Beta_helix domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Right handed beta helix region, putative

Species:

Leishmania braziliensis

UniProt:

A4H350_LEIBR

TriTrypDb:

LbrM.01.0290 , LBRM2903_010007400

Length:

832

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H350

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H350

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.388
CLV_C14_Caspase3-7	263	267	PF00656	0.503
CLV_C14_Caspase3-7	310	314	PF00656	0.585
CLV_C14_Caspase3-7	666	670	PF00656	0.448
CLV_NRD_NRD_1	17	19	PF00675	0.451
CLV_NRD_NRD_1	244	246	PF00675	0.419
CLV_NRD_NRD_1	280	282	PF00675	0.729
CLV_NRD_NRD_1	402	404	PF00675	0.718
CLV_NRD_NRD_1	464	466	PF00675	0.784
CLV_NRD_NRD_1	546	548	PF00675	0.573
CLV_PCSK_KEX2_1	17	19	PF00082	0.451
CLV_PCSK_KEX2_1	244	246	PF00082	0.419
CLV_PCSK_KEX2_1	280	282	PF00082	0.729
CLV_PCSK_KEX2_1	401	403	PF00082	0.710
CLV_PCSK_KEX2_1	464	466	PF00082	0.772
CLV_PCSK_KEX2_1	545	547	PF00082	0.606
CLV_PCSK_PC7_1	276	282	PF00082	0.629
CLV_PCSK_SKI1_1	17	21	PF00082	0.417
CLV_PCSK_SKI1_1	223	227	PF00082	0.470
CLV_PCSK_SKI1_1	244	248	PF00082	0.545
CLV_Separin_Metazoa	227	231	PF03568	0.592
CLV_Separin_Metazoa	306	310	PF03568	0.573
DEG_APCC_DBOX_1	3	11	PF00400	0.422
DEG_Kelch_Keap1_1	115	120	PF01344	0.534
DEG_Nend_UBRbox_2	1	3	PF02207	0.440
DEG_SPOP_SBC_1	103	107	PF00917	0.552
DEG_SPOP_SBC_1	350	354	PF00917	0.551
DEG_SPOP_SBC_1	443	447	PF00917	0.580
DEG_SPOP_SBC_1	457	461	PF00917	0.533
DOC_ANK_TNKS_1	308	315	PF00023	0.578
DOC_CDC14_PxL_1	656	664	PF14671	0.551
DOC_CKS1_1	187	192	PF01111	0.557
DOC_CKS1_1	375	380	PF01111	0.563
DOC_CKS1_1	470	475	PF01111	0.725
DOC_CYCLIN_RxL_1	242	253	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	96	102	PF00134	0.554
DOC_MAPK_gen_1	280	286	PF00069	0.733
DOC_MAPK_gen_1	618	626	PF00069	0.320
DOC_MAPK_gen_1	806	814	PF00069	0.375
DOC_MAPK_MEF2A_6	230	238	PF00069	0.594
DOC_MAPK_MEF2A_6	610	617	PF00069	0.350
DOC_MAPK_RevD_3	531	547	PF00069	0.526
DOC_PP1_RVXF_1	189	195	PF00149	0.627
DOC_PP2B_LxvP_1	534	537	PF13499	0.548
DOC_PP2B_LxvP_1	96	99	PF13499	0.564
DOC_USP7_MATH_1	114	118	PF00917	0.586
DOC_USP7_MATH_1	183	187	PF00917	0.524
DOC_USP7_MATH_1	307	311	PF00917	0.769
DOC_USP7_MATH_1	350	354	PF00917	0.751
