Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CUE domain/Domain of unknown function (DUF1771)/Smr domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H345_LEIBR

TriTrypDb:

LbrM.01.0240 , LBRM2903_010007000

Length:

886

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H345

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H345

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	10
GO:0032182	ubiquitin-like protein binding	3	10
GO:0043130	ubiquitin binding	4	10
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.655
CLV_NRD_NRD_1	250	252	PF00675	0.617
CLV_NRD_NRD_1	321	323	PF00675	0.713
CLV_NRD_NRD_1	358	360	PF00675	0.582
CLV_NRD_NRD_1	398	400	PF00675	0.722
CLV_NRD_NRD_1	731	733	PF00675	0.277
CLV_NRD_NRD_1	771	773	PF00675	0.469
CLV_NRD_NRD_1	817	819	PF00675	0.271
CLV_NRD_NRD_1	93	95	PF00675	0.580
CLV_NRD_NRD_1	98	100	PF00675	0.473
CLV_PCSK_FUR_1	96	100	PF00082	0.441
CLV_PCSK_KEX2_1	2	4	PF00082	0.715
CLV_PCSK_KEX2_1	321	323	PF00082	0.695
CLV_PCSK_KEX2_1	358	360	PF00082	0.554
CLV_PCSK_KEX2_1	398	400	PF00082	0.565
CLV_PCSK_KEX2_1	731	733	PF00082	0.271
CLV_PCSK_KEX2_1	771	773	PF00082	0.444
CLV_PCSK_KEX2_1	817	819	PF00082	0.274
CLV_PCSK_KEX2_1	841	843	PF00082	0.293
CLV_PCSK_KEX2_1	93	95	PF00082	0.605
CLV_PCSK_KEX2_1	98	100	PF00082	0.475
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.715
CLV_PCSK_PC1ET2_1	841	843	PF00082	0.414
CLV_PCSK_PC7_1	94	100	PF00082	0.502
CLV_PCSK_SKI1_1	722	726	PF00082	0.405
CLV_PCSK_SKI1_1	761	765	PF00082	0.206
CLV_PCSK_SKI1_1	831	835	PF00082	0.318
CLV_PCSK_SKI1_1	868	872	PF00082	0.383
CLV_Separin_Metazoa	628	632	PF03568	0.340
DEG_APCC_DBOX_1	741	749	PF00400	0.193
DEG_Nend_UBRbox_1	1	4	PF02207	0.677
DEG_SPOP_SBC_1	305	309	PF00917	0.680
DEG_SPOP_SBC_1	56	60	PF00917	0.639
DEG_SPOP_SBC_1	76	80	PF00917	0.445
DOC_CYCLIN_RxL_1	741	752	PF00134	0.193
DOC_MAPK_gen_1	614	622	PF00069	0.547
DOC_MAPK_gen_1	779	788	PF00069	0.289
DOC_MAPK_gen_1	824	832	PF00069	0.311
DOC_MAPK_gen_1	868	877	PF00069	0.421
DOC_MAPK_gen_1	96	106	PF00069	0.348
DOC_MAPK_MEF2A_6	347	355	PF00069	0.362
DOC_MAPK_MEF2A_6	614	622	PF00069	0.424
DOC_MAPK_MEF2A_6	871	879	PF00069	0.396
DOC_PP2B_LxvP_1	438	441	PF13499	0.617
DOC_PP4_MxPP_1	241	244	PF00568	0.484
DOC_USP7_MATH_1	217	221	PF00917	0.614
DOC_USP7_MATH_1	305	309	PF00917	0.678
DOC_USP7_MATH_1	404	408	PF00917	0.669
DOC_USP7_MATH_1	439	443	PF00917	0.728
DOC_USP7_MATH_1	462	466	PF00917	0.577
