cwf21 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H343_LEIBR

TriTrypDb:

LbrM.01.0220 , LBRM2903_010006800

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H343

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H343

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	161	163	PF00675	0.512
CLV_NRD_NRD_1	167	169	PF00675	0.513
CLV_NRD_NRD_1	53	55	PF00675	0.650
CLV_PCSK_KEX2_1	160	162	PF00082	0.512
CLV_PCSK_KEX2_1	167	169	PF00082	0.513
CLV_PCSK_KEX2_1	180	182	PF00082	0.479
CLV_PCSK_KEX2_1	53	55	PF00082	0.651
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.397
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.475
CLV_PCSK_SKI1_1	78	82	PF00082	0.371
DEG_Nend_Nbox_1	1	3	PF02207	0.475
DEG_SPOP_SBC_1	136	140	PF00917	0.644
DOC_CYCLIN_RxL_1	73	85	PF00134	0.298
DOC_MAPK_gen_1	73	81	PF00069	0.405
DOC_MAPK_MEF2A_6	73	81	PF00069	0.371
DOC_USP7_MATH_1	144	148	PF00917	0.559
DOC_USP7_UBL2_3	112	116	PF12436	0.530
DOC_USP7_UBL2_3	125	129	PF12436	0.546
LIG_14-3-3_CanoR_1	23	33	PF00244	0.505
LIG_Actin_WH2_2	59	75	PF00022	0.438
LIG_APCC_ABBA_1	79	84	PF00400	0.383
LIG_APCC_ABBAyCdc20_2	78	84	PF00400	0.357
LIG_LIR_Gen_1	102	111	PF02991	0.470
LIG_LIR_Nem_3	102	107	PF02991	0.472
LIG_NRBOX	76	82	PF00104	0.305
LIG_Pex14_2	130	134	PF04695	0.428
LIG_SH2_STAP1	104	108	PF00017	0.416
LIG_SH2_STAT5	18	21	PF00017	0.458
LIG_TRAF2_1	154	157	PF00917	0.613
LIG_TRAF2_1	169	172	PF00917	0.390
LIG_TRAF2_1	33	36	PF00917	0.609
MOD_CK1_1	149	155	PF00069	0.532
MOD_CK1_1	184	190	PF00069	0.425
MOD_CK2_1	151	157	PF00069	0.563
MOD_CK2_1	160	166	PF00069	0.459
MOD_GlcNHglycan	146	149	PF01048	0.671
MOD_GlcNHglycan	15	18	PF01048	0.418
MOD_GlcNHglycan	26	29	PF01048	0.511
MOD_GSK3_1	135	142	PF00069	0.622
MOD_GSK3_1	6	13	PF00069	0.367
MOD_N-GLC_1	24	29	PF02516	0.512
MOD_NEK2_1	103	108	PF00069	0.359
MOD_NEK2_1	151	156	PF00069	0.622
MOD_PKA_1	160	166	PF00069	0.389
MOD_PKA_2	160	166	PF00069	0.631
MOD_Plk_2-3	92	98	PF00069	0.456
MOD_Plk_4	103	109	PF00069	0.385
TRG_ENDOCYTIC_2	104	107	PF00928	0.445
TRG_ENDOCYTIC_2	2	5	PF00928	0.447
TRG_ER_diArg_1	167	170	PF00400	0.542
TRG_ER_diArg_1	21	24	PF00400	0.531
TRG_ER_diArg_1	75	78	PF00400	0.456
TRG_NLS_Bipartite_1	167	184	PF00514	0.498
TRG_NLS_MonoExtC_3	179	185	PF00514	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8C9	Leptomonas seymouri	66%	100%
A0A0S4IKH1	Bodo saltans	41%	93%
A0A1X0P2X2	Trypanosomatidae	47%	100%
A0A3R7MZG4	Trypanosoma rangeli	46%	100%
A0A3S5H4T7	Leishmania donovani	79%	93%
A4HRE0	Leishmania infantum	79%	93%
C9ZXF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AC08	Leishmania major	77%	100%
E9AJA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
Q38FI2	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	40%	100%