Sm domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LSM domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H331_LEIBR

TriTrypDb:

LbrM.01.0190 , LBRM2903_010006500

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000932	P-body	5	1
GO:0005681	spliceosomal complex	3	4
GO:0005688	U6 snRNP	5	1
GO:0005730	nucleolus	5	1
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	4
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	4
GO:0140513	nuclear protein-containing complex	2	4
GO:1990904	ribonucleoprotein complex	2	4

Expansion

Sequence features

A4H331

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H331

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	4
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	4
GO:0000398	mRNA splicing, via spliceosome	8	4
GO:0006139	nucleobase-containing compound metabolic process	3	4
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	4
GO:0006397	mRNA processing	7	4
GO:0006725	cellular aromatic compound metabolic process	3	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008380	RNA splicing	7	4
GO:0009987	cellular process	1	4
GO:0016070	RNA metabolic process	5	4
GO:0016071	mRNA metabolic process	6	4
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	4
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0046483	heterocycle metabolic process	3	4
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	4
GO:1901360	organic cyclic compound metabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003723	RNA binding	4	4
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.531
DEG_APCC_DBOX_1	23	31	PF00400	0.556
DOC_MAPK_HePTP_8	56	68	PF00069	0.556
DOC_MAPK_MEF2A_6	49	58	PF00069	0.550
DOC_MAPK_MEF2A_6	59	68	PF00069	0.444
DOC_WW_Pin1_4	44	49	PF00397	0.481
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_LIR_Gen_1	31	38	PF02991	0.517
LIG_LIR_Nem_3	31	37	PF02991	0.517
LIG_NRBOX	4	10	PF00104	0.430
LIG_Pex14_2	68	72	PF04695	0.413
LIG_SH2_STAT3	23	26	PF00017	0.566
LIG_SH2_STAT5	65	68	PF00017	0.517
LIG_SH3_1	45	51	PF00018	0.607
LIG_SH3_3	45	51	PF00018	0.607
MOD_CDK_SPK_2	44	49	PF00069	0.426
MOD_CK1_1	39	45	PF00069	0.556
MOD_CK1_1	4	10	PF00069	0.346
MOD_NEK2_1	68	73	PF00069	0.602
MOD_PKA_2	39	45	PF00069	0.426
MOD_Plk_1	68	74	PF00069	0.510
MOD_Plk_4	4	10	PF00069	0.374
MOD_ProDKin_1	44	50	PF00069	0.481
TRG_DiLeu_BaEn_2	52	58	PF01217	0.556
TRG_ENDOCYTIC_2	65	68	PF00928	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6N5	Leptomonas seymouri	80%	100%
A0A451EJ73	Leishmania donovani	84%	100%
A4HRD7	Leishmania infantum	84%	100%
C9ZXG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	93%
E9AC05	Leishmania major	84%	100%
E9AJA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%