LeishMANIAdb
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Putative cyclophilin 12

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative cyclophilin 12
Gene product:
cyclophilin 12, putative
Species:
Leishmania braziliensis
UniProt:
A4H346_LEIBR
TriTrypDb:
LbrM.01.0250 , LBRM2903_010007100
Length:
337

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 3
GO:0005930 axoneme 2 1
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 5
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Expansion

Sequence features

A4H346
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H346

Function

Biological processes
TermNameLevelCount
GO:0000413 protein peptidyl-prolyl isomerization 7 22
GO:0006457 protein folding 2 10
GO:0006807 nitrogen compound metabolic process 2 22
GO:0008152 metabolic process 1 22
GO:0009987 cellular process 1 10
GO:0018193 peptidyl-amino acid modification 5 22
GO:0018208 peptidyl-proline modification 6 22
GO:0019538 protein metabolic process 3 22
GO:0036211 protein modification process 4 22
GO:0043170 macromolecule metabolic process 3 22
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Molecular functions
TermNameLevelCount
GO:0003755 peptidyl-prolyl cis-trans isomerase activity 3 22
GO:0003824 catalytic activity 1 22
GO:0005488 binding 1 2
GO:0016018 cyclosporin A binding 4 2
GO:0016853 isomerase activity 2 22
GO:0016859 cis-trans isomerase activity 3 22
GO:0033218 amide binding 2 2
GO:0042277 peptide binding 3 2
GO:0140096 catalytic activity, acting on a protein 2 22
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 223 227 PF00656 0.261
CLV_C14_Caspase3-7 50 54 PF00656 0.443
CLV_NRD_NRD_1 284 286 PF00675 0.257
CLV_NRD_NRD_1 51 53 PF00675 0.398
CLV_PCSK_KEX2_1 284 286 PF00082 0.257
CLV_PCSK_KEX2_1 51 53 PF00082 0.395
CLV_PCSK_SKI1_1 105 109 PF00082 0.471
CLV_PCSK_SKI1_1 140 144 PF00082 0.440
CLV_PCSK_SKI1_1 222 226 PF00082 0.392
CLV_PCSK_SKI1_1 46 50 PF00082 0.324
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IL84 Leptomonas seymouri 57% 100%
A0A0S4IKA5 Bodo saltans 36% 100%
A0A3Q8ICB3 Leishmania donovani 27% 100%
A0A3R7M7E5 Trypanosoma rangeli 44% 100%
A0A3S5H7U6 Leishmania donovani 36% 100%
A0A3S7X325 Leishmania donovani 26% 100%
A0A3S7X410 Leishmania donovani 35% 100%
A0A3S7XB52 Leishmania donovani 33% 100%
A0A451EJ79 Leishmania donovani 83% 100%
A4HCI8 Leishmania braziliensis 25% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS