Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H341_LEIBR

TriTrypDb:

LbrM.01.0200 , LBRM2903_010006600

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H341

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H341

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	7	11	PF00656	0.520
CLV_C14_Caspase3-7	86	90	PF00656	0.566
CLV_MEL_PAP_1	293	299	PF00089	0.566
CLV_NRD_NRD_1	199	201	PF00675	0.547
CLV_NRD_NRD_1	26	28	PF00675	0.821
CLV_NRD_NRD_1	295	297	PF00675	0.571
CLV_NRD_NRD_1	407	409	PF00675	0.578
CLV_NRD_NRD_1	42	44	PF00675	0.560
CLV_PCSK_FUR_1	24	28	PF00082	0.554
CLV_PCSK_KEX2_1	199	201	PF00082	0.543
CLV_PCSK_KEX2_1	24	26	PF00082	0.820
CLV_PCSK_KEX2_1	295	297	PF00082	0.571
CLV_PCSK_KEX2_1	325	327	PF00082	0.654
CLV_PCSK_KEX2_1	407	409	PF00082	0.691
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.654
CLV_PCSK_PC7_1	403	409	PF00082	0.535
CLV_PCSK_SKI1_1	290	294	PF00082	0.446
CLV_PCSK_SKI1_1	427	431	PF00082	0.474
DEG_APCC_DBOX_1	224	232	PF00400	0.462
DEG_SPOP_SBC_1	106	110	PF00917	0.528
DOC_CKS1_1	95	100	PF01111	0.523
DOC_CYCLIN_yClb5_NLxxxL_5	230	239	PF00134	0.326
DOC_MAPK_gen_1	245	253	PF00069	0.350
DOC_MAPK_gen_1	43	51	PF00069	0.557
DOC_MAPK_gen_1	439	448	PF00069	0.664
DOC_MAPK_MEF2A_6	245	253	PF00069	0.490
DOC_MAPK_MEF2A_6	439	448	PF00069	0.507
DOC_PP2B_LxvP_1	121	124	PF13499	0.554
DOC_PP4_FxxP_1	364	367	PF00568	0.590
DOC_USP7_MATH_1	169	173	PF00917	0.674
DOC_USP7_MATH_1	273	277	PF00917	0.499
DOC_USP7_MATH_1	304	308	PF00917	0.645
DOC_USP7_MATH_1	35	39	PF00917	0.543
DOC_USP7_MATH_1	367	371	PF00917	0.641
DOC_USP7_MATH_1	402	406	PF00917	0.624
DOC_USP7_MATH_1	409	413	PF00917	0.622
DOC_USP7_MATH_1	83	87	PF00917	0.786
DOC_USP7_UBL2_3	40	44	PF12436	0.626
DOC_USP7_UBL2_3	67	71	PF12436	0.517
DOC_WW_Pin1_4	107	112	PF00397	0.612
DOC_WW_Pin1_4	14	19	PF00397	0.671
DOC_WW_Pin1_4	300	305	PF00397	0.674
DOC_WW_Pin1_4	340	345	PF00397	0.654
DOC_WW_Pin1_4	363	368	PF00397	0.635
DOC_WW_Pin1_4	419	424	PF00397	0.606
DOC_WW_Pin1_4	49	54	PF00397	0.515
DOC_WW_Pin1_4	94	99	PF00397	0.562
LIG_14-3-3_CanoR_1	174	183	PF00244	0.510
LIG_14-3-3_CanoR_1	225	231	PF00244	0.580
LIG_14-3-3_CanoR_1	258	265	PF00244	0.345
LIG_14-3-3_CanoR_1	357	362	PF00244	0.613
LIG_14-3-3_CanoR_1	408	414	PF00244	0.637
LIG_14-3-3_CanoR_1	65	73	PF00244	0.521
LIG_BIR_III_2	313	317	PF00653	0.549
LIG_Clathr_ClatBox_1	191	195	PF01394	0.484
