Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H365_LEIBR

TriTrypDb:

LbrM.01.0440 , LBRM2903_010009100

Length:

814

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H365

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H365

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.643
CLV_C14_Caspase3-7	743	747	PF00656	0.500
CLV_NRD_NRD_1	154	156	PF00675	0.623
CLV_NRD_NRD_1	166	168	PF00675	0.411
CLV_NRD_NRD_1	237	239	PF00675	0.686
CLV_NRD_NRD_1	313	315	PF00675	0.412
CLV_NRD_NRD_1	380	382	PF00675	0.594
CLV_NRD_NRD_1	563	565	PF00675	0.599
CLV_NRD_NRD_1	617	619	PF00675	0.564
CLV_NRD_NRD_1	647	649	PF00675	0.459
CLV_NRD_NRD_1	698	700	PF00675	0.522
CLV_NRD_NRD_1	772	774	PF00675	0.618
CLV_PCSK_KEX2_1	154	156	PF00082	0.581
CLV_PCSK_KEX2_1	166	168	PF00082	0.420
CLV_PCSK_KEX2_1	236	238	PF00082	0.557
CLV_PCSK_KEX2_1	313	315	PF00082	0.412
CLV_PCSK_KEX2_1	350	352	PF00082	0.604
CLV_PCSK_KEX2_1	380	382	PF00082	0.594
CLV_PCSK_KEX2_1	563	565	PF00082	0.578
CLV_PCSK_KEX2_1	647	649	PF00082	0.467
CLV_PCSK_KEX2_1	772	774	PF00082	0.618
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.604
CLV_PCSK_PC7_1	162	168	PF00082	0.574
CLV_PCSK_PC7_1	233	239	PF00082	0.550
CLV_PCSK_SKI1_1	167	171	PF00082	0.669
CLV_PCSK_SKI1_1	313	317	PF00082	0.426
CLV_PCSK_SKI1_1	342	346	PF00082	0.572
CLV_PCSK_SKI1_1	370	374	PF00082	0.497
CLV_PCSK_SKI1_1	419	423	PF00082	0.482
CLV_PCSK_SKI1_1	443	447	PF00082	0.510
CLV_PCSK_SKI1_1	462	466	PF00082	0.251
CLV_PCSK_SKI1_1	521	525	PF00082	0.606
CLV_PCSK_SKI1_1	566	570	PF00082	0.570
CLV_PCSK_SKI1_1	636	640	PF00082	0.449
CLV_PCSK_SKI1_1	685	689	PF00082	0.489
CLV_PCSK_SKI1_1	699	703	PF00082	0.470
CLV_PCSK_SKI1_1	797	801	PF00082	0.639
DEG_APCC_DBOX_1	166	174	PF00400	0.674
DEG_APCC_DBOX_1	341	349	PF00400	0.471
DEG_APCC_DBOX_1	717	725	PF00400	0.537
DEG_Kelch_Keap1_1	255	260	PF01344	0.563
DEG_Nend_UBRbox_3	1	3	PF02207	0.800
DOC_CKS1_1	121	126	PF01111	0.634
DOC_CKS1_1	749	754	PF01111	0.600
DOC_CYCLIN_RxL_1	633	643	PF00134	0.510
DOC_CYCLIN_RxL_1	697	704	PF00134	0.396
DOC_CYCLIN_RxL_1	794	802	PF00134	0.677
DOC_CYCLIN_yCln2_LP_2	362	368	PF00134	0.442
DOC_MAPK_gen_1	218	225	PF00069	0.710
DOC_MAPK_gen_1	350	358	PF00069	0.622
DOC_MAPK_gen_1	563	573	PF00069	0.705
DOC_MAPK_MEF2A_6	218	225	PF00069	0.710
DOC_MAPK_MEF2A_6	380	388	PF00069	0.473
DOC_MAPK_MEF2A_6	564	573	PF00069	0.563
DOC_MAPK_NFAT4_5	566	574	PF00069	0.445
DOC_PP1_RVXF_1	186	192	PF00149	0.624
DOC_PP1_RVXF_1	460	466	PF00149	0.288
DOC_PP1_RVXF_1	568	574	PF00149	0.557
DOC_PP2B_LxvP_1	764	767	PF13499	0.542
