Dymeclin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dymeclin

Gene product:

Dyggve-Melchior-Clausen syndrome protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H364_LEIBR

TriTrypDb:

LbrM.01.0430 , LBRM2903_010009000

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H364

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H364

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	655	659	PF00656	0.231
CLV_C14_Caspase3-7	770	774	PF00656	0.179
CLV_NRD_NRD_1	5	7	PF00675	0.339
CLV_NRD_NRD_1	706	708	PF00675	0.477
CLV_NRD_NRD_1	729	731	PF00675	0.379
CLV_NRD_NRD_1	80	82	PF00675	0.358
CLV_PCSK_KEX2_1	706	708	PF00082	0.475
CLV_PCSK_KEX2_1	80	82	PF00082	0.358
CLV_PCSK_SKI1_1	105	109	PF00082	0.322
CLV_PCSK_SKI1_1	148	152	PF00082	0.291
CLV_PCSK_SKI1_1	172	176	PF00082	0.339
CLV_PCSK_SKI1_1	313	317	PF00082	0.291
CLV_PCSK_SKI1_1	433	437	PF00082	0.494
CLV_PCSK_SKI1_1	475	479	PF00082	0.351
CLV_PCSK_SKI1_1	501	505	PF00082	0.379
CLV_PCSK_SKI1_1	672	676	PF00082	0.506
CLV_PCSK_SKI1_1	69	73	PF00082	0.262
CLV_Separin_Metazoa	77	81	PF03568	0.474
DOC_ANK_TNKS_1	621	628	PF00023	0.283
DOC_CKS1_1	248	253	PF01111	0.379
DOC_CYCLIN_RxL_1	167	179	PF00134	0.539
DOC_CYCLIN_RxL_1	472	482	PF00134	0.422
DOC_CYCLIN_RxL_1	66	76	PF00134	0.484
DOC_CYCLIN_RxL_1	667	676	PF00134	0.179
DOC_MAPK_FxFP_2	441	444	PF00069	0.262
DOC_MAPK_gen_1	67	74	PF00069	0.481
DOC_MAPK_HePTP_8	356	368	PF00069	0.418
DOC_MAPK_MEF2A_6	359	368	PF00069	0.388
DOC_MAPK_MEF2A_6	439	448	PF00069	0.339
DOC_MAPK_MEF2A_6	535	544	PF00069	0.207
DOC_PP1_RVXF_1	220	226	PF00149	0.402
DOC_PP1_RVXF_1	431	437	PF00149	0.291
DOC_PP1_RVXF_1	65	71	PF00149	0.454
DOC_PP1_SILK_1	497	502	PF00149	0.303
DOC_PP2B_LxvP_1	266	269	PF13499	0.491
DOC_PP4_FxxP_1	248	251	PF00568	0.379
DOC_PP4_FxxP_1	441	444	PF00568	0.248
DOC_PP4_FxxP_1	792	795	PF00568	0.237
DOC_USP7_MATH_1	16	20	PF00917	0.542
DOC_USP7_MATH_1	288	292	PF00917	0.408
DOC_USP7_MATH_1	355	359	PF00917	0.379
DOC_USP7_MATH_1	411	415	PF00917	0.225
DOC_USP7_MATH_1	483	487	PF00917	0.513
DOC_USP7_MATH_1	57	61	PF00917	0.587
DOC_USP7_MATH_1	756	760	PF00917	0.222
DOC_WW_Pin1_4	200	205	PF00397	0.539
DOC_WW_Pin1_4	226	231	PF00397	0.483
DOC_WW_Pin1_4	247	252	PF00397	0.379
DOC_WW_Pin1_4	342	347	PF00397	0.480
DOC_WW_Pin1_4	467	472	PF00397	0.539
DOC_WW_Pin1_4	694	699	PF00397	0.304
DOC_WW_Pin1_4	783	788	PF00397	0.255
DOC_WW_Pin1_4	90	95	PF00397	0.539
LIG_14-3-3_CanoR_1	148	154	PF00244	0.526
LIG_14-3-3_CanoR_1	172	178	PF00244	0.575
LIG_14-3-3_CanoR_1	313	322	PF00244	0.522
LIG_14-3-3_CanoR_1	357	367	PF00244	0.587
LIG_14-3-3_CanoR_1	439	444	PF00244	0.317
LIG_14-3-3_CanoR_1	535	542	PF00244	0.366
LIG_14-3-3_CanoR_1	549	555	PF00244	0.304
LIG_14-3-3_CanoR_1	750	755	PF00244	0.179