DOC_USP7_MATH_1	376	380	PF00917	0.687
DOC_USP7_MATH_1	384	388	PF00917	0.627
DOC_USP7_MATH_1	395	399	PF00917	0.508
DOC_USP7_MATH_1	423	427	PF00917	0.670
DOC_USP7_MATH_1	443	447	PF00917	0.583
DOC_USP7_MATH_1	457	461	PF00917	0.533
DOC_USP7_MATH_1	51	55	PF00917	0.590
DOC_USP7_MATH_1	566	570	PF00917	0.512
DOC_USP7_MATH_1	646	650	PF00917	0.633
DOC_WW_Pin1_4	126	131	PF00397	0.671
DOC_WW_Pin1_4	181	186	PF00397	0.669
DOC_WW_Pin1_4	287	292	PF00397	0.594
DOC_WW_Pin1_4	363	368	PF00397	0.652
DOC_WW_Pin1_4	374	379	PF00397	0.588
DOC_WW_Pin1_4	418	423	PF00397	0.732
DOC_WW_Pin1_4	426	431	PF00397	0.715
DOC_WW_Pin1_4	444	449	PF00397	0.725
DOC_WW_Pin1_4	453	458	PF00397	0.623
DOC_WW_Pin1_4	466	471	PF00397	0.600
DOC_WW_Pin1_4	474	479	PF00397	0.634
DOC_WW_Pin1_4	502	507	PF00397	0.692
DOC_WW_Pin1_4	510	515	PF00397	0.685
DOC_WW_Pin1_4	521	526	PF00397	0.649
DOC_WW_Pin1_4	538	543	PF00397	0.516
DOC_WW_Pin1_4	549	554	PF00397	0.390
LIG_14-3-3_CanoR_1	17	26	PF00244	0.381
LIG_14-3-3_CanoR_1	230	238	PF00244	0.569
LIG_14-3-3_CanoR_1	280	287	PF00244	0.600
LIG_14-3-3_CanoR_1	349	358	PF00244	0.636
LIG_14-3-3_CanoR_1	401	410	PF00244	0.701
LIG_14-3-3_CanoR_1	424	432	PF00244	0.718
LIG_14-3-3_CanoR_1	451	456	PF00244	0.728
LIG_14-3-3_CanoR_1	46	55	PF00244	0.665
LIG_14-3-3_CanoR_1	546	552	PF00244	0.545
LIG_14-3-3_CanoR_1	618	626	PF00244	0.370
LIG_14-3-3_CanoR_1	69	73	PF00244	0.816
LIG_14-3-3_CanoR_1	806	814	PF00244	0.279
LIG_BRCT_BRCA1_1	652	656	PF00533	0.580
LIG_CSL_BTD_1	550	553	PF09270	0.525
LIG_FHA_1	187	193	PF00498	0.709
LIG_FHA_1	224	230	PF00498	0.492
LIG_FHA_1	346	352	PF00498	0.566
LIG_FHA_1	450	456	PF00498	0.770
LIG_FHA_1	640	646	PF00498	0.493
LIG_FHA_1	696	702	PF00498	0.399
LIG_FHA_1	71	77	PF00498	0.580
LIG_FHA_1	751	757	PF00498	0.375
LIG_FHA_1	793	799	PF00498	0.399
LIG_FHA_1	809	815	PF00498	0.239
LIG_FHA_2	18	24	PF00498	0.404
LIG_FHA_2	261	267	PF00498	0.647
LIG_FHA_2	280	286	PF00498	0.542
LIG_FHA_2	497	503	PF00498	0.554
LIG_FHA_2	745	751	PF00498	0.399
LIG_LIR_Apic_2	270	275	PF02991	0.546
LIG_LIR_Gen_1	232	243	PF02991	0.529
LIG_LIR_Nem_3	232	238	PF02991	0.538
LIG_LIR_Nem_3	251	257	PF02991	0.391
LIG_LIR_Nem_3	708	712	PF02991	0.249
LIG_LYPXL_SIV_4	597	605	PF13949	0.517
LIG_MYND_1	538	542	PF01753	0.592
LIG_NRBOX	224	230	PF00104	0.604
LIG_PCNA_yPIPBox_3	222	230	PF02747	0.498
LIG_PCNA_yPIPBox_3	616	630	PF02747	0.322
LIG_Pex14_2	235	239	PF04695	0.552
LIG_SH2_STAP1	581	585	PF00017	0.471
LIG_SH2_STAT3	802	805	PF00017	0.249
LIG_SH2_STAT5	44	47	PF00017	0.442
LIG_SH2_STAT5	713	716	PF00017	0.399
LIG_SH2_STAT5	742	745	PF00017	0.399
LIG_SH2_STAT5	818	821	PF00017	0.399
LIG_SH3_2	475	480	PF14604	0.564
LIG_SH3_3	281	287	PF00018	0.720
LIG_SH3_3	309	315	PF00018	0.613
LIG_SH3_3	362	368	PF00018	0.739
LIG_SH3_3	372	378	PF00018	0.579
LIG_SH3_3	427	433	PF00018	0.672
LIG_SH3_3	467	473	PF00018	0.735
LIG_SH3_3	503	509	PF00018	0.646
LIG_SH3_3	515	521	PF00018	0.680
LIG_SH3_3	571	577	PF00018	0.451
LIG_SH3_3	601	607	PF00018	0.577
LIG_SH3_3	657	663	PF00018	0.552
LIG_SH3_3	77	83	PF00018	0.555
LIG_SH3_3	96	102	PF00018	0.531
LIG_SUMO_SIM_par_1	663	669	PF11976	0.448
LIG_SUMO_SIM_par_1	702	708	PF11976	0.249
LIG_TRAF2_1	250	253	PF00917	0.559
LIG_TRAF2_1	747	750	PF00917	0.399
LIG_TRAF2_1	785	788	PF00917	0.399
LIG_TYR_ITIM	579	584	PF00017	0.467
LIG_WRC_WIRS_1	123	128	PF05994	0.538
LIG_WRC_WIRS_1	706	711	PF05994	0.249
LIG_WW_2	430	433	PF00397	0.541
LIG_WW_3	273	277	PF00397	0.551
LIG_WW_3	421	425	PF00397	0.678
LIG_WW_3	477	481	PF00397	0.574
LIG_WW_3	517	521	PF00397	0.723
MOD_CDC14_SPxK_1	421	424	PF00782	0.684
MOD_CDC14_SPxK_1	477	480	PF00782	0.568
MOD_CDK_SPK_2	186	191	PF00069	0.662
MOD_CDK_SPK_2	466	471	PF00069	0.672
MOD_CDK_SPxK_1	418	424	PF00069	0.692
MOD_CDK_SPxK_1	474	480	PF00069	0.568
MOD_CDK_SPxK_1	514	520	PF00069	0.726
MOD_CDK_SPxxK_3	181	188	PF00069	0.674
MOD_CDK_SPxxK_3	444	451	PF00069	0.727
MOD_CDK_SPxxK_3	538	545	PF00069	0.651
MOD_CK1_1	181	187	PF00069	0.653
MOD_CK1_1	216	222	PF00069	0.567
MOD_CK1_1	260	266	PF00069	0.491
MOD_CK1_1	330	336	PF00069	0.570
MOD_CK1_1	414	420	PF00069	0.606
MOD_CK1_1	426	432	PF00069	0.756
MOD_CK1_1	446	452	PF00069	0.649
MOD_CK1_1	456	462	PF00069	0.705
MOD_CK1_1	463	469	PF00069	0.652
MOD_CK1_1	474	480	PF00069	0.549
MOD_CK1_1	488	494	PF00069	0.558
MOD_CK1_1	50	56	PF00069	0.680
MOD_CK1_1	524	530	PF00069	0.600
MOD_CK1_1	654	660	PF00069	0.611
MOD_CK1_1	68	74	PF00069	0.650
MOD_CK1_1	705	711	PF00069	0.249
MOD_CK1_1	744	750	PF00069	0.249
MOD_CK1_1	807	813	PF00069	0.249
MOD_CK2_1	114	120	PF00069	0.590
MOD_CK2_1	218	224	PF00069	0.557
MOD_CK2_1	279	285	PF00069	0.586
MOD_CK2_1	363	369	PF00069	0.645
MOD_CK2_1	619	625	PF00069	0.471
MOD_CK2_1	743	749	PF00069	0.399
MOD_CK2_1	782	788	PF00069	0.332
MOD_CK2_1	791	797	PF00069	0.377
MOD_GlcNHglycan	133	136	PF01048	0.699
MOD_GlcNHglycan	178	181	PF01048	0.657
MOD_GlcNHglycan	259	262	PF01048	0.575
MOD_GlcNHglycan	309	312	PF01048	0.690
MOD_GlcNHglycan	378	381	PF01048	0.693
MOD_GlcNHglycan	418	421	PF01048	0.770
MOD_GlcNHglycan	465	468	PF01048	0.839
MOD_GlcNHglycan	487	490	PF01048	0.722
MOD_GlcNHglycan	49	52	PF01048	0.562
MOD_GlcNHglycan	568	571	PF01048	0.488
MOD_GlcNHglycan	58	61	PF01048	0.701
MOD_GlcNHglycan	595	598	PF01048	0.571
MOD_GlcNHglycan	648	651	PF01048	0.603
MOD_GlcNHglycan	784	787	PF01048	0.249
MOD_GlcNHglycan	96	99	PF01048	0.657
MOD_GSK3_1	122	129	PF00069	0.659
MOD_GSK3_1	140	147	PF00069	0.583
MOD_GSK3_1	195	202	PF00069	0.620
MOD_GSK3_1	213	220	PF00069	0.499
MOD_GSK3_1	294	301	PF00069	0.605
MOD_GSK3_1	345	352	PF00069	0.712
MOD_GSK3_1	393	400	PF00069	0.588
MOD_GSK3_1	411	418	PF00069	0.678
MOD_GSK3_1	442	449	PF00069	0.747
MOD_GSK3_1	453	460	PF00069	0.604
MOD_GSK3_1	47	54	PF00069	0.667
MOD_GSK3_1	484	491	PF00069	0.700
MOD_GSK3_1	510	517	PF00069	0.758
MOD_GSK3_1	547	554	PF00069	0.590
MOD_GSK3_1	646	653	PF00069	0.648
MOD_GSK3_1	737	744	PF00069	0.249
MOD_GSK3_1	804	811	PF00069	0.249
MOD_N-GLC_1	750	755	PF02516	0.375
MOD_NEK2_1	10	15	PF00069	0.541
MOD_NEK2_1	178	183	PF00069	0.598
MOD_NEK2_1	229	234	PF00069	0.645
MOD_NEK2_1	257	262	PF00069	0.470
MOD_NEK2_1	351	356	PF00069	0.560
MOD_NEK2_1	415	420	PF00069	0.658
MOD_NEK2_1	458	463	PF00069	0.582
MOD_NEK2_1	652	657	PF00069	0.496
MOD_NEK2_1	673	678	PF00069	0.444
MOD_NEK2_1	737	742	PF00069	0.399
MOD_NEK2_1	766	771	PF00069	0.399
MOD_NEK2_2	493	498	PF00069	0.688
MOD_PIKK_1	193	199	PF00454	0.660
MOD_PIKK_1	237	243	PF00454	0.667
MOD_PIKK_1	552	558	PF00454	0.552
MOD_PIKK_1	619	625	PF00454	0.321
MOD_PIKK_1	639	645	PF00454	0.493
MOD_PK_1	199	205	PF00069	0.555
MOD_PKA_1	17	23	PF00069	0.385
MOD_PKA_1	401	407	PF00069	0.701
MOD_PKA_2	115	121	PF00069	0.562
MOD_PKA_2	17	23	PF00069	0.385
MOD_PKA_2	213	219	PF00069	0.574
MOD_PKA_2	229	235	PF00069	0.531
MOD_PKA_2	279	285	PF00069	0.578
