Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H362_LEIBR

TriTrypDb:

LbrM.01.0410 , LBRM2903_010008800

Length:

141

Annotations

LeishMANIAdb annotations

This protein appears to have an Ala-rich signal peptide and a single TM segment

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4H362

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H362

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.661
CLV_NRD_NRD_1	54	56	PF00675	0.430
CLV_PCSK_FUR_1	52	56	PF00082	0.491
CLV_PCSK_KEX2_1	54	56	PF00082	0.456
DEG_Nend_UBRbox_1	1	4	PF02207	0.561
DOC_MAPK_gen_1	96	105	PF00069	0.530
DOC_MAPK_MEF2A_6	99	107	PF00069	0.340
DOC_USP7_MATH_1	32	36	PF00917	0.606
LIG_14-3-3_CanoR_1	19	24	PF00244	0.576
LIG_14-3-3_CanoR_1	85	91	PF00244	0.558
LIG_Actin_WH2_2	11	26	PF00022	0.681
LIG_BRCT_BRCA1_1	43	47	PF00533	0.603
LIG_FXI_DFP_1	67	71	PF00024	0.469
LIG_IBAR_NPY_1	117	119	PF08397	0.308
LIG_Integrin_RGD_1	120	122	PF01839	0.520
LIG_LIR_Apic_2	122	127	PF02991	0.412
LIG_LIR_Gen_1	64	74	PF02991	0.705
LIG_LIR_Nem_3	64	70	PF02991	0.632
LIG_SH2_CRK	48	52	PF00017	0.601
LIG_SH2_STAT5	114	117	PF00017	0.523
LIG_SH3_2	71	76	PF14604	0.665
LIG_SH3_3	112	118	PF00018	0.499
LIG_SH3_3	68	74	PF00018	0.632
LIG_TRFH_1	114	118	PF08558	0.436
MOD_CK1_1	22	28	PF00069	0.780
MOD_CK2_1	55	61	PF00069	0.675
MOD_GlcNHglycan	30	33	PF01048	0.487
MOD_GSK3_1	130	137	PF00069	0.423
MOD_GSK3_1	19	26	PF00069	0.712
MOD_GSK3_1	28	35	PF00069	0.613
MOD_NEK2_1	23	28	PF00069	0.691
MOD_NEK2_1	40	45	PF00069	0.643
MOD_NEK2_1	6	11	PF00069	0.630
MOD_PKA_2	23	29	PF00069	0.720
MOD_PKA_2	84	90	PF00069	0.563
MOD_SUMO_rev_2	128	137	PF00179	0.460
TRG_ENDOCYTIC_2	48	51	PF00928	0.582
TRG_ER_diArg_1	10	13	PF00400	0.651
TRG_ER_diArg_1	76	79	PF00400	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILJ0	Leptomonas seymouri	55%	89%
A0A1X0P2P5	Trypanosomatidae	47%	100%
A0A3S5H4U8	Leishmania donovani	65%	75%
A4HRF9	Leishmania infantum	66%	75%
C9ZXI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	72%
E9AC27	Leishmania major	65%	100%
E9AJC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	74%
V5BH39	Trypanosoma cruzi	44%	100%