Protein unc-93 homolog A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF791), putative

Species:

Leishmania braziliensis

UniProt:

A4H370_LEIBR

TriTrypDb:

LbrM.01.0490 , LBRM2903_010009600

Length:

582

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H370

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H370

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	6
GO:0008509	monoatomic anion transmembrane transporter activity	4	6
GO:0015075	monoatomic ion transmembrane transporter activity	3	6
GO:0015098	molybdate ion transmembrane transporter activity	5	6
GO:0015103	inorganic anion transmembrane transporter activity	4	6
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	6
GO:0022857	transmembrane transporter activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.677
CLV_C14_Caspase3-7	198	202	PF00656	0.618
CLV_C14_Caspase3-7	491	495	PF00656	0.398
CLV_C14_Caspase3-7	544	548	PF00656	0.597
CLV_C14_Caspase3-7	72	76	PF00656	0.405
CLV_NRD_NRD_1	124	126	PF00675	0.368
CLV_PCSK_KEX2_1	124	126	PF00082	0.345
CLV_PCSK_SKI1_1	63	67	PF00082	0.405
DEG_COP1_1	368	377	PF00400	0.405
DEG_MDM2_SWIB_1	504	512	PF02201	0.346
DEG_Nend_UBRbox_3	1	3	PF02207	0.404
DEG_ODPH_VHL_1	235	248	PF01847	0.234
DEG_SCF_FBW7_1	227	234	PF00400	0.405
DEG_SPOP_SBC_1	14	18	PF00917	0.409
DEG_SPOP_SBC_1	315	319	PF00917	0.596
DEG_SPOP_SBC_1	466	470	PF00917	0.594
DOC_CDC14_PxL_1	371	379	PF14671	0.405
DOC_CKS1_1	228	233	PF01111	0.272
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.362
DOC_MAPK_gen_1	124	132	PF00069	0.494
DOC_MAPK_gen_1	55	64	PF00069	0.632
DOC_MAPK_JIP1_4	212	218	PF00069	0.546
DOC_MAPK_MEF2A_6	124	132	PF00069	0.543
DOC_MAPK_MEF2A_6	355	362	PF00069	0.546
DOC_MAPK_MEF2A_6	432	440	PF00069	0.464
DOC_MAPK_NFAT4_5	125	133	PF00069	0.546
DOC_PP2B_LxvP_1	347	350	PF13499	0.674
DOC_PP2B_LxvP_1	372	375	PF13499	0.405
DOC_PP4_FxxP_1	38	41	PF00568	0.405
DOC_PP4_FxxP_1	403	406	PF00568	0.405
DOC_USP7_MATH_1	138	142	PF00917	0.411
DOC_USP7_MATH_1	158	162	PF00917	0.221
DOC_USP7_MATH_1	23	27	PF00917	0.489
DOC_USP7_MATH_1	231	235	PF00917	0.449
DOC_USP7_MATH_1	259	263	PF00917	0.697
DOC_USP7_MATH_1	298	302	PF00917	0.692
DOC_USP7_MATH_1	315	319	PF00917	0.722
DOC_USP7_MATH_1	321	325	PF00917	0.718
DOC_USP7_MATH_1	466	470	PF00917	0.689
DOC_USP7_MATH_1	541	545	PF00917	0.626
DOC_USP7_MATH_1	69	73	PF00917	0.405
DOC_WW_Pin1_4	112	117	PF00397	0.384
DOC_WW_Pin1_4	177	182	PF00397	0.646
DOC_WW_Pin1_4	21	26	PF00397	0.388
DOC_WW_Pin1_4	227	232	PF00397	0.405
DOC_WW_Pin1_4	57	62	PF00397	0.521
LIG_14-3-3_CanoR_1	124	132	PF00244	0.494
LIG_14-3-3_CanoR_1	254	258	PF00244	0.373
LIG_14-3-3_CanoR_1	426	436	PF00244	0.513
LIG_14-3-3_CterR_2	578	582	PF00244	0.601
LIG_APCC_ABBA_1	377	382	PF00400	0.346
LIG_BRCT_BRCA1_1	382	386	PF00533	0.346
LIG_BRCT_BRCA1_1	79	83	PF00533	0.405
LIG_BRCT_BRCA1_1	96	100	PF00533	0.221
LIG_Clathr_ClatBox_1	512	516	PF01394	0.344
LIG_CSL_BTD_1	372	375	PF09270	0.405
LIG_deltaCOP1_diTrp_1	29	38	PF00928	0.451
LIG_deltaCOP1_diTrp_1	505	514	PF00928	0.346
LIG_FHA_1	104	110	PF00498	0.414
LIG_FHA_1	158	164	PF00498	0.459
LIG_FHA_1	202	208	PF00498	0.661
LIG_FHA_1	228	234	PF00498	0.405
LIG_FHA_1	268	274	PF00498	0.612
LIG_FHA_1	366	372	PF00498	0.405
LIG_FHA_1	374	380	PF00498	0.322
LIG_FHA_1	400	406	PF00498	0.405
LIG_FHA_1	437	443	PF00498	0.405
LIG_FHA_1	45	51	PF00498	0.373
LIG_FHA_1	455	461	PF00498	0.402
LIG_FHA_1	469	475	PF00498	0.448
LIG_FHA_1	480	486	PF00498	0.368
LIG_FHA_1	519	525	PF00498	0.435
LIG_FHA_2	163	169	PF00498	0.466
LIG_FHA_2	428	434	PF00498	0.546
LIG_LIR_Apic_2	401	406	PF02991	0.546
LIG_LIR_Apic_2	431	437	PF02991	0.468
LIG_LIR_Gen_1	145	155	PF02991	0.254
LIG_LIR_Gen_1	223	233	PF02991	0.267
LIG_LIR_Gen_1	505	515	PF02991	0.346
LIG_LIR_Nem_3	145	151	PF02991	0.254
LIG_LIR_Nem_3	223	228	PF02991	0.267
LIG_LIR_Nem_3	383	389	PF02991	0.346
LIG_LIR_Nem_3	450	454	PF02991	0.308
LIG_LIR_Nem_3	46	51	PF02991	0.405
LIG_LIR_Nem_3	505	511	PF02991	0.346
LIG_MYND_1	37	41	PF01753	0.405
LIG_MYND_3	374	378	PF01753	0.405
LIG_Pex14_1	461	465	PF04695	0.677
LIG_Pex14_2	362	366	PF04695	0.405
LIG_Pex14_2	386	390	PF04695	0.405
LIG_Pex14_2	504	508	PF04695	0.346
LIG_SH2_CRK	434	438	PF00017	0.489
LIG_SH2_CRK	451	455	PF00017	0.308
LIG_SH2_PTP2	225	228	PF00017	0.247
LIG_SH2_SRC	336	339	PF00017	0.646
LIG_SH2_SRC	434	437	PF00017	0.464
LIG_SH2_STAP1	336	340	PF00017	0.568
LIG_SH2_STAP1	89	93	PF00017	0.375
LIG_SH2_STAT5	225	228	PF00017	0.392
LIG_SH2_STAT5	245	248	PF00017	0.405
LIG_SH2_STAT5	523	526	PF00017	0.332
LIG_SH3_3	17	23	PF00018	0.522
LIG_SH3_3	225	231	PF00018	0.272
LIG_SUMO_SIM_anti_2	468	477	PF11976	0.448
LIG_SUMO_SIM_par_1	214	220	PF11976	0.356
LIG_SUMO_SIM_par_1	375	383	PF11976	0.405
LIG_SUMO_SIM_par_1	416	422	PF11976	0.405
LIG_SUMO_SIM_par_1	438	443	PF11976	0.247
LIG_SUMO_SIM_par_1	69	75	PF11976	0.483
LIG_TYR_ITIM	243	248	PF00017	0.405
LIG_TYR_ITIM	449	454	PF00017	0.308
LIG_UBA3_1	474	479	PF00899	0.405
LIG_WRC_WIRS_1	272	277	PF05994	0.614
LIG_WRC_WIRS_1	395	400	PF05994	0.405
MOD_CDK_SPxK_1	57	63	PF00069	0.515
MOD_CK1_1	141	147	PF00069	0.464
MOD_CK1_1	301	307	PF00069	0.681
MOD_CK1_1	317	323	PF00069	0.752
MOD_CK1_1	339	345	PF00069	0.660
MOD_CK1_1	401	407	PF00069	0.546
MOD_CK1_1	424	430	PF00069	0.460
MOD_CK1_1	468	474	PF00069	0.524
MOD_CK1_1	94	100	PF00069	0.353
MOD_CK2_1	162	168	PF00069	0.531
MOD_CK2_1	419	425	PF00069	0.344
MOD_CMANNOS	266	269	PF00535	0.407
MOD_DYRK1A_RPxSP_1	57	61	PF00069	0.529
MOD_GlcNHglycan	140	143	PF01048	0.510
MOD_GlcNHglycan	155	158	PF01048	0.284
MOD_GlcNHglycan	160	163	PF01048	0.202
MOD_GlcNHglycan	201	204	PF01048	0.506
