Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H327_LEIBR

TriTrypDb:

LbrM.01.0150 , LBRM2903_010006100

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H327

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H327

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.406
CLV_C14_Caspase3-7	94	98	PF00656	0.581
CLV_NRD_NRD_1	118	120	PF00675	0.658
CLV_NRD_NRD_1	12	14	PF00675	0.593
CLV_NRD_NRD_1	131	133	PF00675	0.622
CLV_NRD_NRD_1	188	190	PF00675	0.603
CLV_PCSK_FUR_1	129	133	PF00082	0.588
CLV_PCSK_KEX2_1	118	120	PF00082	0.658
CLV_PCSK_KEX2_1	12	14	PF00082	0.593
CLV_PCSK_KEX2_1	131	133	PF00082	0.622
CLV_PCSK_KEX2_1	188	190	PF00082	0.385
CLV_PCSK_KEX2_1	208	210	PF00082	0.358
CLV_PCSK_KEX2_1	270	272	PF00082	0.656
CLV_PCSK_KEX2_1	561	563	PF00082	0.815
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.435
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.656
CLV_PCSK_PC1ET2_1	561	563	PF00082	0.815
CLV_PCSK_PC7_1	127	133	PF00082	0.588
CLV_PCSK_PC7_1	204	210	PF00082	0.419
CLV_PCSK_PC7_1	557	563	PF00082	0.566
CLV_PCSK_SKI1_1	209	213	PF00082	0.442
CLV_PCSK_SKI1_1	247	251	PF00082	0.384
CLV_PCSK_SKI1_1	34	38	PF00082	0.565
CLV_PCSK_SKI1_1	441	445	PF00082	0.717
DEG_COP1_1	477	488	PF00400	0.608
DEG_SPOP_SBC_1	151	155	PF00917	0.701
DEG_SPOP_SBC_1	412	416	PF00917	0.835
DOC_CKS1_1	264	269	PF01111	0.538
DOC_CKS1_1	365	370	PF01111	0.586
DOC_CKS1_1	512	517	PF01111	0.598
DOC_CKS1_1	518	523	PF01111	0.555
DOC_CKS1_1	66	71	PF01111	0.635
DOC_MAPK_gen_1	223	231	PF00069	0.775
DOC_PP2B_LxvP_1	366	369	PF13499	0.655
DOC_PP2B_LxvP_1	54	57	PF13499	0.751
DOC_PP4_FxxP_1	388	391	PF00568	0.567
DOC_SPAK_OSR1_1	562	566	PF12202	0.706
DOC_USP7_MATH_1	113	117	PF00917	0.663
DOC_USP7_MATH_1	242	246	PF00917	0.662
DOC_USP7_MATH_1	320	324	PF00917	0.827
DOC_USP7_MATH_1	380	384	PF00917	0.754
DOC_USP7_MATH_1	396	400	PF00917	0.571
DOC_USP7_MATH_1	412	416	PF00917	0.571
DOC_USP7_MATH_1	464	468	PF00917	0.609
DOC_USP7_MATH_1	474	478	PF00917	0.644
DOC_USP7_MATH_1	5	9	PF00917	0.555
DOC_USP7_MATH_1	555	559	PF00917	0.703
DOC_USP7_MATH_1	85	89	PF00917	0.596
DOC_USP7_MATH_1	96	100	PF00917	0.537
DOC_WW_Pin1_4	106	111	PF00397	0.750
DOC_WW_Pin1_4	145	150	PF00397	0.808
DOC_WW_Pin1_4	233	238	PF00397	0.636
DOC_WW_Pin1_4	263	268	PF00397	0.545
DOC_WW_Pin1_4	316	321	PF00397	0.733
DOC_WW_Pin1_4	364	369	PF00397	0.626
DOC_WW_Pin1_4	413	418	PF00397	0.592
DOC_WW_Pin1_4	454	459	PF00397	0.845
DOC_WW_Pin1_4	480	485	PF00397	0.690
DOC_WW_Pin1_4	511	516	PF00397	0.749
DOC_WW_Pin1_4	517	522	PF00397	0.638
DOC_WW_Pin1_4	65	70	PF00397	0.632
LIG_14-3-3_CanoR_1	142	146	PF00244	0.813
LIG_14-3-3_CanoR_1	181	187	PF00244	0.499
LIG_14-3-3_CanoR_1	213	219	PF00244	0.543
LIG_14-3-3_CanoR_1	311	320	PF00244	0.795
LIG_14-3-3_CanoR_1	34	39	PF00244	0.617
LIG_14-3-3_CanoR_1	533	539	PF00244	0.611
