RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H369_LEIBR

TriTrypDb:

LbrM.01.0480 , LBRM2903_010009500

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H369

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H369

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007165	signal transduction	2	1
GO:0007264	small GTPase mediated signal transduction	4	1
GO:0007265	Ras protein signal transduction	5	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0035556	intracellular signal transduction	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.807
CLV_C14_Caspase3-7	453	457	PF00656	0.750
CLV_NRD_NRD_1	192	194	PF00675	0.621
CLV_NRD_NRD_1	201	203	PF00675	0.861
CLV_NRD_NRD_1	349	351	PF00675	0.335
CLV_NRD_NRD_1	504	506	PF00675	0.647
CLV_NRD_NRD_1	539	541	PF00675	0.632
CLV_NRD_NRD_1	543	545	PF00675	0.630
CLV_NRD_NRD_1	568	570	PF00675	0.396
CLV_NRD_NRD_1	607	609	PF00675	0.598
CLV_PCSK_FUR_1	347	351	PF00082	0.346
CLV_PCSK_FUR_1	501	505	PF00082	0.581
CLV_PCSK_FUR_1	540	544	PF00082	0.630
CLV_PCSK_KEX2_1	192	194	PF00082	0.621
CLV_PCSK_KEX2_1	349	351	PF00082	0.335
CLV_PCSK_KEX2_1	501	503	PF00082	0.627
CLV_PCSK_KEX2_1	504	506	PF00082	0.642
CLV_PCSK_KEX2_1	539	541	PF00082	0.632
CLV_PCSK_KEX2_1	542	544	PF00082	0.630
CLV_PCSK_PC7_1	539	545	PF00082	0.630
CLV_PCSK_SKI1_1	379	383	PF00082	0.346
CLV_PCSK_SKI1_1	44	48	PF00082	0.553
CLV_PCSK_SKI1_1	543	547	PF00082	0.626
CLV_PCSK_SKI1_1	569	573	PF00082	0.397
CLV_Separin_Metazoa	14	18	PF03568	0.577
DEG_Nend_UBRbox_4	1	3	PF02207	0.508
DEG_SPOP_SBC_1	423	427	PF00917	0.761
DOC_CKS1_1	185	190	PF01111	0.854
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.741
DOC_PP2B_LxvP_1	55	58	PF13499	0.754
DOC_PP4_FxxP_1	75	78	PF00568	0.544
DOC_SPAK_OSR1_1	313	317	PF12202	0.545
DOC_USP7_MATH_1	186	190	PF00917	0.711
DOC_USP7_MATH_1	303	307	PF00917	0.411
DOC_USP7_MATH_1	418	422	PF00917	0.826
DOC_USP7_MATH_1	423	427	PF00917	0.746
DOC_USP7_MATH_1	513	517	PF00917	0.534
DOC_USP7_MATH_1	631	635	PF00917	0.657
DOC_USP7_MATH_2	58	64	PF00917	0.573
DOC_WW_Pin1_4	174	179	PF00397	0.791
DOC_WW_Pin1_4	184	189	PF00397	0.639
DOC_WW_Pin1_4	191	196	PF00397	0.774
DOC_WW_Pin1_4	228	233	PF00397	0.688
DOC_WW_Pin1_4	244	249	PF00397	0.642
LIG_14-3-3_CanoR_1	176	185	PF00244	0.788
LIG_14-3-3_CanoR_1	211	220	PF00244	0.674
LIG_14-3-3_CanoR_1	313	317	PF00244	0.495
LIG_14-3-3_CanoR_1	372	382	PF00244	0.599
LIG_14-3-3_CanoR_1	502	511	PF00244	0.488
LIG_14-3-3_CanoR_1	93	99	PF00244	0.572
LIG_APCC_ABBA_1	380	385	PF00400	0.620
LIG_APCC_ABBAyCdc20_2	379	385	PF00400	0.546
LIG_BIR_III_2	64	68	PF00653	0.661
