LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H330_LEIBR
TriTrypDb:
LbrM.01.0180 , LBRM2903_010006400
Length:
116

Annotations

LeishMANIAdb annotations

A protein with dubious structure and function. It might not even be a membrane protein.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A4H330
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H330

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 75 79 PF00656 0.569
CLV_NRD_NRD_1 68 70 PF00675 0.402
CLV_PCSK_FUR_1 69 73 PF00082 0.422
CLV_PCSK_KEX2_1 45 47 PF00082 0.379
CLV_PCSK_KEX2_1 68 70 PF00082 0.425
CLV_PCSK_KEX2_1 71 73 PF00082 0.414
CLV_PCSK_PC1ET2_1 45 47 PF00082 0.379
CLV_PCSK_PC1ET2_1 71 73 PF00082 0.433
CLV_PCSK_PC7_1 41 47 PF00082 0.366
CLV_PCSK_SKI1_1 68 72 PF00082 0.432
CLV_Separin_Metazoa 65 69 PF03568 0.522
DEG_SCF_FBW7_1 89 94 PF00400 0.600
DOC_CKS1_1 86 91 PF01111 0.595
DOC_MAPK_gen_1 45 52 PF00069 0.533
DOC_MAPK_MEF2A_6 45 54 PF00069 0.532
DOC_PP1_RVXF_1 15 21 PF00149 0.284
DOC_USP7_MATH_1 4 8 PF00917 0.445
DOC_WW_Pin1_4 85 90 PF00397 0.595
LIG_14-3-3_CanoR_1 105 111 PF00244 0.516
LIG_Actin_WH2_2 21 38 PF00022 0.328
LIG_BIR_II_1 1 5 PF00653 0.384
LIG_BIR_III_1 1 5 PF00653 0.487
LIG_BIR_III_3 1 5 PF00653 0.487
LIG_FHA_1 81 87 PF00498 0.699
LIG_LIR_Gen_1 48 58 PF02991 0.563
LIG_LIR_Gen_1 7 13 PF02991 0.433
LIG_LIR_Nem_3 48 54 PF02991 0.562
LIG_LIR_Nem_3 7 12 PF02991 0.450
LIG_Pex14_2 30 34 PF04695 0.284
LIG_SH2_CRK 32 36 PF00017 0.284
LIG_SH2_NCK_1 9 13 PF00017 0.301
LIG_SH2_SRC 51 54 PF00017 0.506
LIG_SH2_STAT5 51 54 PF00017 0.583
LIG_SUMO_SIM_par_1 106 112 PF11976 0.557
MOD_CK1_1 109 115 PF00069 0.529
MOD_CK1_1 24 30 PF00069 0.413
MOD_CK2_1 4 10 PF00069 0.457
MOD_GSK3_1 87 94 PF00069 0.601
MOD_NEK2_1 21 26 PF00069 0.284
MOD_NEK2_1 35 40 PF00069 0.423
MOD_NEK2_1 80 85 PF00069 0.598
MOD_NEK2_2 106 111 PF00069 0.515
MOD_Plk_4 35 41 PF00069 0.501
MOD_ProDKin_1 85 91 PF00069 0.596
MOD_SUMO_for_1 44 47 PF00179 0.567
TRG_DiLeu_BaEn_4 47 53 PF01217 0.507
TRG_ENDOCYTIC_2 32 35 PF00928 0.283
TRG_ENDOCYTIC_2 51 54 PF00928 0.503
TRG_ENDOCYTIC_2 9 12 PF00928 0.367
TRG_ER_diArg_1 67 69 PF00400 0.570

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P726 Leptomonas seymouri 86% 100%
A0A0S4JLP7 Bodo saltans 61% 100%
A0A1X0P346 Trypanosomatidae 77% 99%
A0A3S5H4T5 Leishmania donovani 92% 100%
A0A422NY34 Trypanosoma rangeli 76% 99%
A4HRD6 Leishmania infantum 92% 100%
C9ZXG1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 71% 99%
E9AC04 Leishmania major 91% 100%
E9AJA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
V5B2R4 Trypanosoma cruzi 74% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS