Putative carboxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carboxylase, putative

Species:

Leishmania braziliensis

UniProt:

A4H339_LEIBR

TriTrypDb:

LbrM.01.0080 , LBRM2903_010005400

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H339

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H339

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	5
GO:0008152	metabolic process	1	5
GO:0009056	catabolic process	2	5
GO:0016042	lipid catabolic process	4	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901575	organic substance catabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016874	ligase activity	2	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0004658	propionyl-CoA carboxylase activity	5	5
GO:0016421	CoA carboxylase activity	4	5
GO:0016885	ligase activity, forming carbon-carbon bonds	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	638	642	PF00656	0.205
CLV_NRD_NRD_1	220	222	PF00675	0.252
CLV_NRD_NRD_1	237	239	PF00675	0.172
CLV_NRD_NRD_1	255	257	PF00675	0.221
CLV_PCSK_KEX2_1	124	126	PF00082	0.264
CLV_PCSK_KEX2_1	237	239	PF00082	0.177
CLV_PCSK_KEX2_1	476	478	PF00082	0.264
CLV_PCSK_KEX2_1	75	77	PF00082	0.182
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.264
CLV_PCSK_PC1ET2_1	476	478	PF00082	0.264
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.182
CLV_PCSK_SKI1_1	193	197	PF00082	0.264
CLV_PCSK_SKI1_1	44	48	PF00082	0.268
CLV_PCSK_SKI1_1	455	459	PF00082	0.289
CLV_PCSK_SKI1_1	597	601	PF00082	0.283
CLV_PCSK_SKI1_1	645	649	PF00082	0.315
DOC_MAPK_gen_1	221	228	PF00069	0.464
DOC_MAPK_gen_1	417	425	PF00069	0.421
DOC_MAPK_gen_1	643	651	PF00069	0.255
DOC_MAPK_HePTP_8	497	509	PF00069	0.468
DOC_MAPK_MEF2A_6	318	327	PF00069	0.421
DOC_MAPK_MEF2A_6	500	509	PF00069	0.499
DOC_MAPK_MEF2A_6	535	543	PF00069	0.421
DOC_MAPK_MEF2A_6	643	651	PF00069	0.255
DOC_PP2B_LxvP_1	226	229	PF13499	0.464
DOC_PP2B_PxIxI_1	538	544	PF00149	0.464
DOC_PP4_FxxP_1	106	109	PF00568	0.421
DOC_USP7_UBL2_3	120	124	PF12436	0.421
DOC_USP7_UBL2_3	189	193	PF12436	0.442
DOC_USP7_UBL2_3	631	635	PF12436	0.307
DOC_WW_Pin1_4	598	603	PF00397	0.256
LIG_14-3-3_CanoR_1	20	30	PF00244	0.421
LIG_14-3-3_CanoR_1	221	227	PF00244	0.464
LIG_14-3-3_CanoR_1	358	362	PF00244	0.477
LIG_14-3-3_CanoR_1	479	488	PF00244	0.517
LIG_Actin_WH2_2	135	152	PF00022	0.464
LIG_Actin_WH2_2	303	320	PF00022	0.464
LIG_Actin_WH2_2	412	429	PF00022	0.421
LIG_APCC_ABBA_1	359	364	PF00400	0.464
LIG_APCC_ABBA_1	382	387	PF00400	0.421
LIG_APCC_ABBAyCdc20_2	358	364	PF00400	0.464
LIG_Clathr_ClatBox_1	661	665	PF01394	0.321
LIG_FHA_1	223	229	PF00498	0.464
LIG_FHA_1	30	36	PF00498	0.421
LIG_FHA_1	302	308	PF00498	0.421
LIG_FHA_1	399	405	PF00498	0.442
LIG_FHA_1	440	446	PF00498	0.421
LIG_FHA_1	555	561	PF00498	0.445
LIG_FHA_1	568	574	PF00498	0.389
LIG_FHA_1	594	600	PF00498	0.299
LIG_FHA_2	142	148	PF00498	0.468
LIG_FHA_2	306	312	PF00498	0.421
LIG_FHA_2	326	332	PF00498	0.410
LIG_FHA_2	36	42	PF00498	0.421
LIG_FHA_2	457	463	PF00498	0.490
LIG_FHA_2	567	573	PF00498	0.456
LIG_FHA_2	636	642	PF00498	0.241
LIG_FHA_2	652	658	PF00498	0.265
LIG_LIR_Apic_2	360	365	PF02991	0.431
LIG_LIR_Apic_2	383	388	PF02991	0.421
LIG_LIR_Gen_1	62	71	PF02991	0.421
LIG_LIR_Nem_3	383	389	PF02991	0.421
LIG_LIR_Nem_3	537	541	PF02991	0.406
LIG_LIR_Nem_3	584	589	PF02991	0.366
LIG_LIR_Nem_3	62	67	PF02991	0.421
LIG_LYPXL_yS_3	157	160	PF13949	0.421
LIG_LYPXL_yS_3	538	541	PF13949	0.468
LIG_Pex14_1	534	538	PF04695	0.421
LIG_PTB_Apo_2	631	638	PF02174	0.179
LIG_PTB_Phospho_1	631	637	PF10480	0.179
LIG_SH2_CRK	386	390	PF00017	0.421
LIG_SH2_CRK	86	90	PF00017	0.421
LIG_SH2_NCK_1	36	40	PF00017	0.464
LIG_SH2_NCK_1	467	471	PF00017	0.290
LIG_SH2_NCK_1	637	641	PF00017	0.179
LIG_SH2_PTP2	494	497	PF00017	0.464
LIG_SH2_SRC	362	365	PF00017	0.431
LIG_SH2_STAP1	467	471	PF00017	0.290
LIG_SH2_STAP1	562	566	PF00017	0.366
LIG_SH2_STAT3	508	511	PF00017	0.468
LIG_SH2_STAT3	562	565	PF00017	0.421
LIG_SH2_STAT5	227	230	PF00017	0.421
LIG_SH2_STAT5	272	275	PF00017	0.421
LIG_SH2_STAT5	289	292	PF00017	0.421
LIG_SH2_STAT5	352	355	PF00017	0.421
LIG_SH2_STAT5	414	417	PF00017	0.421
LIG_SH2_STAT5	444	447	PF00017	0.445
LIG_SH2_STAT5	482	485	PF00017	0.516
LIG_SH2_STAT5	494	497	PF00017	0.409
LIG_SH2_STAT5	508	511	PF00017	0.464
LIG_SH2_STAT5	637	640	PF00017	0.179
LIG_SH2_STAT5	64	67	PF00017	0.421
LIG_SH3_1	362	368	PF00018	0.464
LIG_SH3_3	152	158	PF00018	0.464
LIG_SH3_3	278	284	PF00018	0.418
LIG_SH3_3	296	302	PF00018	0.447
LIG_SH3_3	362	368	PF00018	0.464
LIG_SH3_3	427	433	PF00018	0.421
LIG_SH3_3	533	539	PF00018	0.464
LIG_SH3_3	596	602	PF00018	0.243
LIG_SUMO_SIM_anti_2	308	314	PF11976	0.421
LIG_SUMO_SIM_par_1	31	38	PF11976	0.421
LIG_SUMO_SIM_par_1	322	328	PF11976	0.423
LIG_SUMO_SIM_par_1	622	628	PF11976	0.315
LIG_SUMO_SIM_par_1	659	665	PF11976	0.299
LIG_TRAF2_1	499	502	PF00917	0.503
LIG_TRAF2_1	620	623	PF00917	0.315
LIG_TRAF2_1	654	657	PF00917	0.179
LIG_TRAF2_2	446	451	PF00917	0.291
LIG_TYR_ITIM	384	389	PF00017	0.421
LIG_TYR_ITIM	536	541	PF00017	0.468
LIG_UBA3_1	389	398	PF00899	0.464
LIG_UBA3_1	624	631	PF00899	0.256
MOD_CK1_1	274	280	PF00069	0.464
MOD_CK1_1	380	386	PF00069	0.421
MOD_CK1_1	581	587	PF00069	0.385
MOD_CK1_1	60	66	PF00069	0.421
MOD_CK2_1	35	41	PF00069	0.421
MOD_CK2_1	456	462	PF00069	0.457
MOD_CK2_1	512	518	PF00069	0.464
MOD_CK2_1	651	657	PF00069	0.260
MOD_GlcNHglycan	163	166	PF01048	0.221
MOD_GlcNHglycan	273	276	PF01048	0.264
MOD_GlcNHglycan	373	376	PF01048	0.252
MOD_GlcNHglycan	436	439	PF01048	0.268
MOD_GlcNHglycan	497	500	PF01048	0.166
MOD_GlcNHglycan	96	99	PF01048	0.204
MOD_GSK3_1	301	308	PF00069	0.424
MOD_GSK3_1	434	441	PF00069	0.464
MOD_GSK3_1	456	463	PF00069	0.418
MOD_GSK3_1	574	581	PF00069	0.385
MOD_GSK3_1	589	596	PF00069	0.495
MOD_N-GLC_2	422	424	PF02516	0.221
MOD_NEK2_1	377	382	PF00069	0.385
MOD_NEK2_1	493	498	PF00069	0.429
MOD_NEK2_1	512	517	PF00069	0.335
MOD_NEK2_1	566	571	PF00069	0.421
MOD_NEK2_2	357	362	PF00069	0.464
MOD_OFUCOSY	19	25	PF10250	0.221
MOD_PIKK_1	325	331	PF00454	0.488
MOD_PIKK_1	377	383	PF00454	0.421
MOD_PIKK_1	460	466	PF00454	0.433
MOD_PIKK_1	480	486	PF00454	0.461
MOD_PIKK_1	635	641	PF00454	0.179
MOD_PK_1	231	237	PF00069	0.421
MOD_PKA_2	357	363	PF00069	0.421
MOD_Plk_1	231	237	PF00069	0.421
MOD_Plk_1	477	483	PF00069	0.376
MOD_Plk_1	512	518	PF00069	0.563
MOD_Plk_2-3	110	116	PF00069	0.464
MOD_Plk_2-3	623	629	PF00069	0.256
MOD_Plk_4	222	228	PF00069	0.464
MOD_Plk_4	245	251	PF00069	0.464
MOD_Plk_4	357	363	PF00069	0.471
MOD_Plk_4	547	553	PF00069	0.421
MOD_Plk_4	578	584	PF00069	0.441
MOD_Plk_4	589	595	PF00069	0.523
MOD_Plk_4	60	66	PF00069	0.421
MOD_ProDKin_1	598	604	PF00069	0.256
MOD_SUMO_for_1	475	478	PF00179	0.468
MOD_SUMO_for_1	499	502	PF00179	0.413
MOD_SUMO_rev_2	119	126	PF00179	0.464
MOD_SUMO_rev_2	186	195	PF00179	0.464
MOD_SUMO_rev_2	248	255	PF00179	0.421
MOD_SUMO_rev_2	326	334	PF00179	0.412
MOD_SUMO_rev_2	641	650	PF00179	0.262
TRG_DiLeu_BaEn_1	657	662	PF01217	0.179
TRG_DiLeu_BaEn_4	622	628	PF01217	0.315
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.424
TRG_ENDOCYTIC_2	157	160	PF00928	0.421
TRG_ENDOCYTIC_2	184	187	PF00928	0.468
TRG_ENDOCYTIC_2	386	389	PF00928	0.421
TRG_ENDOCYTIC_2	494	497	PF00928	0.464
TRG_ENDOCYTIC_2	538	541	PF00928	0.468
TRG_ENDOCYTIC_2	64	67	PF00928	0.421
TRG_ENDOCYTIC_2	86	89	PF00928	0.421
TRG_NES_CRM1_1	578	591	PF08389	0.429
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.221
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.264
TRG_Pf-PMV_PEXEL_1	510	514	PF00026	0.242

