Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinesin-13 1, putative

Species:

Leishmania braziliensis

UniProt:

A4H337_LEIBR

TriTrypDb:

LbrM.01.0060 , LBRM2903_010005200

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	14
GO:0099080	supramolecular complex	2	14
GO:0099081	supramolecular polymer	3	14
GO:0099512	supramolecular fiber	4	14
GO:0099513	polymeric cytoskeletal fiber	5	14
GO:0110165	cellular anatomical entity	1	14
GO:0000922	spindle pole	2	1
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4H337

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H337

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	14
GO:0007018	microtubule-based movement	3	14
GO:0009987	cellular process	1	14
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007019	microtubule depolymerization	5	1
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022411	cellular component disassembly	4	1
GO:0031109	microtubule polymerization or depolymerization	4	1
GO:0032984	protein-containing complex disassembly	5	1
GO:0043933	protein-containing complex organization	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051261	protein depolymerization	6	1
GO:0051983	regulation of chromosome segregation	4	1
GO:0065007	biological regulation	1	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003774	cytoskeletal motor activity	1	14
GO:0003777	microtubule motor activity	2	14
GO:0005488	binding	1	14
GO:0005515	protein binding	2	14
GO:0005524	ATP binding	5	14
GO:0008017	microtubule binding	5	14
GO:0008092	cytoskeletal protein binding	3	14
GO:0015631	tubulin binding	4	14
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140657	ATP-dependent activity	1	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.289
CLV_C14_Caspase3-7	80	84	PF00656	0.718
CLV_NRD_NRD_1	102	104	PF00675	0.750
CLV_NRD_NRD_1	124	126	PF00675	0.411
CLV_NRD_NRD_1	133	135	PF00675	0.249
CLV_NRD_NRD_1	170	172	PF00675	0.343
CLV_NRD_NRD_1	18	20	PF00675	0.498
CLV_NRD_NRD_1	253	255	PF00675	0.147
CLV_NRD_NRD_1	274	276	PF00675	0.333
CLV_NRD_NRD_1	454	456	PF00675	0.484
CLV_NRD_NRD_1	478	480	PF00675	0.729
CLV_NRD_NRD_1	501	503	PF00675	0.532
CLV_NRD_NRD_1	630	632	PF00675	0.483
CLV_PCSK_KEX2_1	101	103	PF00082	0.758
CLV_PCSK_KEX2_1	124	126	PF00082	0.414
CLV_PCSK_KEX2_1	135	137	PF00082	0.252
CLV_PCSK_KEX2_1	18	20	PF00082	0.498
CLV_PCSK_KEX2_1	253	255	PF00082	0.147
CLV_PCSK_KEX2_1	274	276	PF00082	0.333
CLV_PCSK_KEX2_1	339	341	PF00082	0.362
CLV_PCSK_KEX2_1	448	450	PF00082	0.436
CLV_PCSK_KEX2_1	454	456	PF00082	0.475
CLV_PCSK_KEX2_1	478	480	PF00082	0.737
CLV_PCSK_KEX2_1	501	503	PF00082	0.503
CLV_PCSK_KEX2_1	543	545	PF00082	0.544
CLV_PCSK_KEX2_1	567	569	PF00082	0.684
CLV_PCSK_KEX2_1	629	631	PF00082	0.483
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.417
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.295
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.276
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.419
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.544
CLV_PCSK_PC1ET2_1	567	569	PF00082	0.603
CLV_PCSK_PC1ET2_1	629	631	PF00082	0.452
CLV_PCSK_PC7_1	474	480	PF00082	0.549
CLV_PCSK_PC7_1	563	569	PF00082	0.607
CLV_PCSK_SKI1_1	178	182	PF00082	0.203
CLV_PCSK_SKI1_1	243	247	PF00082	0.273
CLV_PCSK_SKI1_1	290	294	PF00082	0.333
CLV_PCSK_SKI1_1	36	40	PF00082	0.439
CLV_PCSK_SKI1_1	378	382	PF00082	0.249
CLV_PCSK_SKI1_1	445	449	PF00082	0.409
CLV_Separin_Metazoa	406	410	PF03568	0.203
DEG_APCC_DBOX_1	273	281	PF00400	0.203
DOC_CYCLIN_RxL_1	375	385	PF00134	0.249
DOC_MAPK_gen_1	124	133	PF00069	0.369
DOC_MAPK_gen_1	162	170	PF00069	0.333
DOC_MAPK_gen_1	253	259	PF00069	0.347
DOC_MAPK_MEF2A_6	124	133	PF00069	0.365
DOC_MAPK_MEF2A_6	162	170	PF00069	0.333
DOC_MAPK_MEF2A_6	327	336	PF00069	0.292
DOC_USP7_MATH_1	153	157	PF00917	0.444
DOC_USP7_MATH_1	312	316	PF00917	0.431
DOC_USP7_MATH_1	500	504	PF00917	0.595
DOC_USP7_MATH_1	539	543	PF00917	0.649
DOC_USP7_MATH_1	545	549	PF00917	0.644
DOC_USP7_MATH_1	578	582	PF00917	0.486
DOC_USP7_MATH_1	632	636	PF00917	0.446
DOC_USP7_MATH_1	74	78	PF00917	0.555
DOC_USP7_UBL2_3	335	339	PF12436	0.282
DOC_USP7_UBL2_3	343	347	PF12436	0.203
DOC_WW_Pin1_4	422	427	PF00397	0.249
DOC_WW_Pin1_4	491	496	PF00397	0.581
DOC_WW_Pin1_4	87	92	PF00397	0.631
LIG_14-3-3_CanoR_1	102	112	PF00244	0.516
LIG_14-3-3_CanoR_1	24	30	PF00244	0.319
LIG_14-3-3_CanoR_1	254	260	PF00244	0.341
LIG_14-3-3_CanoR_1	449	457	PF00244	0.633
LIG_14-3-3_CanoR_1	478	484	PF00244	0.551
LIG_14-3-3_CanoR_1	501	506	PF00244	0.693
LIG_14-3-3_CanoR_1	509	515	PF00244	0.695
LIG_14-3-3_CanoR_1	623	633	PF00244	0.454
LIG_Actin_WH2_2	48	63	PF00022	0.321
LIG_AP2alpha_2	488	490	PF02296	0.442
LIG_BRCT_BRCA1_1	344	348	PF00533	0.215
LIG_FHA_1	108	114	PF00498	0.452
LIG_FHA_1	146	152	PF00498	0.254
LIG_FHA_1	403	409	PF00498	0.249
LIG_FHA_1	416	422	PF00498	0.249
LIG_FHA_1	454	460	PF00498	0.605
LIG_FHA_1	479	485	PF00498	0.611
LIG_FHA_1	494	500	PF00498	0.468
LIG_FHA_2	203	209	PF00498	0.290
LIG_FHA_2	32	38	PF00498	0.489
LIG_FHA_2	347	353	PF00498	0.249
LIG_FHA_2	367	373	PF00498	0.122
LIG_FHA_2	636	642	PF00498	0.456
LIG_Integrin_isoDGR_2	272	274	PF01839	0.203
LIG_LIR_Gen_1	144	153	PF02991	0.427
LIG_LIR_Gen_1	244	252	PF02991	0.271
LIG_LIR_Gen_1	345	354	PF02991	0.258
LIG_LIR_Nem_3	144	150	PF02991	0.414
LIG_LIR_Nem_3	244	249	PF02991	0.264
LIG_LIR_Nem_3	258	263	PF02991	0.225
LIG_LIR_Nem_3	345	351	PF02991	0.256
LIG_LIR_Nem_3	44	49	PF02991	0.398
LIG_LIR_Nem_3	565	569	PF02991	0.551
LIG_LIR_Nem_3	585	590	PF02991	0.456
LIG_LRP6_Inhibitor_1	593	599	PF00058	0.251
LIG_NRBOX	266	272	PF00104	0.249
LIG_PCNA_TLS_4	630	637	PF02747	0.454
LIG_Pex14_2	181	185	PF04695	0.203
LIG_Pex14_2	25	29	PF04695	0.446
LIG_RPA_C_Fungi	618	630	PF08784	0.455
LIG_SH2_NCK_1	238	242	PF00017	0.203
LIG_SH2_PTP2	173	176	PF00017	0.147
LIG_SH2_SRC	173	176	PF00017	0.147
LIG_SH2_SRC	590	593	PF00017	0.326
LIG_SH2_STAP1	238	242	PF00017	0.203
LIG_SH2_STAP1	440	444	PF00017	0.249
LIG_SH2_STAT5	105	108	PF00017	0.460
LIG_SH2_STAT5	12	15	PF00017	0.432
LIG_SH2_STAT5	173	176	PF00017	0.249
LIG_SH2_STAT5	590	593	PF00017	0.370
LIG_SH2_STAT5	66	69	PF00017	0.346
LIG_SH3_3	109	115	PF00018	0.567
LIG_SUMO_SIM_par_1	379	385	PF11976	0.220
LIG_UBA3_1	331	339	PF00899	0.218
LIG_UBA3_1	380	384	PF00899	0.278
LIG_WRC_WIRS_1	256	261	PF05994	0.203
LIG_WRC_WIRS_1	633	638	PF05994	0.456
MOD_CDK_SPxxK_3	87	94	PF00069	0.628
MOD_CK1_1	222	228	PF00069	0.249
MOD_CK1_1	28	34	PF00069	0.429
MOD_CK1_1	315	321	PF00069	0.230
MOD_CK1_1	325	331	PF00069	0.287
MOD_CK1_1	342	348	PF00069	0.249
MOD_CK1_1	402	408	PF00069	0.249
MOD_CK1_1	477	483	PF00069	0.618
MOD_CK1_1	507	513	PF00069	0.615
MOD_CK1_1	515	521	PF00069	0.598
MOD_CK1_1	558	564	PF00069	0.532
MOD_CK1_1	635	641	PF00069	0.514
MOD_CK2_1	136	142	PF00069	0.167
MOD_CK2_1	255	261	PF00069	0.255
MOD_CK2_1	295	301	PF00069	0.228
MOD_CK2_1	366	372	PF00069	0.249
MOD_CK2_1	614	620	PF00069	0.435
MOD_CK2_1	86	92	PF00069	0.599
MOD_Cter_Amidation	272	275	PF01082	0.333
MOD_Cter_Amidation	99	102	PF01082	0.523
MOD_GlcNHglycan	138	141	PF01048	0.228
MOD_GlcNHglycan	154	158	PF01048	0.143
MOD_GlcNHglycan	2	5	PF01048	0.556
MOD_GlcNHglycan	210	213	PF01048	0.284
MOD_GlcNHglycan	221	224	PF01048	0.291
MOD_GlcNHglycan	263	266	PF01048	0.221
MOD_GlcNHglycan	344	347	PF01048	0.215
MOD_GlcNHglycan	44	49	PF01048	0.477
MOD_GlcNHglycan	560	563	PF01048	0.657
MOD_GlcNHglycan	72	75	PF01048	0.621
MOD_GlcNHglycan	76	79	PF01048	0.682
MOD_GSK3_1	103	110	PF00069	0.469
MOD_GSK3_1	141	148	PF00069	0.242
MOD_GSK3_1	24	31	PF00069	0.329
MOD_GSK3_1	290	297	PF00069	0.252
MOD_GSK3_1	312	319	PF00069	0.223
MOD_GSK3_1	321	328	PF00069	0.192
MOD_GSK3_1	338	345	PF00069	0.203
MOD_GSK3_1	449	456	PF00069	0.604
MOD_GSK3_1	470	477	PF00069	0.673
MOD_GSK3_1	478	485	PF00069	0.536
MOD_GSK3_1	489	496	PF00069	0.538
MOD_GSK3_1	500	507	PF00069	0.619
MOD_GSK3_1	510	517	PF00069	0.580
MOD_GSK3_1	525	532	PF00069	0.483
MOD_GSK3_1	558	565	PF00069	0.652
MOD_GSK3_1	70	77	PF00069	0.515
MOD_N-GLC_1	195	200	PF02516	0.147
MOD_N-GLC_1	321	326	PF02516	0.203
MOD_N-GLC_1	376	381	PF02516	0.249
MOD_NEK2_1	202	207	PF00069	0.399
MOD_NEK2_1	25	30	PF00069	0.448
MOD_NEK2_1	399	404	PF00069	0.288
MOD_NEK2_1	408	413	PF00069	0.288
MOD_NEK2_1	505	510	PF00069	0.623
MOD_NEK2_1	514	519	PF00069	0.633
MOD_NEK2_1	525	530	PF00069	0.456
MOD_NEK2_1	72	77	PF00069	0.506
MOD_NEK2_2	210	215	PF00069	0.249
MOD_PIKK_1	516	522	PF00454	0.529
MOD_PIKK_1	6	12	PF00454	0.400
MOD_PIKK_1	635	641	PF00454	0.484
MOD_PKA_1	124	130	PF00069	0.367
MOD_PKA_1	339	345	PF00069	0.333
MOD_PKA_1	478	484	PF00069	0.645
MOD_PKA_1	501	507	PF00069	0.537
MOD_PKA_2	107	113	PF00069	0.453
MOD_PKA_2	124	130	PF00069	0.358
MOD_PKA_2	247	253	PF00069	0.381
MOD_PKA_2	339	345	PF00069	0.375
MOD_PKA_2	366	372	PF00069	0.203
MOD_PKA_2	399	405	PF00069	0.249
