Putative DNA excision/repair protein SNF2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA excision/repair protein SNF2, putative

Species:

Leishmania braziliensis

UniProt:

A4H349_LEIBR

TriTrypDb:

LbrM.01.0280 , LBRM2903_010007300

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H349

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H349

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0008094	ATP-dependent activity, acting on DNA	2	10
GO:0016491	oxidoreductase activity	2	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0051213	dioxygenase activity	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140097	catalytic activity, acting on DNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0140657	ATP-dependent activity	1	10
GO:0140658	ATP-dependent chromatin remodeler activity	3	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10
GO:0015616	DNA translocase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.456
CLV_C14_Caspase3-7	411	415	PF00656	0.474
CLV_C14_Caspase3-7	586	590	PF00656	0.374
CLV_C14_Caspase3-7	596	600	PF00656	0.585
CLV_NRD_NRD_1	233	235	PF00675	0.233
CLV_NRD_NRD_1	246	248	PF00675	0.223
CLV_NRD_NRD_1	383	385	PF00675	0.217
CLV_NRD_NRD_1	421	423	PF00675	0.274
CLV_NRD_NRD_1	659	661	PF00675	0.650
CLV_NRD_NRD_1	99	101	PF00675	0.258
CLV_PCSK_FUR_1	391	395	PF00082	0.216
CLV_PCSK_FUR_1	92	96	PF00082	0.275
CLV_PCSK_KEX2_1	233	235	PF00082	0.223
CLV_PCSK_KEX2_1	383	385	PF00082	0.237
CLV_PCSK_KEX2_1	393	395	PF00082	0.186
CLV_PCSK_KEX2_1	421	423	PF00082	0.274
CLV_PCSK_KEX2_1	507	509	PF00082	0.529
CLV_PCSK_KEX2_1	659	661	PF00082	0.665
CLV_PCSK_KEX2_1	94	96	PF00082	0.224
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.162
CLV_PCSK_PC1ET2_1	507	509	PF00082	0.529
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.224
CLV_PCSK_SKI1_1	159	163	PF00082	0.317
CLV_PCSK_SKI1_1	228	232	PF00082	0.166
CLV_PCSK_SKI1_1	393	397	PF00082	0.223
CLV_PCSK_SKI1_1	489	493	PF00082	0.291
CLV_PCSK_SKI1_1	537	541	PF00082	0.444
CLV_PCSK_SKI1_1	545	549	PF00082	0.357
CLV_PCSK_SKI1_1	685	689	PF00082	0.501
CLV_PCSK_SKI1_1	723	727	PF00082	0.488
DEG_APCC_DBOX_1	102	110	PF00400	0.474
DEG_APCC_DBOX_1	540	548	PF00400	0.388
DEG_APCC_DBOX_1	574	582	PF00400	0.383
DEG_SCF_FBW7_1	610	617	PF00400	0.514
DOC_CYCLIN_RxL_1	382	392	PF00134	0.436
DOC_MAPK_DCC_7	101	111	PF00069	0.506
DOC_MAPK_gen_1	247	255	PF00069	0.426
DOC_MAPK_gen_1	383	389	PF00069	0.425
DOC_MAPK_gen_1	391	401	PF00069	0.425
DOC_MAPK_MEF2A_6	103	111	PF00069	0.465
DOC_MAPK_MEF2A_6	247	255	PF00069	0.424
DOC_MAPK_MEF2A_6	36	44	PF00069	0.419
DOC_MAPK_MEF2A_6	368	377	PF00069	0.287
DOC_MAPK_RevD_3	369	384	PF00069	0.222
DOC_PP1_RVXF_1	383	390	PF00149	0.423