LIG_14-3-3_CanoR_1	815	824	PF00244	0.410
LIG_Actin_WH2_2	532	547	PF00022	0.253
LIG_Actin_WH2_2	606	624	PF00022	0.339
LIG_Actin_WH2_2	92	107	PF00022	0.504
LIG_APCC_ABBA_1	193	198	PF00400	0.444
LIG_BIR_III_4	732	736	PF00653	0.179
LIG_BRCT_BRCA1_1	441	445	PF00533	0.248
LIG_BRCT_BRCA1_1	788	792	PF00533	0.237
LIG_BRCT_BRCA1_1	9	13	PF00533	0.539
LIG_EH1_1	167	175	PF00400	0.379
LIG_FHA_1	12	18	PF00498	0.539
LIG_FHA_1	140	146	PF00498	0.537
LIG_FHA_1	190	196	PF00498	0.483
LIG_FHA_1	314	320	PF00498	0.558
LIG_FHA_1	450	456	PF00498	0.318
LIG_FHA_1	468	474	PF00498	0.545
LIG_FHA_1	539	545	PF00498	0.303
LIG_FHA_1	596	602	PF00498	0.261
LIG_FHA_1	613	619	PF00498	0.218
LIG_FHA_1	63	69	PF00498	0.455
LIG_FHA_1	669	675	PF00498	0.337
LIG_FHA_1	91	97	PF00498	0.463
LIG_FHA_2	21	27	PF00498	0.465
LIG_FHA_2	393	399	PF00498	0.247
LIG_FHA_2	419	425	PF00498	0.222
LIG_FHA_2	559	565	PF00498	0.345
LIG_FHA_2	569	575	PF00498	0.372
LIG_FHA_2	600	606	PF00498	0.358
LIG_FHA_2	761	767	PF00498	0.356
LIG_FHA_2	768	774	PF00498	0.238
LIG_LIR_Apic_2	789	795	PF02991	0.237
LIG_LIR_Gen_1	194	204	PF02991	0.448
LIG_LIR_Gen_1	240	248	PF02991	0.541
LIG_LIR_Gen_1	306	315	PF02991	0.539
LIG_LIR_Gen_1	348	356	PF02991	0.509
LIG_LIR_Gen_1	442	453	PF02991	0.331
LIG_LIR_Gen_1	789	797	PF02991	0.233
LIG_LIR_Nem_3	166	171	PF02991	0.524
LIG_LIR_Nem_3	194	199	PF02991	0.452
LIG_LIR_Nem_3	219	223	PF02991	0.495
LIG_LIR_Nem_3	240	244	PF02991	0.481
LIG_LIR_Nem_3	306	311	PF02991	0.539
LIG_LIR_Nem_3	348	352	PF02991	0.509
LIG_LIR_Nem_3	361	366	PF02991	0.387
LIG_LIR_Nem_3	442	448	PF02991	0.289
LIG_LIR_Nem_3	742	746	PF02991	0.179
LIG_LIR_Nem_3	789	793	PF02991	0.229
LIG_LYPXL_yS_3	443	446	PF13949	0.308
LIG_MLH1_MIPbox_1	9	13	PF16413	0.539
LIG_NRBOX	170	176	PF00104	0.539
LIG_NRBOX	209	215	PF00104	0.510
LIG_NRBOX	369	375	PF00104	0.372
LIG_NRBOX	98	104	PF00104	0.458
LIG_PCNA_yPIPBox_3	501	514	PF02747	0.248
LIG_Pex14_2	241	245	PF04695	0.546
LIG_Pex14_2	441	445	PF04695	0.248
LIG_Pex14_2	792	796	PF04695	0.237
LIG_SH2_CRK	743	747	PF00017	0.179
LIG_SH2_PTP2	371	374	PF00017	0.334
LIG_SH2_SRC	783	786	PF00017	0.175
LIG_SH2_STAP1	37	41	PF00017	0.379
LIG_SH2_STAP1	481	485	PF00017	0.539
LIG_SH2_STAP1	644	648	PF00017	0.239
LIG_SH2_STAT3	531	534	PF00017	0.262
LIG_SH2_STAT3	617	620	PF00017	0.291
LIG_SH2_STAT5	12	15	PF00017	0.448
LIG_SH2_STAT5	264	267	PF00017	0.539
LIG_SH2_STAT5	337	340	PF00017	0.456
LIG_SH2_STAT5	371	374	PF00017	0.289
LIG_SH2_STAT5	531	534	PF00017	0.284
LIG_SH2_STAT5	617	620	PF00017	0.291
LIG_SH2_STAT5	648	651	PF00017	0.343
LIG_SH2_STAT5	743	746	PF00017	0.179
LIG_SH3_3	152	158	PF00018	0.462
LIG_SH3_3	291	297	PF00018	0.491
LIG_SH3_3	47	53	PF00018	0.523
LIG_SH3_3	510	516	PF00018	0.248
LIG_SH3_3	573	579	PF00018	0.179
