Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H358_LEIBR

TriTrypDb:

LbrM.01.0370 , LBRM2903_010008400

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0005787	signal peptidase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1

Expansion

Sequence features

A4H358

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H358

Function

Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	1
GO:0006508	proteolysis	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008233	peptidase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.438
CLV_NRD_NRD_1	129	131	PF00675	0.404
CLV_PCSK_SKI1_1	130	134	PF00082	0.378
CLV_PCSK_SKI1_1	31	35	PF00082	0.399
CLV_PCSK_SKI1_1	55	59	PF00082	0.380
CLV_PCSK_SKI1_1	60	64	PF00082	0.330
DOC_MAPK_FxFP_2	188	191	PF00069	0.517
DOC_MAPK_gen_1	130	139	PF00069	0.530
DOC_MAPK_MEF2A_6	133	141	PF00069	0.512
DOC_PP4_FxxP_1	164	167	PF00568	0.621
DOC_PP4_FxxP_1	188	191	PF00568	0.501
DOC_USP7_MATH_1	204	208	PF00917	0.559
DOC_WW_Pin1_4	162	167	PF00397	0.589
LIG_14-3-3_CanoR_1	140	148	PF00244	0.563
LIG_14-3-3_CanoR_1	31	40	PF00244	0.549
LIG_BRCT_BRCA1_1	160	164	PF00533	0.594
LIG_BRCT_BRCA1_1	184	188	PF00533	0.606
LIG_BRCT_BRCA1_1	85	89	PF00533	0.349
LIG_FHA_1	21	27	PF00498	0.548
LIG_FHA_1	32	38	PF00498	0.527
LIG_LIR_Apic_2	161	167	PF02991	0.627
LIG_LIR_Apic_2	185	191	PF02991	0.514
LIG_LIR_Gen_1	168	177	PF02991	0.473
LIG_LIR_Gen_1	84	95	PF02991	0.255
LIG_LIR_Nem_3	144	150	PF02991	0.663
LIG_LIR_Nem_3	168	173	PF02991	0.495
LIG_LIR_Nem_3	176	182	PF02991	0.531
LIG_LIR_Nem_3	28	33	PF02991	0.518
LIG_LIR_Nem_3	39	43	PF02991	0.588
LIG_LIR_Nem_3	84	90	PF02991	0.334
LIG_NRP_CendR_1	208	211	PF00754	0.326
LIG_PCNA_yPIPBox_3	195	209	PF02747	0.599
LIG_PTB_Apo_2	5	12	PF02174	0.517
LIG_PTB_Phospho_1	5	11	PF10480	0.514
LIG_SH2_CRK	30	34	PF00017	0.564
LIG_SH2_NCK_1	11	15	PF00017	0.553
LIG_SH2_NCK_1	170	174	PF00017	0.551
LIG_SH2_STAT5	40	43	PF00017	0.518
LIG_SH2_STAT5	71	74	PF00017	0.300
LIG_SH3_3	143	149	PF00018	0.542
LIG_TRAF2_1	193	196	PF00917	0.437
LIG_TYR_ITIM	41	46	PF00017	0.651
LIG_TYR_ITSM	166	173	PF00017	0.460
MOD_CK1_1	165	171	PF00069	0.629
MOD_CK1_1	76	82	PF00069	0.186
MOD_CK2_1	168	174	PF00069	0.578
MOD_GlcNHglycan	113	116	PF01048	0.332
MOD_GlcNHglycan	78	81	PF01048	0.565
MOD_GSK3_1	158	165	PF00069	0.622
MOD_NEK2_1	1	6	PF00069	0.709
MOD_NEK2_1	111	116	PF00069	0.468
MOD_NEK2_1	182	187	PF00069	0.601
MOD_NEK2_1	73	78	PF00069	0.503
MOD_NEK2_1	83	88	PF00069	0.266
MOD_NEK2_1	98	103	PF00069	0.320
MOD_PIKK_1	139	145	PF00454	0.588
MOD_PKA_2	139	145	PF00069	0.545
MOD_Plk_1	173	179	PF00069	0.587
MOD_Plk_4	165	171	PF00069	0.523
MOD_Plk_4	2	8	PF00069	0.644
MOD_Plk_4	25	31	PF00069	0.451
MOD_Plk_4	83	89	PF00069	0.340
MOD_Plk_4	98	104	PF00069	0.412
MOD_ProDKin_1	162	168	PF00069	0.586
MOD_SUMO_for_1	151	154	PF00179	0.515
TRG_ENDOCYTIC_2	170	173	PF00928	0.531
TRG_ENDOCYTIC_2	179	182	PF00928	0.497
TRG_ENDOCYTIC_2	30	33	PF00928	0.558
TRG_ENDOCYTIC_2	43	46	PF00928	0.574
TRG_ER_diLys_1	208	211	PF00400	0.633
TRG_NLS_MonoExtN_4	127	134	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JMH0	Bodo saltans	30%	77%
A0A1X0P325	Trypanosomatidae	33%	94%
A0A3S5H4U6	Leishmania donovani	75%	100%
A0A3S5ISA1	Trypanosoma rangeli	26%	92%
A4HRF5	Leishmania infantum	75%	100%
C9ZXH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	96%
E9AC23	Leishmania major	74%	100%
E9AJC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%