Plus3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H340_LEIBR

TriTrypDb:

LbrM.01.0090 , LBRM2903_010005500

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H340

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H340

PDB structure(s): 7aih_As , 7am2_As , 7ane_As

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.442
CLV_NRD_NRD_1	165	167	PF00675	0.545
CLV_NRD_NRD_1	179	181	PF00675	0.505
CLV_NRD_NRD_1	185	187	PF00675	0.625
CLV_NRD_NRD_1	2	4	PF00675	0.507
CLV_NRD_NRD_1	44	46	PF00675	0.373
CLV_PCSK_FUR_1	143	147	PF00082	0.430
CLV_PCSK_KEX2_1	145	147	PF00082	0.459
CLV_PCSK_KEX2_1	165	167	PF00082	0.336
CLV_PCSK_KEX2_1	185	187	PF00082	0.379
CLV_PCSK_KEX2_1	2	4	PF00082	0.507
CLV_PCSK_KEX2_1	44	46	PF00082	0.420
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.459
CLV_PCSK_SKI1_1	181	185	PF00082	0.497
CLV_PCSK_SKI1_1	2	6	PF00082	0.477
DEG_APCC_DBOX_1	44	52	PF00400	0.368
DEG_Nend_UBRbox_1	1	4	PF02207	0.511
DEG_SPOP_SBC_1	202	206	PF00917	0.511
DOC_CKS1_1	118	123	PF01111	0.402
DOC_MAPK_gen_1	44	51	PF00069	0.361
DOC_USP7_MATH_1	190	194	PF00917	0.550
DOC_USP7_MATH_1	201	205	PF00917	0.676
DOC_WW_Pin1_4	117	122	PF00397	0.395
LIG_14-3-3_CanoR_1	159	163	PF00244	0.576
LIG_14-3-3_CanoR_1	31	39	PF00244	0.460
LIG_Clathr_ClatBox_1	48	52	PF01394	0.375
LIG_FHA_1	15	21	PF00498	0.430
LIG_FHA_1	7	13	PF00498	0.500
LIG_FHA_1	72	78	PF00498	0.371
LIG_FHA_2	159	165	PF00498	0.524
LIG_FHA_2	203	209	PF00498	0.583
LIG_FHA_2	38	44	PF00498	0.383
LIG_LIR_Nem_3	43	49	PF02991	0.363
LIG_PCNA_yPIPBox_3	220	234	PF02747	0.476
LIG_Sin3_3	23	30	PF02671	0.449
LIG_SUMO_SIM_par_1	3	9	PF11976	0.445
LIG_UBA3_1	118	123	PF00899	0.462
LIG_UBA3_1	139	145	PF00899	0.478
LIG_WW_3	234	238	PF00397	0.657
MOD_CDK_SPxK_1	117	123	PF00069	0.399
MOD_CK1_1	204	210	PF00069	0.643
MOD_CK1_1	222	228	PF00069	0.522
MOD_CK2_1	202	208	PF00069	0.636
MOD_GlcNHglycan	126	130	PF01048	0.487
MOD_GlcNHglycan	230	233	PF01048	0.666
MOD_GlcNHglycan	35	38	PF01048	0.470
MOD_GSK3_1	130	137	PF00069	0.609
MOD_GSK3_1	33	40	PF00069	0.438
MOD_N-GLC_1	219	224	PF02516	0.477
MOD_NEK2_1	173	178	PF00069	0.550
MOD_NEK2_1	6	11	PF00069	0.418
MOD_PIKK_1	130	136	PF00454	0.692
MOD_PKA_2	151	157	PF00069	0.506
MOD_PKA_2	158	164	PF00069	0.536
MOD_PKA_2	173	179	PF00069	0.391
MOD_PKA_2	228	234	PF00069	0.633
MOD_PKA_2	37	43	PF00069	0.394
MOD_Plk_1	166	172	PF00069	0.433
MOD_Plk_1	219	225	PF00069	0.609
MOD_Plk_2-3	158	164	PF00069	0.491
MOD_Plk_4	222	228	PF00069	0.521
MOD_Plk_4	58	64	PF00069	0.345
MOD_ProDKin_1	117	123	PF00069	0.402
TRG_ER_diArg_1	1	3	PF00400	0.513
TRG_ER_diArg_1	184	186	PF00400	0.373
TRG_ER_diArg_1	44	46	PF00400	0.373
TRG_Pf-PMV_PEXEL_1	146	151	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	186	191	PF00026	0.654
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N8	Leptomonas seymouri	75%	100%
A0A0S4JMA4	Bodo saltans	60%	100%
A0A451EJ64	Leishmania donovani	75%	96%
A4HRC7	Leishmania infantum	75%	96%
C9ZXG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9ABZ5	Leishmania major	75%	100%
E9AJ92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	95%