Glycosyl transferase family 11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glycosyl transferase family 11, putative

Species:

Leishmania braziliensis

UniProt:

A4H325_LEIBR

TriTrypDb:

LbrM.01.0130 , LBRM2903_010005900

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H325

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H325

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0006486	protein glycosylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019538	protein metabolic process	3	1
GO:0036065	fucosylation	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043413	macromolecule glycosylation	3	1
GO:0070085	glycosylation	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008107	galactoside 2-alpha-L-fucosyltransferase activity	7	12
GO:0008417	fucosyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12
GO:0031127	alpha-(1,2)-fucosyltransferase activity	6	12
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.350
CLV_NRD_NRD_1	76	78	PF00675	0.512
CLV_PCSK_KEX2_1	140	142	PF00082	0.350
CLV_PCSK_SKI1_1	165	169	PF00082	0.488
CLV_PCSK_SKI1_1	258	262	PF00082	0.326
CLV_PCSK_SKI1_1	77	81	PF00082	0.269
DEG_APCC_DBOX_1	164	172	PF00400	0.435
DEG_APCC_DBOX_1	257	265	PF00400	0.322
DEG_APCC_DBOX_1	287	295	PF00400	0.411
DEG_ODPH_VHL_1	187	200	PF01847	0.399
DEG_SPOP_SBC_1	28	32	PF00917	0.449
DOC_CYCLIN_RxL_1	199	210	PF00134	0.353
DOC_CYCLIN_RxL_1	74	82	PF00134	0.276
DOC_MAPK_gen_1	221	230	PF00069	0.382
DOC_MAPK_MEF2A_6	223	232	PF00069	0.371
DOC_MAPK_MEF2A_6	258	265	PF00069	0.316
DOC_MAPK_NFAT4_5	258	266	PF00069	0.333
DOC_PP1_RVXF_1	200	207	PF00149	0.329
DOC_PP2B_LxvP_1	196	199	PF13499	0.472
DOC_USP7_MATH_1	28	32	PF00917	0.425
DOC_USP7_MATH_2	112	118	PF00917	0.245
DOC_WW_Pin1_4	172	177	PF00397	0.516
DOC_WW_Pin1_4	247	252	PF00397	0.572
DOC_WW_Pin1_4	56	61	PF00397	0.521
LIG_14-3-3_CanoR_1	211	217	PF00244	0.347
LIG_14-3-3_CanoR_1	288	292	PF00244	0.453
LIG_14-3-3_CanoR_1	46	55	PF00244	0.266
LIG_AP2alpha_1	147	151	PF02296	0.501
LIG_APCC_ABBA_1	203	208	PF00400	0.308
LIG_APCC_ABBAyCdc20_2	202	208	PF00400	0.325
LIG_BRCT_BRCA1_1	297	301	PF00533	0.300
LIG_BRCT_BRCA1_1	96	100	PF00533	0.333
LIG_BRCT_BRCA1_2	297	303	PF00533	0.411
LIG_EH1_1	5	13	PF00400	0.306
LIG_eIF4E_1	224	230	PF01652	0.266
LIG_EVH1_1	179	183	PF00568	0.418
LIG_EVH1_1	62	66	PF00568	0.337
LIG_EVH1_2	63	67	PF00568	0.333
LIG_FHA_1	132	138	PF00498	0.368
LIG_FHA_1	71	77	PF00498	0.546
LIG_Integrin_RGD_1	141	143	PF01839	0.356
LIG_LIR_Gen_1	143	151	PF02991	0.354
LIG_LIR_Nem_3	143	147	PF02991	0.360
LIG_LIR_Nem_3	149	154	PF02991	0.334
LIG_LIR_Nem_3	280	285	PF02991	0.266
LIG_LIR_Nem_3	39	44	PF02991	0.344
LIG_LIR_Nem_3	98	104	PF02991	0.342
LIG_LYPXL_yS_3	104	107	PF13949	0.355
LIG_MYND_1	60	64	PF01753	0.367
