Thioredoxin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Thioredoxin

Gene product:

thioredoxin, putative

Species:

Leishmania braziliensis

UniProt:

A4H351_LEIBR

TriTrypDb:

LbrM.01.0300 , LBRM2903_010007600

Length:

107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H351

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H351

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0015035	protein-disulfide reductase activity	3	8
GO:0015036	disulfide oxidoreductase activity	4	8
GO:0016491	oxidoreductase activity	2	8
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	52	56	PF00082	0.327
DOC_USP7_UBL2_3	35	39	PF12436	0.396
LIG_14-3-3_CanoR_1	43	47	PF00244	0.473
LIG_FHA_1	18	24	PF00498	0.443
LIG_FHA_1	60	66	PF00498	0.387
LIG_FHA_1	73	79	PF00498	0.308
LIG_LIR_Apic_2	27	33	PF02991	0.308
LIG_LIR_Gen_1	45	56	PF02991	0.347
LIG_LIR_Gen_1	75	84	PF02991	0.327
LIG_LIR_Nem_3	10	15	PF02991	0.308
LIG_LIR_Nem_3	45	51	PF02991	0.312
LIG_LIR_Nem_3	75	79	PF02991	0.327
LIG_Pex14_2	26	30	PF04695	0.308
LIG_PTB_Apo_2	47	54	PF02174	0.415
LIG_SH2_SRC	87	90	PF00017	0.440
LIG_SH2_STAT5	87	90	PF00017	0.387
LIG_SUMO_SIM_anti_2	20	25	PF11976	0.389
LIG_WRC_WIRS_1	73	78	PF05994	0.308
MOD_GlcNHglycan	26	29	PF01048	0.387
MOD_GSK3_1	42	49	PF00069	0.319
MOD_GSK3_1	59	66	PF00069	0.357
MOD_N-GLC_1	59	64	PF02516	0.337
MOD_PKA_2	42	48	PF00069	0.399
MOD_Plk_2-3	42	48	PF00069	0.331
MOD_Plk_4	19	25	PF00069	0.388
MOD_Plk_4	72	78	PF00069	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL85	Leptomonas seymouri	34%	69%
A0A0N1PD08	Leptomonas seymouri	85%	100%
A0A0S4IQ93	Bodo saltans	27%	77%
A0A0S4ISI9	Bodo saltans	40%	70%
A0A0S4IZF8	Bodo saltans	67%	100%
A0A1X0P2Q9	Trypanosomatidae	65%	100%
A0A3Q8IGH5	Leishmania donovani	39%	69%
A0A3R7NZW1	Trypanosoma rangeli	63%	100%
A0A3S5H4U0	Leishmania donovani	94%	100%
A0A509AQW5	Plasmodium berghei (strain Anka)	33%	68%
A4HRE8	Leishmania infantum	94%	100%
C9K7C5	Alternaria alternata	36%	91%
C9ZXF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AC16	Leishmania major	93%	100%
E9AJB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O14463	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
O17486	Echinococcus granulosus	38%	100%
O22022	Cyanidioschyzon merolae (strain NIES-3377 / 10D)	38%	100%
O64394	Triticum aestivum	32%	84%
O64432	Brassica campestris	32%	87%
O65049	Picea mariana	31%	86%
O94504	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	80%
O96952	Geodia cydonium	40%	100%
O97508	Equus caballus	40%	100%
O97680	Bos taurus	42%	100%
P00275	Corynebacterium nephridii	39%	100%
P07887	Corynebacterium nephridii	30%	99%
P08628	Oryctolagus cuniculus	42%	100%
P08629	Gallus gallus	38%	100%
P0A0K4	Staphylococcus aureus (strain Mu50 / ATCC 700699)	36%	100%
P0A0K5	Staphylococcus aureus (strain MW2)	36%	100%
P0A0K6	Staphylococcus aureus	36%	100%
P0A4L1	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	29%	100%
P0A4L2	Nostoc sp. (strain ATCC 29151 / PCC 7119)	29%	100%
P0A617	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	38%	92%
P10472	Chlorobaculum thiosulfatiphilum	28%	99%
P10599	Homo sapiens	44%	100%
P10639	Mus musculus	42%	100%
P11232	Rattus norvegicus	42%	100%
P12243	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	31%	100%
P22217	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P22803	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P23400	Chlamydomonas reinhardtii	29%	76%
P25372	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	36%	84%
P29429	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	34%	97%
P29445	Dictyostelium discoideum	40%	100%
P29447	Dictyostelium discoideum	39%	100%
P29448	Arabidopsis thaliana	36%	94%
P29449	Nicotiana tabacum	34%	85%
P29451	Macaca mulatta	44%	100%
P33791	Kitasatospora aureofaciens	34%	100%
P34723	Penicillium chrysogenum	34%	100%
P37395	Cyanidium caldarium	38%	100%
P42115	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	84%
P47370	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	33%	100%
P47938	Drosophila melanogaster	33%	100%
P50254	Neopyropia yezoensis	32%	100%
P50338	Griffithsia pacifica	29%	98%
P50413	Ovis aries	41%	100%
P51225	Porphyra purpurea	30%	100%
P52230	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	32%	97%
P52231	Synechocystis sp. (strain PCC 6803 / Kazusa)	32%	100%
P52233	Acidithiobacillus ferridurans	37%	99%
P60226	Drosophila yakuba	33%	100%
P66928	Helicobacter pylori (strain ATCC 700392 / 26695)	31%	100%
P66929	Helicobacter pylori (strain J99 / ATCC 700824)	31%	100%
P68176	Brassica oleracea	32%	87%
P68177	Brassica napus	32%	87%
P75512	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	33%	100%
P80028	Chlamydomonas reinhardtii	33%	95%
P82460	Sus scrofa	42%	100%
P85801	Populus jackii	26%	77%
P99122	Staphylococcus aureus (strain N315)	36%	100%
P9WG66	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	38%	92%
P9WG67	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	38%	92%
Q07090	Nicotiana tabacum	34%	91%
Q09433	Caenorhabditis elegans	29%	93%
Q0DKF1	Oryza sativa subsp. japonica	24%	81%
Q1RQI9	Malassezia sympodialis	34%	100%
Q1RQJ0	Neosartorya fumigata	39%	97%
Q1RQJ1	Neosartorya fumigata	37%	99%
Q2FHT6	Staphylococcus aureus (strain USA300)	36%	100%
Q2FZD2	Staphylococcus aureus (strain NCTC 8325 / PS 47)	36%	100%
Q2YXD0	Staphylococcus aureus (strain bovine RF122 / ET3-1)	36%	100%
Q38879	Arabidopsis thaliana	38%	80%
Q39239	Arabidopsis thaliana	36%	90%
Q39241	Arabidopsis thaliana	27%	91%
Q39362	Brassica napus	36%	90%
Q42403	Arabidopsis thaliana	32%	91%
Q43636	Ricinus communis	37%	91%
Q4UNK3	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	31%	100%
Q5HGT9	Staphylococcus aureus (strain COL)	36%	100%
Q5HQ29	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	35%	100%
Q5R9M3	Pongo abelii	43%	100%
Q5UR29	Acanthamoeba polyphaga mimivirus	37%	78%
Q68Y00	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	34%	100%
Q69AB1	Rattus norvegicus	37%	84%
Q69AB2	Mus musculus	35%	84%
Q6GA69	Staphylococcus aureus (strain MSSA476)	36%	100%
Q6GHU0	Staphylococcus aureus (strain MRSA252)	36%	100%
Q6XHI1	Drosophila yakuba	34%	100%
Q6Z4I3	Oryza sativa subsp. japonica	40%	78%
Q75GM1	Oryza sativa subsp. japonica	27%	79%
Q7KQL8	Plasmodium falciparum (isolate 3D7)	33%	100%
Q7M1B9	Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)	33%	97%
Q851R5	Oryza sativa subsp. japonica	33%	80%
Q8CPL5	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	35%	100%
Q8GXV2	Arabidopsis thaliana	28%	69%
Q8IFW4	Drosophila melanogaster	37%	68%
Q8KE49	Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)	28%	98%
Q8LDI5	Arabidopsis thaliana	27%	91%
Q93VQ9	Arabidopsis thaliana	30%	67%
Q96419	Fagopyrum esculentum	33%	92%
Q98TX1	Ophiophagus hannah	33%	100%
Q9AS75	Oryza sativa subsp. japonica	23%	82%
Q9BDJ3	Callithrix jacchus	44%	100%
Q9C9Y6	Arabidopsis thaliana	30%	76%
Q9CAS1	Arabidopsis thaliana	32%	72%
Q9CM49	Pasteurella multocida (strain Pm70)	33%	100%
Q9DGI3	Ictalurus punctatus	36%	100%
Q9LXZ8	Arabidopsis thaliana	30%	69%
Q9UW02	Coprinus comatus	28%	100%
Q9V429	Drosophila melanogaster	37%	100%
Q9XIF4	Arabidopsis thaliana	34%	83%