Putative cyclophilin 12

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 12, putative

Species:

Leishmania braziliensis

UniProt:

A4H346_LEIBR

TriTrypDb:

LbrM.01.0250 , LBRM2903_010007100

Length:

337

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	3
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4H346

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H346

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	22
GO:0006807	nitrogen compound metabolic process	2	22
GO:0008152	metabolic process	1	22
GO:0018193	peptidyl-amino acid modification	5	22
GO:0018208	peptidyl-proline modification	6	22
GO:0019538	protein metabolic process	3	22
GO:0036211	protein modification process	4	22
GO:0043170	macromolecule metabolic process	3	22
GO:0043412	macromolecule modification	4	22
GO:0044238	primary metabolic process	2	22
GO:0071704	organic substance metabolic process	2	22
GO:1901564	organonitrogen compound metabolic process	3	22
GO:0006457	protein folding	2	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	22
GO:0003824	catalytic activity	1	22
GO:0016853	isomerase activity	2	22
GO:0016859	cis-trans isomerase activity	3	22
GO:0140096	catalytic activity, acting on a protein	2	22
GO:0005488	binding	1	2
GO:0016018	cyclosporin A binding	4	2
GO:0033218	amide binding	2	2
GO:0042277	peptide binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.261
CLV_C14_Caspase3-7	50	54	PF00656	0.443
CLV_NRD_NRD_1	284	286	PF00675	0.257
CLV_NRD_NRD_1	51	53	PF00675	0.398
CLV_PCSK_KEX2_1	284	286	PF00082	0.257
CLV_PCSK_KEX2_1	51	53	PF00082	0.395
CLV_PCSK_SKI1_1	105	109	PF00082	0.471
CLV_PCSK_SKI1_1	140	144	PF00082	0.440
CLV_PCSK_SKI1_1	222	226	PF00082	0.392
CLV_PCSK_SKI1_1	46	50	PF00082	0.324
CLV_Separin_Metazoa	43	47	PF03568	0.346
DEG_SPOP_SBC_1	273	277	PF00917	0.207
DOC_MAPK_gen_1	146	155	PF00069	0.337
DOC_MAPK_MEF2A_6	148	157	PF00069	0.303
DOC_PP1_RVXF_1	162	168	PF00149	0.312
DOC_PP1_RVXF_1	291	298	PF00149	0.378
DOC_PP2B_LxvP_1	205	208	PF13499	0.173
DOC_PP2B_LxvP_1	42	45	PF13499	0.341
DOC_USP7_MATH_1	273	277	PF00917	0.325
DOC_USP7_MATH_1	54	58	PF00917	0.435
DOC_USP7_MATH_1	68	72	PF00917	0.509
DOC_USP7_MATH_1	84	88	PF00917	0.447
DOC_WW_Pin1_4	194	199	PF00397	0.259
DOC_WW_Pin1_4	317	322	PF00397	0.276
LIG_14-3-3_CanoR_1	105	113	PF00244	0.493
LIG_14-3-3_CanoR_1	186	191	PF00244	0.415
LIG_14-3-3_CanoR_1	284	290	PF00244	0.336
LIG_BIR_III_4	261	265	PF00653	0.262
LIG_BRCT_BRCA1_1	276	280	PF00533	0.459
LIG_FHA_1	253	259	PF00498	0.390
LIG_FHA_1	277	283	PF00498	0.194
LIG_FHA_1	37	43	PF00498	0.488
LIG_FHA_2	221	227	PF00498	0.416
LIG_FHA_2	326	332	PF00498	0.349
LIG_LIR_Apic_2	253	259	PF02991	0.294
LIG_LIR_Gen_1	168	176	PF02991	0.327
LIG_LIR_Gen_1	53	62	PF02991	0.495
LIG_LIR_Nem_3	168	173	PF02991	0.372
LIG_LIR_Nem_3	200	205	PF02991	0.173
LIG_LIR_Nem_3	218	224	PF02991	0.264
LIG_LIR_Nem_3	5	10	PF02991	0.432
LIG_LIR_Nem_3	53	58	PF02991	0.493
LIG_PDZ_Class_1	332	337	PF00595	0.400
LIG_Pex14_1	166	170	PF04695	0.378
LIG_REV1ctd_RIR_1	218	226	PF16727	0.245
LIG_REV1ctd_RIR_1	46	56	PF16727	0.287
LIG_SH2_CRK	10	14	PF00017	0.444
LIG_SH2_CRK	170	174	PF00017	0.285
LIG_SH2_CRK	256	260	PF00017	0.285
LIG_SH2_GRB2like	27	30	PF00017	0.371
LIG_SH2_NCK_1	170	174	PF00017	0.261
