Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H348_LEIBR

TriTrypDb:

LbrM.01.0270 , LBRM2903_010007200

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H348

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H348

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_Separin_Metazoa	86	90	PF03568	0.704
DEG_MDM2_SWIB_1	60	67	PF02201	0.613
DOC_MAPK_MEF2A_6	12	19	PF00069	0.616
DOC_PP4_FxxP_1	6	9	PF00568	0.487
DOC_PP4_FxxP_1	71	74	PF00568	0.736
DOC_USP7_MATH_1	41	45	PF00917	0.598
DOC_USP7_MATH_1	52	56	PF00917	0.517
LIG_14-3-3_CanoR_1	138	147	PF00244	0.637
LIG_14-3-3_CanoR_1	68	72	PF00244	0.527
LIG_14-3-3_CanoR_1	78	87	PF00244	0.468
LIG_BRCT_BRCA1_1	56	60	PF00533	0.707
LIG_EVH1_2	2	6	PF00568	0.467
LIG_LIR_Apic_2	28	33	PF02991	0.607
LIG_LIR_Apic_2	70	74	PF02991	0.738
LIG_LIR_Nem_3	57	63	PF02991	0.612
LIG_LYPXL_yS_3	32	35	PF13949	0.622
LIG_Pex14_2	60	64	PF04695	0.736
LIG_SH2_CRK	130	134	PF00017	0.612
LIG_SH2_CRK	30	34	PF00017	0.615
LIG_SH2_SRC	30	33	PF00017	0.466
LIG_SH2_STAT5	119	122	PF00017	0.618
LIG_SH3_3	48	54	PF00018	0.654
LIG_SUMO_SIM_anti_2	96	102	PF11976	0.591
LIG_SUMO_SIM_par_1	96	102	PF11976	0.545
MOD_CK1_1	114	120	PF00069	0.684
MOD_GlcNHglycan	104	107	PF01048	0.689
MOD_GlcNHglycan	113	116	PF01048	0.565
MOD_GlcNHglycan	56	59	PF01048	0.587
MOD_GlcNHglycan	60	63	PF01048	0.567
MOD_GlcNHglycan	95	98	PF01048	0.556
MOD_GSK3_1	107	114	PF00069	0.459
MOD_GSK3_1	37	44	PF00069	0.683
MOD_GSK3_1	52	59	PF00069	0.557
MOD_GSK3_1	63	70	PF00069	0.666
MOD_N-GLC_1	138	143	PF02516	0.727
MOD_NEK2_1	10	15	PF00069	0.583
MOD_NEK2_1	111	116	PF00069	0.390
MOD_NEK2_1	25	30	PF00069	0.602
MOD_NEK2_1	63	68	PF00069	0.734
MOD_NEK2_1	87	92	PF00069	0.601
MOD_NEK2_1	99	104	PF00069	0.610
MOD_PIKK_1	25	31	PF00454	0.604
MOD_PKA_2	128	134	PF00069	0.710
MOD_PKA_2	67	73	PF00069	0.502
MOD_Plk_4	107	113	PF00069	0.640
MOD_Plk_4	114	120	PF00069	0.602
MOD_Plk_4	99	105	PF00069	0.692
TRG_ENDOCYTIC_2	130	133	PF00928	0.612
TRG_ENDOCYTIC_2	32	35	PF00928	0.569
TRG_ENDOCYTIC_2	36	39	PF00928	0.570
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P0	Leptomonas seymouri	51%	100%
A0A3S5H4T9	Leishmania donovani	80%	100%
E9AC12	Leishmania major	74%	100%
E9AJA9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%