LIG_APCC_ABBA_1	191	196	PF00400	0.593
LIG_BRCT_BRCA1_1	377	381	PF00533	0.823
LIG_eIF4E_1	33	39	PF01652	0.564
LIG_FHA_1	155	161	PF00498	0.551
LIG_FHA_1	185	191	PF00498	0.516
LIG_FHA_1	33	39	PF00498	0.778
LIG_FHA_1	365	371	PF00498	0.581
LIG_FHA_1	53	59	PF00498	0.461
LIG_FHA_1	535	541	PF00498	0.619
LIG_FHA_1	84	90	PF00498	0.606
LIG_FHA_2	173	179	PF00498	0.656
LIG_FHA_2	264	270	PF00498	0.629
LIG_FHA_2	280	286	PF00498	0.397
LIG_FHA_2	468	474	PF00498	0.584
LIG_FHA_2	554	560	PF00498	0.578
LIG_LIR_Apic_2	289	295	PF02991	0.786
LIG_LIR_Apic_2	387	391	PF02991	0.566
LIG_LIR_Apic_2	60	64	PF02991	0.721
LIG_LIR_Apic_2	73	78	PF02991	0.574
LIG_LIR_Gen_1	192	200	PF02991	0.509
LIG_LIR_Gen_1	248	257	PF02991	0.378
LIG_LIR_Nem_3	192	197	PF02991	0.502
LIG_LIR_Nem_3	248	253	PF02991	0.493
LIG_LIR_Nem_3	269	275	PF02991	0.441
LIG_MYND_1	364	368	PF01753	0.580
LIG_Rb_pABgroove_1	188	196	PF01858	0.600
LIG_SH2_CRK	292	296	PF00017	0.796
LIG_SH2_CRK	421	425	PF00017	0.630
LIG_SH2_CRK	61	65	PF00017	0.717
LIG_SH2_NCK_1	121	125	PF00017	0.698
LIG_SH2_NCK_1	194	198	PF00017	0.584
LIG_SH2_NCK_1	292	296	PF00017	0.796
LIG_SH2_SRC	121	124	PF00017	0.581
LIG_SH2_SRC	194	197	PF00017	0.584
LIG_SH2_SRC	290	293	PF00017	0.794
LIG_SH2_STAP1	194	198	PF00017	0.584
LIG_SH2_STAP1	421	425	PF00017	0.630
LIG_SH2_STAT5	106	109	PF00017	0.698
LIG_SH2_STAT5	173	176	PF00017	0.448
LIG_SH2_STAT5	264	267	PF00017	0.632
LIG_SH2_STAT5	272	275	PF00017	0.540
LIG_SH3_3	291	297	PF00018	0.784
LIG_SH3_3	358	364	PF00018	0.739
LIG_SH3_3	452	458	PF00018	0.602
LIG_SH3_3	482	488	PF00018	0.799
LIG_SH3_3	498	504	PF00018	0.646
LIG_SH3_3	512	518	PF00018	0.636
LIG_SH3_3	520	526	PF00018	0.695
LIG_SH3_3	548	554	PF00018	0.605
LIG_SH3_4	234	241	PF00018	0.556
LIG_SUMO_SIM_par_1	189	196	PF11976	0.463
LIG_TRAF2_1	266	269	PF00917	0.645
LIG_WW_1	418	421	PF00397	0.582
MOD_CDC14_SPxK_1	457	460	PF00782	0.591
MOD_CDC14_SPxK_1	487	490	PF00782	0.606
MOD_CDK_SPK_2	106	111	PF00069	0.583
MOD_CDK_SPK_2	511	516	PF00069	0.595
MOD_CDK_SPxK_1	454	460	PF00069	0.845
MOD_CDK_SPxK_1	484	490	PF00069	0.606
MOD_CDK_SPxxK_3	263	270	PF00069	0.537
MOD_CK1_1	109	115	PF00069	0.790
MOD_CK1_1	144	150	PF00069	0.810
MOD_CK1_1	153	159	PF00069	0.660
MOD_CK1_1	301	307	PF00069	0.831
MOD_CK1_1	353	359	PF00069	0.606
MOD_CK1_1	467	473	PF00069	0.803
MOD_CK1_1	536	542	PF00069	0.618
MOD_CK1_1	73	79	PF00069	0.551
MOD_CK1_1	81	87	PF00069	0.624
MOD_CK2_1	162	168	PF00069	0.651
MOD_CK2_1	172	178	PF00069	0.626
MOD_CK2_1	218	224	PF00069	0.506
MOD_CK2_1	263	269	PF00069	0.640
MOD_CK2_1	279	285	PF00069	0.398
MOD_CK2_1	396	402	PF00069	0.837
MOD_CK2_1	467	473	PF00069	0.582
MOD_CK2_1	553	559	PF00069	0.586
MOD_Cter_Amidation	129	132	PF01082	0.677
MOD_GlcNHglycan	111	114	PF01048	0.792
MOD_GlcNHglycan	352	355	PF01048	0.612
MOD_GlcNHglycan	377	380	PF01048	0.747
