Putative CLC-type chloride channel

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CLC-type chloride channel, putative

Species:

Leishmania braziliensis

UniProt:

A4H342_LEIBR

TriTrypDb:

LbrM.01.0210 , LBRM2903_010006700

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005768	endosome	7	1
GO:0005769	early endosome	8	1
GO:0005794	Golgi apparatus	5	1
GO:0005886	plasma membrane	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4H342

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H342

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0005216	monoatomic ion channel activity	4	12
GO:0005244	voltage-gated monoatomic ion channel activity	4	12
GO:0005247	voltage-gated chloride channel activity	6	12
GO:0005253	monoatomic anion channel activity	5	12
GO:0005254	chloride channel activity	6	12
GO:0008308	voltage-gated monoatomic anion channel activity	5	12
GO:0008509	monoatomic anion transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015103	inorganic anion transmembrane transporter activity	4	12
GO:0015108	chloride transmembrane transporter activity	5	12
GO:0015267	channel activity	4	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0022803	passive transmembrane transporter activity	3	12
GO:0022832	voltage-gated channel activity	6	12
GO:0022836	gated channel activity	5	12
GO:0022857	transmembrane transporter activity	2	12
GO:0005451	obsolete monoatomic cation:proton antiporter activity	5	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015078	proton transmembrane transporter activity	5	1
GO:0015291	secondary active transmembrane transporter activity	4	1
GO:0015297	antiporter activity	5	1
GO:0015298	obsolete solute:monoatomic cation antiporter activity	5	1
GO:0015299	obsolete solute:proton antiporter activity	6	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022853	active monoatomic ion transmembrane transporter activity	4	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	356	358	PF00675	0.237
CLV_NRD_NRD_1	52	54	PF00675	0.424
CLV_NRD_NRD_1	735	737	PF00675	0.439
CLV_NRD_NRD_1	744	746	PF00675	0.364
CLV_PCSK_FUR_1	733	737	PF00082	0.464
CLV_PCSK_FUR_1	740	744	PF00082	0.409
CLV_PCSK_KEX2_1	194	196	PF00082	0.237
CLV_PCSK_KEX2_1	51	53	PF00082	0.420
CLV_PCSK_KEX2_1	67	69	PF00082	0.448
CLV_PCSK_KEX2_1	735	737	PF00082	0.437
CLV_PCSK_KEX2_1	742	744	PF00082	0.374
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.279
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.341
CLV_PCSK_PC7_1	47	53	PF00082	0.340
CLV_PCSK_PC7_1	740	746	PF00082	0.288
CLV_PCSK_SKI1_1	359	363	PF00082	0.258
