fatty-acid-CoA ligase, putative

Species:

Leishmania braziliensis

UniProt:

A4H376_LEIBR

TriTrypDb:

LbrM.01.0560 , LBRM2903_010010800

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 6
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 33

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	4
GO:0005737	cytoplasm	2	4
GO:0005783	endoplasmic reticulum	5	4
GO:0016020	membrane	2	4
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0097014	ciliary plasm	5	4
GO:0099568	cytoplasmic region	3	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4H376

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H376

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	30
GO:0004467	long-chain fatty acid-CoA ligase activity	3	28
GO:0015645	fatty acid ligase activity	2	28
GO:0016405	CoA-ligase activity	4	28
GO:0016874	ligase activity	2	30
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	28
GO:0016878	acid-thiol ligase activity	4	28
GO:0140657	ATP-dependent activity	1	28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	477	481	PF00656	0.138
CLV_NRD_NRD_1	12	14	PF00675	0.613
CLV_NRD_NRD_1	153	155	PF00675	0.445
CLV_NRD_NRD_1	161	163	PF00675	0.429
CLV_NRD_NRD_1	171	173	PF00675	0.445
CLV_NRD_NRD_1	262	264	PF00675	0.619
CLV_NRD_NRD_1	341	343	PF00675	0.176
CLV_NRD_NRD_1	374	376	PF00675	0.248
CLV_NRD_NRD_1	397	399	PF00675	0.233
CLV_NRD_NRD_1	402	404	PF00675	0.244
CLV_NRD_NRD_1	565	567	PF00675	0.254
CLV_NRD_NRD_1	611	613	PF00675	0.324
CLV_PCSK_FUR_1	372	376	PF00082	0.138
CLV_PCSK_KEX2_1	153	155	PF00082	0.594
CLV_PCSK_KEX2_1	170	172	PF00082	0.610
CLV_PCSK_KEX2_1	262	264	PF00082	0.433
CLV_PCSK_KEX2_1	341	343	PF00082	0.392
CLV_PCSK_KEX2_1	374	376	PF00082	0.310
CLV_PCSK_KEX2_1	397	399	PF00082	0.276
CLV_PCSK_KEX2_1	402	404	PF00082	0.275
CLV_PCSK_KEX2_1	565	567	PF00082	0.254
CLV_PCSK_KEX2_1	611	613	PF00082	0.303
CLV_PCSK_PC7_1	398	404	PF00082	0.138
CLV_PCSK_SKI1_1	153	157	PF00082	0.437
CLV_PCSK_SKI1_1	162	166	PF00082	0.426
CLV_PCSK_SKI1_1	229	233	PF00082	0.325
CLV_PCSK_SKI1_1	332	336	PF00082	0.301
CLV_PCSK_SKI1_1	342	346	PF00082	0.299
CLV_PCSK_SKI1_1	386	390	PF00082	0.298
CLV_PCSK_SKI1_1	419	423	PF00082	0.355
CLV_PCSK_SKI1_1	427	431	PF00082	0.303
CLV_PCSK_SKI1_1	494	498	PF00082	0.455
CLV_PCSK_SKI1_1	714	718	PF00082	0.442
DEG_APCC_DBOX_1	152	160	PF00400	0.633
DEG_APCC_DBOX_1	206	214	PF00400	0.336
DEG_APCC_DBOX_1	424	432	PF00400	0.138
DEG_ODPH_VHL_1	210	222	PF01847	0.261
DEG_ODPH_VHL_1	691	702	PF01847	0.220
DEG_SCF_TRCP1_1	106	111	PF00400	0.467
DEG_SPOP_SBC_1	645	649	PF00917	0.342
DOC_CKS1_1	405	410	PF01111	0.247
DOC_CYCLIN_RxL_1	339	347	PF00134	0.409
DOC_CYCLIN_yCln2_LP_2	405	411	PF00134	0.138
DOC_CYCLIN_yCln2_LP_2	720	726	PF00134	0.247
DOC_MAPK_DCC_7	202	210	PF00069	0.387
DOC_MAPK_gen_1	153	159	PF00069	0.583
DOC_MAPK_gen_1	611	619	PF00069	0.172
DOC_MAPK_JIP1_4	214	220	PF00069	0.247
DOC_MAPK_MEF2A_6	202	210	PF00069	0.590
DOC_PP1_RVXF_1	384	391	PF00149	0.138
DOC_USP7_MATH_1	102	106	PF00917	0.465
DOC_USP7_MATH_1	115	119	PF00917	0.456
DOC_USP7_MATH_1	182	186	PF00917	0.578
DOC_USP7_MATH_1	298	302	PF00917	0.559
DOC_USP7_MATH_1	473	477	PF00917	0.258
DOC_USP7_MATH_1	501	505	PF00917	0.307
DOC_USP7_MATH_1	560	564	PF00917	0.168
DOC_USP7_MATH_1	575	579	PF00917	0.325
DOC_USP7_MATH_1	639	643	PF00917	0.396
DOC_USP7_MATH_1	646	650	PF00917	0.330
DOC_USP7_MATH_1	677	681	PF00917	0.323
DOC_USP7_MATH_1	81	85	PF00917	0.445
DOC_USP7_MATH_1	92	96	PF00917	0.461
DOC_WW_Pin1_4	119	124	PF00397	0.444
DOC_WW_Pin1_4	193	198	PF00397	0.423
DOC_WW_Pin1_4	404	409	PF00397	0.293
DOC_WW_Pin1_4	51	56	PF00397	0.728
DOC_WW_Pin1_4	641	646	PF00397	0.373
LIG_14-3-3_CanoR_1	170	178	PF00244	0.454
LIG_14-3-3_CanoR_1	290	299	PF00244	0.399
LIG_14-3-3_CanoR_1	300	305	PF00244	0.385
LIG_14-3-3_CanoR_1	341	345	PF00244	0.347
LIG_14-3-3_CanoR_1	372	378	PF00244	0.364
LIG_14-3-3_CanoR_1	565	571	PF00244	0.313
LIG_14-3-3_CanoR_1	638	644	PF00244	0.676
LIG_Clathr_ClatBox_1	156	160	PF01394	0.426
LIG_FHA_1	119	125	PF00498	0.572
LIG_FHA_1	181	187	PF00498	0.431
LIG_FHA_1	325	331	PF00498	0.400
LIG_FHA_1	405	411	PF00498	0.173
LIG_FHA_1	517	523	PF00498	0.138
LIG_FHA_1	538	544	PF00498	0.306
LIG_FHA_1	550	556	PF00498	0.283
LIG_FHA_1	715	721	PF00498	0.449
LIG_FHA_1	99	105	PF00498	0.769
LIG_FHA_2	222	228	PF00498	0.438
LIG_FHA_2	341	347	PF00498	0.330
LIG_FHA_2	475	481	PF00498	0.287
LIG_LIR_Apic_2	346	351	PF02991	0.314
LIG_LIR_Apic_2	641	646	PF02991	0.671
LIG_LIR_Gen_1	444	454	PF02991	0.297
LIG_LIR_Nem_3	217	223	PF02991	0.385
LIG_LIR_Nem_3	310	314	PF02991	0.276
LIG_LIR_Nem_3	361	366	PF02991	0.286
LIG_LIR_Nem_3	382	388	PF02991	0.138
LIG_LIR_Nem_3	444	450	PF02991	0.297
LIG_LIR_Nem_3	561	567	PF02991	0.138
LIG_SH2_CRK	385	389	PF00017	0.312
LIG_SH2_CRK	643	647	PF00017	0.364
LIG_SH2_CRK	729	733	PF00017	0.371
LIG_SH2_GRB2like	248	251	PF00017	0.402
LIG_SH2_NCK_1	291	295	PF00017	0.394
LIG_SH2_NCK_1	643	647	PF00017	0.364
LIG_SH2_SRC	248	251	PF00017	0.253
LIG_SH2_STAP1	291	295	PF00017	0.394
LIG_SH2_STAP1	712	716	PF00017	0.461
LIG_SH2_STAT3	32	35	PF00017	0.348
LIG_SH2_STAT3	533	536	PF00017	0.281
LIG_SH2_STAT5	223	226	PF00017	0.456
LIG_SH2_STAT5	248	251	PF00017	0.447
LIG_SH2_STAT5	291	294	PF00017	0.566
LIG_SH2_STAT5	314	317	PF00017	0.298
LIG_SH2_STAT5	447	450	PF00017	0.438
LIG_SH2_STAT5	474	477	PF00017	0.214
LIG_SH2_STAT5	613	616	PF00017	0.305
LIG_SH2_STAT5	712	715	PF00017	0.438
LIG_SH3_2	209	214	PF14604	0.312
LIG_SH3_3	145	151	PF00018	0.443
LIG_SH3_3	152	158	PF00018	0.431
LIG_SH3_3	203	209	PF00018	0.576
LIG_SH3_3	361	367	PF00018	0.279
LIG_SH3_3	482	488	PF00018	0.276
LIG_SH3_3	49	55	PF00018	0.462
LIG_SH3_3	633	639	PF00018	0.317
LIG_SUMO_SIM_anti_2	121	128	PF11976	0.624
LIG_SUMO_SIM_anti_2	446	452	PF11976	0.359
LIG_TRAF2_1	158	161	PF00917	0.427
MOD_CK1_1	107	113	PF00069	0.764
MOD_CK1_1	118	124	PF00069	0.722
MOD_CK1_1	140	146	PF00069	0.650
MOD_CK1_1	177	183	PF00069	0.440
MOD_CK1_1	379	385	PF00069	0.216
MOD_CK1_1	512	518	PF00069	0.138
MOD_CK1_1	53	59	PF00069	0.650
MOD_CK1_1	641	647	PF00069	0.582
MOD_CK1_1	648	654	PF00069	0.505
MOD_CK1_1	77	83	PF00069	0.724
MOD_CK1_1	88	94	PF00069	0.461
MOD_GlcNHglycan	106	109	PF01048	0.560
MOD_GlcNHglycan	117	120	PF01048	0.522
MOD_GlcNHglycan	139	142	PF01048	0.601
MOD_GlcNHglycan	302	305	PF01048	0.365
MOD_GlcNHglycan	40	43	PF01048	0.614
MOD_GlcNHglycan	45	48	PF01048	0.623
MOD_GlcNHglycan	464	468	PF01048	0.402
MOD_GlcNHglycan	504	507	PF01048	0.138
MOD_GlcNHglycan	545	549	PF01048	0.308
MOD_GlcNHglycan	55	58	PF01048	0.534
MOD_GlcNHglycan	658	661	PF01048	0.421
MOD_GlcNHglycan	66	69	PF01048	0.533
MOD_GlcNHglycan	670	673	PF01048	0.404
MOD_GlcNHglycan	729	732	PF01048	0.438
MOD_GlcNHglycan	90	93	PF01048	0.468
MOD_GlcNHglycan	94	97	PF01048	0.469
MOD_GSK3_1	115	122	PF00069	0.576
MOD_GSK3_1	137	144	PF00069	0.644
MOD_GSK3_1	170	177	PF00069	0.455
MOD_GSK3_1	271	278	PF00069	0.661
MOD_GSK3_1	340	347	PF00069	0.321
MOD_GSK3_1	376	383	PF00069	0.188
MOD_GSK3_1	43	50	PF00069	0.611
MOD_GSK3_1	452	459	PF00069	0.323
MOD_GSK3_1	474	481	PF00069	0.329
MOD_GSK3_1	51	58	PF00069	0.601
MOD_GSK3_1	512	519	PF00069	0.287
MOD_GSK3_1	641	648	PF00069	0.372
MOD_GSK3_1	652	659	PF00069	0.278
MOD_GSK3_1	710	717	PF00069	0.414
MOD_GSK3_1	77	84	PF00069	0.443
MOD_GSK3_1	86	93	PF00069	0.461
MOD_GSK3_1	98	105	PF00069	0.449
MOD_N-GLC_1	249	254	PF02516	0.263
MOD_NEK2_1	238	243	PF00069	0.368
MOD_NEK2_1	344	349	PF00069	0.341
MOD_NEK2_1	380	385	PF00069	0.303
MOD_NEK2_1	409	414	PF00069	0.254
MOD_NEK2_1	456	461	PF00069	0.272
MOD_NEK2_1	544	549	PF00069	0.396
MOD_NEK2_1	628	633	PF00069	0.433
MOD_NEK2_1	63	68	PF00069	0.627
MOD_NEK2_1	668	673	PF00069	0.365
MOD_NEK2_1	74	79	PF00069	0.702
MOD_NEK2_2	174	179	PF00069	0.624
MOD_NEK2_2	560	565	PF00069	0.248
MOD_PIKK_1	474	480	PF00454	0.172
MOD_PIKK_1	648	654	PF00454	0.572
MOD_PIKK_1	683	689	PF00454	0.387
MOD_PIKK_1	81	87	PF00454	0.450
MOD_PKA_1	170	176	PF00069	0.455
MOD_PKA_2	170	176	PF00069	0.455
MOD_PKA_2	289	295	PF00069	0.700
MOD_PKA_2	307	313	PF00069	0.152
MOD_PKA_2	340	346	PF00069	0.186
MOD_PKA_2	358	364	PF00069	0.418
MOD_PKA_2	373	379	PF00069	0.241
MOD_PKA_2	516	522	PF00069	0.331
MOD_PKA_2	63	69	PF00069	0.610
MOD_PKA_2	727	733	PF00069	0.381
MOD_Plk_4	182	188	PF00069	0.433
MOD_Plk_4	307	313	PF00069	0.356
MOD_Plk_4	358	364	PF00069	0.361
MOD_Plk_4	376	382	PF00069	0.288
MOD_Plk_4	410	416	PF00069	0.219
MOD_Plk_4	446	452	PF00069	0.253
MOD_Plk_4	525	531	PF00069	0.321
MOD_ProDKin_1	119	125	PF00069	0.443
MOD_ProDKin_1	193	199	PF00069	0.424
MOD_ProDKin_1	404	410	PF00069	0.293
MOD_ProDKin_1	51	57	PF00069	0.727
MOD_ProDKin_1	641	647	PF00069	0.373
MOD_SUMO_rev_2	160	165	PF00179	0.689
MOD_SUMO_rev_2	225	231	PF00179	0.374
TRG_DiLeu_BaEn_1	326	331	PF01217	0.359
TRG_DiLeu_BaEn_4	160	166	PF01217	0.431
TRG_ENDOCYTIC_2	314	317	PF00928	0.261
TRG_ENDOCYTIC_2	385	388	PF00928	0.331
TRG_ENDOCYTIC_2	447	450	PF00928	0.138
TRG_ENDOCYTIC_2	729	732	PF00928	0.350
TRG_ER_diArg_1	10	13	PF00400	0.494
TRG_ER_diArg_1	153	155	PF00400	0.445
TRG_ER_diArg_1	169	172	PF00400	0.445
TRG_ER_diArg_1	261	263	PF00400	0.433
TRG_ER_diArg_1	29	32	PF00400	0.613
TRG_ER_diArg_1	299	302	PF00400	0.383
TRG_ER_diArg_1	372	375	PF00400	0.272
TRG_ER_diArg_1	401	403	PF00400	0.207
TRG_ER_diArg_1	425	428	PF00400	0.351
TRG_ER_diArg_1	564	566	PF00400	0.445
TRG_ER_diArg_1	610	612	PF00400	0.454
TRG_NES_CRM1_1	446	458	PF08389	0.409
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	386	391	PF00026	0.243