MOD_PKA_2	408	414	PF00069	0.265
MOD_PKA_2	453	459	PF00069	0.625
MOD_PKA_2	477	483	PF00069	0.591
MOD_PKA_2	500	506	PF00069	0.520
MOD_PKA_2	545	551	PF00069	0.592
MOD_PKA_2	558	564	PF00069	0.492
MOD_PKB_1	101	109	PF00069	0.491
MOD_PKB_1	134	142	PF00069	0.273
MOD_Plk_1	376	382	PF00069	0.249
MOD_Plk_1	431	437	PF00069	0.249
MOD_Plk_4	108	114	PF00069	0.452
MOD_Plk_4	202	208	PF00069	0.252
MOD_Plk_4	224	230	PF00069	0.249
MOD_Plk_4	255	261	PF00069	0.282
MOD_Plk_4	302	308	PF00069	0.346
MOD_Plk_4	376	382	PF00069	0.249
MOD_Plk_4	408	414	PF00069	0.203
MOD_Plk_4	501	507	PF00069	0.626
MOD_Plk_4	614	620	PF00069	0.329
MOD_Plk_4	632	638	PF00069	0.416
MOD_ProDKin_1	422	428	PF00069	0.249
MOD_ProDKin_1	491	497	PF00069	0.580
MOD_ProDKin_1	87	93	PF00069	0.631
MOD_SUMO_for_1	598	601	PF00179	0.371
MOD_SUMO_rev_2	158	166	PF00179	0.337
MOD_SUMO_rev_2	328	336	PF00179	0.203
MOD_SUMO_rev_2	442	450	PF00179	0.190
TRG_AP2beta_CARGO_1	244	253	PF09066	0.147
TRG_DiLeu_BaEn_1	620	625	PF01217	0.355
TRG_DiLeu_BaEn_2	384	390	PF01217	0.389
TRG_DiLeu_LyEn_5	620	625	PF01217	0.355
TRG_ENDOCYTIC_2	173	176	PF00928	0.310
TRG_ENDOCYTIC_2	49	52	PF00928	0.414
TRG_ER_diArg_1	101	103	PF00400	0.629
TRG_ER_diArg_1	133	136	PF00400	0.228
TRG_ER_diArg_1	17	19	PF00400	0.490
TRG_ER_diArg_1	253	255	PF00400	0.147
TRG_ER_diArg_1	274	276	PF00400	0.333
TRG_ER_diArg_1	58	61	PF00400	0.341
TRG_ER_diArg_1	580	583	PF00400	0.540
TRG_ER_diArg_1	621	624	PF00400	0.453
TRG_NLS_Bipartite_1	124	138	PF00514	0.355
TRG_NLS_MonoCore_2	542	547	PF00514	0.435
TRG_NLS_MonoExtC_3	123	128	PF00514	0.507
TRG_NLS_MonoExtN_4	124	129	PF00514	0.370
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.322
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.203
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.203
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	582	586	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	623	628	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P6	Leptomonas seymouri	72%	100%
A0A0S4IP49	Bodo saltans	26%	82%
A0A1X0NJN6	Trypanosomatidae	27%	100%
A0A1X0NQ03	Trypanosomatidae	27%	80%
A0A1X0P2U1	Trypanosomatidae	47%	94%
A0A3S5H4S8	Leishmania donovani	88%	99%
A0A3S7WST0	Leishmania donovani	46%	100%
A0A3S7X9Y1	Leishmania donovani	34%	100%
A0A422NY45	Trypanosoma rangeli	57%	95%
A4H7F1	Leishmania braziliensis	45%	91%
A4HAQ7	Leishmania braziliensis	26%	100%
A4HND6	Leishmania braziliensis	34%	100%
A4HRC5	Leishmania infantum	88%	99%
A4HSA6	Leishmania infantum	33%	100%
A4HVT9	Leishmania infantum	46%	100%
A4IC09	Leishmania infantum	34%	100%
C9ZXH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	96%
E9ABZ2	Leishmania major	88%	100%
E9AFU7	Leishmania major	34%	100%
E9AJ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
E9B6Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q5R9Y9	Pongo abelii	40%	89%
Q940Y8	Arabidopsis thaliana	39%	97%
V5D311	Trypanosoma cruzi	47%	98%