DOC_PP4_FxxP_1	358	361	PF00568	0.516
DOC_PP4_FxxP_1	811	814	PF00568	0.779
DOC_USP7_MATH_1	205	209	PF00917	0.484
DOC_USP7_MATH_1	248	252	PF00917	0.669
DOC_USP7_MATH_1	322	326	PF00917	0.364
DOC_USP7_MATH_1	37	41	PF00917	0.771
DOC_USP7_MATH_1	372	376	PF00917	0.555
DOC_USP7_MATH_1	410	414	PF00917	0.642
DOC_USP7_MATH_1	503	507	PF00917	0.627
DOC_USP7_MATH_1	806	810	PF00917	0.744
DOC_USP7_MATH_1	90	94	PF00917	0.527
DOC_USP7_UBL2_3	726	730	PF12436	0.428
DOC_WW_Pin1_4	120	125	PF00397	0.573
DOC_WW_Pin1_4	244	249	PF00397	0.731
DOC_WW_Pin1_4	289	294	PF00397	0.733
DOC_WW_Pin1_4	422	427	PF00397	0.494
DOC_WW_Pin1_4	64	69	PF00397	0.787
DOC_WW_Pin1_4	72	77	PF00397	0.508
DOC_WW_Pin1_4	748	753	PF00397	0.613
LIG_14-3-3_CanoR_1	11	17	PF00244	0.520
LIG_14-3-3_CanoR_1	218	224	PF00244	0.697
LIG_14-3-3_CanoR_1	443	451	PF00244	0.540
LIG_14-3-3_CanoR_1	487	491	PF00244	0.477
LIG_14-3-3_CanoR_1	521	529	PF00244	0.605
LIG_14-3-3_CanoR_1	685	690	PF00244	0.497
LIG_14-3-3_CanoR_1	756	762	PF00244	0.546
LIG_14-3-3_CanoR_1	778	787	PF00244	0.423
LIG_Actin_WH2_2	472	489	PF00022	0.446
LIG_BIR_III_2	765	769	PF00653	0.600
LIG_BRCT_BRCA1_1	12	16	PF00533	0.670
LIG_BRCT_BRCA1_1	354	358	PF00533	0.586
LIG_Clathr_ClatBox_1	571	575	PF01394	0.437
LIG_deltaCOP1_diTrp_1	448	455	PF00928	0.452
LIG_deltaCOP1_diTrp_1	694	701	PF00928	0.609
LIG_FHA_1	140	146	PF00498	0.628
LIG_FHA_1	272	278	PF00498	0.645
LIG_FHA_1	328	334	PF00498	0.452
LIG_FHA_1	357	363	PF00498	0.460
LIG_FHA_1	403	409	PF00498	0.412
LIG_FHA_1	458	464	PF00498	0.469
LIG_FHA_1	663	669	PF00498	0.445
LIG_FHA_1	779	785	PF00498	0.618
LIG_FHA_1	81	87	PF00498	0.759
LIG_FHA_1	90	96	PF00498	0.492
LIG_FHA_2	296	302	PF00498	0.514
LIG_FHA_2	522	528	PF00498	0.601
LIG_FHA_2	550	556	PF00498	0.652
LIG_FHA_2	720	726	PF00498	0.495
LIG_FHA_2	741	747	PF00498	0.454
LIG_FHA_2	758	764	PF00498	0.293
LIG_GSK3_LRP6_1	72	77	PF00069	0.508
LIG_IBAR_NPY_1	304	306	PF08397	0.395
LIG_LIR_Apic_2	355	361	PF02991	0.561
LIG_LIR_Apic_2	809	814	PF02991	0.637
LIG_LIR_Gen_1	222	232	PF02991	0.654
LIG_LIR_Gen_1	448	458	PF02991	0.445
LIG_LIR_Gen_1	683	691	PF02991	0.456
LIG_LIR_Gen_1	725	736	PF02991	0.327
LIG_LIR_Gen_1	751	761	PF02991	0.554
LIG_LIR_Nem_3	150	156	PF02991	0.547
LIG_LIR_Nem_3	222	228	PF02991	0.638
LIG_LIR_Nem_3	448	454	PF02991	0.433
LIG_LIR_Nem_3	683	689	PF02991	0.450
LIG_LIR_Nem_3	725	731	PF02991	0.442
LIG_LIR_Nem_3	751	757	PF02991	0.561
LIG_MLH1_MIPbox_1	12	16	PF16413	0.670
LIG_MYND_3	345	349	PF01753	0.556
LIG_NRBOX	449	455	PF00104	0.545
LIG_NRBOX	623	629	PF00104	0.551