LIG_BRCT_BRCA1_1	268	272	PF00533	0.564
LIG_BRCT_BRCA1_1	377	381	PF00533	0.546
LIG_FHA_1	196	202	PF00498	0.581
LIG_FHA_1	215	221	PF00498	0.542
LIG_FHA_1	368	374	PF00498	0.475
LIG_FHA_1	436	442	PF00498	0.559
LIG_FHA_1	478	484	PF00498	0.543
LIG_FHA_1	54	60	PF00498	0.627
LIG_FHA_1	551	557	PF00498	0.675
LIG_FHA_1	566	572	PF00498	0.411
LIG_FHA_1	601	607	PF00498	0.664
LIG_FHA_2	328	334	PF00498	0.546
LIG_FHA_2	423	429	PF00498	0.651
LIG_FHA_2	43	49	PF00498	0.432
LIG_LIR_Gen_1	11	20	PF02991	0.654
LIG_LIR_Gen_1	120	130	PF02991	0.762
LIG_LIR_Gen_1	297	307	PF02991	0.515
LIG_LIR_Gen_1	315	323	PF02991	0.387
LIG_LIR_Gen_1	330	339	PF02991	0.546
LIG_LIR_Nem_3	11	15	PF02991	0.693
LIG_LIR_Nem_3	120	125	PF02991	0.748
LIG_LIR_Nem_3	269	275	PF02991	0.525
LIG_LIR_Nem_3	297	302	PF02991	0.515
LIG_LIR_Nem_3	315	320	PF02991	0.394
LIG_LIR_Nem_3	330	334	PF02991	0.546
LIG_MYND_1	195	199	PF01753	0.574
LIG_PCNA_PIPBox_1	581	590	PF02747	0.532
LIG_PDZ_Class_1	630	635	PF00595	0.552
LIG_SH2_CRK	28	32	PF00017	0.590
LIG_SH2_CRK	299	303	PF00017	0.411
LIG_SH2_CRK	317	321	PF00017	0.584
LIG_SH2_STAP1	331	335	PF00017	0.546
LIG_SH2_STAP1	479	483	PF00017	0.544
LIG_SH2_STAP1	494	498	PF00017	0.565
LIG_SH2_STAT3	478	481	PF00017	0.650
LIG_SH2_STAT5	20	23	PF00017	0.602
LIG_SH2_STAT5	28	31	PF00017	0.591
LIG_SH2_STAT5	281	284	PF00017	0.512
LIG_SH2_STAT5	479	482	PF00017	0.542
LIG_SH2_STAT5	549	552	PF00017	0.676
LIG_SH2_STAT5	61	64	PF00017	0.730
LIG_SH3_3	182	188	PF00018	0.850
LIG_SH3_3	204	210	PF00018	0.589
LIG_SH3_3	226	232	PF00018	0.636
LIG_SH3_3	246	252	PF00018	0.597
LIG_SUMO_SIM_anti_2	11	17	PF11976	0.580
LIG_SUMO_SIM_anti_2	385	394	PF11976	0.571
LIG_SUMO_SIM_anti_2	552	559	PF11976	0.653
LIG_SUMO_SIM_par_1	66	71	PF11976	0.675
LIG_TRAF2_1	46	49	PF00917	0.614
LIG_TRAF2_1	470	473	PF00917	0.577
LIG_TRAF2_1	618	621	PF00917	0.603
LIG_WW_3	208	212	PF00397	0.547
MOD_CDK_SPxxK_3	195	202	PF00069	0.707
MOD_CK1_1	177	183	PF00069	0.786
MOD_CK1_1	214	220	PF00069	0.690
MOD_CK1_1	360	366	PF00069	0.546
MOD_CK1_1	427	433	PF00069	0.555
MOD_CK1_1	524	530	PF00069	0.567
MOD_CK1_1	590	596	PF00069	0.368
MOD_CK2_1	117	123	PF00069	0.765
MOD_CK2_1	42	48	PF00069	0.468
MOD_CK2_1	422	428	PF00069	0.766
MOD_CK2_1	467	473	PF00069	0.681
MOD_CK2_1	8	14	PF00069	0.629
MOD_CK2_1	92	98	PF00069	0.566
MOD_GlcNHglycan	136	139	PF01048	0.844
MOD_GlcNHglycan	182	185	PF01048	0.783
MOD_GlcNHglycan	213	216	PF01048	0.636
MOD_GlcNHglycan	303	306	PF01048	0.411
MOD_GlcNHglycan	359	362	PF01048	0.346
MOD_GlcNHglycan	414	417	PF01048	0.740
MOD_GlcNHglycan	443	446	PF01048	0.625
MOD_GlcNHglycan	515	518	PF01048	0.593
