Putative poly(A) export protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly(A) export protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H357_LEIBR

TriTrypDb:

LbrM.01.0360 , LBRM2903_010008300

Length:

246

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	4
GO:0140513	nuclear protein-containing complex	2	1
GO:0005840	ribosome	5	3
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:1990904	ribonucleoprotein complex	2	3

Expansion

Sequence features

A4H357

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H357

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	10
GO:0006406	mRNA export from nucleus	6	10
GO:0006810	transport	3	10
GO:0006913	nucleocytoplasmic transport	5	10
GO:0009987	cellular process	1	10
GO:0015931	nucleobase-containing compound transport	5	10
GO:0046907	intracellular transport	3	10
GO:0050657	nucleic acid transport	6	10
GO:0050658	RNA transport	4	10
GO:0051028	mRNA transport	5	10
GO:0051168	nuclear export	6	10
GO:0051169	nuclear transport	4	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051236	establishment of RNA localization	3	10
GO:0051641	cellular localization	2	10
GO:0051649	establishment of localization in cell	3	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	6	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0051276	chromosome organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	186	188	PF00675	0.608
CLV_PCSK_SKI1_1	109	113	PF00082	0.516
CLV_PCSK_SKI1_1	188	192	PF00082	0.583
DEG_Nend_Nbox_1	1	3	PF02207	0.382
DOC_CYCLIN_yCln2_LP_2	60	66	PF00134	0.502
DOC_PP1_RVXF_1	126	132	PF00149	0.435
DOC_PP1_RVXF_1	41	47	PF00149	0.423
DOC_PP2B_LxvP_1	25	28	PF13499	0.589
DOC_PP2B_LxvP_1	98	101	PF13499	0.462
DOC_USP7_UBL2_3	230	234	PF12436	0.376
LIG_14-3-3_CanoR_1	109	117	PF00244	0.565
LIG_14-3-3_CanoR_1	128	132	PF00244	0.247
LIG_14-3-3_CterR_2	243	246	PF00244	0.541
LIG_FHA_1	164	170	PF00498	0.582
LIG_FHA_1	199	205	PF00498	0.608
LIG_FHA_1	78	84	PF00498	0.520
LIG_LIR_Gen_1	130	136	PF02991	0.593
LIG_LIR_Gen_1	23	31	PF02991	0.597
LIG_LIR_Nem_3	130	134	PF02991	0.325
LIG_LIR_Nem_3	23	27	PF02991	0.575
LIG_SH2_CRK	117	121	PF00017	0.560
LIG_SH2_SRC	220	223	PF00017	0.547
LIG_SH2_STAP1	220	224	PF00017	0.421
LIG_SH2_STAT3	233	236	PF00017	0.628
LIG_SH2_STAT3	87	90	PF00017	0.574
LIG_SH2_STAT5	153	156	PF00017	0.591
LIG_SH3_3	159	165	PF00018	0.432
LIG_SUMO_SIM_par_1	166	172	PF11976	0.535
MOD_CK1_1	148	154	PF00069	0.551
MOD_GlcNHglycan	171	174	PF01048	0.498
MOD_GlcNHglycan	206	209	PF01048	0.437
MOD_GlcNHglycan	230	233	PF01048	0.374
MOD_GSK3_1	209	216	PF00069	0.446
MOD_GSK3_1	23	30	PF00069	0.516
MOD_N-GLC_1	155	160	PF02516	0.304
MOD_N-GLC_1	177	182	PF02516	0.549
MOD_N-GLC_1	4	9	PF02516	0.395
MOD_N-GLC_2	159	161	PF02516	0.399
MOD_NEK2_1	155	160	PF00069	0.415
MOD_NEK2_1	228	233	PF00069	0.505
MOD_NEK2_1	4	9	PF00069	0.542
MOD_PIKK_1	198	204	PF00454	0.618
MOD_PIKK_1	29	35	PF00454	0.601
MOD_PIKK_1	4	10	PF00454	0.369
MOD_PKA_2	127	133	PF00069	0.438
MOD_Plk_1	148	154	PF00069	0.579
MOD_Plk_1	177	183	PF00069	0.552
MOD_Plk_1	209	215	PF00069	0.360
MOD_Plk_4	127	133	PF00069	0.438
MOD_Plk_4	177	183	PF00069	0.552
MOD_Plk_4	213	219	PF00069	0.441
MOD_SUMO_rev_2	39	44	PF00179	0.462
TRG_ENDOCYTIC_2	117	120	PF00928	0.566
TRG_NES_CRM1_1	90	102	PF08389	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1W5T363	Penicillium oxalicum	29%	71%
A0A1X0P3S0	Trypanosomatidae	55%	70%
A0A3S5H4U5	Leishmania donovani	91%	80%
A0A3S5ISA2	Trypanosoma rangeli	52%	70%
A4HRF4	Leishmania infantum	91%	80%
A5GFN6	Sus scrofa	29%	67%
C9ZXH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	70%
E9AC22	Leishmania major	91%	100%
E9AJB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	80%
G0SEA3	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	27%	69%
O42860	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	77%
O43684	Homo sapiens	27%	75%
P40066	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	67%
P41838	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	70%
P78406	Homo sapiens	28%	67%
Q1JQB2	Bos taurus	27%	75%
Q38942	Arabidopsis thaliana	31%	70%
Q3SWS8	Rattus norvegicus	28%	67%
Q4R6D2	Macaca fascicularis	30%	67%
Q54DM1	Dictyostelium discoideum	25%	74%
Q5E9A4	Bos taurus	29%	67%
Q5FVA9	Xenopus tropicalis	29%	67%
Q5RB58	Pongo abelii	27%	75%
Q5RF99	Pongo abelii	28%	67%
Q7ZWF0	Danio rerio	28%	67%
Q8C570	Mus musculus	28%	67%
Q9C701	Arabidopsis thaliana	29%	73%
Q9LJN8	Arabidopsis thaliana	27%	72%
Q9W2E7	Drosophila melanogaster	28%	71%
Q9WVA3	Mus musculus	27%	75%
Q9XWH0	Caenorhabditis elegans	24%	72%
Q9YGY3	Xenopus laevis	27%	75%
S8ASK6	Penicillium oxalicum (strain 114-2 / CGMCC 5302)	29%	71%
V5B5G8	Trypanosoma cruzi	53%	70%