CLV_PCSK_SKI1_1	416	420	PF00082	0.462
CLV_PCSK_SKI1_1	578	582	PF00082	0.333
CLV_PCSK_SKI1_1	682	686	PF00082	0.362
CLV_PCSK_SKI1_1	700	704	PF00082	0.243
DEG_SCF_FBW7_1	382	387	PF00400	0.301
DOC_AGCK_PIF_1	429	434	PF00069	0.297
DOC_CKS1_1	381	386	PF01111	0.282
DOC_CYCLIN_RxL_1	680	690	PF00134	0.503
DOC_CYCLIN_yClb5_NLxxxL_5	659	668	PF00134	0.538
DOC_MAPK_gen_1	362	371	PF00069	0.450
DOC_MAPK_gen_1	562	569	PF00069	0.602
DOC_MAPK_gen_1	623	631	PF00069	0.543
DOC_MAPK_gen_1	710	716	PF00069	0.493
DOC_MAPK_MEF2A_6	221	228	PF00069	0.237
DOC_PP4_FxxP_1	265	268	PF00568	0.282
DOC_PP4_FxxP_1	327	330	PF00568	0.237
DOC_PP4_FxxP_1	381	384	PF00568	0.298
DOC_USP7_MATH_1	104	108	PF00917	0.385
DOC_USP7_MATH_1	174	178	PF00917	0.492
DOC_USP7_MATH_1	239	243	PF00917	0.331
DOC_USP7_MATH_1	384	388	PF00917	0.279
DOC_USP7_MATH_1	4	8	PF00917	0.737
DOC_USP7_MATH_1	403	407	PF00917	0.194
DOC_USP7_MATH_1	651	655	PF00917	0.673
DOC_USP7_MATH_1	677	681	PF00917	0.571
DOC_USP7_UBL2_3	358	362	PF12436	0.370
DOC_USP7_UBL2_3	572	576	PF12436	0.428
DOC_WW_Pin1_4	380	385	PF00397	0.282
DOC_WW_Pin1_4	399	404	PF00397	0.253
DOC_WW_Pin1_4	59	64	PF00397	0.642
LIG_14-3-3_CanoR_1	100	109	PF00244	0.212
LIG_14-3-3_CanoR_1	416	422	PF00244	0.334
LIG_14-3-3_CanoR_1	646	651	PF00244	0.575
LIG_14-3-3_CanoR_1	68	74	PF00244	0.540
LIG_14-3-3_CanoR_1	754	761	PF00244	0.506
LIG_BRCT_BRCA1_1	236	240	PF00533	0.258
LIG_BRCT_BRCA1_1	281	285	PF00533	0.531
LIG_BRCT_BRCA1_1	472	476	PF00533	0.263
LIG_Clathr_ClatBox_1	672	676	PF01394	0.603
LIG_deltaCOP1_diTrp_1	29	38	PF00928	0.488
LIG_eIF4E_1	283	289	PF01652	0.479
LIG_FHA_1	19	25	PF00498	0.603
LIG_FHA_1	202	208	PF00498	0.342
LIG_FHA_1	295	301	PF00498	0.293
LIG_FHA_1	308	314	PF00498	0.220
LIG_FHA_1	343	349	PF00498	0.384
LIG_FHA_1	374	380	PF00498	0.373
LIG_FHA_1	431	437	PF00498	0.238
LIG_FHA_1	505	511	PF00498	0.291
LIG_FHA_1	516	522	PF00498	0.425
LIG_FHA_1	544	550	PF00498	0.522
LIG_FHA_1	612	618	PF00498	0.501
LIG_FHA_1	663	669	PF00498	0.534
LIG_FHA_1	691	697	PF00498	0.592
LIG_FHA_1	747	753	PF00498	0.651
LIG_KLC1_Yacidic_2	564	568	PF13176	0.627
LIG_LIR_Apic_2	520	526	PF02991	0.438
LIG_LIR_Gen_1	222	232	PF02991	0.237
LIG_LIR_Gen_1	29	38	PF02991	0.566
LIG_LIR_Gen_1	344	353	PF02991	0.298
LIG_LIR_Gen_1	426	436	PF02991	0.386
LIG_LIR_Gen_1	546	551	PF02991	0.597
LIG_LIR_Gen_1	564	574	PF02991	0.581
LIG_LIR_Gen_1	642	651	PF02991	0.563
LIG_LIR_Gen_1	656	667	PF02991	0.589
LIG_LIR_Gen_1	712	719	PF02991	0.527
LIG_LIR_LC3C_4	21	25	PF02991	0.668
LIG_LIR_Nem_3	133	137	PF02991	0.281
LIG_LIR_Nem_3	150	154	PF02991	0.282
LIG_LIR_Nem_3	171	175	PF02991	0.499
LIG_LIR_Nem_3	222	228	PF02991	0.237
