Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H328_LEIBR

TriTrypDb:

LbrM.01.0160 , LBRM2903_010006200

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H328

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H328

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.524
CLV_NRD_NRD_1	113	115	PF00675	0.639
CLV_NRD_NRD_1	240	242	PF00675	0.730
CLV_NRD_NRD_1	266	268	PF00675	0.551
CLV_NRD_NRD_1	275	277	PF00675	0.543
CLV_NRD_NRD_1	289	291	PF00675	0.544
CLV_NRD_NRD_1	311	313	PF00675	0.746
CLV_PCSK_KEX2_1	112	114	PF00082	0.648
CLV_PCSK_KEX2_1	240	242	PF00082	0.730
CLV_PCSK_KEX2_1	266	268	PF00082	0.548
CLV_PCSK_KEX2_1	275	277	PF00082	0.547
CLV_PCSK_KEX2_1	310	312	PF00082	0.759
DEG_APCC_DBOX_1	83	91	PF00400	0.431
DEG_SPOP_SBC_1	337	341	PF00917	0.552
DEG_SPOP_SBC_1	346	350	PF00917	0.491
DOC_CKS1_1	230	235	PF01111	0.698
DOC_MAPK_gen_1	290	297	PF00069	0.630
DOC_PIKK_1	282	289	PF02985	0.708
DOC_PP2B_LxvP_1	175	178	PF13499	0.536
DOC_PP4_FxxP_1	38	41	PF00568	0.439
DOC_USP7_MATH_1	10	14	PF00917	0.602
DOC_USP7_MATH_1	317	321	PF00917	0.824
DOC_USP7_MATH_1	337	341	PF00917	0.515
DOC_USP7_MATH_1	4	8	PF00917	0.606
DOC_USP7_MATH_1	65	69	PF00917	0.342
DOC_WW_Pin1_4	192	197	PF00397	0.681
DOC_WW_Pin1_4	207	212	PF00397	0.565
DOC_WW_Pin1_4	229	234	PF00397	0.718
DOC_WW_Pin1_4	36	41	PF00397	0.662
LIG_14-3-3_CanoR_1	149	154	PF00244	0.439
LIG_14-3-3_CanoR_1	220	230	PF00244	0.570
LIG_14-3-3_CanoR_1	251	260	PF00244	0.579
LIG_14-3-3_CanoR_1	327	332	PF00244	0.681
LIG_14-3-3_CanoR_1	338	343	PF00244	0.724
LIG_Actin_WH2_2	134	151	PF00022	0.446
LIG_Actin_WH2_2	72	90	PF00022	0.588
LIG_APCC_ABBA_1	95	100	PF00400	0.374
LIG_BRCT_BRCA1_1	151	155	PF00533	0.440
LIG_FHA_1	202	208	PF00498	0.556
LIG_FHA_1	37	43	PF00498	0.643
LIG_FHA_2	278	284	PF00498	0.520
LIG_FHA_2	52	58	PF00498	0.458
LIG_LIR_Gen_1	68	76	PF02991	0.440
LIG_LIR_Nem_3	68	72	PF02991	0.437
LIG_PDZ_Class_1	359	364	PF00595	0.553
LIG_Pex14_2	155	159	PF04695	0.450
LIG_PTB_Apo_2	168	175	PF02174	0.496
LIG_PTB_Apo_2	32	39	PF02174	0.466
LIG_PTB_Phospho_1	168	174	PF10480	0.498
LIG_SH2_GRB2like	33	36	PF00017	0.473
LIG_SH2_NCK_1	253	257	PF00017	0.567
LIG_SH2_SRC	33	36	PF00017	0.530
LIG_SH2_STAP1	253	257	PF00017	0.574
LIG_SH2_STAT5	174	177	PF00017	0.535
LIG_SH2_STAT5	33	36	PF00017	0.473
LIG_UBA3_1	285	291	PF00899	0.555
LIG_WRC_WIRS_1	52	57	PF05994	0.460
LIG_WW_3	324	328	PF00397	0.802
MOD_CDC14_SPxK_1	195	198	PF00782	0.744
MOD_CDK_SPxK_1	192	198	PF00069	0.744
MOD_CDK_SPxK_1	229	235	PF00069	0.576
MOD_CK1_1	191	197	PF00069	0.769
MOD_CK1_1	206	212	PF00069	0.562
MOD_CK1_1	222	228	PF00069	0.781
MOD_CK1_1	261	267	PF00069	0.724
MOD_CK1_1	270	276	PF00069	0.627
MOD_CK1_1	277	283	PF00069	0.533
MOD_CK1_1	316	322	PF00069	0.672
