Nocturnin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Nocturnin

Gene product:

Endonuclease/Exonuclease/phosphatase family, putative

Species:

Leishmania braziliensis

UniProt:

A4H336_LEIBR

TriTrypDb:

LbrM.01.0050 , LBRM2903_010005100

Length:

553

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H336

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H336

Function

Biological processes
Term	Name	Level	Count
GO:0007623	circadian rhythm	2	11
GO:0010468	regulation of gene expression	5	11
GO:0019222	regulation of metabolic process	3	11
GO:0032501	multicellular organismal process	1	11
GO:0032922	circadian regulation of gene expression	2	11
GO:0048511	rhythmic process	1	11
GO:0050789	regulation of biological process	2	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	11
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004527	exonuclease activity	5	11
GO:0004532	RNA exonuclease activity	5	11
GO:0004535	poly(A)-specific ribonuclease activity	8	11
GO:0004540	RNA nuclease activity	4	11
GO:0008408	3'-5' exonuclease activity	6	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	11
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0004519	endonuclease activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.385
CLV_C14_Caspase3-7	301	305	PF00656	0.426
CLV_C14_Caspase3-7	36	40	PF00656	0.573
CLV_NRD_NRD_1	156	158	PF00675	0.289
CLV_NRD_NRD_1	210	212	PF00675	0.272
CLV_NRD_NRD_1	3	5	PF00675	0.561
CLV_NRD_NRD_1	395	397	PF00675	0.331
CLV_NRD_NRD_1	480	482	PF00675	0.311
CLV_NRD_NRD_1	73	75	PF00675	0.535
CLV_NRD_NRD_1	90	92	PF00675	0.330
CLV_PCSK_KEX2_1	156	158	PF00082	0.290
CLV_PCSK_KEX2_1	29	31	PF00082	0.465
CLV_PCSK_KEX2_1	3	5	PF00082	0.561
CLV_PCSK_KEX2_1	478	480	PF00082	0.252
CLV_PCSK_KEX2_1	73	75	PF00082	0.488
CLV_PCSK_KEX2_1	90	92	PF00082	0.342
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.465
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.344
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.479
CLV_PCSK_SKI1_1	179	183	PF00082	0.289
CLV_PCSK_SKI1_1	297	301	PF00082	0.349
CLV_PCSK_SKI1_1	373	377	PF00082	0.386
CLV_PCSK_SKI1_1	549	553	PF00082	0.603
CLV_Separin_Metazoa	162	166	PF03568	0.335
CLV_Separin_Metazoa	335	339	PF03568	0.404
DEG_APCC_DBOX_1	156	164	PF00400	0.270
DEG_APCC_DBOX_1	296	304	PF00400	0.349
DEG_APCC_KENBOX_2	481	485	PF00400	0.193
DEG_Nend_Nbox_1	1	3	PF02207	0.546
DEG_ODPH_VHL_1	151	163	PF01847	0.193
DOC_CKS1_1	428	433	PF01111	0.459
DOC_MAPK_gen_1	156	163	PF00069	0.404
DOC_MAPK_gen_1	265	273	PF00069	0.271
DOC_MAPK_gen_1	3	9	PF00069	0.613
DOC_MAPK_MEF2A_6	267	275	PF00069	0.271
