Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H361_LEIBR

TriTrypDb:

LbrM.01.0400 , LBRM2903_010008700

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H361

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H361

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	386	388	PF00675	0.409
CLV_NRD_NRD_1	393	395	PF00675	0.500
CLV_NRD_NRD_1	577	579	PF00675	0.482
CLV_NRD_NRD_1	734	736	PF00675	0.710
CLV_NRD_NRD_1	97	99	PF00675	0.489
CLV_PCSK_KEX2_1	388	390	PF00082	0.444
CLV_PCSK_KEX2_1	393	395	PF00082	0.500
CLV_PCSK_KEX2_1	514	516	PF00082	0.480
CLV_PCSK_KEX2_1	577	579	PF00082	0.482
CLV_PCSK_KEX2_1	734	736	PF00082	0.710
CLV_PCSK_KEX2_1	97	99	PF00082	0.445
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.444
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.480
CLV_PCSK_PC7_1	389	395	PF00082	0.582
CLV_PCSK_SKI1_1	328	332	PF00082	0.422
CLV_PCSK_SKI1_1	53	57	PF00082	0.327
CLV_PCSK_SKI1_1	548	552	PF00082	0.344
CLV_PCSK_SKI1_1	618	622	PF00082	0.536
DEG_APCC_DBOX_1	514	522	PF00400	0.544
DEG_APCC_DBOX_1	52	60	PF00400	0.360
DEG_Nend_UBRbox_4	1	3	PF02207	0.335
DEG_SCF_FBW7_1	422	428	PF00400	0.539
DEG_SPOP_SBC_1	417	421	PF00917	0.839
DEG_SPOP_SBC_1	425	429	PF00917	0.734
DOC_CKS1_1	422	427	PF01111	0.539
DOC_CKS1_1	48	53	PF01111	0.321
DOC_CYCLIN_RxL_1	47	57	PF00134	0.354
DOC_CYCLIN_RxL_1	731	739	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	320	326	PF00134	0.469
DOC_CYCLIN_yCln2_LP_2	48	54	PF00134	0.322
DOC_CYCLIN_yCln2_LP_2	490	496	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.279
DOC_MAPK_DCC_7	45	54	PF00069	0.453
DOC_MAPK_gen_1	274	283	PF00069	0.269
DOC_MAPK_gen_1	331	340	PF00069	0.380
DOC_MAPK_gen_1	45	54	PF00069	0.256
DOC_MAPK_gen_1	568	575	PF00069	0.433
DOC_MAPK_gen_1	97	104	PF00069	0.428
DOC_MAPK_HePTP_8	36	48	PF00069	0.322
DOC_MAPK_HePTP_8	94	106	PF00069	0.417
DOC_MAPK_MEF2A_6	131	139	PF00069	0.454
DOC_MAPK_MEF2A_6	276	285	PF00069	0.350
DOC_MAPK_MEF2A_6	334	342	PF00069	0.370
DOC_MAPK_MEF2A_6	39	48	PF00069	0.326
DOC_MAPK_MEF2A_6	97	106	PF00069	0.489
DOC_MAPK_NFAT4_5	337	345	PF00069	0.353
DOC_PP1_RVXF_1	101	107	PF00149	0.456
DOC_PP1_RVXF_1	732	739	PF00149	0.534
DOC_PP2B_LxvP_1	320	323	PF13499	0.468
DOC_PP2B_LxvP_1	415	418	PF13499	0.627
DOC_PP2B_LxvP_1	46	49	PF13499	0.277
DOC_PP2B_LxvP_1	472	475	PF13499	0.510
DOC_PP4_MxPP_1	439	442	PF00568	0.516
DOC_USP7_MATH_1	220	224	PF00917	0.673
DOC_USP7_MATH_1	237	241	PF00917	0.351
DOC_USP7_MATH_1	250	254	PF00917	0.431
DOC_USP7_MATH_1	308	312	PF00917	0.508
DOC_USP7_MATH_1	416	420	PF00917	0.697
DOC_USP7_MATH_1	426	430	PF00917	0.736
DOC_USP7_MATH_1	494	498	PF00917	0.604
DOC_USP7_MATH_1	543	547	PF00917	0.505
DOC_USP7_MATH_1	683	687	PF00917	0.693
DOC_USP7_MATH_1	696	700	PF00917	0.639
DOC_USP7_MATH_1	702	706	PF00917	0.513
DOC_USP7_UBL2_3	621	625	PF12436	0.541
DOC_WW_Pin1_4	214	219	PF00397	0.347
DOC_WW_Pin1_4	296	301	PF00397	0.345
DOC_WW_Pin1_4	418	423	PF00397	0.748
DOC_WW_Pin1_4	47	52	PF00397	0.420
