DUF1279 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H356_LEIBR

TriTrypDb:

LbrM.01.0350 , LBRM2903_010008200

Length:

150

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H356

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H356

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.445
CLV_PCSK_KEX2_1	127	129	PF00082	0.455
CLV_PCSK_KEX2_1	17	19	PF00082	0.412
CLV_PCSK_KEX2_1	82	84	PF00082	0.509
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.383
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.509
CLV_PCSK_SKI1_1	10	14	PF00082	0.420
DEG_Nend_Nbox_1	1	3	PF02207	0.649
DOC_CDC14_PxL_1	120	128	PF14671	0.463
DOC_CKS1_1	110	115	PF01111	0.377
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.324
DOC_PP1_RVXF_1	8	15	PF00149	0.692
DOC_WW_Pin1_4	109	114	PF00397	0.377
LIG_14-3-3_CanoR_1	10	15	PF00244	0.620
LIG_14-3-3_CanoR_1	128	134	PF00244	0.586
LIG_14-3-3_CanoR_1	142	150	PF00244	0.565
LIG_14-3-3_CanoR_1	17	22	PF00244	0.648
LIG_14-3-3_CanoR_1	83	87	PF00244	0.334
LIG_14-3-3_CanoR_1	90	98	PF00244	0.322
LIG_Actin_WH2_2	113	129	PF00022	0.368
LIG_CSL_BTD_1	110	113	PF09270	0.377
LIG_FHA_1	21	27	PF00498	0.532
LIG_FHA_1	46	52	PF00498	0.311
LIG_GBD_Chelix_1	43	51	PF00786	0.377
LIG_LIR_Gen_1	105	114	PF02991	0.377
LIG_LIR_Gen_1	71	79	PF02991	0.391
LIG_LIR_Nem_3	105	110	PF02991	0.327
LIG_LIR_Nem_3	121	126	PF02991	0.526
LIG_LIR_Nem_3	71	76	PF02991	0.370
LIG_LYPXL_yS_3	123	126	PF13949	0.578
LIG_NRBOX	42	48	PF00104	0.348
LIG_PCNA_PIPBox_1	58	67	PF02747	0.394
LIG_PCNA_yPIPBox_3	58	72	PF02747	0.395
LIG_Pex14_2	107	111	PF04695	0.377
LIG_REV1ctd_RIR_1	84	94	PF16727	0.313
LIG_SH2_PTP2	73	76	PF00017	0.423
LIG_SH2_STAT3	55	58	PF00017	0.404
LIG_SH2_STAT5	125	128	PF00017	0.627
LIG_SH2_STAT5	36	39	PF00017	0.295
LIG_SH2_STAT5	49	52	PF00017	0.323
LIG_SH2_STAT5	55	58	PF00017	0.425
LIG_SH2_STAT5	73	76	PF00017	0.315
LIG_SH3_3	111	117	PF00018	0.464
LIG_SUMO_SIM_par_1	22	27	PF11976	0.492
LIG_UBA3_1	61	66	PF00899	0.381
MOD_CK1_1	109	115	PF00069	0.377
MOD_CK1_1	20	26	PF00069	0.657
MOD_CK2_1	135	141	PF00069	0.528
MOD_Cter_Amidation	80	83	PF01082	0.517
MOD_GlcNHglycan	93	96	PF01048	0.615
MOD_GSK3_1	102	109	PF00069	0.380
MOD_N-GLC_1	39	44	PF02516	0.318
MOD_N-GLC_1	99	104	PF02516	0.495
MOD_NEK2_1	1	6	PF00069	0.609
MOD_NEK2_1	106	111	PF00069	0.298
MOD_PIKK_1	127	133	PF00454	0.596
MOD_PKA_1	127	133	PF00069	0.575
MOD_PKA_1	17	23	PF00069	0.591
MOD_PKA_1	82	88	PF00069	0.316
MOD_PKA_2	127	133	PF00069	0.575
MOD_PKA_2	17	23	PF00069	0.605
MOD_PKA_2	82	88	PF00069	0.368
MOD_PKA_2	89	95	PF00069	0.364
MOD_Plk_1	39	45	PF00069	0.318
MOD_Plk_2-3	135	141	PF00069	0.528
MOD_Plk_2-3	75	81	PF00069	0.487
MOD_Plk_4	102	108	PF00069	0.381
MOD_Plk_4	39	45	PF00069	0.380
MOD_ProDKin_1	109	115	PF00069	0.377
TRG_ENDOCYTIC_2	123	126	PF00928	0.638
TRG_ENDOCYTIC_2	35	38	PF00928	0.303
TRG_ENDOCYTIC_2	53	56	PF00928	0.478
TRG_ENDOCYTIC_2	73	76	PF00928	0.391
TRG_ER_diArg_1	17	19	PF00400	0.605
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IR53	Bodo saltans	39%	78%
A0A451EJ88	Leishmania donovani	73%	100%
C9ZPP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	67%
E9AC21	Leishmania major	75%	100%
E9AG17	Leishmania infantum	73%	100%
E9AJB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
V5DDB3	Trypanosoma cruzi	33%	100%