DNA-damage inducible protein DDI1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-damage inducible protein DDI1-like protein

Species:

Leishmania braziliensis

UniProt:

A4H334_LEIBR

TriTrypDb:

LbrM.01.0030 , LBRM2903_010011600

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H334

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H334

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0019538	protein metabolic process	3	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004175	endopeptidase activity	4	5
GO:0004190	aspartic-type endopeptidase activity	5	5
GO:0008233	peptidase activity	3	5
GO:0016787	hydrolase activity	2	5
GO:0070001	aspartic-type peptidase activity	4	5
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	282	284	PF00675	0.209
CLV_NRD_NRD_1	334	336	PF00675	0.761
CLV_PCSK_KEX2_1	216	218	PF00082	0.209
CLV_PCSK_KEX2_1	282	284	PF00082	0.213
CLV_PCSK_KEX2_1	334	336	PF00082	0.772
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.209
CLV_PCSK_SKI1_1	10	14	PF00082	0.589
CLV_PCSK_SKI1_1	344	348	PF00082	0.732
CLV_PCSK_SKI1_1	50	54	PF00082	0.383
DEG_SCF_TRCP1_1	206	212	PF00400	0.393
DEG_SIAH_1	139	147	PF03145	0.504
DEG_SPOP_SBC_1	95	99	PF00917	0.456
DOC_CDC14_PxL_1	370	378	PF14671	0.456
DOC_MAPK_gen_1	231	239	PF00069	0.409
DOC_MAPK_gen_1	282	290	PF00069	0.393
DOC_MAPK_gen_1	381	391	PF00069	0.421
DOC_MAPK_MEF2A_6	231	239	PF00069	0.486
DOC_MAPK_MEF2A_6	282	290	PF00069	0.404
DOC_MAPK_MEF2A_6	85	93	PF00069	0.350
DOC_PP1_RVXF_1	299	305	PF00149	0.308
DOC_PP2B_LxvP_1	190	193	PF13499	0.453
DOC_PP2B_LxvP_1	92	95	PF13499	0.391
DOC_USP7_MATH_1	120	124	PF00917	0.790
DOC_USP7_MATH_1	185	189	PF00917	0.409
DOC_USP7_MATH_1	209	213	PF00917	0.393
DOC_USP7_MATH_1	300	304	PF00917	0.333
DOC_USP7_MATH_1	57	61	PF00917	0.591
DOC_USP7_UBL2_3	198	202	PF12436	0.413
DOC_WW_Pin1_4	177	182	PF00397	0.453
LIG_14-3-3_CanoR_1	10	15	PF00244	0.443
LIG_14-3-3_CanoR_1	16	20	PF00244	0.364
LIG_14-3-3_CanoR_1	186	190	PF00244	0.409
LIG_14-3-3_CanoR_1	50	58	PF00244	0.399
LIG_14-3-3_CanoR_1	96	106	PF00244	0.488
LIG_FHA_1	250	256	PF00498	0.526
LIG_FHA_1	269	275	PF00498	0.397
LIG_FHA_1	51	57	PF00498	0.420
LIG_FHA_1	86	92	PF00498	0.414
LIG_FHA_1	97	103	PF00498	0.466
LIG_LIR_Gen_1	182	192	PF02991	0.450
LIG_LIR_Gen_1	292	302	PF02991	0.469
LIG_LIR_Gen_1	387	394	PF02991	0.342
LIG_LIR_Gen_1	408	417	PF02991	0.237
LIG_LIR_LC3C_4	87	91	PF02991	0.326
LIG_LIR_Nem_3	182	187	PF02991	0.411
LIG_LIR_Nem_3	292	297	PF02991	0.452
LIG_LIR_Nem_3	387	391	PF02991	0.342
LIG_LIR_Nem_3	408	412	PF02991	0.237
LIG_PCNA_yPIPBox_3	216	228	PF02747	0.409
LIG_PROFILIN_1	125	131	PF00235	0.536
LIG_Rb_pABgroove_1	111	119	PF01858	0.519
LIG_SH2_CRK	161	165	PF00017	0.354