DOC_WW_Pin1_4	658	663	PF00397	0.483
DOC_WW_Pin1_4	7	12	PF00397	0.463
LIG_14-3-3_CanoR_1	208	212	PF00244	0.357
LIG_14-3-3_CanoR_1	232	237	PF00244	0.402
LIG_14-3-3_CanoR_1	292	297	PF00244	0.445
LIG_14-3-3_CanoR_1	369	373	PF00244	0.522
LIG_14-3-3_CanoR_1	376	380	PF00244	0.489
LIG_14-3-3_CanoR_1	387	392	PF00244	0.366
LIG_14-3-3_CanoR_1	410	416	PF00244	0.526
LIG_14-3-3_CanoR_1	434	440	PF00244	0.758
LIG_14-3-3_CanoR_1	450	456	PF00244	0.655
LIG_14-3-3_CanoR_1	577	583	PF00244	0.447
LIG_14-3-3_CanoR_1	618	624	PF00244	0.512
LIG_14-3-3_CanoR_1	636	642	PF00244	0.346
LIG_Actin_WH2_2	360	378	PF00022	0.448
LIG_Actin_WH2_2	569	586	PF00022	0.536
LIG_APCC_ABBA_1	84	89	PF00400	0.230
LIG_BRCT_BRCA1_1	187	191	PF00533	0.442
LIG_EH1_1	256	264	PF00400	0.291
LIG_eIF4E_1	297	303	PF01652	0.438
LIG_FHA_1	231	237	PF00498	0.688
LIG_FHA_1	375	381	PF00498	0.485
LIG_FHA_1	442	448	PF00498	0.734
LIG_FHA_1	586	592	PF00498	0.495
LIG_FHA_2	369	375	PF00498	0.517
LIG_FHA_2	444	450	PF00498	0.691
LIG_FHA_2	594	600	PF00498	0.396
LIG_FHA_2	80	86	PF00498	0.417
LIG_Integrin_isoDGR_2	716	718	PF01839	0.540
LIG_LIR_Apic_2	148	153	PF02991	0.341
LIG_LIR_Apic_2	294	300	PF02991	0.323
LIG_LIR_Gen_1	109	118	PF02991	0.241
LIG_LIR_Gen_1	321	332	PF02991	0.370
LIG_LIR_Gen_1	85	95	PF02991	0.428
LIG_LIR_Nem_3	199	205	PF02991	0.306
LIG_LIR_Nem_3	295	301	PF02991	0.310
LIG_LIR_Nem_3	321	327	PF02991	0.350
LIG_LIR_Nem_3	85	90	PF02991	0.427
LIG_MLH1_MIPbox_1	188	192	PF16413	0.409
LIG_NRBOX	159	165	PF00104	0.431
LIG_NRBOX	3	9	PF00104	0.471
LIG_NRBOX	603	609	PF00104	0.409
LIG_RPA_C_Fungi	93	105	PF08784	0.419
LIG_SH2_CRK	150	154	PF00017	0.320
LIG_SH2_NCK_1	502	506	PF00017	0.652
LIG_SH2_PTP2	343	346	PF00017	0.481
LIG_SH2_SRC	343	346	PF00017	0.502
LIG_SH2_STAP1	565	569	PF00017	0.540
LIG_SH2_STAT5	241	244	PF00017	0.470
LIG_SH2_STAT5	297	300	PF00017	0.325
LIG_SH2_STAT5	319	322	PF00017	0.477
LIG_SH2_STAT5	343	346	PF00017	0.481
LIG_SH2_STAT5	42	45	PF00017	0.440
LIG_SH2_STAT5	676	679	PF00017	0.450
LIG_SH3_3	17	23	PF00018	0.494
LIG_SH3_3	392	398	PF00018	0.651
LIG_SH3_3	419	425	PF00018	0.738
LIG_SH3_3	719	725	PF00018	0.531
LIG_SUMO_SIM_anti_2	107	112	PF11976	0.239
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.386
LIG_TRAF2_1	505	508	PF00917	0.583
LIG_TRAF2_1	550	553	PF00917	0.480
LIG_TRAF2_1	647	650	PF00917	0.595
LIG_TRAF2_1	77	80	PF00917	0.394
LIG_UBA3_1	633	638	PF00899	0.506
MOD_CDK_SPxK_1	47	53	PF00069	0.251
MOD_CK1_1	210	216	PF00069	0.404
MOD_CK1_1	223	229	PF00069	0.617
MOD_CK1_1	3	9	PF00069	0.498
MOD_CK1_1	311	317	PF00069	0.599
MOD_CK1_1	428	434	PF00069	0.625
MOD_CK1_1	497	503	PF00069	0.549
MOD_CK1_1	658	664	PF00069	0.744
MOD_CK2_1	368	374	PF00069	0.616
MOD_CK2_1	443	449	PF00069	0.795
MOD_CK2_1	543	549	PF00069	0.598
MOD_CK2_1	555	561	PF00069	0.400
MOD_CK2_1	593	599	PF00069	0.532
MOD_CK2_1	644	650	PF00069	0.588
MOD_Cter_Amidation	95	98	PF01082	0.279
MOD_GlcNHglycan	225	228	PF01048	0.591
MOD_GlcNHglycan	314	317	PF01048	0.507