LIG_PCNA_PIPBox_1	584	593	PF02747	0.669
LIG_PCNA_yPIPBox_3	786	800	PF02747	0.721
LIG_Pex14_1	451	455	PF04695	0.287
LIG_Pex14_1	697	701	PF04695	0.552
LIG_Pex14_2	127	131	PF04695	0.656
LIG_Rb_pABgroove_1	633	641	PF01858	0.544
LIG_RPA_C_Fungi	613	625	PF08784	0.614
LIG_SH2_CRK	611	615	PF00017	0.565
LIG_SH2_NCK_1	579	583	PF00017	0.633
LIG_SH2_SRC	579	582	PF00017	0.640
LIG_SH2_SRC	77	80	PF00017	0.545
LIG_SH2_STAP1	682	686	PF00017	0.488
LIG_SH2_STAT3	15	18	PF00017	0.695
LIG_SH2_STAT5	121	124	PF00017	0.650
LIG_SH2_STAT5	15	18	PF00017	0.642
LIG_SH2_STAT5	77	80	PF00017	0.781
LIG_SH3_3	1	7	PF00018	0.772
LIG_SH3_3	67	73	PF00018	0.669
LIG_SH3_3	746	752	PF00018	0.545
LIG_SH3_3	781	787	PF00018	0.441
LIG_SUMO_SIM_par_1	330	336	PF11976	0.586
LIG_TRAF2_1	525	528	PF00917	0.559
LIG_TYR_ITIM	577	582	PF00017	0.451
LIG_TYR_ITIM	609	614	PF00017	0.392
LIG_UBA3_1	454	462	PF00899	0.427
LIG_UBA3_1	571	578	PF00899	0.431
LIG_WRC_WIRS_1	131	136	PF05994	0.424
LIG_WW_3	3	7	PF00397	0.764
MOD_CDC14_SPxK_1	247	250	PF00782	0.560
MOD_CDK_SPxK_1	244	250	PF00069	0.563
MOD_CK1_1	139	145	PF00069	0.655
MOD_CK1_1	251	257	PF00069	0.731
MOD_CK1_1	292	298	PF00069	0.665
MOD_CK1_1	425	431	PF00069	0.641
MOD_CK1_1	489	495	PF00069	0.536
MOD_CK1_1	50	56	PF00069	0.787
MOD_CK1_1	693	699	PF00069	0.611
MOD_CK1_1	93	99	PF00069	0.666
MOD_CK2_1	144	150	PF00069	0.559
MOD_CK2_1	254	260	PF00069	0.562
MOD_CK2_1	428	434	PF00069	0.689
MOD_CK2_1	503	509	PF00069	0.570
MOD_CK2_1	521	527	PF00069	0.343
MOD_CK2_1	532	538	PF00069	0.542
MOD_CK2_1	549	555	PF00069	0.676
MOD_CK2_1	719	725	PF00069	0.405
MOD_GlcNHglycan	12	15	PF01048	0.691
MOD_GlcNHglycan	138	141	PF01048	0.625
MOD_GlcNHglycan	146	149	PF01048	0.652
MOD_GlcNHglycan	207	210	PF01048	0.500
MOD_GlcNHglycan	229	232	PF01048	0.625
MOD_GlcNHglycan	250	253	PF01048	0.769
MOD_GlcNHglycan	257	260	PF01048	0.727
MOD_GlcNHglycan	278	281	PF01048	0.816
MOD_GlcNHglycan	40	43	PF01048	0.688
MOD_GlcNHglycan	431	434	PF01048	0.539
MOD_GlcNHglycan	559	563	PF01048	0.614
MOD_GlcNHglycan	703	706	PF01048	0.517
MOD_GlcNHglycan	808	811	PF01048	0.573
MOD_GlcNHglycan	91	95	PF01048	0.530
MOD_GSK3_1	219	226	PF00069	0.655
MOD_GSK3_1	244	251	PF00069	0.704
MOD_GSK3_1	285	292	PF00069	0.623
MOD_GSK3_1	352	359	PF00069	0.484
MOD_GSK3_1	422	429	PF00069	0.665
MOD_GSK3_1	46	53	PF00069	0.750
MOD_GSK3_1	482	489	PF00069	0.507
MOD_GSK3_1	492	499	PF00069	0.503
MOD_GSK3_1	64	71	PF00069	0.690
MOD_GSK3_1	776	783	PF00069	0.471
MOD_GSK3_1	802	809	PF00069	0.526
MOD_GSK3_1	86	93	PF00069	0.678
MOD_LATS_1	400	406	PF00433	0.337
MOD_N-GLC_1	254	259	PF02516	0.663
