GYF domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H338_LEIBR

TriTrypDb:

LbrM.01.0070 , LBRM2903_010005300

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H338

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H338

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.472
CLV_NRD_NRD_1	172	174	PF00675	0.394
CLV_NRD_NRD_1	75	77	PF00675	0.449
CLV_PCSK_KEX2_1	120	122	PF00082	0.472
CLV_PCSK_KEX2_1	2	4	PF00082	0.588
CLV_PCSK_KEX2_1	75	77	PF00082	0.411
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.568
CLV_PCSK_SKI1_1	177	181	PF00082	0.453
CLV_PCSK_SKI1_1	67	71	PF00082	0.441
DEG_Nend_UBRbox_1	1	4	PF02207	0.575
DEG_SCF_FBW7_1	48	55	PF00400	0.371
DEG_SPOP_SBC_1	33	37	PF00917	0.539
DOC_CYCLIN_RxL_1	63	72	PF00134	0.336
DOC_MAPK_DCC_7	121	131	PF00069	0.453
DOC_MAPK_gen_1	105	113	PF00069	0.446
DOC_MAPK_gen_1	120	126	PF00069	0.361
DOC_MAPK_gen_1	173	182	PF00069	0.458
DOC_MAPK_MEF2A_6	173	182	PF00069	0.458
DOC_USP7_MATH_1	16	20	PF00917	0.521
DOC_USP7_MATH_1	33	37	PF00917	0.539
DOC_USP7_MATH_1	9	13	PF00917	0.530
DOC_WW_Pin1_4	29	34	PF00397	0.532
DOC_WW_Pin1_4	48	53	PF00397	0.432
LIG_14-3-3_CanoR_1	177	183	PF00244	0.446
LIG_14-3-3_CanoR_1	3	8	PF00244	0.555
LIG_Clathr_ClatBox_1	39	43	PF01394	0.473
LIG_FHA_1	18	24	PF00498	0.582
LIG_FHA_1	49	55	PF00498	0.362
LIG_LIR_Apic_2	43	48	PF02991	0.461
LIG_SH2_NCK_1	45	49	PF00017	0.447
LIG_SH2_SRC	45	48	PF00017	0.482
LIG_SH2_STAT5	158	161	PF00017	0.464
LIG_SUMO_SIM_par_1	34	44	PF11976	0.471
LIG_TRAF2_1	115	118	PF00917	0.454
LIG_TRAF2_1	41	44	PF00917	0.606
MOD_CK1_1	19	25	PF00069	0.631
MOD_CK1_1	26	32	PF00069	0.554
MOD_CK1_1	34	40	PF00069	0.550
MOD_CK2_1	11	17	PF00069	0.643
MOD_Cter_Amidation	159	162	PF01082	0.464
MOD_GlcNHglycan	13	16	PF01048	0.575
MOD_GlcNHglycan	25	28	PF01048	0.489
MOD_GlcNHglycan	7	10	PF01048	0.641
MOD_GlcNHglycan	77	80	PF01048	0.339
MOD_GSK3_1	17	24	PF00069	0.595
MOD_GSK3_1	29	36	PF00069	0.444
MOD_GSK3_1	48	55	PF00069	0.381
MOD_GSK3_1	5	12	PF00069	0.591
MOD_NEK2_1	23	28	PF00069	0.644
MOD_PIKK_1	94	100	PF00454	0.408
MOD_PKA_1	75	81	PF00069	0.473
MOD_PKA_2	104	110	PF00069	0.446
MOD_PKA_2	119	125	PF00069	0.554
MOD_PKA_2	75	81	PF00069	0.473
MOD_PKB_1	3	11	PF00069	0.582
MOD_Plk_4	35	41	PF00069	0.687
MOD_Plk_4	52	58	PF00069	0.387
MOD_ProDKin_1	29	35	PF00069	0.531
MOD_ProDKin_1	48	54	PF00069	0.427
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.434
TRG_ER_diArg_1	74	76	PF00400	0.452
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	5	10	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8D7	Leptomonas seymouri	53%	100%
A0A451EJ62	Leishmania donovani	81%	100%
E9ABZ3	Leishmania major	82%	100%
E9AJ90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%