DOC_PP1_RVXF_1	186	193	PF00149	0.414
DOC_PP2B_LxvP_1	245	248	PF13499	0.404
DOC_PP2B_LxvP_1	507	510	PF13499	0.271
DOC_PP4_FxxP_1	150	153	PF00568	0.279
DOC_PP4_FxxP_1	495	498	PF00568	0.289
DOC_USP7_MATH_1	13	17	PF00917	0.592
DOC_USP7_MATH_1	217	221	PF00917	0.270
DOC_USP7_MATH_1	311	315	PF00917	0.323
DOC_USP7_MATH_1	378	382	PF00917	0.396
DOC_USP7_UBL2_3	478	482	PF12436	0.314
DOC_WW_Pin1_4	109	114	PF00397	0.511
DOC_WW_Pin1_4	427	432	PF00397	0.368
DOC_WW_Pin1_4	438	443	PF00397	0.396
DOC_WW_Pin1_4	454	459	PF00397	0.384
LIG_14-3-3_CanoR_1	3	8	PF00244	0.522
LIG_14-3-3_CanoR_1	338	342	PF00244	0.333
LIG_14-3-3_CanoR_1	352	358	PF00244	0.345
LIG_14-3-3_CanoR_1	95	100	PF00244	0.360
LIG_APCC_ABBA_1	531	536	PF00400	0.342
LIG_BIR_III_4	104	108	PF00653	0.518
LIG_BIR_III_4	304	308	PF00653	0.335
LIG_BRCT_BRCA1_1	338	342	PF00533	0.193
LIG_deltaCOP1_diTrp_1	185	192	PF00928	0.270
LIG_deltaCOP1_diTrp_1	536	543	PF00928	0.484
LIG_deltaCOP1_diTrp_1	92	99	PF00928	0.356
LIG_eIF4E_1	155	161	PF01652	0.362
LIG_FHA_1	109	115	PF00498	0.517
LIG_FHA_1	270	276	PF00498	0.273
LIG_FHA_1	342	348	PF00498	0.349
LIG_FHA_1	433	439	PF00498	0.193
LIG_FHA_1	498	504	PF00498	0.289
LIG_FHA_2	110	116	PF00498	0.446
LIG_FHA_2	299	305	PF00498	0.363
LIG_FHA_2	326	332	PF00498	0.367
LIG_FHA_2	540	546	PF00498	0.443
LIG_LIR_Apic_2	492	498	PF02991	0.289
LIG_LIR_Gen_1	98	105	PF02991	0.393
LIG_LIR_Nem_3	134	139	PF02991	0.401
LIG_LIR_Nem_3	184	190	PF02991	0.319
LIG_LIR_Nem_3	490	496	PF02991	0.271
LIG_LIR_Nem_3	541	546	PF02991	0.466
LIG_LIR_Nem_3	92	96	PF02991	0.369
LIG_MLH1_MIPbox_1	338	342	PF16413	0.193
LIG_MYND_1	149	153	PF01753	0.279
LIG_NRBOX	159	165	PF00104	0.270
LIG_PCNA_yPIPBox_3	179	190	PF02747	0.310
LIG_Pex14_1	539	543	PF04695	0.515
LIG_SH2_CRK	195	199	PF00017	0.271
LIG_SH2_CRK	402	406	PF00017	0.335
LIG_SH2_SRC	139	142	PF00017	0.405
LIG_SH2_SRC	496	499	PF00017	0.335
LIG_SH2_STAP1	367	371	PF00017	0.407
LIG_SH2_STAT3	488	491	PF00017	0.326
LIG_SH2_STAT5	189	192	PF00017	0.305
LIG_SH2_STAT5	274	277	PF00017	0.406
LIG_SH2_STAT5	371	374	PF00017	0.351
LIG_SH3_3	116	122	PF00018	0.375
LIG_SH3_3	345	351	PF00018	0.289
LIG_SH3_3	456	462	PF00018	0.298
LIG_SH3_3	74	80	PF00018	0.426
LIG_SUMO_SIM_anti_2	472	478	PF11976	0.335
LIG_SUMO_SIM_par_1	298	304	PF11976	0.404
LIG_SUMO_SIM_par_1	505	514	PF11976	0.271
LIG_TRAF2_1	226	229	PF00917	0.404
LIG_TRAF2_1	387	390	PF00917	0.334
LIG_TYR_ITIM	193	198	PF00017	0.349
LIG_WRC_WIRS_1	96	101	PF05994	0.371
MOD_CK1_1	314	320	PF00069	0.314
MOD_CK1_1	381	387	PF00069	0.284
MOD_CK1_1	457	463	PF00069	0.363
MOD_CK1_1	82	88	PF00069	0.440