LIG_SH3_3	80	86	PF00018	0.491
LIG_SH3_3	818	824	PF00018	0.545
LIG_Sin3_3	389	396	PF02671	0.179
LIG_SUMO_SIM_anti_2	348	354	PF11976	0.581
LIG_SUMO_SIM_anti_2	365	371	PF11976	0.240
LIG_SUMO_SIM_anti_2	451	458	PF11976	0.290
LIG_SUMO_SIM_anti_2	700	706	PF11976	0.263
LIG_SUMO_SIM_anti_2	776	782	PF11976	0.339
LIG_SUMO_SIM_par_1	451	458	PF11976	0.309
LIG_SUMO_SIM_par_1	491	496	PF11976	0.370
LIG_TRAF2_1	395	398	PF00917	0.179
LIG_TRAF2_1	609	612	PF00917	0.280
LIG_TRAF2_1	782	785	PF00917	0.339
LIG_TYR_ITIM	369	374	PF00017	0.289
LIG_TYR_ITIM	642	647	PF00017	0.248
LIG_UBA3_1	103	112	PF00899	0.578
LIG_UBA3_1	318	327	PF00899	0.448
LIG_UBA3_1	539	546	PF00899	0.176
MOD_CK1_1	271	277	PF00069	0.555
MOD_CK1_1	278	284	PF00069	0.509
MOD_CK1_1	286	292	PF00069	0.418
MOD_CK1_1	358	364	PF00069	0.528
MOD_CK1_1	557	563	PF00069	0.218
MOD_CK1_1	588	594	PF00069	0.309
MOD_CK1_1	596	602	PF00069	0.255
MOD_CK1_1	749	755	PF00069	0.332
MOD_CK1_1	786	792	PF00069	0.180
MOD_CK2_1	303	309	PF00069	0.462
MOD_CK2_1	359	365	PF00069	0.513
MOD_CK2_1	392	398	PF00069	0.320
MOD_CK2_1	558	564	PF00069	0.255
MOD_CK2_1	568	574	PF00069	0.228
MOD_CK2_1	599	605	PF00069	0.354
MOD_CK2_1	694	700	PF00069	0.310
MOD_CK2_1	760	766	PF00069	0.329
MOD_CK2_1	779	785	PF00069	0.306
MOD_GlcNHglycan	114	117	PF01048	0.322
MOD_GlcNHglycan	277	280	PF01048	0.324
MOD_GlcNHglycan	286	289	PF01048	0.314
MOD_GlcNHglycan	290	293	PF01048	0.302
MOD_GlcNHglycan	353	356	PF01048	0.334
MOD_GlcNHglycan	536	539	PF01048	0.477
MOD_GlcNHglycan	550	553	PF01048	0.484
MOD_GlcNHglycan	602	605	PF01048	0.501
MOD_GlcNHglycan	721	724	PF01048	0.523
MOD_GlcNHglycan	725	728	PF01048	0.547
MOD_GlcNHglycan	732	736	PF01048	0.583
MOD_GlcNHglycan	802	805	PF01048	0.678
MOD_GSK3_1	108	115	PF00069	0.499
MOD_GSK3_1	16	23	PF00069	0.484
MOD_GSK3_1	173	180	PF00069	0.482
MOD_GSK3_1	209	216	PF00069	0.419
MOD_GSK3_1	246	253	PF00069	0.519
MOD_GSK3_1	271	278	PF00069	0.528
MOD_GSK3_1	283	290	PF00069	0.541
MOD_GSK3_1	351	358	PF00069	0.559
MOD_GSK3_1	376	383	PF00069	0.188
MOD_GSK3_1	403	410	PF00069	0.263
MOD_GSK3_1	534	541	PF00069	0.380
MOD_GSK3_1	554	561	PF00069	0.223
MOD_GSK3_1	564	571	PF00069	0.200
MOD_GSK3_1	585	592	PF00069	0.380
MOD_GSK3_1	595	602	PF00069	0.364
MOD_GSK3_1	7	14	PF00069	0.512
MOD_GSK3_1	719	726	PF00069	0.307
MOD_GSK3_1	746	753	PF00069	0.348
MOD_GSK3_1	756	763	PF00069	0.358
MOD_GSK3_1	769	776	PF00069	0.309
MOD_GSK3_1	779	786	PF00069	0.232
MOD_GSK3_1	85	92	PF00069	0.396
MOD_N-GLC_1	42	47	PF02516	0.179
MOD_N-GLC_2	566	568	PF02516	0.379
MOD_NEK2_1	108	113	PF00069	0.520
MOD_NEK2_1	122	127	PF00069	0.467
MOD_NEK2_1	139	144	PF00069	0.465
MOD_NEK2_1	149	154	PF00069	0.474
MOD_NEK2_1	173	178	PF00069	0.426
MOD_NEK2_1	199	204	PF00069	0.481