LIG_LIR_Nem_3	237	243	PF02991	0.237
LIG_LIR_Nem_3	282	288	PF02991	0.441
LIG_LIR_Nem_3	29	35	PF02991	0.599
LIG_LIR_Nem_3	344	349	PF02991	0.295
LIG_LIR_Nem_3	36	41	PF02991	0.604
LIG_LIR_Nem_3	426	432	PF02991	0.386
LIG_LIR_Nem_3	546	550	PF02991	0.599
LIG_LIR_Nem_3	564	569	PF02991	0.593
LIG_LIR_Nem_3	603	608	PF02991	0.512
LIG_LIR_Nem_3	642	647	PF02991	0.546
LIG_LIR_Nem_3	656	662	PF02991	0.612
LIG_LIR_Nem_3	712	716	PF02991	0.497
LIG_MYND_1	557	561	PF01753	0.494
LIG_Pex14_1	101	105	PF04695	0.319
LIG_Pex14_1	134	138	PF04695	0.300
LIG_Pex14_2	459	463	PF04695	0.417
LIG_Pex14_2	565	569	PF04695	0.615
LIG_PTB_Apo_2	574	581	PF02174	0.601
LIG_REV1ctd_RIR_1	135	145	PF16727	0.321
LIG_SH2_CRK	491	495	PF00017	0.282
LIG_SH2_CRK	523	527	PF00017	0.531
LIG_SH2_NCK_1	41	45	PF00017	0.482
LIG_SH2_NCK_1	491	495	PF00017	0.282
LIG_SH2_SRC	491	494	PF00017	0.282
LIG_SH2_SRC	547	550	PF00017	0.494
LIG_SH2_SRC	558	561	PF00017	0.505
LIG_SH2_STAP1	41	45	PF00017	0.482
LIG_SH2_STAP1	547	551	PF00017	0.436
LIG_SH2_STAT3	586	589	PF00017	0.590
LIG_SH2_STAT3	71	74	PF00017	0.509
LIG_SH2_STAT5	154	157	PF00017	0.287
LIG_SH2_STAT5	167	170	PF00017	0.296
LIG_SH2_STAT5	196	199	PF00017	0.437
LIG_SH2_STAT5	41	44	PF00017	0.479
LIG_SH2_STAT5	434	437	PF00017	0.388
LIG_SH2_STAT5	474	477	PF00017	0.270
LIG_SH2_STAT5	558	561	PF00017	0.569
LIG_SH2_STAT5	566	569	PF00017	0.575
LIG_SH2_STAT5	644	647	PF00017	0.598
LIG_SH2_STAT5	686	689	PF00017	0.522
LIG_SH3_3	22	28	PF00018	0.591
LIG_SUMO_SIM_anti_2	368	373	PF11976	0.377
LIG_TRAF2_1	465	468	PF00917	0.262
LIG_UBA3_1	527	535	PF00899	0.372
LIG_UBA3_1	684	689	PF00899	0.513
LIG_Vh1_VBS_1	493	511	PF01044	0.298
LIG_WRC_WIRS_1	436	441	PF05994	0.318
MOD_CK1_1	212	218	PF00069	0.287
MOD_CK1_1	344	350	PF00069	0.418
MOD_CK1_1	39	45	PF00069	0.647
MOD_CK1_1	612	618	PF00069	0.568
MOD_CK1_1	640	646	PF00069	0.487
MOD_CK1_1	690	696	PF00069	0.529
MOD_CK2_1	130	136	PF00069	0.295
MOD_CK2_1	37	43	PF00069	0.560
MOD_CK2_1	402	408	PF00069	0.216
MOD_CK2_1	462	468	PF00069	0.313
MOD_GlcNHglycan	102	105	PF01048	0.486
MOD_GlcNHglycan	106	109	PF01048	0.483
MOD_GlcNHglycan	176	179	PF01048	0.262
MOD_GlcNHglycan	188	191	PF01048	0.206
MOD_GlcNHglycan	214	217	PF01048	0.282
MOD_GlcNHglycan	236	239	PF01048	0.527
MOD_GlcNHglycan	386	389	PF01048	0.454
MOD_GlcNHglycan	568	572	PF01048	0.233
MOD_GlcNHglycan	609	612	PF01048	0.279
MOD_GlcNHglycan	758	761	PF01048	0.492
MOD_GSK3_1	100	107	PF00069	0.293
MOD_GSK3_1	380	387	PF00069	0.342
MOD_GSK3_1	399	406	PF00069	0.262
MOD_GSK3_1	417	424	PF00069	0.269
MOD_GSK3_1	462	469	PF00069	0.317
MOD_GSK3_1	470	477	PF00069	0.262