DOC_PP2B_LxvP_1	58	61	PF13499	0.506
DOC_PP2B_LxvP_1	718	721	PF13499	0.500
DOC_USP7_MATH_1	122	126	PF00917	0.500
DOC_USP7_MATH_1	143	147	PF00917	0.463
DOC_USP7_MATH_1	214	218	PF00917	0.453
DOC_USP7_MATH_1	315	319	PF00917	0.429
DOC_USP7_MATH_1	511	515	PF00917	0.496
DOC_USP7_MATH_1	721	725	PF00917	0.675
DOC_WW_Pin1_4	162	167	PF00397	0.423
DOC_WW_Pin1_4	414	419	PF00397	0.558
DOC_WW_Pin1_4	610	615	PF00397	0.667
DOC_WW_Pin1_4	625	630	PF00397	0.630
DOC_WW_Pin1_4	711	716	PF00397	0.668
LIG_14-3-3_CanoR_1	213	223	PF00244	0.366
LIG_14-3-3_CanoR_1	228	233	PF00244	0.381
LIG_14-3-3_CanoR_1	256	264	PF00244	0.527
LIG_14-3-3_CanoR_1	378	387	PF00244	0.454
LIG_14-3-3_CanoR_1	407	413	PF00244	0.498
LIG_14-3-3_CanoR_1	489	496	PF00244	0.292
LIG_14-3-3_CanoR_1	569	578	PF00244	0.409
LIG_14-3-3_CanoR_1	723	728	PF00244	0.574
LIG_BIR_III_4	650	654	PF00653	0.508
LIG_BRCT_BRCA1_1	712	716	PF00533	0.503
LIG_deltaCOP1_diTrp_1	172	180	PF00928	0.423
LIG_FHA_1	111	117	PF00498	0.445
LIG_FHA_1	317	323	PF00498	0.506
LIG_FHA_1	324	330	PF00498	0.506
LIG_FHA_1	35	41	PF00498	0.423
LIG_FHA_1	439	445	PF00498	0.438
LIG_FHA_1	53	59	PF00498	0.423
LIG_FHA_1	593	599	PF00498	0.612
LIG_FHA_2	125	131	PF00498	0.474
LIG_FHA_2	288	294	PF00498	0.474
LIG_FHA_2	409	415	PF00498	0.496
LIG_FHA_2	493	499	PF00498	0.295
LIG_IBAR_NPY_1	351	353	PF08397	0.452
LIG_LIR_Gen_1	130	139	PF02991	0.423
LIG_LIR_Gen_1	172	181	PF02991	0.420
LIG_LIR_Gen_1	283	291	PF02991	0.358
LIG_LIR_LC3C_4	55	60	PF02991	0.474
LIG_LIR_Nem_3	112	117	PF02991	0.415
LIG_LIR_Nem_3	130	134	PF02991	0.523
LIG_LIR_Nem_3	172	178	PF02991	0.448
LIG_LIR_Nem_3	283	289	PF02991	0.358
LIG_LIR_Nem_3	534	539	PF02991	0.467
LIG_LIR_Nem_3	97	102	PF02991	0.455
LIG_MYND_2	61	65	PF01753	0.366
LIG_NRBOX	324	330	PF00104	0.366
LIG_NRBOX	394	400	PF00104	0.432
LIG_PCNA_PIPBox_1	174	183	PF02747	0.506
LIG_PCNA_yPIPBox_3	478	491	PF02747	0.415
LIG_Pex14_1	68	72	PF04695	0.474
LIG_Pex14_2	171	175	PF04695	0.453
LIG_PTB_Apo_2	500	507	PF02174	0.356
LIG_SH2_CRK	104	108	PF00017	0.451
LIG_SH2_CRK	114	118	PF00017	0.408
LIG_SH2_PTP2	131	134	PF00017	0.506
LIG_SH2_STAP1	265	269	PF00017	0.506
LIG_SH2_STAP1	48	52	PF00017	0.474
LIG_SH2_STAT3	48	51	PF00017	0.506
LIG_SH2_STAT3	501	504	PF00017	0.348
LIG_SH2_STAT3	6	9	PF00017	0.351
LIG_SH2_STAT5	131	134	PF00017	0.444
LIG_SH2_STAT5	538	541	PF00017	0.439
LIG_SH3_3	523	529	PF00018	0.715
LIG_SH3_3	56	62	PF00018	0.506
LIG_SUMO_SIM_anti_2	455	461	PF11976	0.424
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.425
LIG_SUMO_SIM_anti_2	560	566	PF11976	0.548
LIG_SUMO_SIM_par_1	184	189	PF11976	0.366
LIG_SUMO_SIM_par_1	318	326	PF11976	0.427
LIG_SUMO_SIM_par_1	455	461	PF11976	0.467
LIG_SUMO_SIM_par_1	716	722	PF11976	0.488