MOD_NEK2_1	213	218	PF00069	0.430
MOD_NEK2_1	223	228	PF00069	0.510
MOD_NEK2_1	301	306	PF00069	0.539
MOD_NEK2_1	380	385	PF00069	0.250
MOD_NEK2_1	391	396	PF00069	0.226
MOD_NEK2_1	400	405	PF00069	0.145
MOD_NEK2_1	448	453	PF00069	0.313
MOD_NEK2_1	554	559	PF00069	0.269
MOD_PIKK_1	411	417	PF00454	0.179
MOD_PIKK_1	455	461	PF00454	0.284
MOD_PK_1	721	727	PF00069	0.179
MOD_PKA_2	108	114	PF00069	0.529
MOD_PKA_2	358	364	PF00069	0.379
MOD_PKA_2	407	413	PF00069	0.356
MOD_PKA_2	534	540	PF00069	0.351
MOD_PKA_2	548	554	PF00069	0.297
MOD_PKA_2	593	599	PF00069	0.301
MOD_PKA_2	749	755	PF00069	0.261
MOD_PKA_2	814	820	PF00069	0.464
MOD_PKB_1	357	365	PF00069	0.379
MOD_Plk_1	189	195	PF00069	0.524
MOD_Plk_1	37	43	PF00069	0.379
MOD_Plk_2-3	773	779	PF00069	0.339
MOD_Plk_4	209	215	PF00069	0.485
MOD_Plk_4	237	243	PF00069	0.534
MOD_Plk_4	345	351	PF00069	0.524
MOD_Plk_4	376	382	PF00069	0.229
MOD_Plk_4	449	455	PF00069	0.341
MOD_Plk_4	596	602	PF00069	0.285
MOD_Plk_4	612	618	PF00069	0.184
MOD_Plk_4	627	633	PF00069	0.209
MOD_Plk_4	750	756	PF00069	0.291
MOD_Plk_4	797	803	PF00069	0.362
MOD_ProDKin_1	200	206	PF00069	0.539
MOD_ProDKin_1	226	232	PF00069	0.483
MOD_ProDKin_1	247	253	PF00069	0.379
MOD_ProDKin_1	342	348	PF00069	0.480
MOD_ProDKin_1	467	473	PF00069	0.539
MOD_ProDKin_1	694	700	PF00069	0.304
MOD_ProDKin_1	783	789	PF00069	0.255
MOD_ProDKin_1	90	96	PF00069	0.539
MOD_SUMO_rev_2	479	486	PF00179	0.379
TRG_DiLeu_BaEn_1	365	370	PF01217	0.381
TRG_DiLeu_BaEn_1	387	392	PF01217	0.348
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.379
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.553
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.491
TRG_ENDOCYTIC_2	371	374	PF00928	0.274
TRG_ENDOCYTIC_2	443	446	PF00928	0.308
TRG_ENDOCYTIC_2	644	647	PF00928	0.239
TRG_ENDOCYTIC_2	743	746	PF00928	0.179
TRG_ENDOCYTIC_2	790	793	PF00928	0.230
TRG_ER_diArg_1	356	359	PF00400	0.379
TRG_ER_diArg_1	649	652	PF00400	0.246
TRG_ER_diArg_1	67	70	PF00400	0.449
TRG_ER_diArg_1	705	707	PF00400	0.278
TRG_ER_diArg_1	79	81	PF00400	0.492
TRG_ER_FFAT_2	8	18	PF00635	0.491
TRG_NES_CRM1_1	612	626	PF08389	0.291
TRG_Pf-PMV_PEXEL_1	433	437	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.222
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	608	612	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6M9	Leptomonas seymouri	55%	98%
A0A0S4JPV7	Bodo saltans	25%	100%
A0A1X0P2R5	Trypanosomatidae	33%	100%
A0A3S5H4V0	Leishmania donovani	74%	100%
A0A422NY99	Trypanosoma rangeli	33%	100%
A4HRG1	Leishmania infantum	74%	100%
C9ZXI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AC29	Leishmania major	73%	97%
E9AJC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
V5AX12	Trypanosoma cruzi	32%	100%