Glycoprotein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Glycoprotein

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania braziliensis

UniProt:

A4H335_LEIBR

TriTrypDb:

LbrM.01.0040 , LBRM2903_010005000

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 15, no: 2
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A4H335

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H335

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	275	277	PF00675	0.387
CLV_NRD_NRD_1	282	284	PF00675	0.425
CLV_PCSK_FUR_1	273	277	PF00082	0.388
CLV_PCSK_KEX2_1	160	162	PF00082	0.539
CLV_PCSK_KEX2_1	273	275	PF00082	0.405
CLV_PCSK_KEX2_1	281	283	PF00082	0.450
CLV_PCSK_KEX2_1	75	77	PF00082	0.386
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.602
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.386
CLV_PCSK_SKI1_1	105	109	PF00082	0.627
CLV_PCSK_SKI1_1	112	116	PF00082	0.615
CLV_PCSK_SKI1_1	224	228	PF00082	0.628
CLV_PCSK_SKI1_1	233	237	PF00082	0.641
DEG_Nend_UBRbox_1	1	4	PF02207	0.603
DEG_SPOP_SBC_1	24	28	PF00917	0.435
DEG_SPOP_SBC_1	59	63	PF00917	0.276
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.327
DOC_USP7_MATH_1	204	208	PF00917	0.453
DOC_USP7_MATH_1	210	214	PF00917	0.429
DOC_USP7_MATH_1	297	301	PF00917	0.634
DOC_USP7_MATH_1	69	73	PF00917	0.365
DOC_USP7_UBL2_3	238	242	PF12436	0.299
DOC_WW_Pin1_4	126	131	PF00397	0.493
LIG_14-3-3_CanoR_1	2	6	PF00244	0.479
LIG_14-3-3_CanoR_1	306	311	PF00244	0.662
LIG_BRCT_BRCA1_1	176	180	PF00533	0.406
LIG_BRCT_BRCA1_1	3	7	PF00533	0.440
LIG_BRCT_BRCA1_1	35	39	PF00533	0.296
LIG_deltaCOP1_diTrp_1	100	108	PF00928	0.389
LIG_eIF4E_1	157	163	PF01652	0.423
LIG_FHA_1	109	115	PF00498	0.481
LIG_FHA_1	126	132	PF00498	0.298
LIG_FHA_1	179	185	PF00498	0.340
LIG_FHA_1	325	331	PF00498	0.737
LIG_FHA_2	127	133	PF00498	0.508
LIG_FHA_2	140	146	PF00498	0.428
LIG_LIR_Apic_2	232	237	PF02991	0.460
LIG_LIR_Gen_1	138	149	PF02991	0.451
LIG_LIR_Gen_1	177	188	PF02991	0.397
LIG_LIR_Gen_1	4	14	PF02991	0.197
LIG_LIR_Gen_1	47	55	PF02991	0.298
LIG_LIR_Nem_3	100	104	PF02991	0.371
LIG_LIR_Nem_3	138	144	PF02991	0.447
LIG_LIR_Nem_3	151	155	PF02991	0.387
LIG_LIR_Nem_3	177	183	PF02991	0.353
LIG_LIR_Nem_3	186	190	PF02991	0.337
LIG_LIR_Nem_3	4	10	PF02991	0.349
LIG_LIR_Nem_3	47	51	PF02991	0.298
LIG_SH2_CRK	104	108	PF00017	0.433
LIG_SH2_GRB2like	141	144	PF00017	0.343
LIG_SH2_GRB2like	290	293	PF00017	0.770
LIG_SH2_PTP2	256	259	PF00017	0.324
LIG_SH2_SRC	188	191	PF00017	0.463
LIG_SH2_STAP1	25	29	PF00017	0.309
LIG_SH2_STAT3	290	293	PF00017	0.653
LIG_SH2_STAT5	141	144	PF00017	0.419
LIG_SH2_STAT5	188	191	PF00017	0.380