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P580	Leptomonas seymouri	32%	100%
A0A0N1IG93	Leptomonas seymouri	31%	100%
A0A0S4IKS1	Bodo saltans	34%	100%
A0A0S4ILZ2	Bodo saltans	33%	100%
A0A1X0P2W9	Trypanosomatidae	30%	100%
A0A1X0P304	Trypanosomatidae	39%	68%
A0A1X0P3Q5	Trypanosomatidae	31%	100%
A0A1X0P428	Trypanosomatidae	33%	100%
A0A3R7M7X9	Trypanosoma rangeli	32%	100%
A0A3R7N023	Trypanosoma rangeli	33%	100%
A0A3S5H4V6	Leishmania donovani	33%	100%
A0A422NFF5	Trypanosoma rangeli	32%	100%
A0A422NQH3	Trypanosoma rangeli	30%	100%
A0A451EJA5	Leishmania donovani	31%	100%
A0A451EJA6	Leishmania donovani	30%	100%
A0A451EJM7	Leishmania donovani	30%	100%
A4H374	Leishmania braziliensis	32%	100%
A4H3J5	Leishmania braziliensis	29%	100%
A4HRH2	Leishmania infantum	31%	100%
A4HRH3	Leishmania infantum	30%	100%
A4HRH5	Leishmania infantum	33%	100%
A4HRT4	Leishmania infantum	31%	100%
C9ZXK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZXK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZXK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
C9ZXK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
D0A233	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AC40	Leishmania major	32%	100%
E9AC41	Leishmania major	30%	100%
E9AC43	Leishmania major	33%	100%
E9ACH0	Leishmania major	30%	100%
E9AJD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AJD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AJD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AJD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AJQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
P18163	Rattus norvegicus	23%	100%
P41216	Mus musculus	24%	100%
Q9CAP8	Arabidopsis thaliana	25%	100%
Q9XIA9	Arabidopsis thaliana	24%	100%
V5AX22	Trypanosoma cruzi	33%	100%
V5AZ02	Trypanosoma cruzi	30%	100%
V5BCF5	Trypanosoma cruzi	33%	100%
V5BH13	Trypanosoma cruzi	33%	100%
V5BLJ2	Trypanosoma cruzi	32%	100%