LIG_TRAF2_1	495	498	PF00917	0.292
LIG_TYR_ITIM	129	134	PF00017	0.375
LIG_WRC_WIRS_1	398	403	PF05994	0.331
MOD_CDK_SPxxK_3	414	421	PF00069	0.331
MOD_CK1_1	150	156	PF00069	0.406
MOD_CK1_1	316	322	PF00069	0.218
MOD_CK1_1	452	458	PF00069	0.179
MOD_CK1_1	615	621	PF00069	0.531
MOD_CK1_1	632	638	PF00069	0.628
MOD_CK1_1	66	72	PF00069	0.249
MOD_CK1_1	692	698	PF00069	0.503
MOD_CK2_1	243	249	PF00069	0.331
MOD_CK2_1	287	293	PF00069	0.218
MOD_CK2_1	414	420	PF00069	0.328
MOD_CK2_1	492	498	PF00069	0.292
MOD_CK2_1	516	522	PF00069	0.570
MOD_CK2_1	554	560	PF00069	0.461
MOD_GlcNHglycan	124	127	PF01048	0.214
MOD_GlcNHglycan	149	152	PF01048	0.288
MOD_GlcNHglycan	196	199	PF01048	0.331
MOD_GlcNHglycan	207	211	PF01048	0.222
MOD_GlcNHglycan	275	278	PF01048	0.383
MOD_GlcNHglycan	304	307	PF01048	0.346
MOD_GlcNHglycan	308	311	PF01048	0.329
MOD_GlcNHglycan	315	318	PF01048	0.288
MOD_GlcNHglycan	451	454	PF01048	0.263
MOD_GlcNHglycan	466	469	PF01048	0.252
MOD_GlcNHglycan	518	521	PF01048	0.647
MOD_GlcNHglycan	614	617	PF01048	0.670
MOD_GlcNHglycan	699	702	PF01048	0.685
MOD_GlcNHglycan	722	726	PF01048	0.652
MOD_GSK3_1	143	150	PF00069	0.263
MOD_GSK3_1	192	199	PF00069	0.232
MOD_GSK3_1	302	309	PF00069	0.186
MOD_GSK3_1	311	318	PF00069	0.343
MOD_GSK3_1	383	390	PF00069	0.321
MOD_GSK3_1	460	467	PF00069	0.274
MOD_GSK3_1	511	518	PF00069	0.422
MOD_GSK3_1	608	615	PF00069	0.649
MOD_GSK3_1	623	630	PF00069	0.596
MOD_GSK3_1	705	712	PF00069	0.622
MOD_N-GLC_1	608	613	PF02516	0.510
MOD_N-GLC_2	590	592	PF02516	0.388
MOD_NEK2_1	110	115	PF00069	0.276
MOD_NEK2_1	124	129	PF00069	0.364
MOD_NEK2_1	181	186	PF00069	0.329
MOD_NEK2_1	323	328	PF00069	0.289
MOD_NEK2_1	34	39	PF00069	0.259
MOD_NEK2_1	387	392	PF00069	0.267
MOD_NEK2_1	408	413	PF00069	0.331
MOD_NEK2_1	439	444	PF00069	0.283
MOD_NEK2_1	449	454	PF00069	0.319
MOD_NEK2_1	512	517	PF00069	0.386
MOD_NEK2_1	52	57	PF00069	0.259
MOD_NEK2_1	705	710	PF00069	0.646
MOD_NEK2_2	143	148	PF00069	0.179
MOD_PIKK_1	408	414	PF00454	0.331
MOD_PIKK_1	439	445	PF00454	0.259
MOD_PIKK_1	569	575	PF00454	0.322
MOD_PIKK_1	629	635	PF00454	0.728
MOD_PIKK_1	689	695	PF00454	0.528
MOD_PIKK_1	705	711	PF00454	0.623
MOD_PKA_1	383	389	PF00069	0.179
MOD_PKA_1	94	100	PF00069	0.179
MOD_PKA_2	255	261	PF00069	0.375
MOD_PKA_2	383	389	PF00069	0.301
MOD_PKA_2	406	412	PF00069	0.449
MOD_PKA_2	94	100	PF00069	0.179
MOD_Plk_1	608	614	PF00069	0.509
MOD_Plk_1	664	670	PF00069	0.615
MOD_Plk_4	124	130	PF00069	0.331
MOD_Plk_4	143	149	PF00069	0.143
MOD_Plk_4	181	187	PF00069	0.259
MOD_Plk_4	196	202	PF00069	0.259
MOD_Plk_4	323	329	PF00069	0.295
MOD_Plk_4	335	341	PF00069	0.428
MOD_Plk_4	383	389	PF00069	0.278
MOD_Plk_4	397	403	PF00069	0.304
MOD_Plk_4	53	59	PF00069	0.323