MOD_CK1_1	340	346	PF00069	0.700
MOD_CK1_1	347	353	PF00069	0.641
MOD_CK1_1	51	57	PF00069	0.598
MOD_CK2_1	158	164	PF00069	0.473
MOD_CK2_1	301	307	PF00069	0.485
MOD_CK2_1	65	71	PF00069	0.363
MOD_Cter_Amidation	238	241	PF01082	0.589
MOD_GlcNHglycan	215	218	PF01048	0.662
MOD_GlcNHglycan	224	227	PF01048	0.569
MOD_GlcNHglycan	237	240	PF01048	0.524
MOD_GlcNHglycan	315	318	PF01048	0.769
MOD_GlcNHglycan	319	322	PF01048	0.818
MOD_GlcNHglycan	351	354	PF01048	0.574
MOD_GlcNHglycan	7	10	PF01048	0.736
MOD_GSK3_1	121	128	PF00069	0.412
MOD_GSK3_1	184	191	PF00069	0.768
MOD_GSK3_1	192	199	PF00069	0.685
MOD_GSK3_1	203	210	PF00069	0.525
MOD_GSK3_1	220	227	PF00069	0.759
MOD_GSK3_1	231	238	PF00069	0.576
MOD_GSK3_1	261	268	PF00069	0.718
MOD_GSK3_1	270	277	PF00069	0.737
MOD_GSK3_1	313	320	PF00069	0.620
MOD_GSK3_1	336	343	PF00069	0.655
MOD_GSK3_1	344	351	PF00069	0.577
MOD_GSK3_1	352	359	PF00069	0.798
MOD_GSK3_1	47	54	PF00069	0.418
MOD_GSK3_1	75	82	PF00069	0.580
MOD_LATS_1	218	224	PF00433	0.566
MOD_LATS_1	249	255	PF00433	0.573
MOD_N-GLC_1	149	154	PF02516	0.439
MOD_NEK2_1	133	138	PF00069	0.555
MOD_NEK2_1	148	153	PF00069	0.353
MOD_NEK2_1	186	191	PF00069	0.562
MOD_NEK2_1	203	208	PF00069	0.671
MOD_NEK2_1	259	264	PF00069	0.791
MOD_NEK2_1	342	347	PF00069	0.584
MOD_NEK2_1	354	359	PF00069	0.776
MOD_NEK2_1	79	84	PF00069	0.578
MOD_PIKK_1	125	131	PF00454	0.377
MOD_PIKK_1	186	192	PF00454	0.768
MOD_PIKK_1	82	88	PF00454	0.453
MOD_PK_1	113	119	PF00069	0.516
MOD_PK_1	149	155	PF00069	0.441
MOD_PK_1	188	194	PF00069	0.546
MOD_PKA_1	113	119	PF00069	0.516
MOD_PKA_1	240	246	PF00069	0.592
MOD_PKA_2	113	119	PF00069	0.467
MOD_PKA_2	148	154	PF00069	0.439
MOD_PKA_2	219	225	PF00069	0.575
MOD_PKA_2	240	246	PF00069	0.592
MOD_PKA_2	265	271	PF00069	0.557
MOD_PKA_2	274	280	PF00069	0.533
MOD_PKA_2	295	301	PF00069	0.522
MOD_PKA_2	313	319	PF00069	0.552
MOD_PKA_2	326	332	PF00069	0.595
MOD_PKA_2	337	343	PF00069	0.590
MOD_Plk_1	149	155	PF00069	0.462
MOD_Plk_4	133	139	PF00069	0.588
MOD_Plk_4	203	209	PF00069	0.748
MOD_ProDKin_1	192	198	PF00069	0.683
MOD_ProDKin_1	207	213	PF00069	0.567
MOD_ProDKin_1	229	235	PF00069	0.719
MOD_ProDKin_1	36	42	PF00069	0.663
MOD_SUMO_rev_2	298	302	PF00179	0.450
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.590
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.577
TRG_ENDOCYTIC_2	253	256	PF00928	0.569
TRG_ENDOCYTIC_2	69	72	PF00928	0.423
TRG_ER_diArg_1	111	114	PF00400	0.617
TRG_ER_diArg_1	275	278	PF00400	0.581
TRG_ER_diArg_1	310	312	PF00400	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P3	Leptomonas seymouri	49%	92%
A0A3S5H4T3	Leishmania donovani	71%	100%
A4HRD4	Leishmania infantum	71%	100%
E9AC02	Leishmania major	66%	100%
E9AJ99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%