LIG_SH2_STAT5	219	222	PF00017	0.365
LIG_SH2_STAT5	256	259	PF00017	0.403
LIG_SH2_STAT5	29	32	PF00017	0.243
LIG_SH3_1	198	204	PF00018	0.411
LIG_SH3_3	161	167	PF00018	0.362
LIG_SH3_3	198	204	PF00018	0.479
LIG_SUMO_SIM_anti_2	258	264	PF11976	0.390
LIG_TRAF2_1	65	68	PF00917	0.351
LIG_TYR_ITIM	119	124	PF00017	0.420
MOD_CK1_1	215	221	PF00069	0.463
MOD_CK1_1	305	311	PF00069	0.604
MOD_CK1_1	314	320	PF00069	0.651
MOD_CK1_1	33	39	PF00069	0.336
MOD_CK2_1	326	332	PF00069	0.761
MOD_CK2_1	62	68	PF00069	0.331
MOD_Cter_Amidation	158	161	PF01082	0.628
MOD_GlcNHglycan	137	140	PF01048	0.664
MOD_GlcNHglycan	167	170	PF01048	0.642
MOD_GlcNHglycan	206	209	PF01048	0.679
MOD_GlcNHglycan	214	217	PF01048	0.659
MOD_GlcNHglycan	32	35	PF01048	0.537
MOD_GlcNHglycan	62	65	PF01048	0.523
MOD_GlcNHglycan	71	74	PF01048	0.517
MOD_GlcNHglycan	79	82	PF01048	0.534
MOD_GSK3_1	131	138	PF00069	0.467
MOD_GSK3_1	139	146	PF00069	0.452
MOD_GSK3_1	171	178	PF00069	0.422
MOD_GSK3_1	19	26	PF00069	0.327
MOD_GSK3_1	211	218	PF00069	0.493
MOD_GSK3_1	302	309	PF00069	0.639
MOD_GSK3_1	311	318	PF00069	0.655
MOD_GSK3_1	320	327	PF00069	0.626
MOD_GSK3_1	55	62	PF00069	0.315
MOD_N-GLC_1	153	158	PF02516	0.665
MOD_N-GLC_1	318	323	PF02516	0.430
MOD_NEK2_1	1	6	PF00069	0.474
MOD_NEK2_1	107	112	PF00069	0.434
MOD_NEK2_1	302	307	PF00069	0.639
MOD_NEK2_1	315	320	PF00069	0.624
MOD_NEK2_1	60	65	PF00069	0.260
MOD_PIKK_1	227	233	PF00454	0.486
MOD_PKA_2	1	7	PF00069	0.546
MOD_PKA_2	108	114	PF00069	0.400
MOD_PKA_2	305	311	PF00069	0.647
MOD_Plk_1	153	159	PF00069	0.459
MOD_Plk_2-3	326	332	PF00069	0.730
MOD_Plk_4	153	159	PF00069	0.433
MOD_Plk_4	306	312	PF00069	0.660
MOD_ProDKin_1	126	132	PF00069	0.495
TRG_ENDOCYTIC_2	104	107	PF00928	0.406
TRG_ENDOCYTIC_2	121	124	PF00928	0.358
TRG_ENDOCYTIC_2	141	144	PF00928	0.361
TRG_ENDOCYTIC_2	256	259	PF00928	0.406
TRG_ER_diArg_1	273	276	PF00400	0.665
TRG_ER_diArg_1	281	283	PF00400	0.713

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P471	Leptomonas seymouri	36%	100%
A0A0N1I022	Leptomonas seymouri	49%	97%
A0A1X0NWG7	Trypanosomatidae	24%	90%
A0A1X0NWG9	Trypanosomatidae	26%	91%
A0A1X0NXT1	Trypanosomatidae	24%	91%
A0A1X0NY10	Trypanosomatidae	26%	100%
A0A3Q8IBH3	Leishmania donovani	35%	100%
A0A3S5H4S6	Leishmania donovani	85%	100%
A4HRC3	Leishmania infantum	85%	100%
A4HYN5	Leishmania infantum	36%	100%
E9ABZ0	Leishmania major	84%	100%
E9AI94	Leishmania braziliensis	34%	100%
E9AJ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
E9AUH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4QD05	Leishmania major	34%	100%
V5DS51	Trypanosoma cruzi	27%	94%