MOD_GSK3_1	52	59	PF00069	0.659
MOD_GSK3_1	607	614	PF00069	0.458
MOD_GSK3_1	752	759	PF00069	0.501
MOD_N-GLC_1	600	605	PF02516	0.391
MOD_N-GLC_1	662	667	PF02516	0.285
MOD_N-GLC_2	126	128	PF02516	0.618
MOD_NEK2_1	116	121	PF00069	0.290
MOD_NEK2_1	168	173	PF00069	0.311
MOD_NEK2_1	209	214	PF00069	0.298
MOD_NEK2_1	300	305	PF00069	0.314
MOD_NEK2_1	307	312	PF00069	0.249
MOD_NEK2_1	341	346	PF00069	0.289
MOD_NEK2_1	421	426	PF00069	0.342
MOD_NEK2_1	432	437	PF00069	0.342
MOD_NEK2_1	462	467	PF00069	0.314
MOD_NEK2_1	515	520	PF00069	0.437
MOD_NEK2_1	567	572	PF00069	0.491
MOD_NEK2_1	600	605	PF00069	0.540
MOD_NEK2_1	687	692	PF00069	0.523
MOD_NEK2_2	677	682	PF00069	0.576
MOD_PIKK_1	651	657	PF00454	0.526
MOD_PKA_1	52	58	PF00069	0.714
MOD_PKA_2	52	58	PF00069	0.654
MOD_PKA_2	753	759	PF00069	0.502
MOD_PKA_2	761	767	PF00069	0.515
MOD_PKB_1	635	643	PF00069	0.461
MOD_Plk_1	116	122	PF00069	0.327
MOD_Plk_1	367	373	PF00069	0.218
MOD_Plk_1	403	409	PF00069	0.258
MOD_Plk_1	612	618	PF00069	0.524
MOD_Plk_1	637	643	PF00069	0.565
MOD_Plk_1	677	683	PF00069	0.573
MOD_Plk_2-3	130	136	PF00069	0.381
MOD_Plk_2-3	31	37	PF00069	0.560
MOD_Plk_4	183	189	PF00069	0.531
MOD_Plk_4	367	373	PF00069	0.192
MOD_Plk_4	435	441	PF00069	0.318
MOD_Plk_4	470	476	PF00069	0.249
MOD_Plk_4	612	618	PF00069	0.530
MOD_Plk_4	640	646	PF00069	0.536
MOD_ProDKin_1	380	386	PF00069	0.282
MOD_ProDKin_1	399	405	PF00069	0.253
MOD_ProDKin_1	59	65	PF00069	0.640
MOD_SUMO_for_1	561	564	PF00179	0.534
MOD_SUMO_for_1	702	705	PF00179	0.428
MOD_SUMO_rev_2	177	187	PF00179	0.479
MOD_SUMO_rev_2	548	557	PF00179	0.538
TRG_ENDOCYTIC_2	154	157	PF00928	0.287
TRG_ENDOCYTIC_2	491	494	PF00928	0.304
TRG_ENDOCYTIC_2	547	550	PF00928	0.609
TRG_ENDOCYTIC_2	566	569	PF00928	0.610
TRG_ENDOCYTIC_2	644	647	PF00928	0.598
TRG_ENDOCYTIC_2	701	704	PF00928	0.597
TRG_ER_diArg_1	50	53	PF00400	0.643
TRG_ER_diArg_1	634	637	PF00400	0.574
TRG_ER_diArg_1	740	743	PF00400	0.573
TRG_NLS_MonoExtN_4	355	361	PF00514	0.479
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	591	595	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	736	741	PF00026	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6P9	Leptomonas seymouri	78%	100%
A0A0N1IHR6	Leptomonas seymouri	28%	66%
A0A0N1IJL2	Leptomonas seymouri	24%	87%
A0A0S4IKD3	Bodo saltans	57%	100%
A0A0S4IL39	Bodo saltans	54%	100%
A0A0S4JG93	Bodo saltans	24%	90%
A0A1X0NKT6	Trypanosomatidae	26%	80%
A0A1X0NSH7	Trypanosomatidae	25%	83%
A0A1X0P2R6	Trypanosomatidae	63%	100%
A0A3Q8IH43	Leishmania donovani	24%	87%
A0A3R7KRB4	Trypanosoma rangeli	23%	85%
A0A3S5IRJ9	Trypanosoma rangeli	26%	78%
A0A422NY59	Trypanosoma rangeli	66%	100%
