Pseudouridylate synthase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pseudouridylate synthase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H352_LEIBR

TriTrypDb:

LbrM.01.0310 , LBRM2903_010007700

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H352

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H352

PDB structure(s): 7am2_BZ

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0009982	pseudouridine synthase activity	4	12
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.441
CLV_NRD_NRD_1	149	151	PF00675	0.674
CLV_NRD_NRD_1	2	4	PF00675	0.705
CLV_NRD_NRD_1	319	321	PF00675	0.255
CLV_NRD_NRD_1	34	36	PF00675	0.635
CLV_NRD_NRD_1	358	360	PF00675	0.478
CLV_NRD_NRD_1	368	370	PF00675	0.303
CLV_NRD_NRD_1	49	51	PF00675	0.527
CLV_NRD_NRD_1	7	9	PF00675	0.667
CLV_NRD_NRD_1	98	100	PF00675	0.487
CLV_PCSK_FUR_1	147	151	PF00082	0.454
CLV_PCSK_FUR_1	96	100	PF00082	0.471
CLV_PCSK_KEX2_1	102	104	PF00082	0.362
CLV_PCSK_KEX2_1	149	151	PF00082	0.674
CLV_PCSK_KEX2_1	2	4	PF00082	0.705
CLV_PCSK_KEX2_1	243	245	PF00082	0.255
CLV_PCSK_KEX2_1	319	321	PF00082	0.255
CLV_PCSK_KEX2_1	34	36	PF00082	0.634
CLV_PCSK_KEX2_1	398	400	PF00082	0.546
CLV_PCSK_KEX2_1	7	9	PF00082	0.667
CLV_PCSK_KEX2_1	86	88	PF00082	0.453
CLV_PCSK_KEX2_1	98	100	PF00082	0.448
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.386
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.255
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.546
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.464
CLV_PCSK_PC7_1	239	245	PF00082	0.255
CLV_PCSK_PC7_1	3	9	PF00082	0.597
CLV_PCSK_PC7_1	98	104	PF00082	0.357
CLV_PCSK_SKI1_1	395	399	PF00082	0.415
DEG_COP1_1	113	123	PF00400	0.441
DEG_Nend_UBRbox_1	1	4	PF02207	0.722
DOC_CYCLIN_yCln2_LP_2	199	205	PF00134	0.541
DOC_CYCLIN_yCln2_LP_2	400	406	PF00134	0.561
DOC_MAPK_gen_1	102	114	PF00069	0.416
DOC_MAPK_gen_1	32	42	PF00069	0.598
DOC_MAPK_gen_1	359	366	PF00069	0.492
DOC_MAPK_MEF2A_6	34	42	PF00069	0.613
DOC_MAPK_MEF2A_6	359	366	PF00069	0.497
DOC_MAPK_NFAT4_5	35	43	PF00069	0.627
DOC_PP1_RVXF_1	109	115	PF00149	0.408
DOC_PP1_RVXF_1	396	403	PF00149	0.407
DOC_PP2B_LxvP_1	130	133	PF13499	0.489
DOC_PP2B_LxvP_1	331	334	PF13499	0.488
DOC_PP4_FxxP_1	354	357	PF00568	0.384
DOC_USP7_MATH_1	121	125	PF00917	0.526
DOC_USP7_MATH_1	219	223	PF00917	0.395
LIG_14-3-3_CanoR_1	107	114	PF00244	0.408
LIG_14-3-3_CanoR_1	2	7	PF00244	0.492
LIG_14-3-3_CanoR_1	204	213	PF00244	0.560
LIG_APCC_ABBA_1	266	271	PF00400	0.455
LIG_APCC_ABBA_1	351	356	PF00400	0.399
LIG_APCC_ABBAyCdc20_2	265	271	PF00400	0.455
LIG_EVH1_2	259	263	PF00568	0.541
LIG_FHA_1	107	113	PF00498	0.406
LIG_FHA_1	195	201	PF00498	0.489
LIG_FHA_1	384	390	PF00498	0.367
LIG_G3BP_FGDF_1	305	310	PF02136	0.480
LIG_GBD_Chelix_1	192	200	PF00786	0.341
LIG_LIR_Apic_2	352	357	PF02991	0.401
LIG_LIR_Gen_1	113	121	PF02991	0.376
LIG_LIR_Gen_1	309	316	PF02991	0.451
LIG_LIR_Gen_1	54	65	PF02991	0.423
LIG_LIR_Gen_1	79	89	PF02991	0.401
LIG_LIR_LC3C_4	115	119	PF02991	0.370
LIG_LIR_Nem_3	113	117	PF02991	0.386
LIG_LIR_Nem_3	249	254	PF02991	0.465
LIG_LIR_Nem_3	306	310	PF02991	0.450
LIG_LIR_Nem_3	312	316	PF02991	0.451
LIG_LIR_Nem_3	394	400	PF02991	0.432
LIG_LIR_Nem_3	54	60	PF02991	0.415
LIG_LIR_Nem_3	79	85	PF02991	0.471
LIG_Pex14_1	10	14	PF04695	0.639
LIG_PTB_Apo_2	245	252	PF02174	0.455
LIG_PTB_Phospho_1	245	251	PF10480	0.455
LIG_SH2_CRK	105	109	PF00017	0.471
LIG_SH2_CRK	57	61	PF00017	0.518
LIG_SH2_GRB2like	205	208	PF00017	0.466
LIG_SH2_STAT5	105	108	PF00017	0.467
LIG_SH2_STAT5	205	208	PF00017	0.466
LIG_SH3_3	115	121	PF00018	0.401
LIG_SH3_3	181	187	PF00018	0.455
LIG_SH3_3	253	259	PF00018	0.455
LIG_SH3_3	279	285	PF00018	0.480
LIG_SH3_3	382	388	PF00018	0.376
LIG_SH3_3	406	412	PF00018	0.412
LIG_SH3_5	78	82	PF00018	0.520
LIG_SUMO_SIM_anti_2	115	122	PF11976	0.368