MOD_N-GLC_1	712	717	PF02516	0.514
MOD_NEK2_1	223	228	PF00069	0.662
MOD_NEK2_1	278	283	PF00069	0.739
MOD_NEK2_1	356	361	PF00069	0.438
MOD_NEK2_1	486	491	PF00069	0.506
MOD_NEK2_1	529	534	PF00069	0.601
MOD_NEK2_1	540	545	PF00069	0.482
MOD_NEK2_1	596	601	PF00069	0.510
MOD_NEK2_1	701	706	PF00069	0.344
MOD_NEK2_1	757	762	PF00069	0.509
MOD_NEK2_2	47	52	PF00069	0.535
MOD_PIKK_1	292	298	PF00454	0.736
MOD_PIKK_1	580	586	PF00454	0.607
MOD_PIKK_1	653	659	PF00454	0.470
MOD_PIKK_1	719	725	PF00454	0.563
MOD_PIKK_1	740	746	PF00454	0.351
MOD_PKA_2	10	16	PF00069	0.523
MOD_PKA_2	106	112	PF00069	0.745
MOD_PKA_2	219	225	PF00069	0.721
MOD_PKA_2	322	328	PF00069	0.591
MOD_PKA_2	37	43	PF00069	0.535
MOD_PKA_2	486	492	PF00069	0.473
MOD_PKA_2	540	546	PF00069	0.396
MOD_Plk_1	223	229	PF00069	0.673
MOD_Plk_1	497	503	PF00069	0.561
MOD_Plk_1	529	535	PF00069	0.641
MOD_Plk_1	693	699	PF00069	0.385
MOD_Plk_1	719	725	PF00069	0.402
MOD_Plk_1	90	96	PF00069	0.527
MOD_Plk_2-3	690	696	PF00069	0.553
MOD_Plk_4	130	136	PF00069	0.601
MOD_Plk_4	328	334	PF00069	0.451
MOD_Plk_4	352	358	PF00069	0.634
MOD_Plk_4	529	535	PF00069	0.583
MOD_Plk_4	59	65	PF00069	0.529
MOD_ProDKin_1	120	126	PF00069	0.572
MOD_ProDKin_1	244	250	PF00069	0.733
MOD_ProDKin_1	289	295	PF00069	0.732
MOD_ProDKin_1	422	428	PF00069	0.497
MOD_ProDKin_1	64	70	PF00069	0.782
MOD_ProDKin_1	72	78	PF00069	0.513
MOD_ProDKin_1	748	754	PF00069	0.603
MOD_SUMO_for_1	577	580	PF00179	0.454
TRG_DiLeu_BaEn_1	753	758	PF01217	0.537
TRG_DiLeu_LyEn_5	753	758	PF01217	0.560
TRG_ENDOCYTIC_2	394	397	PF00928	0.551
TRG_ENDOCYTIC_2	579	582	PF00928	0.439
TRG_ENDOCYTIC_2	611	614	PF00928	0.573
TRG_ENDOCYTIC_2	686	689	PF00928	0.482
TRG_ER_diArg_1	153	155	PF00400	0.669
TRG_ER_diArg_1	218	221	PF00400	0.691
TRG_ER_diArg_1	236	238	PF00400	0.487
TRG_ER_diArg_1	312	314	PF00400	0.411
TRG_ER_diArg_1	563	566	PF00400	0.565
TRG_ER_diArg_1	647	649	PF00400	0.467
TRG_ER_diArg_1	772	774	PF00400	0.624
TRG_ER_FFAT_2	115	126	PF00635	0.635
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	636	640	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	797	802	PF00026	0.710

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDX8	Leptomonas seymouri	44%	100%
A0A0S4JLD6	Bodo saltans	26%	100%
A0A1X0P2X9	Trypanosomatidae	25%	100%
A0A451EJ96	Leishmania donovani	68%	99%
A4HRG2	Leishmania infantum	68%	99%
C9ZXI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AC30	Leishmania major	67%	98%
E9AJC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
V5DD57	Trypanosoma cruzi	25%	100%