MOD_GlcNHglycan	589	592	PF01048	0.520
MOD_GSK3_1	113	120	PF00069	0.552
MOD_GSK3_1	180	187	PF00069	0.745
MOD_GSK3_1	191	198	PF00069	0.795
MOD_GSK3_1	210	217	PF00069	0.692
MOD_GSK3_1	280	287	PF00069	0.512
MOD_GSK3_1	356	363	PF00069	0.533
MOD_GSK3_1	38	45	PF00069	0.409
MOD_GSK3_1	408	415	PF00069	0.777
MOD_GSK3_1	418	425	PF00069	0.639
MOD_GSK3_1	428	435	PF00069	0.556
MOD_GSK3_1	450	457	PF00069	0.588
MOD_GSK3_1	522	529	PF00069	0.599
MOD_GSK3_1	583	590	PF00069	0.633
MOD_N-GLC_1	374	379	PF02516	0.346
MOD_N-GLC_1	428	433	PF02516	0.557
MOD_N-GLC_1	467	472	PF02516	0.586
MOD_NEK2_1	280	285	PF00069	0.512
MOD_NEK2_1	294	299	PF00069	0.282
MOD_NEK2_1	42	47	PF00069	0.620
MOD_NEK2_1	450	455	PF00069	0.595
MOD_NEK2_1	526	531	PF00069	0.505
MOD_NEK2_1	53	58	PF00069	0.635
MOD_NEK2_1	583	588	PF00069	0.602
MOD_NEK2_2	124	129	PF00069	0.723
MOD_NEK2_2	312	317	PF00069	0.542
MOD_PIKK_1	186	192	PF00454	0.626
MOD_PIKK_1	477	483	PF00454	0.644
MOD_PIKK_1	600	606	PF00454	0.531
MOD_PIKK_1	611	617	PF00454	0.421
MOD_PKA_1	503	509	PF00069	0.424
MOD_PKA_2	210	216	PF00069	0.634
MOD_PKA_2	312	318	PF00069	0.493
MOD_PKA_2	357	363	PF00069	0.448
MOD_PKA_2	373	379	PF00069	0.448
MOD_PKA_2	503	509	PF00069	0.635
MOD_PKA_2	92	98	PF00069	0.566
MOD_PKB_1	372	380	PF00069	0.618
MOD_PKB_1	501	509	PF00069	0.423
MOD_PKB_1	542	550	PF00069	0.720
MOD_Plk_1	522	528	PF00069	0.486
MOD_Plk_2-3	145	151	PF00069	0.831
MOD_Plk_2-3	8	14	PF00069	0.720
MOD_Plk_4	117	123	PF00069	0.690
MOD_Plk_4	124	130	PF00069	0.636
MOD_Plk_4	38	44	PF00069	0.521
MOD_Plk_4	454	460	PF00069	0.740
MOD_Plk_4	8	14	PF00069	0.720
MOD_ProDKin_1	174	180	PF00069	0.792
MOD_ProDKin_1	184	190	PF00069	0.640
MOD_ProDKin_1	191	197	PF00069	0.776
MOD_ProDKin_1	228	234	PF00069	0.688
MOD_ProDKin_1	244	250	PF00069	0.644
MOD_SUMO_rev_2	489	499	PF00179	0.426
TRG_DiLeu_BaEn_1	385	390	PF01217	0.533
TRG_DiLeu_BaEn_4	48	54	PF01217	0.631
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.597
TRG_ENDOCYTIC_2	28	31	PF00928	0.591
TRG_ENDOCYTIC_2	299	302	PF00928	0.411
TRG_ENDOCYTIC_2	317	320	PF00928	0.586
TRG_ENDOCYTIC_2	331	334	PF00928	0.546
TRG_ENDOCYTIC_2	479	482	PF00928	0.642
TRG_ENDOCYTIC_2	564	567	PF00928	0.551
TRG_ER_diArg_1	347	350	PF00400	0.531
TRG_ER_diArg_1	501	504	PF00400	0.626
TRG_ER_diArg_1	539	542	PF00400	0.629
TRG_ER_diArg_1	543	545	PF00400	0.630
TRG_ER_diArg_1	599	602	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L0	Leptomonas seymouri	42%	75%
A0A3S5H4V1	Leishmania donovani	71%	85%
A4HRG6	Leishmania infantum	71%	85%
E9AC34	Leishmania major	70%	100%
E9AJD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	85%