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.307
LIG_SUMO_SIM_par_1	115	122	PF11976	0.368
LIG_TRAF2_1	44	47	PF00917	0.558
LIG_TYR_ITIM	55	60	PF00017	0.415
LIG_UBA3_1	236	243	PF00899	0.307
LIG_Vh1_VBS_1	210	228	PF01044	0.202
LIG_WRC_WIRS_1	307	312	PF05994	0.302
MOD_CK1_1	140	146	PF00069	0.691
MOD_CK1_1	309	315	PF00069	0.323
MOD_CK1_1	49	55	PF00069	0.527
MOD_CK2_1	131	137	PF00069	0.533
MOD_CK2_1	16	22	PF00069	0.668
MOD_CK2_1	300	306	PF00069	0.323
MOD_Cter_Amidation	100	103	PF01082	0.469
MOD_GlcNHglycan	133	136	PF01048	0.496
MOD_GlcNHglycan	155	158	PF01048	0.516
MOD_GlcNHglycan	180	183	PF01048	0.392
MOD_GlcNHglycan	220	224	PF01048	0.323
MOD_GlcNHglycan	229	232	PF01048	0.305
MOD_GlcNHglycan	302	305	PF01048	0.323
MOD_GlcNHglycan	344	347	PF01048	0.394
MOD_GSK3_1	137	144	PF00069	0.638
MOD_N-GLC_1	194	199	PF02516	0.364
MOD_N-GLC_1	300	305	PF02516	0.323
MOD_NEK2_1	141	146	PF00069	0.618
MOD_NEK2_1	153	158	PF00069	0.316
MOD_NEK2_1	227	232	PF00069	0.307
MOD_NEK2_1	393	398	PF00069	0.380
MOD_PIKK_1	141	147	PF00454	0.680
MOD_PIKK_1	205	211	PF00454	0.454
MOD_PIKK_1	58	64	PF00454	0.419
MOD_PIKK_1	71	77	PF00454	0.407
MOD_PKA_1	103	109	PF00069	0.416
MOD_PKA_1	2	8	PF00069	0.464
MOD_PKA_2	103	109	PF00069	0.423
MOD_PKA_2	2	8	PF00069	0.464
MOD_PKA_2	203	209	PF00069	0.449
MOD_PKA_2	49	55	PF00069	0.549
MOD_Plk_1	300	306	PF00069	0.323
MOD_Plk_1	393	399	PF00069	0.404
MOD_Plk_4	10	16	PF00069	0.548
MOD_Plk_4	121	127	PF00069	0.474
MOD_Plk_4	246	252	PF00069	0.323
MOD_Plk_4	306	312	PF00069	0.302
MOD_Plk_4	349	355	PF00069	0.405
MOD_SUMO_for_1	169	172	PF00179	0.398
TRG_DiLeu_BaEn_1	113	118	PF01217	0.390
TRG_DiLeu_BaEn_2	305	311	PF01217	0.307
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.392
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.397
TRG_ENDOCYTIC_2	105	108	PF00928	0.467
TRG_ENDOCYTIC_2	251	254	PF00928	0.307
TRG_ENDOCYTIC_2	57	60	PF00928	0.516
TRG_ENDOCYTIC_2	82	85	PF00928	0.400
TRG_ER_diArg_1	1	3	PF00400	0.674
TRG_ER_diArg_1	103	105	PF00400	0.456
TRG_ER_diArg_1	265	268	PF00400	0.307
TRG_ER_diArg_1	6	8	PF00400	0.649
TRG_ER_diArg_1	97	99	PF00400	0.473
TRG_NLS_Bipartite_1	86	106	PF00514	0.450
TRG_NLS_MonoExtN_4	99	106	PF00514	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I599	Leptomonas seymouri	85%	100%
A0A0S4J1Y1	Bodo saltans	67%	100%
A0A1X0P2Q5	Trypanosomatidae	71%	100%
A0A3S5H4U1	Leishmania donovani	93%	100%
A0A422NY76	Trypanosoma rangeli	74%	100%
A4HRE9	Leishmania infantum	93%	100%
C9ZXE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AC17	Leishmania major	93%	100%
E9AJB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P0AA39	Escherichia coli (strain K12)	22%	100%
P0AA40	Shigella flexneri	22%	100%
P44433	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	23%	100%
P59835	Haemophilus ducreyi (strain 35000HP / ATCC 700724)	24%	100%
P74346	Synechocystis sp. (strain PCC 6803 / Kazusa)	24%	100%
Q28C59	Xenopus tropicalis	27%	100%
Q4QQT0	Rattus norvegicus	26%	100%
Q5E9Z1	Bos taurus	25%	100%
Q6DBR0	Danio rerio	27%	100%
Q87N15	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	22%	100%
Q89AH2	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	21%	100%
Q8D8G1	Vibrio vulnificus (strain CMCP6)	21%	100%
Q8FIP7	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	22%	100%
Q8X8J3	Escherichia coli O157:H7	22%	100%
Q8Z7J7	Salmonella typhi	22%	100%
Q8ZQ16	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	22%	100%
Q96CM3	Homo sapiens	25%	100%
Q9CM51	Pasteurella multocida (strain Pm70)	22%	100%
Q9CWX4	Mus musculus	26%	100%
Q9HZM9	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	21%	100%
Q9KQH0	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	22%	100%
Q9LT72	Arabidopsis thaliana	25%	87%
V5B9Z1	Trypanosoma cruzi	72%	100%