LIG_deltaCOP1_diTrp_1	188	194	PF00928	0.644
LIG_deltaCOP1_diTrp_1	262	270	PF00928	0.467
LIG_FHA_1	168	174	PF00498	0.565
LIG_FHA_1	337	343	PF00498	0.509
LIG_FHA_1	393	399	PF00498	0.529
LIG_FHA_1	424	430	PF00498	0.632
LIG_FHA_1	74	80	PF00498	0.526
LIG_FHA_1	82	88	PF00498	0.501
LIG_FHA_2	151	157	PF00498	0.530
LIG_FHA_2	308	314	PF00498	0.726
LIG_FHA_2	336	342	PF00498	0.659
LIG_FHA_2	34	40	PF00498	0.655
LIG_LIR_Gen_1	132	141	PF02991	0.470
LIG_LIR_Gen_1	186	194	PF02991	0.590
LIG_LIR_Gen_1	229	240	PF02991	0.349
LIG_LIR_Nem_3	132	137	PF02991	0.461
LIG_LIR_Nem_3	186	192	PF02991	0.590
LIG_LIR_Nem_3	229	235	PF02991	0.350
LIG_MAD2	439	447	PF02301	0.507
LIG_PTB_Apo_2	55	62	PF02174	0.494
LIG_REV1ctd_RIR_1	59	69	PF16727	0.514
LIG_SH2_CRK	232	236	PF00017	0.324
LIG_SH2_CRK	438	442	PF00017	0.512
LIG_SH2_GRB2like	232	235	PF00017	0.326
LIG_SH2_NCK_1	337	341	PF00017	0.667
LIG_SH2_STAT5	337	340	PF00017	0.634
LIG_SH3_2	20	25	PF14604	0.563
LIG_SH3_3	163	169	PF00018	0.679
LIG_SH3_3	17	23	PF00018	0.746
LIG_SH3_3	438	444	PF00018	0.501
LIG_SH3_3	457	463	PF00018	0.503
LIG_SUMO_SIM_anti_2	227	232	PF11976	0.426
LIG_SUMO_SIM_par_1	161	167	PF11976	0.681
LIG_SUMO_SIM_par_1	52	57	PF11976	0.510
LIG_TYR_ITIM	230	235	PF00017	0.327
LIG_UBA3_1	239	245	PF00899	0.441
LIG_ULM_U2AF65_1	24	29	PF00076	0.620
LIG_WRC_WIRS_1	138	143	PF05994	0.485
LIG_WRC_WIRS_1	191	196	PF05994	0.481
LIG_WW_3	21	25	PF00397	0.538
MOD_CDC14_SPxK_1	21	24	PF00782	0.534
MOD_CDK_SPK_2	14	19	PF00069	0.541
MOD_CDK_SPxK_1	18	24	PF00069	0.532
MOD_CDK_SPxxK_3	18	25	PF00069	0.538
MOD_CDK_SPxxK_3	94	101	PF00069	0.523
MOD_CK1_1	130	136	PF00069	0.540
MOD_CK1_1	147	153	PF00069	0.610
MOD_CK1_1	167	173	PF00069	0.576
MOD_CK1_1	261	267	PF00069	0.483
MOD_CK1_1	300	306	PF00069	0.634
MOD_CK1_1	307	313	PF00069	0.641
MOD_CK1_1	355	361	PF00069	0.525
MOD_CK1_1	38	44	PF00069	0.605
MOD_CK1_1	382	388	PF00069	0.536
MOD_CK1_1	411	417	PF00069	0.615
MOD_CK2_1	159	165	PF00069	0.770
MOD_CK2_1	184	190	PF00069	0.579
MOD_CK2_1	33	39	PF00069	0.697
MOD_CK2_1	340	346	PF00069	0.716
MOD_Cter_Amidation	197	200	PF01082	0.627
MOD_GlcNHglycan	114	117	PF01048	0.638
MOD_GlcNHglycan	129	132	PF01048	0.562
MOD_GlcNHglycan	134	137	PF01048	0.508
MOD_GlcNHglycan	206	209	PF01048	0.524
MOD_GlcNHglycan	33	36	PF01048	0.555
MOD_GlcNHglycan	369	372	PF01048	0.596
MOD_GlcNHglycan	381	384	PF01048	0.764