DOC_USP7_MATH_1	66	70	PF00917	0.692
DOC_USP7_MATH_1	77	81	PF00917	0.729
DOC_USP7_UBL2_3	18	22	PF12436	0.463
DOC_WW_Pin1_4	154	159	PF00397	0.411
DOC_WW_Pin1_4	195	200	PF00397	0.638
DOC_WW_Pin1_4	213	218	PF00397	0.483
DOC_WW_Pin1_4	280	285	PF00397	0.672
DOC_WW_Pin1_4	398	403	PF00397	0.660
DOC_WW_Pin1_4	418	423	PF00397	0.755
DOC_WW_Pin1_4	83	88	PF00397	0.645
LIG_14-3-3_CanoR_1	359	369	PF00244	0.489
LIG_14-3-3_CanoR_1	415	424	PF00244	0.573
LIG_14-3-3_CanoR_1	643	651	PF00244	0.491
LIG_14-3-3_CanoR_1	842	848	PF00244	0.199
LIG_Actin_WH2_2	439	456	PF00022	0.565
LIG_BIR_III_4	263	267	PF00653	0.741
LIG_BRCT_BRCA1_1	107	111	PF00533	0.609
LIG_BRCT_BRCA1_1	78	82	PF00533	0.589
LIG_Clathr_ClatBox_1	655	659	PF01394	0.508
LIG_FHA_1	186	192	PF00498	0.578
LIG_FHA_1	24	30	PF00498	0.408
LIG_FHA_1	267	273	PF00498	0.543
LIG_FHA_1	389	395	PF00498	0.636
LIG_FHA_1	625	631	PF00498	0.560
LIG_FHA_1	643	649	PF00498	0.464
LIG_FHA_1	650	656	PF00498	0.487
LIG_FHA_1	672	678	PF00498	0.617
LIG_FHA_1	702	708	PF00498	0.485
LIG_FHA_1	76	82	PF00498	0.715
LIG_FHA_1	760	766	PF00498	0.193
LIG_FHA_1	796	802	PF00498	0.395
LIG_FHA_1	860	866	PF00498	0.385
LIG_FHA_1	876	882	PF00498	0.497
LIG_FHA_2	371	377	PF00498	0.553
LIG_FHA_2	518	524	PF00498	0.481
LIG_FHA_2	707	713	PF00498	0.521
LIG_HP1_1	491	495	PF01393	0.291
LIG_LIR_Apic_2	152	158	PF02991	0.389
LIG_LIR_Apic_2	676	682	PF02991	0.621
LIG_LIR_Gen_1	225	235	PF02991	0.746
LIG_LIR_Gen_1	581	590	PF02991	0.350
LIG_LIR_Gen_1	774	785	PF02991	0.295
LIG_LIR_Nem_3	108	114	PF02991	0.479
LIG_LIR_Nem_3	225	230	PF02991	0.746
LIG_LIR_Nem_3	283	288	PF02991	0.738
LIG_LIR_Nem_3	484	489	PF02991	0.449
LIG_LIR_Nem_3	559	564	PF02991	0.337
LIG_LIR_Nem_3	581	587	PF02991	0.290
LIG_LIR_Nem_3	712	717	PF02991	0.497
LIG_LIR_Nem_3	729	733	PF02991	0.187
LIG_LIR_Nem_3	774	780	PF02991	0.295
LIG_LIR_Nem_3	846	851	PF02991	0.318
LIG_LYPXL_S_1	847	851	PF13949	0.314
LIG_LYPXL_yS_3	848	851	PF13949	0.314
LIG_MYND_1	240	244	PF01753	0.483
LIG_MYND_1	298	302	PF01753	0.480
LIG_NRBOX	553	559	PF00104	0.193
LIG_PCNA_yPIPBox_3	2	16	PF02747	0.390
LIG_PCNA_yPIPBox_3	550	558	PF02747	0.193
LIG_PTB_Apo_2	332	339	PF02174	0.314
LIG_SH2_CRK	114	118	PF00017	0.445
LIG_SH2_CRK	584	588	PF00017	0.271
LIG_SH2_CRK	777	781	PF00017	0.314
LIG_SH2_PTP2	874	877	PF00017	0.404
LIG_SH2_SRC	874	877	PF00017	0.404
LIG_SH2_STAP1	584	588	PF00017	0.193
LIG_SH2_STAT5	114	117	PF00017	0.498
LIG_SH2_STAT5	153	156	PF00017	0.544
LIG_SH2_STAT5	469	472	PF00017	0.428
