Alpha/beta-hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alpha/beta-hydrolase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H371_LEIBR

TriTrypDb:

LbrM.01.0500 , LBRM2903_010009900

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H371

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H371

PDB structure(s): 3r2j_A , 3r2j_B , 3r2j_C , 3r2j_D

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006753	nucleoside phosphate metabolic process	4	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009117	nucleotide metabolic process	5	1
GO:0009165	nucleotide biosynthetic process	6	1
GO:0009435	NAD biosynthetic process	8	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019359	nicotinamide nucleotide biosynthetic process	7	1
GO:0019362	pyridine nucleotide metabolic process	5	1
GO:0019363	pyridine nucleotide biosynthetic process	6	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019637	organophosphate metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046496	nicotinamide nucleotide metabolic process	6	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0072524	pyridine-containing compound metabolic process	4	1
GO:0072525	pyridine-containing compound biosynthetic process	5	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901293	nucleoside phosphate biosynthetic process	5	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	6
GO:0008936	nicotinamidase activity	5	1
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	1
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.424
CLV_NRD_NRD_1	119	121	PF00675	0.305
CLV_NRD_NRD_1	153	155	PF00675	0.242
CLV_PCSK_KEX2_1	153	155	PF00082	0.242
CLV_PCSK_KEX2_1	51	53	PF00082	0.352
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.153
CLV_PCSK_SKI1_1	153	157	PF00082	0.242
CLV_PCSK_SKI1_1	179	183	PF00082	0.247
DOC_MAPK_gen_1	203	210	PF00069	0.353
DOC_MAPK_RevD_3	37	52	PF00069	0.524
DOC_PP4_FxxP_1	41	44	PF00568	0.424
DOC_USP7_MATH_1	16	20	PF00917	0.534
DOC_USP7_MATH_1	173	177	PF00917	0.426
DOC_USP7_MATH_1	21	25	PF00917	0.421
DOC_USP7_MATH_1	217	221	PF00917	0.494
DOC_USP7_UBL2_3	175	179	PF12436	0.353
DOC_WW_Pin1_4	136	141	PF00397	0.355
DOC_WW_Pin1_4	9	14	PF00397	0.552
LIG_14-3-3_CanoR_1	120	130	PF00244	0.465
LIG_BIR_II_1	1	5	PF00653	0.406
LIG_BRCT_BRCA1_1	65	69	PF00533	0.500
LIG_DLG_GKlike_1	52	60	PF00625	0.353
LIG_FHA_1	110	116	PF00498	0.493
LIG_FHA_1	185	191	PF00498	0.424
LIG_FHA_1	197	203	PF00498	0.405
LIG_FHA_1	2	8	PF00498	0.699
LIG_FHA_1	27	33	PF00498	0.377
LIG_FHA_2	167	173	PF00498	0.424
LIG_LIR_Apic_2	40	44	PF02991	0.424
LIG_LIR_Gen_1	128	134	PF02991	0.431
LIG_LIR_Gen_1	163	171	PF02991	0.469
LIG_LIR_Nem_3	128	133	PF02991	0.416
LIG_LIR_Nem_3	163	167	PF02991	0.415
LIG_LIR_Nem_3	176	181	PF02991	0.413
LIG_NRBOX	142	148	PF00104	0.442
LIG_Pex14_2	164	168	PF04695	0.465
LIG_SH2_STAP1	130	134	PF00017	0.459
LIG_SH2_STAP1	162	166	PF00017	0.459
LIG_SH3_3	10	16	PF00018	0.469
LIG_SH3_3	41	47	PF00018	0.447
LIG_SUMO_SIM_anti_2	28	36	PF11976	0.276
LIG_SUMO_SIM_par_1	179	184	PF11976	0.422
LIG_SUMO_SIM_par_1	206	213	PF11976	0.538
LIG_SUMO_SIM_par_1	28	36	PF11976	0.246
MOD_CK1_1	26	32	PF00069	0.384
MOD_GlcNHglycan	100	103	PF01048	0.272
MOD_GlcNHglycan	130	133	PF01048	0.251
MOD_GlcNHglycan	175	178	PF01048	0.153
MOD_GlcNHglycan	212	215	PF01048	0.374
MOD_GlcNHglycan	63	66	PF01048	0.183
MOD_GSK3_1	21	28	PF00069	0.409
MOD_GSK3_1	3	10	PF00069	0.449
MOD_N-GLC_1	136	141	PF02516	0.153
MOD_N-GLC_1	184	189	PF02516	0.258
MOD_N-GLC_1	217	222	PF02516	0.406
MOD_N-GLC_1	26	31	PF02516	0.399
MOD_N-GLC_2	82	84	PF02516	0.305
MOD_NEK2_1	1	6	PF00069	0.511
MOD_NEK2_1	146	151	PF00069	0.514
MOD_NEK2_1	209	214	PF00069	0.512
MOD_PIKK_1	121	127	PF00454	0.424
MOD_PIKK_1	72	78	PF00454	0.505
MOD_Plk_4	114	120	PF00069	0.485
MOD_Plk_4	52	58	PF00069	0.353
MOD_Plk_4	82	88	PF00069	0.465
MOD_ProDKin_1	136	142	PF00069	0.355
MOD_ProDKin_1	9	15	PF00069	0.553
MOD_SUMO_rev_2	200	205	PF00179	0.521
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.353
TRG_ENDOCYTIC_2	130	133	PF00928	0.411
TRG_ER_diArg_1	153	155	PF00400	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P300	Leptomonas seymouri	60%	100%
A0A1X0P2N6	Trypanosomatidae	46%	82%
A0A3S5H4V3	Leishmania donovani	77%	100%
A0A422NY51	Trypanosoma rangeli	46%	92%
A4HRG8	Leishmania infantum	77%	100%
C9ZXJ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AC36	Leishmania major	79%	100%
E9AJD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
I6XD65	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	37%	100%
P21369	Escherichia coli (strain K12)	39%	100%
P53184	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q9USS0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
V5BLL8	Trypanosoma cruzi	40%	100%