Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H366_LEIBR

TriTrypDb:

LbrM.01.0450 , LBRM2903_010009200

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H366

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H366

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0031123	RNA 3'-end processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071076	RNA 3' uridylation	8	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0050265	RNA uridylyltransferase activity	4	1
GO:0070569	uridylyltransferase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	501	505	PF00656	0.503
CLV_NRD_NRD_1	170	172	PF00675	0.653
CLV_NRD_NRD_1	206	208	PF00675	0.400
CLV_NRD_NRD_1	296	298	PF00675	0.589
CLV_NRD_NRD_1	352	354	PF00675	0.529
CLV_NRD_NRD_1	360	362	PF00675	0.564
CLV_NRD_NRD_1	365	367	PF00675	0.445
CLV_NRD_NRD_1	384	386	PF00675	0.266
CLV_NRD_NRD_1	412	414	PF00675	0.604
CLV_PCSK_FUR_1	382	386	PF00082	0.434
CLV_PCSK_KEX2_1	170	172	PF00082	0.653
CLV_PCSK_KEX2_1	206	208	PF00082	0.400
CLV_PCSK_KEX2_1	296	298	PF00082	0.616
CLV_PCSK_KEX2_1	352	354	PF00082	0.534
CLV_PCSK_KEX2_1	359	361	PF00082	0.552
CLV_PCSK_KEX2_1	365	367	PF00082	0.454
CLV_PCSK_KEX2_1	384	386	PF00082	0.369
CLV_PCSK_KEX2_1	412	414	PF00082	0.471
CLV_PCSK_PC7_1	361	367	PF00082	0.504
CLV_PCSK_SKI1_1	304	308	PF00082	0.696
CLV_PCSK_SKI1_1	366	370	PF00082	0.551
CLV_PCSK_SKI1_1	384	388	PF00082	0.318
CLV_PCSK_SKI1_1	462	466	PF00082	0.339
CLV_PCSK_SKI1_1	74	78	PF00082	0.474
DEG_APCC_DBOX_1	383	391	PF00400	0.422
DEG_APCC_DBOX_1	442	450	PF00400	0.369
DEG_Nend_UBRbox_1	1	4	PF02207	0.564
DEG_SPOP_SBC_1	265	269	PF00917	0.527
DEG_SPOP_SBC_1	368	372	PF00917	0.338
DOC_CKS1_1	509	514	PF01111	0.535
DOC_CYCLIN_RxL_1	142	151	PF00134	0.372
DOC_CYCLIN_RxL_1	459	467	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	116	119	PF00134	0.567
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	466	472	PF00134	0.375
DOC_CYCLIN_yCln2_LP_2	77	83	PF00134	0.628
DOC_MAPK_gen_1	412	418	PF00069	0.334
DOC_MAPK_MEF2A_6	421	428	PF00069	0.346
DOC_PP1_RVXF_1	143	150	PF00149	0.520
DOC_PP2B_LxvP_1	116	119	PF13499	0.567
DOC_PP2B_LxvP_1	158	161	PF13499	0.514
DOC_PP2B_LxvP_1	191	194	PF13499	0.474
DOC_PP2B_LxvP_1	77	80	PF13499	0.645
DOC_PP4_FxxP_1	149	152	PF00568	0.457
DOC_USP7_MATH_1	23	27	PF00917	0.542
DOC_USP7_MATH_1	281	285	PF00917	0.671
DOC_USP7_MATH_1	315	319	PF00917	0.647
DOC_USP7_MATH_1	368	372	PF00917	0.573
DOC_USP7_MATH_1	377	381	PF00917	0.498
DOC_USP7_MATH_1	399	403	PF00917	0.455
DOC_USP7_MATH_1	500	504	PF00917	0.541
DOC_USP7_MATH_1	93	97	PF00917	0.762
DOC_WW_Pin1_4	148	153	PF00397	0.375
DOC_WW_Pin1_4	316	321	PF00397	0.547
DOC_WW_Pin1_4	373	378	PF00397	0.415
DOC_WW_Pin1_4	508	513	PF00397	0.622
LIG_14-3-3_CanoR_1	109	115	PF00244	0.508
LIG_14-3-3_CanoR_1	310	315	PF00244	0.531
LIG_14-3-3_CanoR_1	366	375	PF00244	0.497
LIG_14-3-3_CanoR_1	38	44	PF00244	0.387
LIG_14-3-3_CanoR_1	68	76	PF00244	0.548
LIG_14-3-3_CanoR_1	92	101	PF00244	0.510
LIG_APCC_ABBA_1	492	497	PF00400	0.380
LIG_eIF4E_1	159	165	PF01652	0.477
LIG_FHA_1	187	193	PF00498	0.362
LIG_FHA_1	224	230	PF00498	0.486
LIG_FHA_1	256	262	PF00498	0.548
LIG_FHA_1	370	376	PF00498	0.336
LIG_FHA_1	471	477	PF00498	0.377
LIG_FHA_1	480	486	PF00498	0.396