MOD_PKA_2	298	304	PF00069	0.581
MOD_PKA_2	401	407	PF00069	0.709
MOD_PKA_2	423	429	PF00069	0.727
MOD_PKA_2	450	456	PF00069	0.729
MOD_PKA_2	463	469	PF00069	0.602
MOD_PKA_2	605	611	PF00069	0.554
MOD_PKA_2	68	74	PF00069	0.817
MOD_PKA_2	722	728	PF00069	0.399
MOD_PKA_2	807	813	PF00069	0.399
MOD_PKB_1	191	199	PF00069	0.558
MOD_PKB_1	545	553	PF00069	0.533
MOD_PKB_1	806	814	PF00069	0.375
MOD_Plk_1	199	205	PF00069	0.706
MOD_Plk_1	51	57	PF00069	0.682
MOD_Plk_1	737	743	PF00069	0.347
MOD_Plk_1	744	750	PF00069	0.382
MOD_Plk_4	122	128	PF00069	0.537
MOD_Plk_4	199	205	PF00069	0.586
MOD_Plk_4	268	274	PF00069	0.545
MOD_Plk_4	411	417	PF00069	0.557
MOD_Plk_4	737	743	PF00069	0.399
MOD_Plk_4	767	773	PF00069	0.399
MOD_Plk_4	814	820	PF00069	0.399
MOD_ProDKin_1	126	132	PF00069	0.673
MOD_ProDKin_1	181	187	PF00069	0.672
MOD_ProDKin_1	287	293	PF00069	0.596
MOD_ProDKin_1	363	369	PF00069	0.655
MOD_ProDKin_1	374	380	PF00069	0.590
MOD_ProDKin_1	418	424	PF00069	0.734
MOD_ProDKin_1	426	432	PF00069	0.716
MOD_ProDKin_1	444	450	PF00069	0.726
MOD_ProDKin_1	453	459	PF00069	0.623
MOD_ProDKin_1	466	472	PF00069	0.598
MOD_ProDKin_1	474	480	PF00069	0.638
MOD_ProDKin_1	502	508	PF00069	0.694
MOD_ProDKin_1	510	516	PF00069	0.685
MOD_ProDKin_1	521	527	PF00069	0.649
MOD_ProDKin_1	538	544	PF00069	0.513
MOD_ProDKin_1	549	555	PF00069	0.399
MOD_SUMO_rev_2	622	629	PF00179	0.457
MOD_SUMO_rev_2	635	642	PF00179	0.494
MOD_SUMO_rev_2	744	753	PF00179	0.368
TRG_DiLeu_BaEn_1	155	160	PF01217	0.589
TRG_DiLeu_BaEn_1	224	229	PF01217	0.602
TRG_DiLeu_BaEn_1	767	772	PF01217	0.249
TRG_DiLeu_BaEn_4	252	258	PF01217	0.555
TRG_DiLeu_BaEn_4	5	11	PF01217	0.421
TRG_DiLeu_BaLyEn_6	660	665	PF01217	0.491
TRG_DiLeu_LyEn_5	155	160	PF01217	0.439
TRG_ENDOCYTIC_2	581	584	PF00928	0.467
TRG_ER_diArg_1	16	18	PF00400	0.459
TRG_ER_diArg_1	190	193	PF00400	0.613
TRG_ER_diArg_1	244	246	PF00400	0.419
TRG_ER_diArg_1	401	403	PF00400	0.568
TRG_ER_diArg_1	545	547	PF00400	0.606
TRG_ER_diArg_1	615	618	PF00400	0.477
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.711

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A451EJ81	Leishmania donovani	66%	100%
A4HRE6	Leishmania infantum	67%	90%
E9AC14	Leishmania major	65%	97%
E9AJB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%