MOD_GlcNHglycan	382	385	PF01048	0.659
MOD_GlcNHglycan	388	391	PF01048	0.562
MOD_GlcNHglycan	45	48	PF01048	0.724
MOD_GlcNHglycan	49	53	PF01048	0.735
MOD_GlcNHglycan	548	551	PF01048	0.786
MOD_GlcNHglycan	93	96	PF01048	0.799
MOD_GlcNHglycan	97	101	PF01048	0.737
MOD_GSK3_1	105	112	PF00069	0.640
MOD_GSK3_1	141	148	PF00069	0.812
MOD_GSK3_1	150	157	PF00069	0.667
MOD_GSK3_1	214	221	PF00069	0.504
MOD_GSK3_1	299	306	PF00069	0.720
MOD_GSK3_1	316	323	PF00069	0.680
MOD_GSK3_1	346	353	PF00069	0.707
MOD_GSK3_1	380	387	PF00069	0.692
MOD_GSK3_1	439	446	PF00069	0.718
MOD_GSK3_1	476	483	PF00069	0.744
MOD_GSK3_1	48	55	PF00069	0.561
MOD_GSK3_1	525	532	PF00069	0.756
MOD_GSK3_1	564	571	PF00069	0.747
MOD_GSK3_1	81	88	PF00069	0.797
MOD_GSK3_1	91	98	PF00069	0.658
MOD_N-GLC_1	90	95	PF02516	0.599
MOD_NEK2_1	279	284	PF00069	0.660
MOD_NEK2_1	375	380	PF00069	0.585
MOD_NEK2_1	420	425	PF00069	0.844
MOD_NEK2_1	70	75	PF00069	0.625
MOD_NEK2_1	90	95	PF00069	0.536
MOD_NEK2_2	242	247	PF00069	0.405
MOD_PIKK_1	525	531	PF00454	0.809
MOD_PK_1	162	168	PF00069	0.544
MOD_PKA_2	141	147	PF00069	0.812
MOD_PKA_2	182	188	PF00069	0.498
MOD_PKA_2	299	305	PF00069	0.723
MOD_PKA_2	43	49	PF00069	0.648
MOD_PKA_2	91	97	PF00069	0.808
MOD_Plk_1	401	407	PF00069	0.812
MOD_Plk_1	48	54	PF00069	0.657
MOD_Plk_4	34	40	PF00069	0.776
MOD_Plk_4	401	407	PF00069	0.760
MOD_Plk_4	420	426	PF00069	0.765
MOD_Plk_4	439	445	PF00069	0.601
MOD_Plk_4	85	91	PF00069	0.599
MOD_ProDKin_1	106	112	PF00069	0.749
MOD_ProDKin_1	145	151	PF00069	0.805
MOD_ProDKin_1	233	239	PF00069	0.628
MOD_ProDKin_1	263	269	PF00069	0.542
MOD_ProDKin_1	316	322	PF00069	0.731
MOD_ProDKin_1	364	370	PF00069	0.628
MOD_ProDKin_1	413	419	PF00069	0.590
MOD_ProDKin_1	454	460	PF00069	0.845
MOD_ProDKin_1	480	486	PF00069	0.690
MOD_ProDKin_1	511	517	PF00069	0.750
MOD_ProDKin_1	522	528	PF00069	0.578
MOD_ProDKin_1	65	71	PF00069	0.635
MOD_SUMO_rev_2	433	443	PF00179	0.801
MOD_SUMO_rev_2	558	563	PF00179	0.575
TRG_DiLeu_BaEn_2	558	564	PF01217	0.564
TRG_DiLeu_BaEn_4	268	274	PF01217	0.658
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.384
TRG_ENDOCYTIC_2	121	124	PF00928	0.599
TRG_ENDOCYTIC_2	194	197	PF00928	0.489
TRG_ENDOCYTIC_2	254	257	PF00928	0.370
TRG_ENDOCYTIC_2	272	275	PF00928	0.389
TRG_ENDOCYTIC_2	421	424	PF00928	0.633
TRG_ER_diArg_1	12	14	PF00400	0.593
TRG_ER_diArg_1	128	131	PF00400	0.695
TRG_ER_diArg_1	179	182	PF00400	0.649
TRG_ER_diArg_1	188	190	PF00400	0.365
TRG_ER_diArg_1	41	44	PF00400	0.662
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.751
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	271	276	PF00026	0.675

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4T2	Leishmania donovani	50%	87%
A4HRD3	Leishmania infantum	50%	87%
E9AC01	Leishmania major	50%	98%
E9AJ98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%