LMWPc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Low molecular weight phosphotyrosine protein phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H344_LEIBR

TriTrypDb:

LbrM.01.0230 , LBRM2903_010006900

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H344

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H344

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0004725	protein tyrosine phosphatase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.451
CLV_NRD_NRD_1	170	172	PF00675	0.450
CLV_NRD_NRD_1	192	194	PF00675	0.508
CLV_NRD_NRD_1	200	202	PF00675	0.446
CLV_NRD_NRD_1	224	226	PF00675	0.437
CLV_NRD_NRD_1	99	101	PF00675	0.576
CLV_PCSK_FUR_1	222	226	PF00082	0.300
CLV_PCSK_KEX2_1	200	202	PF00082	0.481
CLV_PCSK_KEX2_1	224	226	PF00082	0.437
CLV_PCSK_KEX2_1	99	101	PF00082	0.560
CLV_PCSK_SKI1_1	210	214	PF00082	0.561
CLV_PCSK_SKI1_1	227	231	PF00082	0.316
CLV_PCSK_SKI1_1	26	30	PF00082	0.328
CLV_PCSK_SKI1_1	5	9	PF00082	0.228
DEG_APCC_DBOX_1	226	234	PF00400	0.472
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.490
DOC_MAPK_gen_1	74	83	PF00069	0.468
DOC_MAPK_MEF2A_6	76	85	PF00069	0.452
DOC_PP2B_LxvP_1	133	136	PF13499	0.417
DOC_PP4_FxxP_1	128	131	PF00568	0.604
DOC_USP7_MATH_1	107	111	PF00917	0.679
DOC_WW_Pin1_4	155	160	PF00397	0.435
LIG_14-3-3_CanoR_1	15	24	PF00244	0.250
LIG_14-3-3_CanoR_1	151	157	PF00244	0.553
LIG_Actin_WH2_2	180	195	PF00022	0.543
LIG_BIR_II_1	1	5	PF00653	0.367
LIG_BRCT_BRCA1_1	117	121	PF00533	0.473
LIG_CSL_BTD_1	156	159	PF09270	0.430
LIG_eIF4E_1	178	184	PF01652	0.422
LIG_FHA_1	168	174	PF00498	0.591
LIG_FHA_1	76	82	PF00498	0.434
LIG_FHA_2	125	131	PF00498	0.369
LIG_FHA_2	213	219	PF00498	0.557
LIG_FHA_2	246	252	PF00498	0.577
LIG_FHA_2	51	57	PF00498	0.452
LIG_GBD_Chelix_1	233	241	PF00786	0.526
LIG_HCF-1_HBM_1	175	178	PF13415	0.462
LIG_LIR_Apic_2	125	131	PF02991	0.561
LIG_LIR_Gen_1	181	192	PF02991	0.442
LIG_LIR_Gen_1	80	89	PF02991	0.400
LIG_LIR_Nem_3	181	187	PF02991	0.433
LIG_LIR_Nem_3	78	82	PF02991	0.381
LIG_PDZ_Class_1	261	266	PF00595	0.525
LIG_Pex14_2	24	28	PF04695	0.449
LIG_SH2_NCK_1	258	262	PF00017	0.561
LIG_SH2_PTP2	82	85	PF00017	0.387
LIG_SH2_STAP1	258	262	PF00017	0.589
LIG_SH2_STAP1	79	83	PF00017	0.397
LIG_SH2_STAT5	101	104	PF00017	0.545
LIG_SH2_STAT5	82	85	PF00017	0.387
LIG_SH2_STAT5	89	92	PF00017	0.475
LIG_SH3_3	156	162	PF00018	0.443
LIG_SH3_3	82	88	PF00018	0.524
LIG_SUMO_SIM_par_1	47	53	PF11976	0.437
MOD_CDK_SPK_2	155	160	PF00069	0.435
MOD_CK1_1	120	126	PF00069	0.616
MOD_CK1_1	62	68	PF00069	0.337
MOD_CK2_1	212	218	PF00069	0.510
MOD_CK2_1	50	56	PF00069	0.404
MOD_CMANNOS	154	157	PF00535	0.435
MOD_GlcNHglycan	117	120	PF01048	0.686
MOD_GlcNHglycan	36	39	PF01048	0.328
MOD_GSK3_1	115	122	PF00069	0.707
MOD_GSK3_1	59	66	PF00069	0.376
MOD_GSK3_1	87	94	PF00069	0.490
MOD_N-GLC_1	59	64	PF02516	0.223
MOD_NEK2_1	117	122	PF00069	0.621
MOD_NEK2_1	229	234	PF00069	0.532
MOD_NEK2_1	34	39	PF00069	0.363
MOD_PIKK_1	101	107	PF00454	0.592
MOD_PIKK_1	15	21	PF00454	0.328
MOD_PIKK_1	59	65	PF00454	0.302
MOD_PKA_1	99	105	PF00069	0.575
MOD_PKA_2	150	156	PF00069	0.535
MOD_PKA_2	167	173	PF00069	0.614
MOD_PKA_2	75	81	PF00069	0.381
MOD_PKA_2	91	97	PF00069	0.459
MOD_PKA_2	99	105	PF00069	0.535
MOD_Plk_1	251	257	PF00069	0.493
MOD_Plk_4	107	113	PF00069	0.473
MOD_Plk_4	160	166	PF00069	0.358
MOD_Plk_4	245	251	PF00069	0.532
MOD_Plk_4	29	35	PF00069	0.256
MOD_ProDKin_1	155	161	PF00069	0.434
MOD_SUMO_rev_2	214	221	PF00179	0.572
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.493
TRG_ENDOCYTIC_2	82	85	PF00928	0.387
TRG_ER_diArg_1	200	202	PF00400	0.361
TRG_ER_diArg_1	223	225	PF00400	0.354
TRG_ER_diArg_1	99	101	PF00400	0.603
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	239	244	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILJ3	Leptomonas seymouri	61%	93%
A0A0S4ING3	Bodo saltans	45%	100%
A0A1X0P2S0	Trypanosomatidae	45%	80%
A0A422NY87	Trypanosoma rangeli	46%	94%
A0A451EJ77	Leishmania donovani	84%	88%
A4HRE1	Leishmania infantum	85%	88%
C9ZXF7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AC09	Leishmania major	84%	100%
E9AJA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	89%
V5AQ10	Trypanosoma cruzi	48%	100%