MOD_Plk_4	60	66	PF00069	0.249
MOD_Plk_4	723	729	PF00069	0.565
MOD_Plk_4	76	82	PF00069	0.259
MOD_ProDKin_1	162	168	PF00069	0.259
MOD_ProDKin_1	414	420	PF00069	0.448
MOD_ProDKin_1	610	616	PF00069	0.665
MOD_ProDKin_1	625	631	PF00069	0.629
MOD_ProDKin_1	711	717	PF00069	0.666
TRG_DiLeu_BaEn_1	560	565	PF01217	0.451
TRG_DiLeu_BaLyEn_6	318	323	PF01217	0.375
TRG_DiLeu_BaLyEn_6	391	396	PF01217	0.208
TRG_ENDOCYTIC_2	114	117	PF00928	0.267
TRG_ENDOCYTIC_2	131	134	PF00928	0.395
TRG_ENDOCYTIC_2	265	268	PF00928	0.283
TRG_ENDOCYTIC_2	536	539	PF00928	0.456
TRG_ER_diArg_1	232	234	PF00400	0.259
TRG_ER_diArg_1	644	647	PF00400	0.708
TRG_ER_diArg_1	659	662	PF00400	0.498
TRG_NLS_MonoExtN_4	98	104	PF00514	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A7	Leptomonas seymouri	23%	66%
A0A0N0P8H3	Leptomonas seymouri	27%	66%
A0A0N1HYE0	Leptomonas seymouri	66%	75%
A0A0P0WGX7	Oryza sativa subsp. japonica	30%	74%
A0A0S4JCY2	Bodo saltans	23%	100%
A0A0S4JHP8	Bodo saltans	24%	81%
A0A1X0NIN9	Trypanosomatidae	25%	70%
A0A1X0NNS9	Trypanosomatidae	21%	67%
A0A1X0NY53	Trypanosomatidae	29%	75%
A0A1X0P3S9	Trypanosomatidae	50%	100%
A0A3Q8IGW7	Leishmania donovani	27%	66%
A0A3R7M571	Trypanosoma rangeli	24%	100%
A0A3R7MS90	Trypanosoma rangeli	50%	100%
A0A3R7MWL4	Trypanosoma rangeli	23%	77%
A0A422MV13	Trypanosoma rangeli	27%	71%
A0A422P4R6	Trypanosoma rangeli	29%	79%
A0A451EJ80	Leishmania donovani	79%	79%
A4HDB9	Leishmania braziliensis	22%	67%
A4HLN1	Leishmania braziliensis	27%	66%
A4HRE5	Leishmania infantum	79%	94%
A4I966	Leishmania infantum	27%	66%
A4PBL4	Oryza sativa subsp. japonica	29%	75%
A6ZL17	Saccharomyces cerevisiae (strain YJM789)	25%	79%
A7ZI07	Escherichia coli O139:H28 (strain E24377A / ETEC)	26%	68%
B0R061	Danio rerio	24%	75%
B3LN76	Saccharomyces cerevisiae (strain RM11-1a)	25%	79%
B3MMA5	Drosophila ananassae	27%	92%
B3NAN8	Drosophila erecta	26%	93%
B4GS98	Drosophila persimilis	27%	93%
B4JCS7	Drosophila grimshawi	26%	93%
B4KHL5	Drosophila mojavensis	27%	93%
B4M9A8	Drosophila virilis	26%	93%
B4MX21	Drosophila willistoni	27%	93%
B4NXB8	Drosophila yakuba	26%	93%
B5VE38	Saccharomyces cerevisiae (strain AWRI1631)	25%	79%
C7GQI8	Saccharomyces cerevisiae (strain JAY291)	25%	79%
C9ZKA7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	77%
C9ZT80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	68%
D0A725	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	76%
D0A743	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	70%
D0A772	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	68%
D0A7Z6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	96%
E7F1C4	Danio rerio	25%	77%
E9AC13	Leishmania major	79%	100%