LIG_SH2_STAT5	634	637	PF00017	0.503
LIG_SH2_STAT5	738	741	PF00017	0.271
LIG_SH2_STAT5	874	877	PF00017	0.392
LIG_SH3_3	237	243	PF00018	0.606
LIG_SH3_3	276	282	PF00018	0.584
LIG_SH3_3	295	301	PF00018	0.481
LIG_SH3_3	617	623	PF00018	0.397
LIG_SH3_3	876	882	PF00018	0.498
LIG_SUMO_SIM_anti_2	490	496	PF11976	0.424
LIG_SUMO_SIM_par_1	553	559	PF11976	0.411
LIG_SUMO_SIM_par_1	652	660	PF11976	0.567
LIG_SUMO_SIM_par_1	784	789	PF11976	0.271
LIG_TRAF2_1	535	538	PF00917	0.488
LIG_TRAF2_1	579	582	PF00917	0.344
LIG_TYR_ITIM	775	780	PF00017	0.349
LIG_WRC_WIRS_1	246	251	PF05994	0.500
MOD_CDK_SPK_2	154	159	PF00069	0.411
MOD_CDK_SPxK_1	195	201	PF00069	0.504
MOD_CDK_SPxK_1	280	286	PF00069	0.618
MOD_CK1_1	169	175	PF00069	0.526
MOD_CK1_1	233	239	PF00069	0.578
MOD_CK1_1	307	313	PF00069	0.648
MOD_CK1_1	314	320	PF00069	0.611
MOD_CK1_1	471	477	PF00069	0.575
MOD_CK1_1	59	65	PF00069	0.629
MOD_CK1_1	601	607	PF00069	0.547
MOD_CK1_1	624	630	PF00069	0.499
MOD_CK1_1	642	648	PF00069	0.431
MOD_CK1_1	657	663	PF00069	0.585
MOD_CK2_1	360	366	PF00069	0.574
MOD_CK2_1	370	376	PF00069	0.429
MOD_CK2_1	469	475	PF00069	0.594
MOD_CK2_1	517	523	PF00069	0.473
MOD_CK2_1	706	712	PF00069	0.523
MOD_Cter_Amidation	769	772	PF01082	0.335
MOD_GlcNHglycan	136	139	PF01048	0.485
MOD_GlcNHglycan	168	171	PF01048	0.546
MOD_GlcNHglycan	232	235	PF01048	0.686
MOD_GlcNHglycan	293	296	PF01048	0.692
MOD_GlcNHglycan	313	316	PF01048	0.548
MOD_GlcNHglycan	362	365	PF01048	0.543
MOD_GlcNHglycan	471	474	PF01048	0.582
MOD_GlcNHglycan	5	8	PF01048	0.557
MOD_GlcNHglycan	500	503	PF01048	0.479
MOD_GlcNHglycan	596	599	PF01048	0.597
MOD_GlcNHglycan	600	603	PF01048	0.640
MOD_GlcNHglycan	63	66	PF01048	0.726
MOD_GlcNHglycan	631	634	PF01048	0.411
MOD_GlcNHglycan	697	700	PF01048	0.629
MOD_GlcNHglycan	708	712	PF01048	0.450
MOD_GlcNHglycan	756	759	PF01048	0.373
MOD_GSK3_1	181	188	PF00069	0.582
MOD_GSK3_1	213	220	PF00069	0.697
MOD_GSK3_1	305	312	PF00069	0.676
MOD_GSK3_1	411	418	PF00069	0.794
MOD_GSK3_1	428	435	PF00069	0.543
MOD_GSK3_1	506	513	PF00069	0.375
MOD_GSK3_1	55	62	PF00069	0.718
MOD_GSK3_1	594	601	PF00069	0.520
MOD_GSK3_1	66	73	PF00069	0.653
MOD_GSK3_1	77	84	PF00069	0.642
MOD_GSK3_1	792	799	PF00069	0.457
MOD_N-GLC_1	592	597	PF02516	0.386
MOD_NEK2_1	311	316	PF00069	0.612
MOD_NEK2_1	411	416	PF00069	0.492
MOD_NEK2_1	498	503	PF00069	0.468
MOD_NEK2_1	70	75	PF00069	0.715
MOD_NEK2_1	81	86	PF00069	0.688
MOD_NEK2_2	77	82	PF00069	0.583