A0A451EJ75	Leishmania donovani	87%	100%
A4HKY2	Leishmania braziliensis	22%	87%
A4HRD9	Leishmania infantum	87%	100%
C9ZY92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	82%
D0AAR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	83%
E9AC07	Leishmania major	86%	100%
E9AHM3	Leishmania infantum	24%	87%
E9AJA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AK82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	68%
E9B3C0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	87%
O18894	Oryctolagus cuniculus	32%	94%
O35454	Mus musculus	29%	88%
O60159	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O70496	Mus musculus	27%	96%
O94287	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
P0C197	Ustilago maydis (strain 521 / FGSC 9021)	33%	68%
P35523	Homo sapiens	27%	78%
P35524	Rattus norvegicus	27%	77%
P35525	Rattus norvegicus	27%	85%
P37020	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	99%
P51788	Homo sapiens	27%	86%
P51789	Oryctolagus cuniculus	27%	86%
P51790	Homo sapiens	32%	94%
P51791	Mus musculus	32%	94%
P51792	Rattus norvegicus	33%	94%
P51793	Homo sapiens	32%	100%
P51794	Rattus norvegicus	32%	100%
P51795	Homo sapiens	32%	94%
P51796	Rattus norvegicus	32%	94%
P51797	Homo sapiens	30%	88%
P51798	Homo sapiens	28%	95%
P51799	Rattus norvegicus	27%	96%
P51800	Homo sapiens	26%	100%
P51801	Homo sapiens	26%	100%
P51802	Rattus norvegicus	26%	100%
P51803	Oryctolagus cuniculus	25%	100%
P51804	Oryctolagus cuniculus	26%	100%
P60300	Arabidopsis thaliana	25%	100%
P92941	Arabidopsis thaliana	24%	99%
P92942	Arabidopsis thaliana	23%	98%
P92943	Arabidopsis thaliana	26%	97%
Q06393	Rattus norvegicus	26%	100%
Q4PKH3	Bos taurus	28%	95%
Q4Q4T5	Leishmania major	25%	87%
Q54AX6	Dictyostelium discoideum	27%	89%
Q54C67	Dictyostelium discoideum	27%	95%
Q54LQ4	Dictyostelium discoideum	25%	77%
Q5RBK4	Pongo abelii	32%	94%
Q5RDJ7	Pongo abelii	32%	96%
Q61418	Mus musculus	32%	100%
Q64347	Mus musculus	28%	77%
Q75JF3	Dictyostelium discoideum	29%	100%
Q86AZ6	Dictyostelium discoideum	28%	94%
Q96282	Arabidopsis thaliana	25%	99%
Q99P66	Cavia porcellus	34%	100%
Q9BMK9	Caenorhabditis elegans	29%	77%
Q9GKE7	Sus scrofa	33%	94%
Q9MZT1	Canis lupus familiaris	27%	79%
Q9R0A1	Mus musculus	27%	85%
Q9R279	Cavia porcellus	32%	94%
Q9TT16	Oryctolagus cuniculus	29%	88%
Q9TTU3	Oryctolagus cuniculus	32%	94%
Q9W701	Xenopus laevis	26%	100%
Q9WU45	Cavia porcellus	28%	85%
Q9WUB6	Mus musculus	26%	100%
Q9WUB7	Mus musculus	25%	100%
Q9WVD4	Mus musculus	32%	94%
V5AY77	Trypanosoma cruzi	25%	79%
V5BEI7	Trypanosoma cruzi	66%	100%
V5BVK3	Trypanosoma cruzi	24%	85%