Putative acidocalcisomal exopolyphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acidocalcisomal exopolyphosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H355_LEIBR

TriTrypDb:

LbrM.01.0340 , LBRM2903_010008100

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H355

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H355

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006797	polyphosphate metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004309	exopolyphosphatase activity	6	8
GO:0005488	binding	1	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.364
CLV_NRD_NRD_1	10	12	PF00675	0.382
CLV_NRD_NRD_1	244	246	PF00675	0.217
CLV_NRD_NRD_1	367	369	PF00675	0.236
CLV_PCSK_KEX2_1	10	12	PF00082	0.347
CLV_PCSK_KEX2_1	244	246	PF00082	0.217
CLV_PCSK_SKI1_1	11	15	PF00082	0.445
CLV_PCSK_SKI1_1	196	200	PF00082	0.392
CLV_PCSK_SKI1_1	77	81	PF00082	0.160
CLV_Separin_Metazoa	241	245	PF03568	0.426
DEG_APCC_DBOX_1	367	375	PF00400	0.426
DEG_APCC_DBOX_1	9	17	PF00400	0.376
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.271
DOC_MAPK_DCC_7	15	25	PF00069	0.394
DOC_MAPK_gen_1	229	237	PF00069	0.473
DOC_MAPK_gen_1	368	374	PF00069	0.426
DOC_MAPK_MEF2A_6	231	239	PF00069	0.448
DOC_PP1_RVXF_1	312	319	PF00149	0.448
DOC_PP2B_LxvP_1	180	183	PF13499	0.292
DOC_PP2B_LxvP_1	237	240	PF13499	0.473
DOC_PP4_FxxP_1	55	58	PF00568	0.468
DOC_USP7_MATH_1	350	354	PF00917	0.447
DOC_USP7_UBL2_3	15	19	PF12436	0.457
DOC_USP7_UBL2_3	253	257	PF12436	0.360
DOC_WW_Pin1_4	196	201	PF00397	0.429
LIG_Actin_WH2_2	141	156	PF00022	0.360
LIG_AP2alpha_1	97	101	PF02296	0.360
LIG_BIR_II_1	1	5	PF00653	0.372
LIG_FHA_1	179	185	PF00498	0.420
LIG_FHA_1	263	269	PF00498	0.511
LIG_FHA_1	322	328	PF00498	0.547
LIG_FHA_1	381	387	PF00498	0.557
LIG_FHA_2	197	203	PF00498	0.332
LIG_LIR_Gen_1	207	215	PF02991	0.456
LIG_LIR_Gen_1	326	336	PF02991	0.418
LIG_LIR_Gen_1	340	348	PF02991	0.346
LIG_LIR_Gen_1	99	109	PF02991	0.360
LIG_LIR_Nem_3	207	211	PF02991	0.378
LIG_LIR_Nem_3	222	227	PF02991	0.200
LIG_LIR_Nem_3	246	250	PF02991	0.417
LIG_LIR_Nem_3	326	331	PF02991	0.504
LIG_LIR_Nem_3	340	344	PF02991	0.393
LIG_LIR_Nem_3	353	359	PF02991	0.405
LIG_LIR_Nem_3	99	104	PF02991	0.360
LIG_PDZ_Class_1	382	387	PF00595	0.558
LIG_Pex14_2	97	101	PF04695	0.360
LIG_Rb_pABgroove_1	41	49	PF01858	0.468
LIG_SH2_STAT3	291	294	PF00017	0.545
LIG_SH2_STAT5	143	146	PF00017	0.448
LIG_SH2_STAT5	356	359	PF00017	0.392
LIG_SH2_STAT5	42	45	PF00017	0.419
LIG_SH3_3	171	177	PF00018	0.490
LIG_SUMO_SIM_par_1	181	188	PF11976	0.283
LIG_UBA3_1	223	231	PF00899	0.296
LIG_WRC_WIRS_1	301	306	PF05994	0.426
LIG_WRC_WIRS_1	328	333	PF05994	0.446
MOD_CK1_1	158	164	PF00069	0.425
MOD_CK1_1	262	268	PF00069	0.467
MOD_CK1_1	330	336	PF00069	0.472
MOD_CK1_1	337	343	PF00069	0.411
MOD_CK1_1	362	368	PF00069	0.451
MOD_CK2_1	235	241	PF00069	0.473
MOD_GlcNHglycan	1	4	PF01048	0.417
MOD_GlcNHglycan	157	160	PF01048	0.217
MOD_GlcNHglycan	304	307	PF01048	0.226
MOD_GlcNHglycan	308	311	PF01048	0.181
MOD_GlcNHglycan	336	339	PF01048	0.201
MOD_GSK3_1	121	128	PF00069	0.435
MOD_GSK3_1	211	218	PF00069	0.318
MOD_GSK3_1	259	266	PF00069	0.521
MOD_GSK3_1	302	309	PF00069	0.365
MOD_GSK3_1	323	330	PF00069	0.474
MOD_GSK3_1	342	349	PF00069	0.454
MOD_GSK3_1	350	357	PF00069	0.457
MOD_GSK3_1	84	91	PF00069	0.428
MOD_N-GLC_1	107	112	PF02516	0.268
MOD_N-GLC_1	121	126	PF02516	0.169
MOD_NEK2_1	107	112	PF00069	0.430
MOD_NEK2_1	235	240	PF00069	0.459
MOD_NEK2_1	300	305	PF00069	0.395
MOD_NEK2_1	339	344	PF00069	0.421
MOD_NEK2_1	88	93	PF00069	0.448
MOD_Plk_1	107	113	PF00069	0.515
MOD_Plk_1	354	360	PF00069	0.386
MOD_Plk_1	84	90	PF00069	0.511
MOD_Plk_4	107	113	PF00069	0.545
MOD_Plk_4	158	164	PF00069	0.425
MOD_Plk_4	175	181	PF00069	0.282
MOD_Plk_4	21	27	PF00069	0.351
MOD_Plk_4	219	225	PF00069	0.251
MOD_Plk_4	323	329	PF00069	0.360
MOD_Plk_4	33	39	PF00069	0.384
MOD_Plk_4	84	90	PF00069	0.453
MOD_ProDKin_1	196	202	PF00069	0.419
MOD_SUMO_rev_2	241	250	PF00179	0.460
TRG_ENDOCYTIC_2	206	209	PF00928	0.390
TRG_ENDOCYTIC_2	247	250	PF00928	0.417
TRG_ENDOCYTIC_2	42	45	PF00928	0.443
TRG_ER_diArg_1	243	245	PF00400	0.417
TRG_ER_diArg_1	9	11	PF00400	0.382
TRG_NES_CRM1_1	103	115	PF08389	0.473
TRG_NES_CRM1_1	274	287	PF08389	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I007	Leptomonas seymouri	56%	100%
A0A0S4IZ18	Bodo saltans	36%	100%
A0A1X0P2Z3	Trypanosomatidae	44%	100%
A0A3S5H4U4	Leishmania donovani	83%	100%
A0A422NY62	Trypanosoma rangeli	43%	100%
A4HRF2	Leishmania infantum	83%	100%
C9ZXE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AC20	Leishmania major	84%	100%
E9AJB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O14094	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
P38698	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	97%
Q5E9Y6	Bos taurus	26%	85%
Q6AYG3	Rattus norvegicus	28%	85%
Q86TP1	Homo sapiens	27%	85%
Q8BIW1	Mus musculus	28%	85%