Putative long-chain-fatty-acid-CoA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

long-chain-fatty-acid-CoA ligase, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H347_LEIBR

TriTrypDb:

LbrM.01.0260 , LBRM2903_010010800

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H347

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H347

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004467	long-chain fatty acid-CoA ligase activity	3	2
GO:0015645	fatty acid ligase activity	2	2
GO:0016405	CoA-ligase activity	4	2
GO:0016874	ligase activity	2	2
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	2
GO:0016878	acid-thiol ligase activity	4	2
GO:0140657	ATP-dependent activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.890
CLV_NRD_NRD_1	143	145	PF00675	0.549
CLV_NRD_NRD_1	170	172	PF00675	0.658
CLV_NRD_NRD_1	203	205	PF00675	0.666
CLV_NRD_NRD_1	339	341	PF00675	0.449
CLV_NRD_NRD_1	406	408	PF00675	0.677
CLV_NRD_NRD_1	421	423	PF00675	0.420
CLV_PCSK_FUR_1	407	411	PF00082	0.663
CLV_PCSK_KEX2_1	101	103	PF00082	0.892
CLV_PCSK_KEX2_1	143	145	PF00082	0.549
CLV_PCSK_KEX2_1	170	172	PF00082	0.658
CLV_PCSK_KEX2_1	205	207	PF00082	0.663
CLV_PCSK_KEX2_1	339	341	PF00082	0.449
CLV_PCSK_KEX2_1	409	411	PF00082	0.656
CLV_PCSK_KEX2_1	421	423	PF00082	0.457
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.663
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.656
CLV_PCSK_SKI1_1	112	116	PF00082	0.884
CLV_PCSK_SKI1_1	170	174	PF00082	0.659
CLV_PCSK_SKI1_1	72	76	PF00082	0.888
DEG_Nend_UBRbox_3	1	3	PF02207	0.661
DEG_SPOP_SBC_1	106	110	PF00917	0.683
DOC_CKS1_1	361	366	PF01111	0.827
DOC_CKS1_1	96	101	PF01111	0.690
DOC_CYCLIN_RxL_1	107	119	PF00134	0.686
DOC_USP7_MATH_1	106	110	PF00917	0.683
DOC_USP7_MATH_1	225	229	PF00917	0.853
DOC_USP7_MATH_1	352	356	PF00917	0.762
DOC_USP7_MATH_1	387	391	PF00917	0.857
DOC_USP7_MATH_1	412	416	PF00917	0.803
DOC_USP7_MATH_1	440	444	PF00917	0.881
DOC_USP7_MATH_2	95	101	PF00917	0.686
DOC_WW_Pin1_4	328	333	PF00397	0.650
DOC_WW_Pin1_4	360	365	PF00397	0.823
DOC_WW_Pin1_4	74	79	PF00397	0.686
DOC_WW_Pin1_4	95	100	PF00397	0.684
LIG_14-3-3_CanoR_1	107	115	PF00244	0.687
LIG_14-3-3_CanoR_1	130	135	PF00244	0.598
LIG_14-3-3_CanoR_1	158	164	PF00244	0.798
LIG_14-3-3_CanoR_1	204	210	PF00244	0.862
LIG_14-3-3_CanoR_1	442	451	PF00244	0.882
LIG_14-3-3_CanoR_1	7	17	PF00244	0.632
LIG_Actin_WH2_2	262	277	PF00022	0.549
LIG_BIR_III_2	448	452	PF00653	0.882
LIG_BIR_III_4	392	396	PF00653	0.863
LIG_CSL_BTD_1	75	78	PF09270	0.685
LIG_CtBP_PxDLS_1	66	72	PF00389	0.672
LIG_deltaCOP1_diTrp_1	256	265	PF00928	0.650
LIG_deltaCOP1_diTrp_1	284	290	PF00928	0.449
LIG_FHA_1	109	115	PF00498	0.685
LIG_FHA_1	252	258	PF00498	0.650
LIG_FHA_1	77	83	PF00498	0.682
LIG_FHA_2	114	120	PF00498	0.681
LIG_FHA_2	122	128	PF00498	0.543
LIG_FHA_2	284	290	PF00498	0.449
LIG_FHA_2	319	325	PF00498	0.650
LIG_LIR_Apic_2	243	249	PF02991	0.650
LIG_LIR_Gen_1	128	139	PF02991	0.594
LIG_LIR_Gen_1	256	267	PF02991	0.650
LIG_LIR_Gen_1	285	296	PF02991	0.449
LIG_LIR_Gen_1	415	425	PF02991	0.788
LIG_LIR_LC3C_4	299	304	PF02991	0.549