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P730	Leptomonas seymouri	85%	100%
A0A0N1HV47	Leptomonas seymouri	37%	97%
A0A0S4IX46	Bodo saltans	39%	98%
A0A0S4JIQ8	Bodo saltans	67%	100%
A0A1X0NJV2	Trypanosomatidae	38%	98%
A0A3Q8IKH3	Leishmania donovani	37%	97%
A0A422NEZ1	Trypanosoma rangeli	39%	98%
A0A451EJ63	Leishmania donovani	93%	100%
A4HJV8	Leishmania braziliensis	37%	97%
A4HRC6	Leishmania infantum	93%	100%
A4I7C0	Leishmania infantum	37%	97%
C9ZWI5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	90%
D3DJ42	Hydrogenobacter thermophilus (strain DSM 6534 / IAM 12695 / TK-6)	47%	100%
E9ABZ4	Leishmania major	92%	100%
E9AJ91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B2B3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	97%
I3R7G3	Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4)	38%	100%
O30019	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	46%	100%
O34544	Bacillus subtilis (strain 168)	49%	100%
P05165	Homo sapiens	53%	91%
P0A509	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	50%	100%
P0DTA4	Sus scrofa	52%	91%
P14882	Rattus norvegicus	52%	90%
P43873	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	49%	100%
P9WPQ2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	50%	100%
P9WPQ3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	50%	100%
Q19842	Caenorhabditis elegans	50%	92%
Q2QMG2	Oryza sativa subsp. japonica	46%	90%
Q42523	Arabidopsis thaliana	37%	91%
Q42777	Glycine max	36%	91%
Q4Q5U3	Leishmania major	37%	100%
Q58626	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	48%	100%
Q5I0C3	Rattus norvegicus	38%	93%
Q5LUF3	Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)	46%	98%
Q612F5	Caenorhabditis briggsae	50%	90%
Q91ZA3	Mus musculus	52%	92%
Q96RQ3	Homo sapiens	40%	92%
Q99MR8	Mus musculus	38%	93%
V5BDW2	Trypanosoma cruzi	37%	95%