Transmembrane protein 208

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF788), putative

Species:

Leishmania braziliensis

UniProt:

A4H363_LEIBR

TriTrypDb:

LbrM.01.0420 , LBRM2903_010008900

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005773	vacuole	5	1
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

A4H363

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H363

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006624	vacuolar protein processing	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	169	171	PF00675	0.264
CLV_NRD_NRD_1	176	178	PF00675	0.263
CLV_NRD_NRD_1	181	183	PF00675	0.456
CLV_PCSK_KEX2_1	169	171	PF00082	0.262
CLV_PCSK_KEX2_1	181	183	PF00082	0.456
CLV_PCSK_PC7_1	177	183	PF00082	0.486
CLV_PCSK_SKI1_1	8	12	PF00082	0.325
DOC_CYCLIN_yCln2_LP_2	122	128	PF00134	0.328
DOC_MAPK_gen_1	11	19	PF00069	0.559
DOC_PP2B_LxvP_1	122	125	PF13499	0.317

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P720	Leptomonas seymouri	73%	100%
A0A0S4ILZ6	Bodo saltans	40%	100%
A0A1X0P3E2	Trypanosomatidae	56%	100%
A0A3S5H4U9	Leishmania donovani	82%	100%
A0A422NY40	Trypanosoma rangeli	55%	100%
A4HRG0	Leishmania infantum	82%	100%
C9ZXI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AC28	Leishmania major	82%	100%
E9AJC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q6NYP0	Danio rerio	27%	100%

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