LIG_LIR_Nem_3	128	134	PF02991	0.611
LIG_LIR_Nem_3	166	172	PF02991	0.839
LIG_LIR_Nem_3	256	262	PF02991	0.650
LIG_LIR_Nem_3	285	291	PF02991	0.449
LIG_LIR_Nem_3	415	420	PF02991	0.762
LIG_PTAP_UEV_1	209	214	PF05743	0.859
LIG_SH2_GRB2like	18	21	PF00017	0.621
LIG_SH2_STAP1	26	30	PF00017	0.640
LIG_SH2_STAT3	18	21	PF00017	0.621
LIG_SH2_STAT5	18	21	PF00017	0.621
LIG_SH2_STAT5	246	249	PF00017	0.650
LIG_SH2_STAT5	26	29	PF00017	0.539
LIG_SH3_3	161	167	PF00018	0.821
LIG_SH3_3	207	213	PF00018	0.857
LIG_SH3_3	326	332	PF00018	0.650
LIG_SH3_3	358	364	PF00018	0.810
LIG_SH3_3	450	456	PF00018	0.878
LIG_SH3_3	47	53	PF00018	0.645
LIG_SH3_3	75	81	PF00018	0.683
LIG_SUMO_SIM_par_1	302	310	PF11976	0.549
LIG_TRFH_1	245	249	PF08558	0.650
LIG_WW_2	80	83	PF00397	0.681
LIG_WW_3	424	428	PF00397	0.855
MOD_CDK_SPxK_1	95	101	PF00069	0.686
MOD_CDK_SPxxK_3	95	102	PF00069	0.686
MOD_CK1_1	208	214	PF00069	0.859
MOD_CK1_1	310	316	PF00069	0.650
MOD_CK1_1	366	372	PF00069	0.844
MOD_CK1_1	39	45	PF00069	0.661
MOD_CK1_1	443	449	PF00069	0.882
MOD_CK2_1	113	119	PF00069	0.682
MOD_CK2_1	130	136	PF00069	0.387
MOD_CK2_1	257	263	PF00069	0.650
MOD_CK2_1	283	289	PF00069	0.449
MOD_CK2_1	318	324	PF00069	0.650
MOD_GlcNHglycan	210	213	PF01048	0.657
MOD_GlcNHglycan	220	223	PF01048	0.529
MOD_GlcNHglycan	308	312	PF01048	0.449
MOD_GlcNHglycan	31	34	PF01048	0.850
MOD_GlcNHglycan	354	357	PF01048	0.572
MOD_GlcNHglycan	389	392	PF01048	0.657
MOD_GlcNHglycan	422	425	PF01048	0.623
MOD_GlcNHglycan	443	446	PF01048	0.680
MOD_GSK3_1	106	113	PF00069	0.684
MOD_GSK3_1	121	128	PF00069	0.459
MOD_GSK3_1	20	27	PF00069	0.626
MOD_GSK3_1	236	243	PF00069	0.650
MOD_GSK3_1	29	36	PF00069	0.540
MOD_GSK3_1	306	313	PF00069	0.549
MOD_GSK3_1	362	369	PF00069	0.836
MOD_GSK3_1	44	51	PF00069	0.463
MOD_GSK3_1	440	447	PF00069	0.881
MOD_GSK3_1	68	75	PF00069	0.679
MOD_NEK2_1	121	126	PF00069	0.654
MOD_NEK2_1	307	312	PF00069	0.650
MOD_NEK2_1	44	49	PF00069	0.654
MOD_NEK2_1	441	446	PF00069	0.882
MOD_NEK2_1	57	62	PF00069	0.486
MOD_NEK2_2	290	295	PF00069	0.449
MOD_PIKK_1	81	87	PF00454	0.690
MOD_PKA_1	170	176	PF00069	0.862
MOD_PKA_1	205	211	PF00069	0.861
MOD_PKA_2	106	112	PF00069	0.685
MOD_PKA_2	157	163	PF00069	0.745
MOD_PKA_2	170	176	PF00069	0.699
MOD_PKA_2	205	211	PF00069	0.861
MOD_PKA_2	420	426	PF00069	0.817
MOD_PKA_2	441	447	PF00069	0.881
MOD_PKA_2	9	15	PF00069	0.629
MOD_Plk_1	283	289	PF00069	0.449
MOD_Plk_4	240	246	PF00069	0.650
MOD_Plk_4	39	45	PF00069	0.661
MOD_Plk_4	412	418	PF00069	0.790
MOD_Plk_4	51	57	PF00069	0.491
MOD_ProDKin_1	328	334	PF00069	0.650
MOD_ProDKin_1	360	366	PF00069	0.824
MOD_ProDKin_1	74	80	PF00069	0.684
MOD_ProDKin_1	95	101	PF00069	0.686
MOD_SUMO_rev_2	320	328	PF00179	0.650
TRG_DiLeu_BaEn_1	324	329	PF01217	0.650
TRG_ER_diArg_1	101	103	PF00400	0.692
TRG_ER_diArg_1	143	145	PF00400	0.549
TRG_ER_diArg_1	169	171	PF00400	0.847
TRG_ER_diArg_1	203	206	PF00400	0.866
TRG_ER_diArg_1	338	340	PF00400	0.650
TRG_ER_diArg_1	420	422	PF00400	0.794
TRG_NLS_MonoCore_2	406	411	PF00514	0.867
TRG_NLS_MonoExtN_4	203	208	PF00514	0.863
TRG_NLS_MonoExtN_4	406	412	PF00514	0.861