LIG_SH2_SRC	211	214	PF00017	0.173
LIG_SH2_STAP1	170	174	PF00017	0.262
LIG_SH2_STAP1	36	40	PF00017	0.430
LIG_SH2_STAT3	131	134	PF00017	0.332
LIG_SH2_STAT5	131	134	PF00017	0.383
LIG_SH2_STAT5	150	153	PF00017	0.286
LIG_SH2_STAT5	170	173	PF00017	0.173
LIG_SH2_STAT5	27	30	PF00017	0.299
LIG_SH2_STAT5	281	284	PF00017	0.262
LIG_SH2_STAT5	294	297	PF00017	0.262
LIG_SUMO_SIM_par_1	38	43	PF11976	0.269
LIG_TYR_ITSM	6	13	PF00017	0.428
LIG_WRC_WIRS_1	4	9	PF05994	0.322
MOD_CDK_SPK_2	317	322	PF00069	0.173
MOD_CK1_1	197	203	PF00069	0.316
MOD_CK1_1	276	282	PF00069	0.306
MOD_CK1_1	83	89	PF00069	0.630
MOD_CK2_1	96	102	PF00069	0.607
MOD_GlcNHglycan	157	160	PF01048	0.173
MOD_GlcNHglycan	199	202	PF01048	0.277
MOD_GlcNHglycan	238	241	PF01048	0.324
MOD_GlcNHglycan	82	85	PF01048	0.528
MOD_GSK3_1	216	223	PF00069	0.280
MOD_GSK3_1	232	239	PF00069	0.388
MOD_GSK3_1	272	279	PF00069	0.193
MOD_GSK3_1	32	39	PF00069	0.376
MOD_GSK3_1	80	87	PF00069	0.542
MOD_N-GLC_1	317	322	PF02516	0.193
MOD_N-GLC_1	69	74	PF02516	0.503
MOD_N-GLC_2	180	182	PF02516	0.329
MOD_NEK2_1	142	147	PF00069	0.523
MOD_NEK2_1	153	158	PF00069	0.354
MOD_NEK2_1	192	197	PF00069	0.207
MOD_NEK2_1	220	225	PF00069	0.347
MOD_NEK2_1	280	285	PF00069	0.327
MOD_NEK2_2	242	247	PF00069	0.350
MOD_PIKK_1	60	66	PF00454	0.508
MOD_PKA_2	185	191	PF00069	0.426
MOD_Plk_1	153	159	PF00069	0.334
MOD_Plk_1	252	258	PF00069	0.312
MOD_Plk_4	216	222	PF00069	0.268
MOD_Plk_4	276	282	PF00069	0.226
MOD_Plk_4	285	291	PF00069	0.274
MOD_ProDKin_1	194	200	PF00069	0.259
MOD_ProDKin_1	317	323	PF00069	0.276
MOD_SUMO_for_1	321	324	PF00179	0.185
TRG_DiLeu_BaEn_1	102	107	PF01217	0.384
TRG_DiLeu_LyEn_5	102	107	PF01217	0.350
TRG_ENDOCYTIC_2	10	13	PF00928	0.433
TRG_ENDOCYTIC_2	150	153	PF00928	0.268
TRG_ENDOCYTIC_2	170	173	PF00928	0.262
TRG_ENDOCYTIC_2	294	297	PF00928	0.340
TRG_ER_diArg_1	284	286	PF00400	0.257
TRG_Pf-PMV_PEXEL_1	105	110	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL84	Leptomonas seymouri	57%	100%
A0A0S4IKA5	Bodo saltans	36%	100%
A0A3Q8ICB3	Leishmania donovani	27%	100%
A0A3R7M7E5	Trypanosoma rangeli	44%	100%
A0A3S5H7U6	Leishmania donovani	36%	100%
A0A3S7X325	Leishmania donovani	26%	100%
A0A3S7X410	Leishmania donovani	35%	100%
A0A3S7XB52	Leishmania donovani	33%	100%
A0A451EJ79	Leishmania donovani	83%	100%
A4HCI8	Leishmania braziliensis	25%	100%
A4HHU7	Leishmania braziliensis	23%	100%
A4HIW9	Leishmania braziliensis	34%	100%
A4HRE3	Leishmania infantum	83%	100%
A4I004	Leishmania infantum	27%	100%
A4I4Z7	Leishmania infantum	26%	100%
A4I698	Leishmania infantum	35%	100%
A4I935	Leishmania infantum	36%	100%
A4IDA1	Leishmania infantum	33%	100%
C9ZQE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZXF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AC11	Leishmania major	83%	99%
E9AJA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AVX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B0C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B1F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B400	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q1RMP7	Bos taurus	29%	100%
Q4Q1A6	Leishmania major	33%	100%
Q4Q6Q9	Leishmania major	35%	100%
Q4Q7V7	Leishmania major	25%	100%
Q4QBK2	Leishmania major	27%	100%
V5B9Y6	Trypanosoma cruzi	43%	100%