LIG_NRBOX	167	173	PF00104	0.466
LIG_PCNA_PIPBox_1	153	162	PF02747	0.383
LIG_PCNA_yPIPBox_3	146	160	PF02747	0.404
LIG_PDZ_Class_2	315	320	PF00595	0.300
LIG_Pex14_1	281	285	PF04695	0.266
LIG_Pex14_1	41	45	PF04695	0.329
LIG_Pex14_2	147	151	PF04695	0.449
LIG_PTB_Apo_2	273	280	PF02174	0.360
LIG_SH2_GRB2like	285	288	PF00017	0.266
LIG_SH2_SRC	23	26	PF00017	0.436
LIG_SH2_STAP1	144	148	PF00017	0.411
LIG_SH2_STAP1	160	164	PF00017	0.271
LIG_SH2_STAT5	144	147	PF00017	0.376
LIG_SH2_STAT5	219	222	PF00017	0.337
LIG_SH2_STAT5	23	26	PF00017	0.436
LIG_SH2_STAT5	285	288	PF00017	0.281
LIG_SH2_STAT5	313	316	PF00017	0.300
LIG_SH3_3	107	113	PF00018	0.346
LIG_SH3_3	177	183	PF00018	0.525
LIG_SH3_3	186	192	PF00018	0.536
LIG_SH3_3	291	297	PF00018	0.266
LIG_SH3_3	299	305	PF00018	0.266
LIG_SH3_3	54	60	PF00018	0.465
LIG_SH3_3	65	71	PF00018	0.333
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.404
LIG_SUMO_SIM_anti_2	259	265	PF11976	0.336
LIG_WW_2	60	63	PF00397	0.509
MOD_CK1_1	131	137	PF00069	0.488
MOD_CK1_1	240	246	PF00069	0.513
MOD_CK1_1	277	283	PF00069	0.290
MOD_CK2_1	28	34	PF00069	0.411
MOD_GlcNHglycan	116	119	PF01048	0.367
MOD_GlcNHglycan	176	179	PF01048	0.677
MOD_GlcNHglycan	238	242	PF01048	0.502
MOD_GlcNHglycan	251	254	PF01048	0.537
MOD_GlcNHglycan	31	34	PF01048	0.538
MOD_GSK3_1	11	18	PF00069	0.383
MOD_GSK3_1	36	43	PF00069	0.506
MOD_N-GLC_1	275	280	PF02516	0.266
MOD_N-GLC_1	46	51	PF02516	0.361
MOD_NEK2_1	11	16	PF00069	0.364
MOD_NEK2_1	212	217	PF00069	0.405
MOD_NEK2_1	264	269	PF00069	0.322
MOD_NEK2_1	274	279	PF00069	0.301
MOD_NEK2_1	55	60	PF00069	0.605
MOD_NEK2_2	128	133	PF00069	0.466
MOD_NEK2_2	40	45	PF00069	0.326
MOD_PIKK_1	264	270	PF00454	0.442
MOD_PIKK_1	46	52	PF00454	0.264
MOD_PKA_2	287	293	PF00069	0.443
MOD_PKA_2	36	42	PF00069	0.452
MOD_Plk_1	142	148	PF00069	0.419
MOD_Plk_1	237	243	PF00069	0.489
MOD_Plk_1	275	281	PF00069	0.266
MOD_Plk_4	106	112	PF00069	0.405
MOD_Plk_4	228	234	PF00069	0.397
MOD_Plk_4	36	42	PF00069	0.377
MOD_ProDKin_1	172	178	PF00069	0.514
MOD_ProDKin_1	247	253	PF00069	0.570
MOD_ProDKin_1	56	62	PF00069	0.518
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.358
TRG_ENDOCYTIC_2	104	107	PF00928	0.336
TRG_ENDOCYTIC_2	144	147	PF00928	0.359
TRG_ER_diArg_1	139	141	PF00400	0.328
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.361

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE7	Leptomonas seymouri	60%	99%
A0A0S4JMG1	Bodo saltans	37%	76%
A0A1X0P2U6	Trypanosomatidae	50%	99%
A0A3S5H4T0	Leishmania donovani	83%	100%
A0A422NY61	Trypanosoma rangeli	53%	100%
A4HRD1	Leishmania infantum	83%	100%
C9ZXG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ABZ9	Leishmania major	83%	99%
E9AJ96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5BBV1	Trypanosoma cruzi	54%	100%