E9AJB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	79%
E9AWQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	67%
E9B407	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	67%
F1Q8K0	Danio rerio	25%	99%
F4I2H2	Arabidopsis thaliana	28%	85%
F4IV45	Arabidopsis thaliana	25%	83%
F4J9M5	Arabidopsis thaliana	29%	66%
F4JY24	Arabidopsis thaliana	27%	68%
F4K128	Arabidopsis thaliana	27%	69%
O10302	Orgyia pseudotsugata multicapsid polyhedrosis virus	27%	100%
O12944	Gallus gallus	26%	100%
O16102	Drosophila melanogaster	26%	82%
O42861	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	79%
O60264	Homo sapiens	29%	69%
O76460	Drosophila melanogaster	26%	93%
P28370	Homo sapiens	27%	69%
P31244	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	93%
P32863	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	81%
P34739	Drosophila melanogaster	22%	69%
P38086	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	76%
P40352	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	67%
P41410	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	86%
P41447	Autographa californica nuclear polyhedrosis virus	24%	100%
P41877	Caenorhabditis elegans	28%	72%
P43610	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	86%
P47264	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	27%	71%
P70270	Mus musculus	26%	98%
P75093	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	26%	71%
P87114	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	77%
P94593	Bacillus subtilis (strain 168)	26%	79%
Q04692	Mus musculus	26%	72%
Q09772	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	90%
Q0PCS3	Arabidopsis thaliana	30%	80%
Q24368	Drosophila melanogaster	29%	71%
Q29KH2	Drosophila pseudoobscura pseudoobscura	27%	93%
Q3B7N1	Bos taurus	28%	81%
Q4Q417	Leishmania major	27%	66%
Q57X81	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	22%	68%
Q5A310	Candida albicans (strain SC5314 / ATCC MYA-2876)	30%	69%
Q5FWR0	Xenopus tropicalis	25%	73%
Q60848	Mus musculus	27%	89%
Q6PFE3	Mus musculus	25%	83%
Q6PGB8	Mus musculus	28%	70%
Q7G8Y3	Oryza sativa subsp. japonica	28%	66%
Q7ZU90	Danio rerio	27%	71%
Q86WJ1	Homo sapiens	27%	81%
Q8RWY3	Arabidopsis thaliana	27%	69%
Q8W103	Arabidopsis thaliana	31%	67%
Q91ZW3	Mus musculus	29%	70%
Q92698	Homo sapiens	26%	98%
Q95216	Oryctolagus cuniculus	24%	73%
Q9CXF7	Mus musculus	28%	81%
Q9DG67	Gallus gallus	26%	80%
Q9NRZ9	Homo sapiens	26%	87%
Q9UR24	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	75%
Q9VL72	Drosophila melanogaster	28%	87%
Q9XFH4	Arabidopsis thaliana	25%	96%
Q9Y620	Homo sapiens	26%	80%
V5B5G3	Trypanosoma cruzi	51%	100%
V5BVU6	Trypanosoma cruzi	28%	85%
V5DIY2	Trypanosoma cruzi	29%	79%
V5DSK3	Trypanosoma cruzi	22%	82%