MOD_GlcNHglycan	261	264	PF01048	0.509
MOD_GlcNHglycan	277	280	PF01048	0.477
MOD_GlcNHglycan	287	290	PF01048	0.512
MOD_GlcNHglycan	296	299	PF01048	0.437
MOD_GlcNHglycan	311	314	PF01048	0.465
MOD_GlcNHglycan	319	322	PF01048	0.536
MOD_GlcNHglycan	442	445	PF01048	0.260
MOD_GlcNHglycan	547	550	PF01048	0.529
MOD_GlcNHglycan	555	558	PF01048	0.457
MOD_GlcNHglycan	93	96	PF01048	0.623
MOD_GSK3_1	10	17	PF00069	0.410
MOD_GSK3_1	138	145	PF00069	0.364
MOD_GSK3_1	153	160	PF00069	0.420
MOD_GSK3_1	197	204	PF00069	0.705
MOD_GSK3_1	216	223	PF00069	0.225
MOD_GSK3_1	227	234	PF00069	0.292
MOD_GSK3_1	267	274	PF00069	0.667
MOD_GSK3_1	294	301	PF00069	0.706
MOD_GSK3_1	317	324	PF00069	0.732
MOD_GSK3_1	336	343	PF00069	0.499
MOD_GSK3_1	394	401	PF00069	0.495
MOD_GSK3_1	424	431	PF00069	0.456
MOD_GSK3_1	436	443	PF00069	0.258
MOD_GSK3_1	466	473	PF00069	0.749
MOD_GSK3_1	53	60	PF00069	0.506
MOD_GSK3_1	541	548	PF00069	0.637
MOD_LATS_1	285	291	PF00433	0.734
MOD_LATS_1	576	582	PF00433	0.601
MOD_N-GLC_1	552	557	PF02516	0.421
MOD_NEK2_1	199	204	PF00069	0.771
MOD_NEK2_1	216	221	PF00069	0.248
MOD_NEK2_1	275	280	PF00069	0.629
MOD_NEK2_1	309	314	PF00069	0.623
MOD_NEK2_1	362	367	PF00069	0.426
MOD_NEK2_1	380	385	PF00069	0.242
MOD_NEK2_1	394	399	PF00069	0.437
MOD_NEK2_1	43	48	PF00069	0.350
MOD_NEK2_1	447	452	PF00069	0.405
MOD_NEK2_1	474	479	PF00069	0.281
MOD_NEK2_1	53	58	PF00069	0.488
MOD_NEK2_1	77	82	PF00069	0.405
MOD_NEK2_1	91	96	PF00069	0.317
MOD_NEK2_2	340	345	PF00069	0.677
MOD_PIKK_1	220	226	PF00454	0.405
MOD_PIKK_1	321	327	PF00454	0.587
MOD_PIKK_1	518	524	PF00454	0.435
MOD_PIKK_1	541	547	PF00454	0.593
MOD_PK_1	287	293	PF00069	0.622
MOD_PKA_2	123	129	PF00069	0.494
MOD_PKA_2	253	259	PF00069	0.386
MOD_Plk_1	31	37	PF00069	0.240
MOD_Plk_1	380	386	PF00069	0.346
MOD_Plk_1	424	430	PF00069	0.417
MOD_Plk_4	103	109	PF00069	0.405
MOD_Plk_4	142	148	PF00069	0.234
MOD_Plk_4	162	168	PF00069	0.526
MOD_Plk_4	23	29	PF00069	0.483
MOD_Plk_4	253	259	PF00069	0.558
MOD_Plk_4	31	37	PF00069	0.319
MOD_Plk_4	362	368	PF00069	0.365
MOD_Plk_4	394	400	PF00069	0.405
MOD_Plk_4	436	442	PF00069	0.346
MOD_Plk_4	456	462	PF00069	0.557
MOD_Plk_4	470	476	PF00069	0.230
MOD_Plk_4	488	494	PF00069	0.535
MOD_ProDKin_1	112	118	PF00069	0.384
MOD_ProDKin_1	177	183	PF00069	0.649
MOD_ProDKin_1	21	27	PF00069	0.387
MOD_ProDKin_1	227	233	PF00069	0.405
MOD_ProDKin_1	57	63	PF00069	0.515
MOD_SUMO_rev_2	180	190	PF00179	0.710
MOD_SUMO_rev_2	491	498	PF00179	0.366
TRG_ENDOCYTIC_2	225	228	PF00928	0.247
TRG_ENDOCYTIC_2	245	248	PF00928	0.405
TRG_ENDOCYTIC_2	451	454	PF00928	0.308
TRG_ER_diArg_1	54	57	PF00400	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4V2	Leishmania donovani	72%	99%
A4HRG7	Leishmania infantum	72%	99%
E9AC35	Leishmania major	72%	100%
E9AJD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%