MOD_GlcNHglycan	545	548	PF01048	0.557
MOD_GlcNHglycan	557	560	PF01048	0.572
MOD_GlcNHglycan	585	588	PF01048	0.532
MOD_GlcNHglycan	657	660	PF01048	0.648
MOD_GlcNHglycan	666	669	PF01048	0.574
MOD_GlcNHglycan	685	688	PF01048	0.557
MOD_GlcNHglycan	704	707	PF01048	0.763
MOD_GlcNHglycan	708	711	PF01048	0.775
MOD_GSK3_1	206	213	PF00069	0.334
MOD_GSK3_1	219	226	PF00069	0.606
MOD_GSK3_1	292	299	PF00069	0.408
MOD_GSK3_1	3	10	PF00069	0.285
MOD_GSK3_1	308	315	PF00069	0.629
MOD_GSK3_1	326	333	PF00069	0.382
MOD_GSK3_1	347	354	PF00069	0.407
MOD_GSK3_1	417	424	PF00069	0.627
MOD_GSK3_1	425	432	PF00069	0.629
MOD_GSK3_1	441	448	PF00069	0.754
MOD_GSK3_1	619	626	PF00069	0.530
MOD_GSK3_1	644	651	PF00069	0.478
MOD_GSK3_1	671	678	PF00069	0.508
MOD_GSK3_1	702	709	PF00069	0.817
MOD_GSK3_1	75	82	PF00069	0.509
MOD_N-GLC_1	250	255	PF02516	0.447
MOD_N-GLC_1	309	314	PF02516	0.583
MOD_N-GLC_2	155	157	PF02516	0.400
MOD_N-GLC_2	38	40	PF02516	0.438
MOD_NEK2_1	363	368	PF00069	0.383
MOD_NEK2_1	375	380	PF00069	0.396
MOD_NEK2_1	443	448	PF00069	0.685
MOD_NEK2_1	583	588	PF00069	0.520
MOD_NEK2_1	619	624	PF00069	0.572
MOD_NEK2_1	648	653	PF00069	0.376
MOD_NEK2_1	657	662	PF00069	0.443
MOD_NEK2_2	120	125	PF00069	0.329
MOD_PIKK_1	210	216	PF00454	0.286
MOD_PIKK_1	353	359	PF00454	0.418
MOD_PIKK_1	426	432	PF00454	0.543
MOD_PIKK_1	671	677	PF00454	0.478
MOD_PK_1	232	238	PF00069	0.383
MOD_PKA_1	387	393	PF00069	0.518
MOD_PKA_2	140	146	PF00069	0.287
MOD_PKA_2	164	170	PF00069	0.355
MOD_PKA_2	207	213	PF00069	0.407
MOD_PKA_2	291	297	PF00069	0.461
MOD_PKA_2	368	374	PF00069	0.435
MOD_PKA_2	375	381	PF00069	0.375
MOD_PKA_2	494	500	PF00069	0.606
MOD_PKA_2	555	561	PF00069	0.533
MOD_PKA_2	576	582	PF00069	0.446
MOD_PKA_2	696	702	PF00069	0.698
MOD_PKA_2	711	717	PF00069	0.767
MOD_Plk_1	250	256	PF00069	0.494
MOD_Plk_1	648	654	PF00069	0.558
MOD_Plk_4	207	213	PF00069	0.407
MOD_Plk_4	237	243	PF00069	0.525
MOD_Plk_4	251	257	PF00069	0.386
MOD_Plk_4	292	298	PF00069	0.368
MOD_Plk_4	3	9	PF00069	0.350
MOD_Plk_4	375	381	PF00069	0.402
MOD_Plk_4	54	60	PF00069	0.409
MOD_Plk_4	648	654	PF00069	0.562
MOD_ProDKin_1	214	220	PF00069	0.361
MOD_ProDKin_1	296	302	PF00069	0.344
MOD_ProDKin_1	418	424	PF00069	0.749
MOD_ProDKin_1	47	53	PF00069	0.422
MOD_ProDKin_1	658	664	PF00069	0.483
MOD_ProDKin_1	7	13	PF00069	0.467
MOD_SUMO_for_1	608	611	PF00179	0.396
MOD_SUMO_rev_2	329	338	PF00179	0.416
TRG_DiLeu_BaLyEn_6	297	302	PF01217	0.323
TRG_ENDOCYTIC_2	319	322	PF00928	0.378
TRG_ER_diArg_1	392	394	PF00400	0.489
TRG_ER_diArg_1	576	578	PF00400	0.481
TRG_ER_diArg_1	734	736	PF00400	0.710
TRG_NES_CRM1_1	273	284	PF08389	0.272

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N7	Leptomonas seymouri	59%	100%
A0A1X0P2P6	Trypanosomatidae	37%	100%
A0A422NY96	Trypanosoma rangeli	37%	100%
A0A451EJ92	Leishmania donovani	76%	99%
A4HRF8	Leishmania infantum	76%	99%
E9AC26	Leishmania major	77%	100%
E9AJC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	99%
V5D5U6	Trypanosoma cruzi	37%	100%