MOD_CK2_1	109	115	PF00069	0.429
MOD_CK2_1	325	331	PF00069	0.367
MOD_CK2_1	42	48	PF00069	0.685
MOD_CK2_1	547	553	PF00069	0.485
MOD_CMANNOS	353	356	PF00535	0.271
MOD_GlcNHglycan	15	18	PF01048	0.622
MOD_GlcNHglycan	44	47	PF01048	0.658
MOD_GlcNHglycan	459	462	PF01048	0.414
MOD_GSK3_1	177	184	PF00069	0.412
MOD_GSK3_1	194	201	PF00069	0.234
MOD_GSK3_1	24	31	PF00069	0.704
MOD_GSK3_1	278	285	PF00069	0.271
MOD_GSK3_1	336	343	PF00069	0.477
MOD_GSK3_1	443	450	PF00069	0.268
MOD_GSK3_1	453	460	PF00069	0.206
MOD_GSK3_1	521	528	PF00069	0.322
MOD_GSK3_1	535	542	PF00069	0.399
MOD_GSK3_1	79	86	PF00069	0.475
MOD_N-GLC_1	177	182	PF02516	0.226
MOD_N-GLC_1	269	274	PF02516	0.311
MOD_N-GLC_1	325	330	PF02516	0.257
MOD_NEK2_1	198	203	PF00069	0.303
MOD_NEK2_1	24	29	PF00069	0.725
MOD_NEK2_1	336	341	PF00069	0.307
MOD_NEK2_1	443	448	PF00069	0.193
MOD_NEK2_1	84	89	PF00069	0.451
MOD_NEK2_2	194	199	PF00069	0.289
MOD_NEK2_2	547	552	PF00069	0.543
MOD_PIKK_1	40	46	PF00454	0.488
MOD_PIKK_1	487	493	PF00454	0.271
MOD_PIKK_1	79	85	PF00454	0.589
MOD_PK_1	3	9	PF00069	0.682
MOD_PKA_1	3	9	PF00069	0.591
MOD_PKA_2	3	9	PF00069	0.548
MOD_PKA_2	33	39	PF00069	0.446
MOD_PKA_2	337	343	PF00069	0.377
MOD_PKA_2	351	357	PF00069	0.294
MOD_Plk_1	177	183	PF00069	0.226
MOD_Plk_1	269	275	PF00069	0.311
MOD_Plk_1	381	387	PF00069	0.284
MOD_Plk_1	535	541	PF00069	0.319
MOD_Plk_4	194	200	PF00069	0.281
MOD_Plk_4	269	275	PF00069	0.408
MOD_Plk_4	298	304	PF00069	0.390
MOD_Plk_4	3	9	PF00069	0.613
MOD_Plk_4	33	39	PF00069	0.683
MOD_Plk_4	337	343	PF00069	0.402
MOD_Plk_4	50	56	PF00069	0.521
MOD_ProDKin_1	109	115	PF00069	0.507
MOD_ProDKin_1	427	433	PF00069	0.368
MOD_ProDKin_1	438	444	PF00069	0.396
MOD_ProDKin_1	454	460	PF00069	0.384
MOD_SUMO_rev_2	45	52	PF00179	0.574
TRG_DiLeu_BaEn_2	145	151	PF01217	0.314
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.193
TRG_ENDOCYTIC_2	189	192	PF00928	0.291
TRG_ENDOCYTIC_2	195	198	PF00928	0.254
TRG_ENDOCYTIC_2	402	405	PF00928	0.335
TRG_ER_diArg_1	155	157	PF00400	0.197
TRG_ER_diArg_1	2	4	PF00400	0.566
TRG_NLS_MonoExtC_3	477	482	PF00514	0.193
TRG_NLS_MonoExtN_4	70	77	PF00514	0.454
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.270
TRG_Pf-PMV_PEXEL_1	549	553	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Q6	Leptomonas seymouri	64%	100%
A0A0S4JIK0	Bodo saltans	41%	87%
A0A1X0P355	Trypanosomatidae	48%	99%
A0A3S5H4S7	Leishmania donovani	84%	100%
A4HRC4	Leishmania infantum	83%	100%
C9ZXH1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9ABZ1	Leishmania major	87%	99%
E9AJ88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5B795	Trypanosoma cruzi	50%	99%