LIG_SH2_NCK_1	161	165	PF00017	0.359
LIG_SH2_SRC	294	297	PF00017	0.245
LIG_SH2_STAP1	315	319	PF00017	0.438
LIG_SH2_STAT5	179	182	PF00017	0.453
LIG_SH2_STAT5	191	194	PF00017	0.413
LIG_SH2_STAT5	265	268	PF00017	0.409
LIG_SH2_STAT5	294	297	PF00017	0.425
LIG_SH3_1	308	314	PF00018	0.387
LIG_SH3_3	122	128	PF00018	0.543
LIG_SH3_3	134	140	PF00018	0.625
LIG_SH3_3	14	20	PF00018	0.330
LIG_SH3_3	308	314	PF00018	0.433
LIG_SH3_3	362	368	PF00018	0.546
LIG_SUMO_SIM_anti_2	68	76	PF11976	0.349
LIG_SUMO_SIM_anti_2	87	94	PF11976	0.273
LIG_SUMO_SIM_par_1	286	292	PF11976	0.398
LIG_UBA3_1	286	291	PF00899	0.490
MOD_CK1_1	339	345	PF00069	0.619
MOD_CK1_1	392	398	PF00069	0.372
MOD_CK1_1	60	66	PF00069	0.499
MOD_CK1_1	97	103	PF00069	0.639
MOD_CK2_1	374	380	PF00069	0.445
MOD_CK2_1	65	71	PF00069	0.570
MOD_GlcNHglycan	206	209	PF01048	0.233
MOD_GlcNHglycan	21	24	PF01048	0.483
MOD_GlcNHglycan	298	301	PF01048	0.405
MOD_GlcNHglycan	320	323	PF01048	0.530
MOD_GlcNHglycan	351	354	PF01048	0.566
MOD_GlcNHglycan	391	394	PF01048	0.367
MOD_GlcNHglycan	64	67	PF01048	0.678
MOD_GSK3_1	116	123	PF00069	0.661
MOD_GSK3_1	15	22	PF00069	0.389
MOD_GSK3_1	2	9	PF00069	0.485
MOD_GSK3_1	296	303	PF00069	0.553
MOD_GSK3_1	338	345	PF00069	0.665
MOD_GSK3_1	58	65	PF00069	0.728
MOD_GSK3_1	66	73	PF00069	0.489
MOD_GSK3_1	94	101	PF00069	0.659
MOD_N-GLC_1	6	11	PF02516	0.334
MOD_NEK2_1	116	121	PF00069	0.547
MOD_NEK2_1	204	209	PF00069	0.408
MOD_NEK2_1	389	394	PF00069	0.215
MOD_NEK2_1	58	63	PF00069	0.527
MOD_NEK2_2	355	360	PF00069	0.525
MOD_PIKK_1	120	126	PF00454	0.549
MOD_PIKK_1	60	66	PF00454	0.658
MOD_PKA_2	15	21	PF00069	0.368
MOD_PKA_2	185	191	PF00069	0.409
MOD_PKA_2	95	101	PF00069	0.590
MOD_Plk_1	268	274	PF00069	0.409
MOD_Plk_1	70	76	PF00069	0.482
MOD_Plk_2-3	268	274	PF00069	0.409
MOD_Plk_4	185	191	PF00069	0.490
MOD_Plk_4	209	215	PF00069	0.413
MOD_Plk_4	300	306	PF00069	0.294
MOD_Plk_4	408	414	PF00069	0.337
MOD_Plk_4	70	76	PF00069	0.537
MOD_Plk_4	85	91	PF00069	0.304
MOD_ProDKin_1	177	183	PF00069	0.453
MOD_SUMO_for_1	84	87	PF00179	0.330
MOD_SUMO_rev_2	392	400	PF00179	0.237
TRG_DiLeu_BaEn_1	220	225	PF01217	0.413
TRG_ENDOCYTIC_2	161	164	PF00928	0.411
TRG_ENDOCYTIC_2	294	297	PF00928	0.425
TRG_ER_diArg_1	230	233	PF00400	0.459
TRG_ER_diArg_1	281	283	PF00400	0.480
TRG_ER_diArg_1	333	335	PF00400	0.775

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJX8	Leptomonas seymouri	40%	91%
A0A1X0P3Q1	Trypanosomatidae	44%	100%
I7HUG0	Leishmania major	62%	100%
P0CS14	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	37%	97%
P0CS15	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	37%	97%
Q1DNB9	Coccidioides immitis (strain RS)	39%	94%
V5BLJ9	Trypanosoma cruzi	40%	88%