MOD_GlcNHglycan	388	391	PF01048	0.664
MOD_GlcNHglycan	404	407	PF01048	0.526
MOD_GlcNHglycan	415	418	PF01048	0.678
MOD_GSK3_1	125	132	PF00069	0.604
MOD_GSK3_1	14	21	PF00069	0.625
MOD_GSK3_1	174	181	PF00069	0.531
MOD_GSK3_1	190	197	PF00069	0.485
MOD_GSK3_1	29	36	PF00069	0.703
MOD_GSK3_1	296	303	PF00069	0.481
MOD_GSK3_1	336	343	PF00069	0.586
MOD_GSK3_1	363	370	PF00069	0.542
MOD_GSK3_1	382	389	PF00069	0.675
MOD_GSK3_1	407	414	PF00069	0.615
MOD_GSK3_1	415	422	PF00069	0.675
MOD_GSK3_1	423	430	PF00069	0.566
MOD_GSK3_1	73	80	PF00069	0.599
MOD_N-GLC_1	144	149	PF02516	0.623
MOD_N-GLC_2	3	5	PF02516	0.476
MOD_NEK2_1	127	132	PF00069	0.619
MOD_NEK2_1	194	199	PF00069	0.496
MOD_NEK2_1	209	214	PF00069	0.387
MOD_NEK2_1	31	36	PF00069	0.544
MOD_NEK2_1	384	389	PF00069	0.666
MOD_NEK2_1	425	430	PF00069	0.484
MOD_NEK2_1	54	59	PF00069	0.567
MOD_NEK2_1	61	66	PF00069	0.528
MOD_NEK2_2	169	174	PF00069	0.519
MOD_NMyristoyl	1	7	PF02799	0.577
MOD_PIKK_1	164	170	PF00454	0.602
MOD_PIKK_1	355	361	PF00454	0.525
MOD_PKA_1	407	413	PF00069	0.531
MOD_PKA_2	198	204	PF00069	0.553
MOD_PKA_2	224	230	PF00069	0.410
MOD_PKA_2	402	408	PF00069	0.655
MOD_Plk_1	209	215	PF00069	0.466
MOD_Plk_1	261	267	PF00069	0.483
MOD_Plk_1	350	356	PF00069	0.537
MOD_Plk_1	38	44	PF00069	0.530
MOD_Plk_2-3	184	190	PF00069	0.579
MOD_Plk_4	159	165	PF00069	0.600
MOD_Plk_4	226	232	PF00069	0.426
MOD_Plk_4	273	279	PF00069	0.429
MOD_Plk_4	83	89	PF00069	0.549
MOD_ProDKin_1	107	113	PF00069	0.611
MOD_ProDKin_1	14	20	PF00069	0.671
MOD_ProDKin_1	300	306	PF00069	0.679
MOD_ProDKin_1	340	346	PF00069	0.657
MOD_ProDKin_1	363	369	PF00069	0.634
MOD_ProDKin_1	419	425	PF00069	0.605
MOD_ProDKin_1	49	55	PF00069	0.510
MOD_ProDKin_1	94	100	PF00069	0.563
TRG_DiLeu_BaEn_1	289	294	PF01217	0.517
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.329
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.508
TRG_ENDOCYTIC_2	232	235	PF00928	0.326
TRG_ENDOCYTIC_2	438	441	PF00928	0.510
TRG_ER_diArg_1	23	26	PF00400	0.748
TRG_ER_diArg_1	294	296	PF00400	0.561
TRG_NLS_Bipartite_1	25	47	PF00514	0.537
TRG_NLS_MonoExtN_4	40	47	PF00514	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I012	Leptomonas seymouri	31%	100%
A0A3S5H4T6	Leishmania donovani	52%	100%
A4HRD8	Leishmania infantum	52%	100%
E9AC06	Leishmania major	52%	100%
E9AJA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%