LIG_FHA_1	83	89	PF00498	0.607
LIG_FHA_2	270	276	PF00498	0.538
LIG_FHA_2	38	44	PF00498	0.426
LIG_FHA_2	499	505	PF00498	0.503
LIG_FHA_2	51	57	PF00498	0.425
LIG_LIR_Apic_2	508	512	PF02991	0.535
LIG_LIR_Nem_3	142	147	PF02991	0.429
LIG_LIR_Nem_3	70	76	PF02991	0.547
LIG_NRBOX	187	193	PF00104	0.383
LIG_Pex14_1	57	61	PF04695	0.492
LIG_PTB_Apo_2	250	257	PF02174	0.530
LIG_PTB_Phospho_1	250	256	PF10480	0.534
LIG_SH2_CRK	144	148	PF00017	0.402
LIG_SH2_CRK	159	163	PF00017	0.539
LIG_SH2_CRK	509	513	PF00017	0.535
LIG_SH2_NCK_1	42	46	PF00017	0.524
LIG_SH2_NCK_1	509	513	PF00017	0.535
LIG_SH2_SRC	159	162	PF00017	0.578
LIG_SH2_STAP1	178	182	PF00017	0.394
LIG_SH2_STAP1	256	260	PF00017	0.517
LIG_SH2_STAP1	42	46	PF00017	0.367
LIG_SH2_STAT5	217	220	PF00017	0.334
LIG_SH2_STAT5	362	365	PF00017	0.410
LIG_SH2_STAT5	395	398	PF00017	0.361
LIG_SH2_STAT5	417	420	PF00017	0.440
LIG_SH2_STAT5	509	512	PF00017	0.535
LIG_SH2_STAT5	570	573	PF00017	0.506
LIG_SH3_1	421	427	PF00018	0.500
LIG_SH3_3	421	427	PF00018	0.503
LIG_SH3_3	522	528	PF00018	0.639
LIG_SH3_3	73	79	PF00018	0.479
LIG_SUMO_SIM_anti_2	113	118	PF11976	0.503
MOD_CDC14_SPxK_1	151	154	PF00782	0.422
MOD_CDK_SPxK_1	148	154	PF00069	0.384
MOD_CK1_1	186	192	PF00069	0.297
MOD_CK1_1	25	31	PF00069	0.585
MOD_CK1_1	264	270	PF00069	0.701
MOD_CK1_1	316	322	PF00069	0.620
MOD_CK1_1	508	514	PF00069	0.561
MOD_GlcNHglycan	263	266	PF01048	0.650
MOD_GlcNHglycan	315	318	PF01048	0.697
MOD_GlcNHglycan	341	344	PF01048	0.580
MOD_GlcNHglycan	397	400	PF01048	0.461
MOD_GlcNHglycan	456	459	PF01048	0.265
MOD_GSK3_1	118	125	PF00069	0.593
MOD_GSK3_1	219	226	PF00069	0.412
MOD_GSK3_1	261	268	PF00069	0.720
MOD_GSK3_1	271	278	PF00069	0.544
MOD_GSK3_1	369	376	PF00069	0.404
MOD_GSK3_1	395	402	PF00069	0.312
MOD_GSK3_1	470	477	PF00069	0.363
MOD_GSK3_1	495	502	PF00069	0.537
MOD_GSK3_1	99	106	PF00069	0.657
MOD_NEK2_1	147	152	PF00069	0.385
MOD_NEK2_1	44	49	PF00069	0.383
MOD_NEK2_1	464	469	PF00069	0.358
MOD_NEK2_1	495	500	PF00069	0.551
MOD_OFUCOSY	220	227	PF10250	0.375
MOD_PIKK_1	37	43	PF00454	0.387
MOD_PIKK_1	403	409	PF00454	0.496
MOD_PK_1	103	109	PF00069	0.499
MOD_PKA_2	275	281	PF00069	0.658
MOD_PKA_2	289	295	PF00069	0.543
MOD_PKA_2	298	304	PF00069	0.552
MOD_PKA_2	37	43	PF00069	0.387
MOD_PKA_2	67	73	PF00069	0.591
MOD_PKB_1	359	367	PF00069	0.363
MOD_Plk_2-3	174	180	PF00069	0.408
MOD_Plk_4	103	109	PF00069	0.560
MOD_Plk_4	112	118	PF00069	0.587
MOD_Plk_4	183	189	PF00069	0.459
MOD_Plk_4	256	262	PF00069	0.518
MOD_Plk_4	298	304	PF00069	0.532
MOD_Plk_4	332	338	PF00069	0.553
MOD_ProDKin_1	148	154	PF00069	0.384
MOD_ProDKin_1	316	322	PF00069	0.549
MOD_ProDKin_1	373	379	PF00069	0.411
MOD_ProDKin_1	508	514	PF00069	0.623
TRG_ENDOCYTIC_2	144	147	PF00928	0.375
TRG_ER_diArg_1	296	299	PF00400	0.636
TRG_ER_diArg_1	352	354	PF00400	0.560
TRG_ER_diArg_1	358	361	PF00400	0.514
TRG_ER_diArg_1	381	384	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	352	357	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	567	572	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL81	Leptomonas seymouri	40%	97%
A0A451EJ97	Leishmania donovani	69%	100%
A4HRG3	Leishmania infantum	69%	90%
E9AC31	Leishmania major	67%	97%
E9AJC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%