MOD_NEK2_2	843	848	PF00069	0.349
MOD_OFUCOSY	102	109	PF10250	0.523
MOD_PIKK_1	23	29	PF00454	0.464
MOD_PIKK_1	571	577	PF00454	0.404
MOD_PK_1	866	872	PF00069	0.402
MOD_PKA_2	141	147	PF00069	0.474
MOD_PKA_2	230	236	PF00069	0.714
MOD_PKA_2	360	366	PF00069	0.449
MOD_PKA_2	453	459	PF00069	0.689
MOD_PKA_2	498	504	PF00069	0.509
MOD_PKA_2	642	648	PF00069	0.486
MOD_PKB_1	368	376	PF00069	0.457
MOD_PKB_1	829	837	PF00069	0.298
MOD_Plk_1	875	881	PF00069	0.564
MOD_Plk_2-3	517	523	PF00069	0.337
MOD_Plk_2-3	654	660	PF00069	0.579
MOD_Plk_4	169	175	PF00069	0.479
MOD_Plk_4	377	383	PF00069	0.344
MOD_Plk_4	526	532	PF00069	0.329
MOD_Plk_4	553	559	PF00069	0.284
MOD_Plk_4	582	588	PF00069	0.266
MOD_Plk_4	77	83	PF00069	0.638
MOD_Plk_4	843	849	PF00069	0.368
MOD_ProDKin_1	154	160	PF00069	0.417
MOD_ProDKin_1	195	201	PF00069	0.639
MOD_ProDKin_1	213	219	PF00069	0.483
MOD_ProDKin_1	280	286	PF00069	0.673
MOD_ProDKin_1	398	404	PF00069	0.659
MOD_ProDKin_1	418	424	PF00069	0.752
MOD_ProDKin_1	83	89	PF00069	0.640
MOD_SUMO_for_1	158	161	PF00179	0.452
TRG_DiLeu_BaEn_1	735	740	PF01217	0.464
TRG_DiLeu_BaEn_2	474	480	PF01217	0.525
TRG_DiLeu_BaEn_4	653	659	PF01217	0.360
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.325
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.490
TRG_DiLeu_BaLyEn_6	741	746	PF01217	0.193
TRG_ENDOCYTIC_2	114	117	PF00928	0.404
TRG_ENDOCYTIC_2	584	587	PF00928	0.271
TRG_ENDOCYTIC_2	777	780	PF00928	0.290
TRG_ENDOCYTIC_2	848	851	PF00928	0.293
TRG_ENDOCYTIC_2	874	877	PF00928	0.369
TRG_ER_diArg_1	321	324	PF00400	0.688
TRG_ER_diArg_1	358	361	PF00400	0.545
TRG_ER_diArg_1	730	732	PF00400	0.271
TRG_ER_diArg_1	742	745	PF00400	0.271
TRG_ER_diArg_1	771	773	PF00400	0.475
TRG_ER_diArg_1	816	818	PF00400	0.274
TRG_ER_diArg_1	824	827	PF00400	0.276
TRG_ER_diArg_1	829	832	PF00400	0.280
TRG_ER_diArg_1	92	94	PF00400	0.656
TRG_Pf-PMV_PEXEL_1	118	123	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	41	46	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	771	776	PF00026	0.286

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE15	Leptomonas seymouri	45%	98%
A0A1X0P3G2	Trypanosomatidae	34%	100%
A0A3R7KV90	Trypanosoma rangeli	35%	100%
A0A3S5H4T8	Leishmania donovani	74%	99%
A4HRE2	Leishmania infantum	74%	99%
C9ZXF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AC10	Leishmania major	74%	100%
E9AJA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	99%
V5D5T7	Trypanosoma cruzi	35%	100%